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1. 发明申请

US20050074865A1 Adzymes and uses thereof 审中-公开
标题翻译：酶及其用途
公开(公告)号：US20050074865A1
公开(公告)日：2005-04-07
申请号：US10792498
申请日：2004-03-02
申请人： Noubar Afeyan , Frank Lee , Gordon Wong , Ruchira Das Gupta , Brian Baynes
发明人： Noubar Afeyan , Frank Lee , Gordon Wong , Ruchira Das Gupta , Brian Baynes
IPC分类号： C12N9/00 , C12N9/50 , C12N9/76 , C12N15/62 , C12N9/64
CPC分类号： C12N9/6427 , C07K2319/00 , C07K2319/01 , C07K2319/33 , C12N9/00 , C12N9/50 , C12N15/62
摘要： Disclosed is a family of novel protein constructs, useful as drugs and for other purposes, termed “adzymes,” comprising an address moiety and a catalytic domain. In some types of disclosed adzymes, the address binds with a binding site on or in functional proximity to a targeted biomolecule, e.g., an extracellular targeted biomolecule, and is disposed adjacent the catalytic domain so that its affinity serves to confer a new specificity to the catalytic domain by increasing the effective local concentration of the target in the vicinity of the catalytic domain. The present invention also provides pharmaceutical compositions comprising these adzymes, methods of making adzymes, DNA's encoding adzymes or parts thereof, and methods of using adzymes, such as for treating human subjects suffering from a disease, such as a disease associated with a soluble or membrane bound molecule, e.g., an allergic or inflammatory disease.
摘要翻译：公开了一种新型蛋白质构建体家族，其用作药物和用于其它目的，称为“腺苷”，包括地址部分和催化结构域。在一些类型的公开的腺体中，该结构域与靶向生物分子（例如细胞外靶向生物分子）功能接近的结合位点结合，并且设置在催化结构域附近，使得其亲和力用于赋予通过增加催化结构域附近靶的有效局部浓度来制备催化结构域。本发明还提供药物组合物，其包含这些腺病，制造腺体的方法，编码DNA的DNA或其部分，以及使用腺病的方法，例如用于治疗患有疾病例如与可溶性或膜相关的疾病结合分子，例如过敏性或炎性疾病。

2. 发明申请

US20050069911A1 Proteome epitope tags and methods of use thereof in protein modification analysis 失效
标题翻译：蛋白质组表位标签及其在蛋白质修饰分析中的应用方法
公开(公告)号：US20050069911A1
公开(公告)日：2005-03-31
申请号：US10773032
申请日：2004-02-05
申请人： Frank Lee , Xun Meng , Noubar Afeyan
发明人： Frank Lee , Xun Meng , Noubar Afeyan
IPC分类号： C12Q1/48 , C40B30/04 , G01N33/543 , G01N33/68 , C12Q1/68 , G01N33/53 , G01N33/537
CPC分类号： G01N33/6803 , B82Y5/00 , B82Y10/00 , C12Q1/48 , C40B30/04 , G01N33/6842
摘要： Disclosed are methods for reliably detecting the presence of proteins, including proteins with various post-translational modifications (phosphorylation, glycosylation, methylation, acetylation, etc.) in a sample by the use of one or more capture agents that recognize and interact with recognition sequences uniquely characteristic of a protein or a set of proteins (Proteome Epitope Tags, or PETs) in the sample. Arrays comprising these capture agents or PETs are also provided.
摘要翻译：公开了通过使用一种或多种识别并与识别序列相互作用的捕获剂来可靠地检测样品中存在蛋白质的方法，包括各种翻译后修饰（磷酸化，糖基化，甲基化，乙酰化等）的蛋白质的存在样品中蛋白质或蛋白质组（Proteome Epitope Tags，或PET）的独特特征。还提供了包含这些捕获剂或PET的阵列。

