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1. 发明专利

BRPI0410851B1 solução aquosa de olanexidina, método de preparação da solução aquosa e desinfetante 未知
公开(公告)号：BRPI0410851B1
公开(公告)日：2016-06-07
申请号：BRPI0410851
申请日：2004-05-25
申请人： OTSUKA PHARMA CO LTD , OTSUKA PHARMA CO LTD
发明人： HAGI AKIFUMI , TSUBOUCHI HIDETSUGU , ISHIKAWA HIROSHI , OHNO HITOSHI , MIYATA KAZUYOSHI , HASHIMOTO KINJI , OHGURO KINUE , IWATA KOUSHI , KIKUCHI MOTOYA , OKAMURA TAKASHI , SATO TETSUYA , INOUE YASUHIDE
IPC分类号： A61K9/08 , A01N25/02 , A01N37/02 , A01N47/44 , A61K9/00 , A61K31/155 , A61K31/191 , A61K31/522 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/34 , A61L2/18 , A61P17/00 , A61P31/00
摘要： "solução aquosa de olanexidina, método de preparação da solução aquosa e desinfetante". a presente invenção proporciona um desinfetante que contém olanexidina em uma concentração suficiente para exibir um eficaz efeito bactericida eficaz e que dificilmente apresenta quaisquer efeitos colaterais, como, por exemplo, irritação da pele. especificamente, a presente invenção refere-se a um desinfetante contendo uma solução aquosa que contém olanexidina e pelo menos uma quantidade eqüimolar de ácido glicônico e substancialmente não contém nenhum ácido diferente de ácido glicônico nem um sal de ácido diferente de ácido glicônico.

2. 发明专利

ES2358740T3 SOLUCION ACUOSA DE OLANEXIDINA, PROCEDIMIENTO PARA SU PREPARACION Y DESINFECTANTE. 未知
公开(公告)号：ES2358740T3
公开(公告)日：2011-05-13
申请号：ES04734736
申请日：2004-05-25
申请人： OTSUKA PHARMA CO LTD , OTSUKA PHARMA CO LTD
发明人： MIYATA KAZUYOSHI , INOUE YASUHIDE , HAGI AKIFUMI , KIKUCHI MOTOYA , OHNO HITOSHI , HASHIMOTO KINJI , OHGURO KINUE , SATO TETSUYA , TSUBOUCHI HIDETSUGU , ISHIKAWA HIROSHI , OKAMURA TAKASHI , IWATA KOUSHI
IPC分类号： A61K31/155 , A01N25/02 , A01N37/02 , A01N47/44 , A61K9/00 , A61K9/08 , A61K31/191 , A61K31/522 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/34 , A61L2/18 , A61P17/00 , A61P31/00
摘要： Solución acuosa que contiene olanexidina y por lo menos una cantidad equimolar de ácido glucónico, y que no contiene sustancialmente ni un ácido distinto al ácido glucónico, ni una sal del ácido distinto al ácido glucónico.

3. 发明公开

EP1062951A4 PREVENTIVE AND THERAPEUTIC AGENT FOR FATTY LIVER 审中-公开
标题翻译：预防和治疗脂肪肝
公开(公告)号：EP1062951A4
公开(公告)日：2001-05-16
申请号：EP99903922
申请日：1999-02-16
申请人： OTSUKA PHARMA CO LTD
发明人： TSUTSUMI KAZUHIKO , INOUE YASUHIDE
IPC分类号： A61K31/66 , A61K31/662 , A61P1/16
CPC分类号： A61K31/683
摘要： A preventive and therapeutic agent for fatty liver having, as an active component, a carboxylic acid amide derivative represented by formula (1) wherein R represents a lower alkyl group and X represents a halogen atom, and a method of treatment using the same.

