专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20050255491A1 Small molecule and peptide arrays and uses thereof 审中-公开
标题翻译：小分子和肽阵列及其用途
公开(公告)号：US20050255491A1
公开(公告)日：2005-11-17
申请号：US10989226
申请日：2004-11-15
申请人： Frank Lee , Xun Meng , Noubar Afeyan , Neal Gordon
发明人： Frank Lee , Xun Meng , Noubar Afeyan , Neal Gordon
IPC分类号： C07H21/04 , C12Q1/68 , C40B40/10 , G01N33/543 , G01N33/68 , G06F19/22
CPC分类号： G01N33/6842 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , B82Y5/00 , B82Y10/00 , C40B40/10 , G01N33/54306 , G01N33/54366 , G01N33/6803 , G16B25/00 , G16B30/00 , G16B40/00 , Y02A90/26
摘要： Disclosed are competition assay methods for reliably detecting the presence and/or quantitation of small molecules (e.g., metabolites) and peptides/proteins in a sample by the use of capture agents specific for immobilized small molecules and/or peptides/proteins. Arrays comprising these small molecules and/or peptides/proteins are also provided.
摘要翻译：公开了通过使用对固定的小分子和/或肽/蛋白质特异性的捕获剂来可靠地检测样品中小分子（例如代谢物）和肽/蛋白质的存在和/或定量的竞争测定方法。还提供了包含这些小分子和/或肽/蛋白质的阵列。

2. 发明申请

US20050069911A1 Proteome epitope tags and methods of use thereof in protein modification analysis 失效
标题翻译：蛋白质组表位标签及其在蛋白质修饰分析中的应用方法
公开(公告)号：US20050069911A1
公开(公告)日：2005-03-31
申请号：US10773032
申请日：2004-02-05
申请人： Frank Lee , Xun Meng , Noubar Afeyan
发明人： Frank Lee , Xun Meng , Noubar Afeyan
IPC分类号： C12Q1/48 , C40B30/04 , G01N33/543 , G01N33/68 , C12Q1/68 , G01N33/53 , G01N33/537
CPC分类号： G01N33/6803 , B82Y5/00 , B82Y10/00 , C12Q1/48 , C40B30/04 , G01N33/6842
摘要： Disclosed are methods for reliably detecting the presence of proteins, including proteins with various post-translational modifications (phosphorylation, glycosylation, methylation, acetylation, etc.) in a sample by the use of one or more capture agents that recognize and interact with recognition sequences uniquely characteristic of a protein or a set of proteins (Proteome Epitope Tags, or PETs) in the sample. Arrays comprising these capture agents or PETs are also provided.
摘要翻译：公开了通过使用一种或多种识别并与识别序列相互作用的捕获剂来可靠地检测样品中存在蛋白质的方法，包括各种翻译后修饰（磷酸化，糖基化，甲基化，乙酰化等）的蛋白质的存在样品中蛋白质或蛋白质组（Proteome Epitope Tags，或PET）的独特特征。还提供了包含这些捕获剂或PET的阵列。

3. 发明申请

US20050074865A1 Adzymes and uses thereof 审中-公开
标题翻译：酶及其用途
公开(公告)号：US20050074865A1
公开(公告)日：2005-04-07
申请号：US10792498
申请日：2004-03-02
申请人： Noubar Afeyan , Frank Lee , Gordon Wong , Ruchira Das Gupta , Brian Baynes
发明人： Noubar Afeyan , Frank Lee , Gordon Wong , Ruchira Das Gupta , Brian Baynes
IPC分类号： C12N9/00 , C12N9/50 , C12N9/76 , C12N15/62 , C12N9/64
CPC分类号： C12N9/6427 , C07K2319/00 , C07K2319/01 , C07K2319/33 , C12N9/00 , C12N9/50 , C12N15/62
摘要： Disclosed is a family of novel protein constructs, useful as drugs and for other purposes, termed “adzymes,” comprising an address moiety and a catalytic domain. In some types of disclosed adzymes, the address binds with a binding site on or in functional proximity to a targeted biomolecule, e.g., an extracellular targeted biomolecule, and is disposed adjacent the catalytic domain so that its affinity serves to confer a new specificity to the catalytic domain by increasing the effective local concentration of the target in the vicinity of the catalytic domain. The present invention also provides pharmaceutical compositions comprising these adzymes, methods of making adzymes, DNA's encoding adzymes or parts thereof, and methods of using adzymes, such as for treating human subjects suffering from a disease, such as a disease associated with a soluble or membrane bound molecule, e.g., an allergic or inflammatory disease.
摘要翻译：公开了一种新型蛋白质构建体家族，其用作药物和用于其它目的，称为“腺苷”，包括地址部分和催化结构域。在一些类型的公开的腺体中，该结构域与靶向生物分子（例如细胞外靶向生物分子）功能接近的结合位点结合，并且设置在催化结构域附近，使得其亲和力用于赋予通过增加催化结构域附近靶的有效局部浓度来制备催化结构域。本发明还提供药物组合物，其包含这些腺病，制造腺体的方法，编码DNA的DNA或其部分，以及使用腺病的方法，例如用于治疗患有疾病例如与可溶性或膜相关的疾病结合分子，例如过敏性或炎性疾病。

