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1. 发明授权

US06186982B1 Subcutaneous drug delivery device with improved filling system 失效
标题翻译：具有改善灌装系统的皮下给药装置
公开(公告)号：US06186982B1
公开(公告)日：2001-02-13
申请号：US09072875
申请日：1998-05-05
申请人： Joseph Gross , Zvi Nitzan , Izrail Tsals , Mario Razonowich , Oz Cabiri , Haim Danon , Gilad Lavi
发明人： Joseph Gross , Zvi Nitzan , Izrail Tsals , Mario Razonowich , Oz Cabiri , Haim Danon , Gilad Lavi
IPC分类号： A61M3700
CPC分类号： A61M5/14248 , A61M5/14276 , A61M5/14593 , A61M5/155 , A61M2005/14252 , A61M2005/1426 , A61M2005/14264
摘要： A subcutaneous drug delivery device having a housing having an internal reservoir in communication with a drug delivery needle via a fluid path. An expandable chamber disposed adjacent to the reservoir forces drug from the reservoir to the needle when supplied with a gas. A flow regulating chamber, in communication with the fluid path, is capable of volumetric changes in response to temperature and/or pressure changes. An increase in the volume of the flow regulating chamber increases flow resistance to the needle and thereby counteracts the corresponding increase in delivery rate resulting from the expansion of the expandable chamber due to the same volumetric changes in response to temperature and/or pressure. The device also includes an improved filling system that enables the reservoir within the device to be filled with drug from a source without regard to filling position and with a decreased risk of injury from needles. Moreover, the filling system provides an accurate measure of drug transferred into the device thus enabling patients to fill the devices and to ensure proper dosage upon delivery.
摘要翻译：一种具有壳体的皮下药物输送装置，该壳体具有经由流体路径与药物输送针连通的内部储存器。邻近储存器设置的可膨胀室在供应气体时迫使药物从储存器到针头。与流体路径连通的流量调节室能够响应于温度和/或压力变化而发生体积变化。流量调节室的体积的增加增加了对针的流动阻力，从而抵消由于响应于温度和/或压力的相同的体积变化而导致的可膨胀室膨胀导致的输送速率的相应增加。还包括一种改进的填充系统，其使装置内的储存器能够从源处填充药物，而不考虑填充位置并且降低针头受伤的风险。此外，填充系统提供了转移到装置中的药物的精确测量，从而使得患者能够填充装置并确保递送时的适当剂量。

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