4. 发明公开

EP1074556A4 PHOSPHONIC ACID DIESTER DERIVATIVES 有权
标题翻译：膦酸二酯衍生物
公开(公告)号：EP1074556A4
公开(公告)日：2002-04-24
申请号：EP99917075
申请日：1999-04-21
申请人： OTSUKA PHARMA CO LTD
发明人： SAKAI YASUHIRO , MIYATA KAZUYOSHI , KAWAMURA KENICHI , TSUDA YOSHIHIKO , INOUE YASUHIDE
IPC分类号： A61K31/66 , A61K31/675 , A61P3/08 , A61P3/10 , A61P31/10 , C07F9/40 , C07F9/58 , C07F9/6509 , A61K31/44 , C07D213/75
CPC分类号： C07F9/650958 , C07F9/4006 , C07F9/4065 , C07F9/588
摘要： Novel phosphonic diester derivatives represented by general formula (1) or pharmacologically acceptable salts thereof which are useful as drugs, wherein R1 represents amino, N-(lower alkyl)amino, N-(lower alkenyl)amino, etc.; R?2 and R3¿ represent each hydrogen, lower alkyl, halogeno, lower alkoxy etc.; R4 represents hydrogen, lower alkyl or phenyl(lower alkyl); R?5 and R6¿ represent each lower alkyl; X, Y and Z are all carbon atoms, or one of X, Y and Z is a nitrogen atom while other two are carbon atoms; and Q represents a single bond or alkylene.

5. 发明公开

EP0749974A4 PHOSPHONIC DIESTER DERIVATIVE 失效
标题翻译： PHOSPHORSÄUREDIESTER衍
公开(公告)号：EP0749974A4
公开(公告)日：1997-12-17
申请号：EP95909996
申请日：1995-02-27
申请人： OTSUKA PHARMA CO LTD
发明人： KUROKI YASUHISA , MIYATA KAZUYOSHI , TSUDA YOSHIHIKO , INOUE YASUHIDE , KANAYA JUN , SATO KEIGO
IPC分类号： C07F9/6512 , A61K31/505 , C07D239/86 , C07D239/91
CPC分类号： C07F9/65128
摘要： A phosphonic diester derivative represented by general formula (1) and useful as a remedy and preventive for hyperlipidemia, hypertension, diabetes, and so forth. In formula (1) R , R , R and R represent each independently hydrogen, lower alkyl, halogen, nitro, etc.; R represents phenyl, lower alkyl, phenylalkyl, etc.; R represents lower alkyl; R represents lower alkoxy, hydroxy, phenyl, or phenylated lower alkoxy or lower alkylamino wherein the phenyl group may be halogenated; X and X represent each oxygen or sulfur; A represents oxygen or a single bond; and Z represents lower alkylene.
摘要翻译：本发明提供下式的膦酸二酯衍生物：其中R 1，R 2，R 3和R 6相同或不同，各自表示氢原子，低级烷基卤素原子，硝基，低级烷氧基，氰基，苯磺酰氨基，苯甲酰氨基，氨基或卤素取代的低级烷基，R 4表示苯基，低级烷基基团，苯基上任选被卤素取代的苯基（低级）烷基，低级烯基，羧基（低级）烷基，（低级）烷氧基 - 羰基（低级）烷基，（低级）烷氧基（低级烷基，低级炔基，苯甲酰基（低级）烷基，氨基，二（低级）烷酰基氨基，苯环上任选具有低级烷氧基的亚苄基氨基或吡啶亚甲基氨基，R 5，表示低级烷基，R 7表示低级烷氧基，羟基，苯基，苯基（低级）烷氧基任选地苯基环或苯基（低级）烷基氨基上的卤素独立地表示氧原子或硫原子，A表示氧原子或单键，Z表示低级亚烷基组。根据本发明的衍生物可用作高脂血症，高血压和糖尿病的治疗或预防组合物。

