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1. 发明申请

US20050074865A1 Adzymes and uses thereof 审中-公开
标题翻译：酶及其用途
公开(公告)号：US20050074865A1
公开(公告)日：2005-04-07
申请号：US10792498
申请日：2004-03-02
申请人： Noubar Afeyan , Frank Lee , Gordon Wong , Ruchira Das Gupta , Brian Baynes
发明人： Noubar Afeyan , Frank Lee , Gordon Wong , Ruchira Das Gupta , Brian Baynes
IPC分类号： C12N9/00 , C12N9/50 , C12N9/76 , C12N15/62 , C12N9/64
CPC分类号： C12N9/6427 , C07K2319/00 , C07K2319/01 , C07K2319/33 , C12N9/00 , C12N9/50 , C12N15/62
摘要： Disclosed is a family of novel protein constructs, useful as drugs and for other purposes, termed “adzymes,” comprising an address moiety and a catalytic domain. In some types of disclosed adzymes, the address binds with a binding site on or in functional proximity to a targeted biomolecule, e.g., an extracellular targeted biomolecule, and is disposed adjacent the catalytic domain so that its affinity serves to confer a new specificity to the catalytic domain by increasing the effective local concentration of the target in the vicinity of the catalytic domain. The present invention also provides pharmaceutical compositions comprising these adzymes, methods of making adzymes, DNA's encoding adzymes or parts thereof, and methods of using adzymes, such as for treating human subjects suffering from a disease, such as a disease associated with a soluble or membrane bound molecule, e.g., an allergic or inflammatory disease.
摘要翻译：公开了一种新型蛋白质构建体家族，其用作药物和用于其它目的，称为“腺苷”，包括地址部分和催化结构域。在一些类型的公开的腺体中，该结构域与靶向生物分子（例如细胞外靶向生物分子）功能接近的结合位点结合，并且设置在催化结构域附近，使得其亲和力用于赋予通过增加催化结构域附近靶的有效局部浓度来制备催化结构域。本发明还提供药物组合物，其包含这些腺病，制造腺体的方法，编码DNA的DNA或其部分，以及使用腺病的方法，例如用于治疗患有疾病例如与可溶性或膜相关的疾病结合分子，例如过敏性或炎性疾病。

2. 发明申请

US20050202500A1 Expression monitoring to high density oligonucleotide arrays 审中-公开
标题翻译：对高密度寡核苷酸阵列的表达监测
公开(公告)号：US20050202500A1
公开(公告)日：2005-09-15
申请号：US11118974
申请日：2005-04-28
申请人： David Lockhart , Eugene Brown , Gordon Wong , Mark Chee , Thomas Gingeras
发明人： David Lockhart , Eugene Brown , Gordon Wong , Mark Chee , Thomas Gingeras
IPC分类号： G01N33/53 , C12N15/09 , C12Q1/68 , G01N15/14 , G01N37/00 , C12P19/34 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： C12Q1/6809 , C12Q1/6837 , G01N15/1475 , C12Q2565/507
摘要： This invention provides methods of monitoring the expression levels of a multiplicity of genes. The methods involve hybridizing a nucleic acid sample to a high density array of oligonucleotide probes where the high density array contains oligonucleotide probes complementary to subsequences of target nucleic acids in the nucleic acid sample. In one embodiment, the method involves providing a pool of target nucleic acids comprising RNA transcripts of one or more target genes, or nucleic acids derived from the RNA transcripts, hybridizing said pool of nucleic acids to an array of oligonucleotide probes immobilized on surface, where the array comprising more than 100 different oligonucleotides and each different oligonucleotide is localized in a predetermined region of the surface, the density of the different oligonucleotides is greater than about 60 different oligonucleotides per 1 cm2, and the olignucleotide probes are complementary to the RNA transcripts or nucleic acids derived from the RNA transcripts; and quantifying the hybridized nucleic acids in the array.
摘要翻译：本发明提供监测多种基因的表达水平的方法。所述方法包括将核酸样品与寡核苷酸探针的高密度阵列杂交，其中高密度阵列含有与核酸样品中靶核酸的子序列互补的寡核苷酸探针。在一个实施方案中，所述方法包括提供包含一个或多个靶基因的RNA转录物或衍生自RNA转录物的核酸的靶核酸库，将所述核酸库与固定在表面上的寡核苷酸探针阵列杂交，其中包含超过100种不同寡核苷酸的阵列和每种不同的寡核苷酸定位在表面的预定区域中，不同寡核苷酸的密度大于每1cm 2大约60个不同的寡核苷酸，并且寡核苷酸探针与衍生自RNA转录物的RNA转录物或核酸互补; 并量化阵列中的杂交核酸。

