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1. 发明申请

US20100047915A1 IDENTIFYING PATIENTS AT RISK FOR LIFE THREATENING ARRHYTHMIAS 审中-公开
标题翻译：识别患有ARRHYTHMIAS生命危险的患者
公开(公告)号：US20100047915A1
公开(公告)日：2010-02-25
申请号：US12606173
申请日：2009-10-26
申请人： Orhan Soykan , Amy C. Dearking , Timothy H. Robinson , Walter H. Olson , Vinod Sharma
发明人： Orhan Soykan , Amy C. Dearking , Timothy H. Robinson , Walter H. Olson , Vinod Sharma
IPC分类号： G01N33/00
CPC分类号： G01N33/6893 , G01N2800/326
摘要： The invention is a method for identifying proteins associated with sudden cardiac death (SCD) and for assessing a patient's risk of SCD by determining the amount of one or more SCD-associated proteins in the patient. Typically, the patient submits a sample, such as a blood sample, which is tested for one or more SCD-associated proteins. Based upon the results of the tests, the patient's risk of SCD may be assessed.
摘要翻译：本发明是鉴定与心脏猝死相关的蛋白质（SCD）的方法，并且通过确定患者中一种或多种与SCD相关的蛋白质的量来评估患者的SCD风险。通常，患者提交样品，例如血液样品，其被测试一种或多种与SCD相关的蛋白质。根据测试结果，可以评估患者SCD的风险。

2. 发明授权

US07608458B2 Identifying patients at risk for life threatening arrhythmias 失效
标题翻译：识别处于危及生命的心律失常风险的患者
公开(公告)号：US07608458B2
公开(公告)日：2009-10-27
申请号：US11157549
申请日：2005-06-21
申请人： Orhan Soykan , Amy C. Dearking , Timothy H. Robinson , Walter H. Olson , Vinod Sharma
发明人： Orhan Soykan , Amy C. Dearking , Timothy H. Robinson , Walter H. Olson , Vinod Sharma
IPC分类号： G01N33/00
CPC分类号： G01N33/6893 , G01N2800/326
摘要： The invention is a method for identifying proteins associated with sudden cardiac death (SCD) and for assessing a patient's risk of SCD by determining the amount of one or more SCD-associated proteins in the patient. Typically, the patient submits a sample, such as a blood sample, which is tested for one or more SCD-associated proteins. Based upon the results of the tests, the patient's risk of SCD may be assessed.
摘要翻译：本发明是鉴定与心脏猝死相关的蛋白质（SCD）的方法，并且通过确定患者中一种或多种与SCD相关的蛋白质的量来评估患者的SCD风险。通常，患者提交样品，例如血液样品，其被测试一种或多种与SCD相关的蛋白质。根据测试结果，可以评估患者SCD的风险。

3. 发明授权

US07622303B2 Methods for identifying patients at risk for life threatening arrhythmias 有权
标题翻译：确定危及生命危险的心律失常患者的方法
公开(公告)号：US07622303B2
公开(公告)日：2009-11-24
申请号：US11050611
申请日：2005-02-03
申请人： Orhan Soykan , Timothy H. Robinson , Walter H. Olson , Vinod Sharma , Amy C. Dearking
发明人： Orhan Soykan , Timothy H. Robinson , Walter H. Olson , Vinod Sharma , Amy C. Dearking
IPC分类号： G01N33/00
CPC分类号： G01N33/6893 , G01N2800/326 , Y10T436/13
摘要： In general, the invention is directed to systems and techniques for assessing a risk of ventricular tachyarrhythmia in a patient by measuring one or more biochemical markers that reflect the health of a patient. Typically, the patient submits a sample, such as a blood sample, which is tested for one or more biomarkers. Based upon the results of the tests, the patient's risk of ventricular tachyarrhythmia may be assessed. When the patient is found to be at risk, the patient may receive an implantable medical device or drug therapy to address the risk.
摘要翻译：通常，本发明涉及通过测量反映患者健康的一种或多种生物化学标记来评估患者的心室性快速性心律失常风险的系统和技术。通常，患者提交样品，例如血液样品，其被测试用于一种或多种生物标志物。根据测试结果，可以评估患者的心室性心律失常风险。当患者被发现处于危险中时，患者可能会接受可植入的医疗设备或药物治疗来解决风险。

4. 发明授权

US08013133B2 Genetic modification of targeted regions of the cardiac conduction system 有权
标题翻译：心脏传导系统目标区域的遗传修饰
公开(公告)号：US08013133B2
公开(公告)日：2011-09-06
申请号：US10423595
申请日：2003-04-25
申请人： Vinod Sharma , Walter H. Olson
发明人： Vinod Sharma , Walter H. Olson
IPC分类号： A61K48/00 , C12N15/00 , C07H21/02
CPC分类号： C12N15/86 , A61K38/177 , A61K48/00 , A61K48/005 , C12N2750/14143
摘要： Disclosed are methods and systems for preventing or treating cardiac dysfunction, particularly cardiac pacing dysfunction by genetic modification of the conduction system of the heart. In one embodiment, the invention provides a method of genetically modifying the cells by delivering to the cells one or more coding sequence in a genetic construct capable of modifying the expression of ion channels of the cells.
摘要翻译：公开了通过心脏传导系统的遗传修饰来预防或治疗心脏功能障碍，特别是心脏起搏功能障碍的方法和系统。在一个实施方案中，本发明提供了通过向细胞递送能够修饰细胞的离子通道的表达的遗传构建体中的一个或多个编码序列来遗传修饰细胞的方法。