3. 发明申请

US20070276129A1 Modular molecular clasps and uses thereof 审中-公开
标题翻译：模块化分子钩扣及其用途
公开(公告)号：US20070276129A1
公开(公告)日：2007-11-29
申请号：US11505630
申请日：2006-08-17
申请人： Carlo Rizzuto , Noubar Afeyan , Frank Lee , George Church , Ruchira Gupta , John Schwartz , Bin Zhang , Alexey Lugovskoy
发明人： Carlo Rizzuto , Noubar Afeyan , Frank Lee , George Church , Ruchira Gupta , John Schwartz , Bin Zhang , Alexey Lugovskoy
IPC分类号： C07K16/46
CPC分类号： C12N15/62 , A61K38/00 , C07K19/00 , C07K2319/00 , C07K2319/21 , C07K2319/30 , C07K2319/60 , C07K2319/74 , G01N33/542
摘要： The present invention provides Modular Molecular Clasps and methods of using these Modular Molecular Clasps in a wide range of applications in the health care industry, e.g., in therapy, in clinical diagnostics, in in vivo imaging or in drug discovery. The Modular Molecular Clasps of the present invention also have industrial and environmental applications, e.g., in environmental diagnostics, industrial diagnostics, food safety, toxicology, catalysis of reactions or high-throughput screening; as well as applications in the agricultural industry and in basic research. Methods of designing the Modular Molecular Clasps, as well as arrays and biosensors comprising these Modular Molecular Clasps are also provided.
摘要翻译：本发明提供了在医疗保健行业的广泛应用中使用这些模块化分子克隆的模块化分子克隆和方法，例如在治疗，临床诊断，体内成像或药物发现中。本发明的模块化分子克隆还具有工业和环境应用，例如在环境诊断，工业诊断，食品安全，毒理学，反应催化或高通量筛选中。以及农业行业的应用和基础研究。还提供了设计模块化分子克隆的方法，以及包含这些模块分子克隆的阵列和生物传感器。

4. 发明申请

US20050255491A1 Small molecule and peptide arrays and uses thereof 审中-公开
标题翻译：小分子和肽阵列及其用途
公开(公告)号：US20050255491A1
公开(公告)日：2005-11-17
申请号：US10989226
申请日：2004-11-15
申请人： Frank Lee , Xun Meng , Noubar Afeyan , Neal Gordon
发明人： Frank Lee , Xun Meng , Noubar Afeyan , Neal Gordon
IPC分类号： C07H21/04 , C12Q1/68 , C40B40/10 , G01N33/543 , G01N33/68 , G06F19/22
CPC分类号： G01N33/6842 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , B82Y5/00 , B82Y10/00 , C40B40/10 , G01N33/54306 , G01N33/54366 , G01N33/6803 , G16B25/00 , G16B30/00 , G16B40/00 , Y02A90/26
摘要： Disclosed are competition assay methods for reliably detecting the presence and/or quantitation of small molecules (e.g., metabolites) and peptides/proteins in a sample by the use of capture agents specific for immobilized small molecules and/or peptides/proteins. Arrays comprising these small molecules and/or peptides/proteins are also provided.
摘要翻译：公开了通过使用对固定的小分子和/或肽/蛋白质特异性的捕获剂来可靠地检测样品中小分子（例如代谢物）和肽/蛋白质的存在和/或定量的竞争测定方法。还提供了包含这些小分子和/或肽/蛋白质的阵列。