4. 发明申请

US20070276129A1 Modular molecular clasps and uses thereof 审中-公开
标题翻译：模块化分子钩扣及其用途
公开(公告)号：US20070276129A1
公开(公告)日：2007-11-29
申请号：US11505630
申请日：2006-08-17
申请人： Carlo Rizzuto , Noubar Afeyan , Frank Lee , George Church , Ruchira Gupta , John Schwartz , Bin Zhang , Alexey Lugovskoy
发明人： Carlo Rizzuto , Noubar Afeyan , Frank Lee , George Church , Ruchira Gupta , John Schwartz , Bin Zhang , Alexey Lugovskoy
IPC分类号： C07K16/46
CPC分类号： C12N15/62 , A61K38/00 , C07K19/00 , C07K2319/00 , C07K2319/21 , C07K2319/30 , C07K2319/60 , C07K2319/74 , G01N33/542
摘要： The present invention provides Modular Molecular Clasps and methods of using these Modular Molecular Clasps in a wide range of applications in the health care industry, e.g., in therapy, in clinical diagnostics, in in vivo imaging or in drug discovery. The Modular Molecular Clasps of the present invention also have industrial and environmental applications, e.g., in environmental diagnostics, industrial diagnostics, food safety, toxicology, catalysis of reactions or high-throughput screening; as well as applications in the agricultural industry and in basic research. Methods of designing the Modular Molecular Clasps, as well as arrays and biosensors comprising these Modular Molecular Clasps are also provided.
摘要翻译：本发明提供了在医疗保健行业的广泛应用中使用这些模块化分子克隆的模块化分子克隆和方法，例如在治疗，临床诊断，体内成像或药物发现中。本发明的模块化分子克隆还具有工业和环境应用，例如在环境诊断，工业诊断，食品安全，毒理学，反应催化或高通量筛选中。以及农业行业的应用和基础研究。还提供了设计模块化分子克隆的方法，以及包含这些模块分子克隆的阵列和生物传感器。

5. 发明申请

US20060080268A1 Method and apparatus for evolutionary design 有权
公开(公告)号：US20060080268A1
公开(公告)日：2006-04-13
申请号：US11229020
申请日：2005-09-16
申请人： Noubar Afeyan , Kamal Malek , Nigel Bufton , Sevan Ficici , Howard Austin , Larry Austin , Honor McClellan
发明人： Noubar Afeyan , Kamal Malek , Nigel Bufton , Sevan Ficici , Howard Austin , Larry Austin , Honor McClellan
IPC分类号： G06F15/18
CPC分类号： G06Q30/02 , G06F17/50 , G06F2217/08 , G06F2217/10 , G06N3/126 , G06N7/005 , G06Q10/101
摘要： The invention involves generating and presenting, typically electronically, a number of design alternatives to persons who are participating in the design, selection, or market research exercise. The participants (referred to as “selectors”) transmit data indicative of their preferences among or between the presented design alternatives, and that data is used to derive a new generation of design alternatives or proposals. The new designs are generated through the use of a computer program exploiting a genetic or evolutionary computational technique. The process is repeated, typically for many iterations or cycles.

6. 发明申请

US20070190546A1 Methods and compositions for sequencing a nucleic acid 审中-公开
标题翻译：用于测序核酸的方法和组合物
公开(公告)号：US20070190546A1
公开(公告)日：2007-08-16
申请号：US11603945
申请日：2006-11-22
申请人： Suhaib Siddiqi , Philip Buzby , Noubar Afeyan , David Liu
发明人： Suhaib Siddiqi , Philip Buzby , Noubar Afeyan , David Liu
IPC分类号： C12Q1/68 , C07H19/04
CPC分类号： C07H21/00 , C12Q1/6869 , C12Q2533/101 , C12Q2525/117 , C12Q2523/107
摘要： The invention provides a family of nucleotide analogs useful in sequencing nucleic acids containing a homopolymer region comprising, for example, two or more base repeats, and to sequencing methods using such nucleotide analogs.
摘要翻译：本发明提供了可用于测序含有例如两个或多个碱基重复序列的均聚物区域的核酸的核苷酸类似物家族，以及使用此类核苷酸类似物的测序方法。