5. 发明授权

US06892094B2 Combined anti-tachycardia pacing (ATP) and high voltage therapy for treating ventricular arrhythmias 有权
标题翻译：联合抗心动过速起搏（ATP）和高压治疗治疗室性心律失常
公开(公告)号：US06892094B2
公开(公告)日：2005-05-10
申请号：US10137517
申请日：2002-04-30
申请人： Kevin T. Ousdigian , Vasant Padmanabhan , Paul J. DeGroot , Walter H. Olson , Vinod Sharma , Cameron J. Kaszas , Paul G. Krause
发明人： Kevin T. Ousdigian , Vasant Padmanabhan , Paul J. DeGroot , Walter H. Olson , Vinod Sharma , Cameron J. Kaszas , Paul G. Krause
IPC分类号： A61N1/365 , A61N1/39
CPC分类号： A61N1/3962 , A61N1/3987
摘要： A system and method for treating an arrhythmia of the heart, involves delivery of anti-tachy pacing (ATP) pulses to the heart, possibly followed by the delivery of a high-voltage shock. ATP delivery is controlled such that the time delivery of any high-voltage shock is not affected by the prior delivery of the ATP pulses. System control may be accomplished using one or more programmable parameters, which may include a user-specified shock energy.
摘要翻译：用于治疗心脏心律失常的系统和方法涉及向心脏递送抗起搏起搏（ATP）脉冲，可能之后传递高压休克。控制ATP递送，使得任何高压休克的时间传递不受ATP脉冲的先前递送的影响。系统控制可以使用一个或多个可编程参数来实现，其可以包括用户指定的冲击能量。

6. 发明授权

US06922585B2 Method and apparatus for predicting recurring ventricular arrhythmias 有权
标题翻译：用于预测复发性室性心律失常的方法和装置
公开(公告)号：US06922585B2
公开(公告)日：2005-07-26
申请号：US10117465
申请日：2002-04-05
申请人： Xiaohong Zhou , Vinod Sharma , Walter H. Olson
发明人： Xiaohong Zhou , Vinod Sharma , Walter H. Olson
IPC分类号： A61B5/0452 , A61B5/0402 , A61B5/046 , A61B5/0464 , A61N1/362 , A61N1/37 , A61N1/39
CPC分类号： A61B5/4035 , A61B5/046 , A61B5/0464 , A61N1/3622 , A61N1/3962
摘要： An implantable medical device and method are provided for assessing autonomic tone and risk factors associated with arrhythmias and, based on this assessment, an early recurrence of ventricular tachycardia or ventricular fibrillation is predicted. Specifically, changes in R—R interval, heart rate variability, patient activity, and myocardial ischemia are measured prior to and after a detected an arrhythmia episode. A recurrence score is calculated as a weighted sum of measured parameters and compared to a prediction criterion. The prediction criterion may be a preset threshold score or an individualized episode template based on previously calculated recurrence scores associated with recurring episodes. Stored parameters and episode-related data may be downloaded for offline analyses for optimizing prediction criteria and monitoring patient status.
摘要翻译：提供了一种用于评估与心律失常相关的自主神经和风险因素的可植入医疗装置和方法，并且基于该评估，预测了室性心动过速或心室颤动的早期复发。具体地，在检测到心律失常发作之前和之后测量R-R间期，心率变异性，患者活动和心肌缺血的变化。计算复发得分作为测量参数的加权和并与预测标准进行比较。预测标准可以是基于先前计算的与重复发作相关联的复发评分的预设阈值评分或个体化发作模板。可以下载存储的参数和与剧集相关的数据用于离线分析，以优化预测标准和监测患者状态。

7. 发明申请

US20100076063A1 GENETIC MODIFICATION OF TARGETED REGIONS OF THE CARDIAC CONDUCTION SYSTEM 有权
标题翻译：心脏导管系统目标区域的遗传修饰
公开(公告)号：US20100076063A1
公开(公告)日：2010-03-25
申请号：US12578198
申请日：2009-10-13
申请人： Vinod Sharma , Walter H. Olson
发明人： Vinod Sharma , Walter H. Olson
IPC分类号： A61K31/7088 , A61P9/10
CPC分类号： C07K14/705 , A61K38/00 , A61K38/177
摘要： Disclosed are compositions, methods and systems for preventing or treating cardiac dysfunction, particularly cardiac pacing dysfunction by genetic modification of cells of targeted regions of the cardiac conduction system. In particular, a bio-pacemaker composition is delivered to cardiac cells to increase the intrinsic pacemaking rate of the cells, wherein the bio-pacemaker composition increases expression of a channel or subunit thereof that produces funny current and a T-type Ca2+ channel or subunit thereof, and expresses one or more molecules that suppresses the expression of the wild type potassium channel.
摘要翻译：公开了用于预防或治疗心脏功能障碍的组合物，方法和系统，特别是心脏起搏功能障碍，通过心脏传导系统的靶向区域的细胞的遗传修饰。特别地，将生物起搏器组合物递送到心脏细胞以增加细胞的固有起搏速率，其中生物起搏器组合物增加产生滑稽电流的通道或其亚基的表达，以及T型Ca 2+通道或亚基并表达抑制野生型钾通道表达的一种或多种分子。

