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1. 发明专利

ES2358740T3 SOLUCION ACUOSA DE OLANEXIDINA, PROCEDIMIENTO PARA SU PREPARACION Y DESINFECTANTE. 未知
公开(公告)号：ES2358740T3
公开(公告)日：2011-05-13
申请号：ES04734736
申请日：2004-05-25
申请人： OTSUKA PHARMA CO LTD , OTSUKA PHARMA CO LTD
发明人： MIYATA KAZUYOSHI , INOUE YASUHIDE , HAGI AKIFUMI , KIKUCHI MOTOYA , OHNO HITOSHI , HASHIMOTO KINJI , OHGURO KINUE , SATO TETSUYA , TSUBOUCHI HIDETSUGU , ISHIKAWA HIROSHI , OKAMURA TAKASHI , IWATA KOUSHI
IPC分类号： A61K31/155 , A01N25/02 , A01N37/02 , A01N47/44 , A61K9/00 , A61K9/08 , A61K31/191 , A61K31/522 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/34 , A61L2/18 , A61P17/00 , A61P31/00
摘要： Solución acuosa que contiene olanexidina y por lo menos una cantidad equimolar de ácido glucónico, y que no contiene sustancialmente ni un ácido distinto al ácido glucónico, ni una sal del ácido distinto al ácido glucónico.

2. 发明专利

BRPI0410851B1 solução aquosa de olanexidina, método de preparação da solução aquosa e desinfetante 未知
公开(公告)号：BRPI0410851B1
公开(公告)日：2016-06-07
申请号：BRPI0410851
申请日：2004-05-25
申请人： OTSUKA PHARMA CO LTD , OTSUKA PHARMA CO LTD
发明人： HAGI AKIFUMI , TSUBOUCHI HIDETSUGU , ISHIKAWA HIROSHI , OHNO HITOSHI , MIYATA KAZUYOSHI , HASHIMOTO KINJI , OHGURO KINUE , IWATA KOUSHI , KIKUCHI MOTOYA , OKAMURA TAKASHI , SATO TETSUYA , INOUE YASUHIDE
IPC分类号： A61K9/08 , A01N25/02 , A01N37/02 , A01N47/44 , A61K9/00 , A61K31/155 , A61K31/191 , A61K31/522 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/34 , A61L2/18 , A61P17/00 , A61P31/00
摘要： "solução aquosa de olanexidina, método de preparação da solução aquosa e desinfetante". a presente invenção proporciona um desinfetante que contém olanexidina em uma concentração suficiente para exibir um eficaz efeito bactericida eficaz e que dificilmente apresenta quaisquer efeitos colaterais, como, por exemplo, irritação da pele. especificamente, a presente invenção refere-se a um desinfetante contendo uma solução aquosa que contém olanexidina e pelo menos uma quantidade eqüimolar de ácido glicônico e substancialmente não contém nenhum ácido diferente de ácido glicônico nem um sal de ácido diferente de ácido glicônico.

3. 发明公开

EP1634589A4 AQUEOUS OLANEXIDINE SOLUTION, METHOD OF PREPARING THE SAME, AND DISINFECTANT 有权
标题翻译：水性OLANEXIDIN解决方案，用于生产和消毒剂
公开(公告)号：EP1634589A4
公开(公告)日：2007-11-07
申请号：EP04734736
申请日：2004-05-25
申请人： OTSUKA PHARMA CO LTD
发明人： MIYATA KAZUYOSHI , INOUE YASUHIDE , HAGI AKIFUMI , KIKUCHI MOTOYA , OHNO HITOSHI , HASHIMOTO KINJI , OHGURO KINUE , SATO TETSUYA , TSUBOUCHI HIDETSUGU , ISHIKAWA HIROSHI , OKAMURA TAKASHI , IWATA KOUSHI
IPC分类号： A61K31/155 , A01N25/02 , A01N37/02 , A01N47/44 , A61K9/00 , A61K9/08 , A61K31/191 , A61K31/522 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/34 , A61L2/18 , A61P17/00 , A61P31/00
CPC分类号： A61K9/0014 , A01N47/44 , A61K31/155 , A61K31/191 , A61K31/522 , A61K45/06 , A61K47/12 , A61L2/18 , A01N37/36 , A01N25/32 , A01N2300/00 , A61K2300/00
摘要： A disinfectant which contains olanexidine in such a concentration that the disinfectant shows an effective bactericidal activity and which is reduced in side effects such as skin irritation. The disinfectant comprises an aqueous solution which contains olanexidine and gluconic acid, the amount of the latter being at least equimolar with the former, and contains substantially none of acids other than gluconic acid and of salts of the acids (other than gluconic acid).