3. 发明申请

US20060177904A1 Secreted proteins and polynucleotides encoding them 失效
公开(公告)号：US20060177904A1
公开(公告)日：2006-08-10
申请号：US11395249
申请日：2006-04-03
申请人： Kenneth Jacobs , John McCoy , Edward LaVallie , Lisa Collins-Racie , David Merberg , Michael Agostino , Robert Steininger , Vikki Spaulding , Gordon Wong , Hilary Clark , Kim Fechtel , Cheryl Evans , Maurice Treacy
发明人： Kenneth Jacobs , John McCoy , Edward LaVallie , Lisa Collins-Racie , David Merberg , Michael Agostino , Robert Steininger , Vikki Spaulding , Gordon Wong , Hilary Clark , Kim Fechtel , Cheryl Evans , Maurice Treacy
IPC分类号： C07H21/04 , C12P21/06 , C12N9/00 , C07K14/47 , C07K16/18
CPC分类号： C07K16/18 , A61K38/00 , C07K14/435 , C07K14/47
摘要： Novel polynucleotides and the proteins encoded thereby are disclosed.

4. 发明申请

US20050255505A1 Identification of molecular sequence signatures and methods involving the same 审中-公开
标题翻译：鉴定分子序列特征及涉及相同的方法
公开(公告)号：US20050255505A1
公开(公告)日：2005-11-17
申请号：US11056579
申请日：2005-02-11
申请人： David Lockhart , Gordon Wong , Pennina Langer-Safer
发明人： David Lockhart , Gordon Wong , Pennina Langer-Safer
IPC分类号： C12Q1/68 , C40B40/06 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： C12Q1/6827 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00689 , B01J2219/00702 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C12Q1/6837 , C40B40/06 , C12Q2565/515
摘要： Novel means and methods for analyzing hybridization data derived from hybridization assays between a target nucleic acid and differently sequenced polynucleotide probes involve selecting probe sets that define reference sequences for sequence signatures and deriving useful data about the nature of the target nucleic acid molecule based on its hybridization to the probes. The methods are useful for determining whether the target contains a nucleic acid or polypeptide sequence signature, whether the target encodes a member of a gene family, or whether the target is derived from one of any number of genes.
摘要翻译：用于分析衍生自靶核酸和不同序列多核苷酸探针之间的杂交测定的杂交数据的新颖方法和方法涉及选择定义用于序列特征的参考序列的探针组，并且基于其杂交获得关于靶核酸分子的性质的有用数据到探头。所述方法对于确定靶是否含有核酸或多肽序列特征，靶是否编码基因家族的成员，或者靶是否衍生自任何数量的基因之一是有用的。

5. 发明申请

US20100266528A1 Systemic Administration of Colony Stimulating Factors to Treat Amyloid Associated Disorders 审中-公开
标题翻译：系统性治疗淀粉样蛋白相关疾病的集落刺激因子
公开(公告)号：US20100266528A1
公开(公告)日：2010-10-21
申请号：US12515374
申请日：2007-11-16
申请人： Gordon Wong , Jane K. Relton
发明人： Gordon Wong , Jane K. Relton
IPC分类号： A61K38/19 , A61K31/7088 , A61P25/28 , A61P29/00 , A61P25/16 , A61P3/10 , A61P9/12
CPC分类号： A61K38/193
摘要： The invention relates a method of treating amyloidosis, diseases and disorders associated with amyloid plaque formation, e.g., Alzheimer's disease by increasing tissue resident macrophage activity in an organ or tissue of an animal requiring treatment by systemic administration of a colony stimulating factor. For example, the activity of bone marrow-derived microglial cells in an organ or tissue can be increased by systemic administration of a colony stimulating factor, particularly macrophage colony stimulating factor, either alone or in combination with additional colony stimulating factors, stem cell factors or other compounds capable of treating amyloidosis.
摘要翻译：本发明涉及一种通过增加需要通过系统性施用集落刺激因子治疗的动物的器官或组织中的组织驻留巨噬细胞活性来治疗淀粉样变性疾病，与淀粉样蛋白斑形成相关的疾病和病症的方法，例如阿尔茨海默氏病。例如，可通过全身施用集落刺激因子，特别是巨噬细胞集落刺激因子，单独或与额外的集落刺激因子，干细胞因子或组合刺激因子组合来增加骨髓来源的小胶质细胞在器官或组织中的活性能够治疗淀粉样变性的其他化合物。