5. 发明授权

US08438186B2 Method and apparatus for creating topological features inside a database system 有权
标题翻译：在数据库系统中创建拓扑特征的方法和装置
公开(公告)号：US08438186B2
公开(公告)日：2013-05-07
申请号：US11293486
申请日：2005-12-02
申请人： Frank Lee
发明人： Frank Lee
IPC分类号： G06F7/00
CPC分类号： G06F17/30595 , G06F17/30241 , G06F17/30607
摘要： A technique used in a relational database management system that provides a topology data model in which topological elements are stored in topology element tables. The technique allows topological elements to be added to the topology element tables while a feature specifier that represents a feature composed of the topological elements is being defined in the topology data model. The feature specifiers are inserted into fields of a feature column in a feature table. The features belonging to a given feature table define a feature layer. A feature layer may have a child feature layer, and in addition to representing a set of topological elements, a feature specifier may represent a set of features belonging to a child feature layer.
摘要翻译：在关系数据库管理系统中使用的技术，其提供拓扑数据模型，其中拓扑元素存储在拓扑元素表中。该技术允许将拓扑元素添加到拓扑元素表，而在拓扑数据模型中定义表示由拓扑元素组成的特征的特征说明符。特征说明符插入到要素表中的要素列的字段中。属性给定特征表的特征定义了一个特征图层。特征层可以具有子特征层，并且除了表示一组拓扑元素之外，特征说明符可以表示属于子特征层的一组特征。

6. 发明授权

US07009120B2 Calibration device for a helical spring scale 失效
标题翻译：螺旋弹簧秤的校准装置
公开(公告)号：US07009120B2
公开(公告)日：2006-03-07
申请号：US10791324
申请日：2004-03-01
申请人： Frank Lee
发明人： Frank Lee
IPC分类号： G01G3/02 , G01G23/01
CPC分类号： G01G3/02
摘要： A scale includes a housing, a first pressing element, a second pressing element, an adjusting unit, a spring, a carrying unit and an indicator. The housing includes a graduation provided thereon and has a lower portion. The adjusting unit is secured to the lower portion of the housing and has a first thread. The first pressing element is slidably secured in said housing and has a second thread engaged with the first thread of said adjusting unit. The adjusting unit can be rotated relative to the first pressing element for moving the first pressing element in the housing in the direction where the spring can be compressed. The second pressing element is slidably received in the housing. The spring is received in the housing and between the first and second pressing elements. The carrying unit is suited for carrying an object to be weighed and is engaged with the second pressing element. The indicator is moved in concert with the second pressing element for aligning with the graduation and for indicating the weight of the object.
摘要翻译：标尺包括壳体，第一按压元件，第二按压元件，调节单元，弹簧，承载单元和指示器。壳体包括设置在其上的刻度并具有下部。调节单元被固定到壳体的下部并且具有第一螺纹。第一按压元件可滑动地固定在所述壳体中，并且具有与所述调节单元的第一螺纹接合的第二螺纹。调节单元可以相对于第一按压元件旋转，用于沿弹簧可压缩的方向移动壳体中的第一按压元件。第二按压元件可滑动地容纳在壳体中。弹簧被容纳在壳体中并且在第一和第二按压元件之间。承载单元适于携带被测量物体并与第二按压元件接合。指示器与第二按压元件协调移动，用于与刻度对准并且用于指示物体的重量。

7. 发明申请

US20060035270A1 Unique recognition sequences and methods of use thereof in protein analysis 审中-公开
标题翻译：蛋白质分析中独特的识别序列及其使用方法
公开(公告)号：US20060035270A1
公开(公告)日：2006-02-16
申请号：US11249847
申请日：2005-10-13
申请人： Frank Lee , Xun Meng , John Chan , Shengsheng Zhang , Stephen Benkovic
发明人： Frank Lee , Xun Meng , John Chan , Shengsheng Zhang , Stephen Benkovic
IPC分类号： C12Q1/68 , G01N33/53 , G06F19/00
CPC分类号： C40B30/04 , B82Y5/00 , B82Y10/00 , B82Y30/00 , C12Q1/48 , G01N33/68 , G01N33/6803 , G01N33/6842 , G01N33/6851 , Y02A90/26
摘要： Disclosed are methods for reliably detecting the presence of proteins in a sample by the use of capture agents that recognize and interact with recognition sequences uniquely characteristic of a set of proteins in the sample. Arrays comprising these capture agents are also provided.
摘要翻译：公开的是通过使用识别和与样品中一组蛋白质唯一特征的识别序列相互作用的捕获剂来可靠地检测样品中蛋白质的存在的方法。还提供了包含这些捕获剂的阵列。