4. 发明公开

EP2394996A4 PHENYLIMIDAZOLE COMPOUNDS 有权转让
标题翻译： PHENYLIMIDAZOLVERBINDUNGEN
公开(公告)号：EP2394996A4
公开(公告)日：2012-09-12
申请号：EP10738531
申请日：2010-02-03
申请人： OTSUKA PHARMA CO LTD
发明人： SHIBUTANI TADAO , IWATA KOUSHI , KIDO SATOSHI
IPC分类号： C07D233/64 , A61K31/4164 , A61K31/4178 , A61P3/04 , A61P3/06 , A61P9/10 , A61P43/00 , C07D233/54 , C07D405/04 , C07D409/04
CPC分类号： C07D233/64 , C07D233/54 , C07D405/04 , C07D409/04

5. 发明公开

EP2783689A4 KERATOCONJUNCTIVAL PROTECTING AGENT, OR KERATOCONJUNCTIVAL DISORDER INHIBITING AGENT 有权
标题翻译：角膜结膜炎用于疾病角结膜保护剂或抑制剂
公开(公告)号：EP2783689A4
公开(公告)日：2015-06-24
申请号：EP12851333
申请日：2012-11-22
申请人： TOYO SUGAR REFINING CO LTD , OTSUKA PHARMA CO LTD
发明人： AIZAWA KYO , IIDA YOSHIHISA , SHIMOIDA TAKASHI , KOTANI YASUHIRO , IWATA KOUSHI , DOI KAZUHISA
IPC分类号： A61K31/7032 , A61P27/02 , C07H15/04
CPC分类号： A61K31/7032 , A61K9/0048 , A61K9/08
摘要： An object of the present invention is to provide a protective agent for the keratoconjunctiva or a suppressive agent for a keratoconjunctival disorder having an excellent suppressive effect on a keratoconjunctival disorder. The invention relates to a protective agent for the keratoconjunctiva or a suppressive agent for a keratoconjunctival disorder containing glucosylglycerol as an active ingredient, use of glucosylglycerol for the manufacture of a pharmaceutical for protecting a keratoconjunctiva or suppressing a keratoconjunctival disorder and a method of protecting a keratoconjunctiva or suppressing a keratoconjunctival disorder comprising administering glucosylglycerol.

6. 发明专利

MX2011008197A COMPUESTOS DE FENILIMIDAZOL. 未知
公开(公告)号：MX2011008197A
公开(公告)日：2011-08-17
申请号：MX2011008197
申请日：2010-02-03
申请人： OTSUKA PHARMA CO LTD
发明人： IWATA KOUSHI , SHIBUTANI TADAO , KIDO SATOSHI
IPC分类号： C07D233/64 , A61K31/4164 , A61K31/4178 , A61P3/04 , A61P3/06 , A61P9/10 , A61P43/00 , C07D405/04 , C07D409/04
摘要： Se provee un producto farmacéutico (agente quimioterapéutico) efectivo en la prevención y tratamiento de hiperlipidemia, obesidad, etc.; un compuesto de fenilimidazol representado por la siguiente fórmula general (1):(ver fórmula (I)) en donde, R1 representa un átomo de hidrógeno, un grupo fenil-alquilo inferior que tiene opcionalmente un sustituyente, o un grupo piridil-alquilo inferior que iene opcionalmente un sustituyente, y el anillo de benceno y el anillo de piridina son opcionalmente sustituidos con 1 ó 2 sustituyentes seleccionados del grupo que consiste de átomos de halógeno, grupo ciano y grupos alquilo inferior halógeno-sustituidos; uno de R2 y R3 representa un átomo de hidrógeno y el otro representa un grupo alquilo inferior; R4 representa un grupo fenilo que tiene opcionalmente un sustituyente; R5 y R6 son los mismos o diferentes, y representan un átomo de hidrógeno o un grupo alquilo inferior; R7 y R8 son los mismos o diferentes, y representan un átomo de hidrógeno o un grupo alquilo inferior; sin embargo, cuando R1 representa un grupo fenil alquilo inferior no sustituido, R2 representa un grupo alquilo inferior, R3 representa un átomo de hidrógeno, R4 representa un grupo fenilo que tiene opcionalmente un sustituyente, y R5 representa un átomo de hidrógeno, R6 no es un átomo de hidrógeno.