6. 发明公开

EP1634589A4 AQUEOUS OLANEXIDINE SOLUTION, METHOD OF PREPARING THE SAME, AND DISINFECTANT 有权
标题翻译：水性OLANEXIDIN解决方案，用于生产和消毒剂
公开(公告)号：EP1634589A4
公开(公告)日：2007-11-07
申请号：EP04734736
申请日：2004-05-25
申请人： OTSUKA PHARMA CO LTD
发明人： MIYATA KAZUYOSHI , INOUE YASUHIDE , HAGI AKIFUMI , KIKUCHI MOTOYA , OHNO HITOSHI , HASHIMOTO KINJI , OHGURO KINUE , SATO TETSUYA , TSUBOUCHI HIDETSUGU , ISHIKAWA HIROSHI , OKAMURA TAKASHI , IWATA KOUSHI
IPC分类号： A61K31/155 , A01N25/02 , A01N37/02 , A01N47/44 , A61K9/00 , A61K9/08 , A61K31/191 , A61K31/522 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/34 , A61L2/18 , A61P17/00 , A61P31/00
CPC分类号： A61K9/0014 , A01N47/44 , A61K31/155 , A61K31/191 , A61K31/522 , A61K45/06 , A61K47/12 , A61L2/18 , A01N37/36 , A01N25/32 , A01N2300/00 , A61K2300/00
摘要： A disinfectant which contains olanexidine in such a concentration that the disinfectant shows an effective bactericidal activity and which is reduced in side effects such as skin irritation. The disinfectant comprises an aqueous solution which contains olanexidine and gluconic acid, the amount of the latter being at least equimolar with the former, and contains substantially none of acids other than gluconic acid and of salts of the acids (other than gluconic acid).

7. 发明公开

EP0882730A4 PHOSPHONIC ACID DIESTER DERIVATIVES 失效
标题翻译： PHOSPHONSAUREDIESTER衍
公开(公告)号：EP0882730A4
公开(公告)日：1999-04-28
申请号：EP96942639
申请日：1996-12-24
申请人： OTSUKA PHARMA CO LTD
发明人： MIYATA KAZUYOSHI , SAKAI YASUHIRO , SHOJI YASUO , TSUDA YOSHIHIKO , INOUE YASUHIDE , SATO KEIGO , MIKI SHINYA
IPC分类号： C07F9/6509 , C07F9/6539 , C07F9/6553 , C07F9/6558 , C07F9/6561 , A61K31/67 , A61K31/675
CPC分类号： C07F9/650964 , C07F9/6539 , C07F9/655345 , C07F9/65583 , C07F9/65586 , C07F9/6561
摘要： Phosphonic acid diester derivatives represented by general formula (1) which are useful as a remedy for hyperlipidemia and diabetes, an antitumor agent and a preventive or remedy for cataract, wherein R represents cycloalkyl, etc.; R represents hydrogen, phenyl or lower alkyl; R and R represent each lower alkyl; and A represents a heterocycle selected from among pyrazine, thiophene and phenyl-substituted thiazole rings.
摘要翻译：通式（1）表示的膦酸二酯衍生物，其用作高脂血症和糖尿病的治疗剂，抗肿瘤剂和白内障的预防剂或治疗剂，其中R 1表示环烷基等。 R2代表氢，苯基或低级烷基; R 3和R 4各自代表低级烷基; A代表选自吡嗪，噻吩和苯基取代的噻唑环的杂环。