8. 发明授权

US5730970A Pharmaceutical compositions comprising human interleukin-4 (IL-4) 失效
标题翻译：包含人白细胞介素-4（IL-4）
公开(公告)号：US5730970A
公开(公告)日：1998-03-24
申请号：US469267
申请日：1995-06-06
申请人： Frank Lee , Takashi Yokota , Ken-ichi Arai , Timothy Mosmann , Donna Rennick
发明人： Frank Lee , Takashi Yokota , Ken-ichi Arai , Timothy Mosmann , Donna Rennick
IPC分类号： A61K38/00 , C07K14/54 , C07K16/24 , C12N15/24 , C12N15/66 , C12N15/70 , C12N15/869 , A61K38/20
CPC分类号： C12N15/70 , C07K14/5406 , C07K16/247 , C12N15/66 , A61K38/00 , C07K2319/02 , Y10S514/825 , Y10S514/885
摘要： A pharmaceutical composition comprising human Interleukin-4 (IL-4).
摘要翻译：包含人白细胞介素-4（IL-4）的药物组合物。

9. 发明授权

US5013824A Human interleukin-4 peptides and conjugates thereof 失效
标题翻译：人白细胞介素-4肽及其缀合物
公开(公告)号：US5013824A
公开(公告)日：1991-05-07
申请号：US909520
申请日：1986-09-19
申请人： John S. Abrams , Takashi Yokota , Frank Lee , Ken-ichi Arai
发明人： John S. Abrams , Takashi Yokota , Frank Lee , Ken-ichi Arai
IPC分类号： A61K38/00 , C07K14/54 , C12N15/66 , C12N15/70 , C12N15/869
CPC分类号： C12N15/70 , C07K14/5406 , C12N15/66 , A61K38/00 , C07K2319/02
摘要： Peptides derived from human interleukin-4 are provided comprising from 6 to 40 amino acids. Conjugates of the peptides and carriers are also provided for the production of polyclonal and/or monoclonal antisera to human interleukin-4.
摘要翻译：提供衍生自人白细胞介素-4的肽包含6至40个氨基酸。还提供肽和载体的缀合物用于生产人白介素-4的多克隆和/或单克隆抗血清。

10. 发明授权

US4065257A Inhibition of dye staining during laundering of textile materials 失效
标题翻译：纺织材料洗涤期间染料染色的抑制
公开(公告)号：US4065257A
公开(公告)日：1977-12-27
申请号：US597861
申请日：1975-07-18
申请人： Gervase Coe , Frank Lee
发明人： Gervase Coe , Frank Lee
IPC分类号： C11D1/44 , C11D1/62 , C11D3/00 , C11D3/30 , D06P1/52 , D06P1/607 , D06P5/04 , D06P5/06
CPC分类号： D06P5/04 , C11D1/44 , C11D1/62 , C11D3/0021 , C11D3/30 , D06P1/52 , D06P1/607 , Y10S8/918 , Y10S8/924
摘要： A method for inhibiting dye-staining during laundering of textile articles with compositions which consist of a soap or detergent composition comprising as dye-staining inhibitorA. a minor proportion of an organic compound containing at least one basic nitrogen atom to which is bound at least one residue containing a polyglycol ether chain, the molecule of this compound containing at least 3 groups having the formula ##STR1## and containing at least 4 carbon atoms not attached to these groups, and/orB. a minor proportion of a reaction product of an aliphatic tertiary polyamine with an aliphatic dihalide.
摘要翻译：一种抑制织物制品洗涤期间染色染色的方法，其组合物由包含染料染色抑制剂A的皂或洗涤剂组合物组成。含有至少一种基本氮原子的有机化合物的少量成分含有多糖醚链的一个残留物，该化合物的分子含有至少3个具有式（I）的组合并且含有至少4个未连接到这些基团上的碳原子和/或B.A的较小比例具有二氧化钛的二元聚酰胺的反应产物。

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