6. 发明申请

US20070104680A1 Antibodies to natural killer stimulatory factor 审中-公开
标题翻译：抗自然杀伤刺激因子的抗体
公开(公告)号：US20070104680A1
公开(公告)日：2007-05-10
申请号：US11504768
申请日：2006-08-16
申请人： Giorgio Trinchieri , Bice Perussia , Stanley Wolf , Steven Clark , Gordon Wong , Rodney Hewick , Michiko Kobayashi
发明人： Giorgio Trinchieri , Bice Perussia , Stanley Wolf , Steven Clark , Gordon Wong , Rodney Hewick , Michiko Kobayashi
IPC分类号： A61K38/19 , A61K38/20 , A61K38/18 , C07K14/52 , C07H21/04 , C12P21/02
CPC分类号： C07K14/5434 , A61K38/00 , C07K14/52
摘要： This application relates to antibodies reactive with a novel homogenous human cytokine, Natural Killer Stimulator Factor (NKSF), having the ability to induce the production of gamia interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing such antibodies.
摘要翻译：本申请涉及具有在人外周血淋巴细胞中诱导体外产生血浆干扰素的能力的新型均质人细胞因子（Natural Killer Stimulator Factor，NKSF）的抗体的抗体和含有该抗体的药物制剂。

7. 发明申请

US20050158746A1 Expression monitoring by hybridization to high density oligonucleotide arrays 审中-公开
公开(公告)号：US20050158746A1
公开(公告)日：2005-07-21
申请号：US10998518
申请日：2004-11-23
申请人： David Lockhart , Eugene Brown , Gordon Wong , Mark Chee , Thomas Gingeras
发明人： David Lockhart , Eugene Brown , Gordon Wong , Mark Chee , Thomas Gingeras
IPC分类号： G01N33/53 , C12N15/09 , C12Q1/68 , G01N15/14 , G01N37/00
CPC分类号： C12Q1/6809 , C12Q1/6837 , G01N15/1475 , C12Q2565/507
摘要： This invention provides methods of monitoring the expression levels of a multiplicity of genes. The methods involve hybridizing a nucleic acid sample to a high density array of oligonucleotide probes where the high density array contains oligonucleotide probes complementary to subsequences of target nucleic acids in the nucleic acid sample. In one embodiment, the method involves providing a pool of target nucleic acids comprising RNA transcripts of one or more target genes, or nucleic acids derived from the RNA transcripts, hybridizing said pool of nucleic acids to an array of oligonucleotide probes immobilized on surface, where the array comprising more than 100 different oligonucleotides and each different oligonucleotide is localized in a predetermined region of the surface, the density of the different oligonucleotides is greater than about 60 different oligonucleotides per 1 cm2, and the olignucleotide probes are complementary to the RNA transcripts or nucleic acids derived from the RNA transcripts; and quantifying the hybridized nucleic acids in the array.

8. 发明申请

US20050069927A1 Identification of molecular sequence signatures and methods involving the same 有权
公开(公告)号：US20050069927A1
公开(公告)日：2005-03-31
申请号：US10911065
申请日：2004-08-04
申请人： David Lockhart , Gordon Wong , Pennina Langer-Safer
发明人： David Lockhart , Gordon Wong , Pennina Langer-Safer
IPC分类号： C12Q1/68 , C40B40/06 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： C12Q1/6827 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00689 , B01J2219/00702 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C12Q1/6837 , C40B40/06 , C12Q2565/515
摘要： Novel means and methods for analyzing hybridization data derived from hybridization assays between a target nucleic acid and differently sequenced polynucleotide probes involve selecting probe sets that define reference sequences for sequence signatures and deriving useful data about the nature of the target nucleic acid molecule based on its hybridization to the probes. The methods are useful for determining whether the target contains a nucleic acid or polypeptide sequence signature, whether the target encodes a member of a gene family, or whether the target is derived from one of any number of genes.

9. 发明申请

US20050003491A1 Secreted proteins and polynucleotides encoding them 审中-公开
标题翻译：分泌蛋白质和编码它们的多核苷酸
公开(公告)号：US20050003491A1
公开(公告)日：2005-01-06
申请号：US10913553
申请日：2004-08-09
申请人： Kenneth Jacobs , John McCoy , Edward LaVallie , Lisa Collins-Racie , Cheryl Evans , David Merberg , Maurice Treacy , Michael Agostino , Robert Steininger , Vikki Spaulding , Gordon Wong , Hilary Clark , Kim Fechtel
发明人： Kenneth Jacobs , John McCoy , Edward LaVallie , Lisa Collins-Racie , Cheryl Evans , David Merberg , Maurice Treacy , Michael Agostino , Robert Steininger , Vikki Spaulding , Gordon Wong , Hilary Clark , Kim Fechtel
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C07K14/475 , C07K14/52 , C07K14/575 , C07K14/705 , C07H21/04 , C07K16/18 , C12N9/00 , C12P21/04
CPC分类号： C07K14/475 , A61K38/00 , A61K48/00 , C07K14/47 , C07K14/52 , C07K14/575 , C07K14/705
摘要： Novel polynucleotides and the proteins encoded thereby are disclosed.
摘要翻译：公开了新的多核苷酸和由此编码的蛋白质。

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