8. 发明专利

CA2750704A1 PHENYLIMIDAZOLE COMPOUNDS 未知
公开(公告)号：CA2750704A1
公开(公告)日：2010-08-12
申请号：CA2750704
申请日：2010-02-03
申请人： OTSUKA PHARMA CO LTD
发明人： SHIBUTANI TADAO , IWATA KOUSHI , KIDO SATOSHI
IPC分类号： C07D233/64 , A61K31/4164 , A61K31/4178 , A61P3/04 , A61P3/06 , A61P9/10 , A61P43/00 , C07D405/04 , C07D409/04
摘要： Provided are drugs which are efficacious in preventing and treating hyperlipidemia, obesity, and so on. Phenylimidazole compounds represented by general formula (1) [wherein R1 represents a hydrogen atom, a phenyl-lower alkyl group, or a pyridyl-lower alkyl group; either R2 or R3 represents a hydrogen atom, and the other represents a lower alkoxy group; R4 represents an optionally substituted phenyl group; R5 and R6 may be the same or different and each represents a hydrogen atom or a lower alkyl group; and R7 and R8 may be the same or different and each represents a hydrogen atom or a lower alkoxy group, with the proviso that R6 must not be a hydrogen atom in cases when R1 is an unsubstituted phenyl-lower alkyl group, R2 is a lower alkoxy group, R3 is a hydrogen atom, R4 is an optionally substituted phenyl group, and R5 is a hydrogen atom].

9. 发明专利

AU2008356303A1 Lipoprotein lipase-activating compositions comprising benzene derivates 未知
公开(公告)号：AU2008356303A1
公开(公告)日：2009-11-19
申请号：AU2008356303
申请日：2008-05-14
申请人： OTSUKA PHARMA CO LTD
发明人： PARADKAR VIDYADHAR M , OKAMURA TAKASHI , IWATA KOUSHI , NEAGU IRINA , SHIBUTANI TADAO , SAIONZ KURT W , OHLMEYER MICHAEL
IPC分类号： C07D233/58 , A61K31/4164 , A61K31/4184 , A61K31/4188 , A61K31/428 , A61K31/4745 , A61K31/519 , A61P3/04 , A61P3/06 , C07D235/18 , C07D277/66 , C07D471/04 , C07D487/04 , C07D513/04

10. 发明专利

NZ625350A Protective agent for keratoconjunctiva or suppressive agent for keratoconjunctival disorder 未知
公开(公告)号：NZ625350A
公开(公告)日：2016-02-26
申请号：NZ62535012
申请日：2012-11-22
申请人： TOYO SUGAR REFINING CO LTD , OTSUKA PHARMA CO LTD
发明人： AIZAWA KYO , IIDA YOSHIHISA , SHIMOIDA TAKASHI , KOTANI YASUHIRO , IWATA KOUSHI , DOI KAZUHISA
IPC分类号： A61K31/7032 , A61P27/02 , C07H15/04
摘要： Disclosed is the use of glucosylglycerol for the manufacture of a pharmaceutical for protecting a keratoconjunctiva or suppressing a keratoconjunctival disorder. The protection of the keratoconjunctiva or the suppression of the a keratoconjunctival disorder may include a protection of the keratoconjunctiva against an endogenous disease of Sjogren’s syndrome, Stevens-Johnson syndrome, or dry eye syndrome (dry eye) or an exogenous disease due to post-surgery, a drug, an injury, or the wearing of a contact lens or the suppression of the keratoconjunctival disorder due to said diseases.

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