8. 发明公开

EP0655456A4 PHOSPHONIC DIESTER DERIVATIVE. 失效
标题翻译： DERIVATPHOSPHONSÄUREDIESTER。
公开(公告)号：EP0655456A4
公开(公告)日：1996-03-27
申请号：EP94917137
申请日：1994-05-31
申请人： OTSUKA PHARMA CO LTD
发明人： KUROGI YASUHISA , MIYATA KAZUYOSHI , NAKAMURA SHIZUO , KONDO MITSUYOSHI , IWAMOTO TAKESHI , NABA CHIEKO , TSUDA YOSHIHIKO , INOUE YASUHIDE , KANAYA JUN , SATO KEIGO
IPC分类号： C07F9/6512 , C07F9/6558 , A61K31/675
CPC分类号： C07F9/65583 , C07F9/65128
摘要： A phosphonic diester derivative represented by general formula (1) and useful as remedies for hyperlipidemia, hypertension, diabetes, and so forth. In said formula, A represents oxygen or sulfur; R , R , R and R represent each independently hydrogen, lower alkoxy, nitro, lower alkyl, halogenated lower alkyl or halogen; R represents phenyl, -B-R (wherein B represents oxygen or sulfur; and R represents hydrogen, lower alkyl, cycloalkyl, phenyl, phenylated lower alkyl wherein the phenyl may be halogenated, phenoxylated lower alkyl, lower-alkoxy carbonyl-substituted lower alkyl, carboxylated lower alkyl or lower alkenyl) or -NR R (wherein R and R represent each independently hydrogen, lower alkyl, amino or cycloalkyl, or R and R are combined together to form lower alkylene); and R and R represent each independently hydrogen or lower alkyl.

9. 发明公开

EP0638581A4 PHOSPHONIC DIESTER DERIVATIVE. 失效转让
标题翻译：磷酸二酯 - 衍生物。
公开(公告)号：EP0638581A4
公开(公告)日：1995-04-12
申请号：EP94906377
申请日：1994-02-10
申请人： OTSUKA PHARMA CO LTD
发明人： SHOJI YASUO SHINSEIBIRU , TSUDA YOSHIHIKO , TSUTSUMI KAZUHIKO , INOUE YASUHIDE
IPC分类号： A61K31/00 , A61K31/675 , C07F9/6506 , C07F9/6541 , C07F9/6561
CPC分类号： C07F9/6561 , C07F9/6541
摘要： A phosphonic diester derivative represented by general formula (I), which is excellent is hypolipidemic and hypoglycemic effects, reduced in the side effects, and hence useful for treating and preventing hyperlipidemia, treating cataract, and treating and preventing diabetes, wherein R?1, R2, R3 and R4¿ represent each independently hydrogen, lower alkyl, lower alkoxy, halogenated lower alkyl, nitro, halogen, cyano, phenylthio, phenylsulfinyl, phenylsulfonyl, phenylated lower alkoxy, phenylated lower alkylthio or benzoyloxy substituted by di(lower alkoxy)phosphorylated lower alkyl, provided R?3 and R4¿ may be combined together to form -CH = CH-CH = CH-; R5 represents hydrogen, lower alkyl or phenyl; R?6 and R7¿ represent each independently lower alkoxy, phenyl or phenylated lower alkoxy; A represents optionally phenylated lower alkylene; B represents a benzene or thiophene ring; D represents -CO-, -CS- or -SO¿2?-; E represents (a), (b) or (c) wherein R?8¿ represents lower alkyl; Z represents a single bond or -O-; Y represents optionally phenylated lower alkylene or vinylene; and n represents 0 or 1.
摘要翻译：通式（I）所示的膦酸二酯衍生物具有降血脂和降血糖作用，降低副作用，因此可用于治疗和预防高脂血症，治疗白内障和治疗和预防糖尿病，其中R 1，低级烷基，低级烷氧基，卤代低级烷基，硝基，卤素，氰基，苯硫基，苯基亚磺酰基，苯基磺酰基，苯基化低级烷氧基，苯基化低级烷基硫基或被二（低级烷氧基）磷酸化取代的苯甲酰氧基条件是R 3和R 4可以结合在一起形成-CH = CH-CH = CH-; R5代表氢，低级烷基或苯基; R6和R7代表各自独立的低级烷氧基，苯基或苯基化的低级烷氧基; A代表任选苯基化的低级亚烷基; B代表苯或噻吩环; D表示-CO - ， - CS-或-SO 2 - ; - E代表（a），（b）或（c），其中R 8代表低级烷基; Z表示单键或-O-; Y代表任选苯基化的低级亚烷基或亚乙烯基; 并且n代表0或1。

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