8. 发明授权

US07415307B2 Ischemia detection based on cardiac conduction time 有权
标题翻译：基于心脏传导时间的缺血检测
公开(公告)号：US07415307B2
公开(公告)日：2008-08-19
申请号：US10284900
申请日：2002-10-31
申请人： Vinod Sharma , Walter H. Olson
发明人： Vinod Sharma , Walter H. Olson
IPC分类号： A61N1/00
CPC分类号： A61B5/05 , A61B5/7203 , A61N1/362
摘要： Methods and process for detection of myocardial ischemia involve detection and analysis of changes in electrical conduction velocity within the heart to monitor changes in the condition of the cardiac muscle and indicate possible ischemia. Conduction velocity slows considerably when oxygen supply to the heart is reduced. Analysis of electrical conduction velocity can be used to verify the occurrence of myocardial ischemia in a more reliable manner. Changes in conduction velocity may be monitored based on conduction time between electrodes positioned in the left and right ventricles of the heart. The electrodes may be endocardial or epicardial electrodes. In general, the techniques may involve launching a stimulation waveform at one electrode and sensing a local cardiac depolarization at another electrode to assess conduction time.
摘要翻译：用于检测心肌缺血的方法和过程涉及检测和分析心脏内电传导速度的变化，以监测心肌状况的变化并指示可能的缺血。当心脏供氧减少时，传导速度显着减慢。电传导速度分析可以更可靠地验证心肌缺血的发生。可以基于位于心脏左心室和右心室的电极之间的传导时间来监测传导速度的变化。电极可以是心内膜或心外膜电极。通常，这些技术可以涉及在一个电极处发射刺激波形并感测另一个电极处的局部心脏去极化以评估传导时间。

9. 发明授权

US08642747B2 Genetic modification of targeted regions of the cardiac conduction system 有权
标题翻译：心脏传导系统目标区域的遗传修饰
公开(公告)号：US08642747B2
公开(公告)日：2014-02-04
申请号：US13224593
申请日：2011-09-02
申请人： Vinod Sharma , Walter H. Olson
发明人： Vinod Sharma , Walter H. Olson
IPC分类号： A61K48/00 , C12N15/00 , C07H21/02
CPC分类号： C12N15/86 , A61K38/177 , A61K48/00 , A61K48/005 , C12N2750/14143
摘要： Disclosed are methods and systems for preventing or treating cardiac dysfunction, particularly cardiac pacing dysfunction by genetic modification of the conduction system of the heart. In one embodiment, the invention provides a method of genetically modifying the cells by delivering to the cells one or more coding sequence in a genetic construct capable of modifying the expression of ion channels of the cells.
摘要翻译：公开了通过心脏传导系统的遗传修饰来预防或治疗心脏功能障碍，特别是心脏起搏功能障碍的方法和系统。在一个实施方案中，本发明提供了通过向细胞递送能够修饰细胞的离子通道的表达的遗传构建体中的一个或多个编码序列来遗传修饰细胞的方法。

10. 发明授权

US09096685B2 Genetic modification of targeted regions of the cardiac conduction system 有权
标题翻译：心脏传导系统目标区域的遗传修饰
公开(公告)号：US09096685B2
公开(公告)日：2015-08-04
申请号：US12578198
申请日：2009-10-13
申请人： Vinod Sharma , Walter H. Olson
发明人： Vinod Sharma , Walter H. Olson
IPC分类号： A61K31/70 , A61K48/00 , C12N15/00 , C07K14/705 , A61K38/17 , C07K1/00
CPC分类号： C07K14/705 , A61K38/00 , A61K38/177
摘要： Disclosed are compositions, methods and systems for preventing or treating cardiac dysfunction, particularly cardiac pacing dysfunction by genetic modification of cells of targeted regions of the cardiac conduction system. In particular, a bio-pacemaker composition is delivered to cardiac cells to increase the intrinsic pacemaking rate of the cells, wherein the bio-pacemaker composition increases expression of a channel or subunit thereof that produces funny current and a T-type Ca2+ channel or subunit thereof, and expresses one or more molecules that suppresses the expression of the wild type potassium channel.
摘要翻译：公开了用于预防或治疗心脏功能障碍的组合物，方法和系统，特别是心脏起搏功能障碍，通过心脏传导系统的靶向区域的细胞的遗传修饰。特别地，将生物起搏器组合物递送到心脏细胞以增加细胞的固有起搏速率，其中生物起搏器组合物增加产生滑稽电流的通道或其亚基的表达，以及T型Ca 2+通道或亚基并表达抑制野生型钾通道表达的一种或多种分子。

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