7. 发明申请

US20060115429A1 Biological systems analysis 审中-公开
标题翻译：生物系统分析
公开(公告)号：US20060115429A1
公开(公告)日：2006-06-01
申请号：US10999512
申请日：2004-11-30
申请人： Noubar Afeyan , Aram Adourian , Amir Handzel , Brian Baynes
发明人： Noubar Afeyan , Aram Adourian , Amir Handzel , Brian Baynes
IPC分类号： A61K49/00 , G06F19/00 , A61B5/00
CPC分类号： A61K49/0004 , G06K9/6267
摘要： Disclosed are methods for the practice of systems pharmacology, systems toxicology, and systems pathology using patterns, such as images, reflective of the biological state of subjects such as humans or experimental mammals. The patterns are generated from data obtained from one or more samples from one or more subjects by applying certain data treatment techniques, and are reflective of the biochemistry of the subjects. The patterns are used in drug selection and discovery, assessment of toxicity and drug efficacy, segmentation of populations, discovery of disease subtypes, as surrogate end points, in the assessment of therapeutic options, and for diagnosis and prognosis of disease.
摘要翻译：公开了使用诸如图像的图案来实现系统药理学，系统毒理学和系统病理学的方法，其反映了诸如人类或实验哺乳动物的受试者的生物学状态。通过应用某些数据处理技术，从一个或多个受试者的一个或多个样本获得的数据生成图案，并且反映了受试者的生物化学。这些模式用于药物选择和发现，评估毒性和药物功效，人群分割，发现疾病亚型，作为替代终点，评估治疗选择，以及疾病诊断和预后。

8. 发明申请

US20070282666A1 Method and apparatus for evolutionary design 有权
标题翻译：进化设计的方法和装置
公开(公告)号：US20070282666A1
公开(公告)日：2007-12-06
申请号：US11726350
申请日：2007-03-21
申请人： Noubar Afeyan , Kamal Malek , Nigel Bufton , Sevan Ficici , Howard Austin , Larry Austin , Honor McClellan
发明人： Noubar Afeyan , Kamal Malek , Nigel Bufton , Sevan Ficici , Howard Austin , Larry Austin , Honor McClellan
IPC分类号： G06F9/44
CPC分类号： G06Q30/02 , G06F17/50 , G06F2217/08 , G06F2217/10 , G06N3/126 , G06N7/005 , G06Q10/101
摘要： The invention involves generating and presenting, typically electronically, a number of design alternatives to persons who are participating in the design, selection, or market research exercise. The participants (referred to as “selectors”) transmit data indicative of their preferences among or between the presented design alternatives, and that data is used to derive a new generation of design alternatives or proposals. The new designs are generated through the use of a computer program exploiting a genetic or evolutionary computational technique. The process is repeated, typically for many iterations or cycles.
摘要翻译：本发明涉及通常以电子方式生成和呈现参与设计，选择或市场研究活动的人的许多设计替代方案。参与者（称为“选择者”）在所提供的设计替代方案之间或之间传送指示其偏好的数据，并且该数据用于导出新一代的设计替代方案或提案。新设计是通过使用利用遗传或进化计算技术的计算机程序产生的。该过程重复，通常用于许多迭代或循环。

9. 发明授权

US06794148B2 High speed, automated, continuous flow, multi-dimensional molecular selection and analysis 有权
标题翻译：高速，自动化，连续流动，多维分子选择和分析
公开(公告)号：US06794148B2
公开(公告)日：2004-09-21
申请号：US10006630
申请日：2001-12-05
申请人： Satish Jindal , Fred Regnier , Kevin Williams , Noubar Afeyan , Sandeep Paliwal , David Evans , Aruna Pingali
发明人： Satish Jindal , Fred Regnier , Kevin Williams , Noubar Afeyan , Sandeep Paliwal , David Evans , Aruna Pingali
IPC分类号： G01N3350
CPC分类号： G01N30/463 , G01N30/7233 , G01N30/88 , G01N2030/027 , G01N2030/8813 , G01N2030/8831
摘要： The invention provides novel methods for screening a sample to select a ligand to a target of interest and for obtaining information about the ligand and its binding characteristics. Specifically, the claimed multi-dimensional methods involve combining a solution of heterogeneous ligands with the target of interest to screen the ligands on the basis of one or more binding characteristics. Ligands having the first binding characteristic bind to the target of interest thereby to form a target/ligand complex. The complex then optionally is separated from the unbound components using any of a variety of separation techniques, e.g., size exclusion. At least one of the complex or unbound components then is introduced to a second “dimension”. The second dimension is capable of separating components based upon a second binding characteristic. One then elutes the ligand having the desired binding characteristics.
摘要翻译：本发明提供了筛选样品以选择目的靶标的配体并获得关于配体及其结合特征的信息的新方法。具体地，所要求保护的多维方法包括将异构配体的溶液与感兴趣的靶结合在一个或多个结合特征的基础上筛选配体。具有第一结合特征的配体与感兴趣的靶结合，从而形成靶/配体复合物。然后任选地使用各种分离技术（例如尺寸排阻）中的未结合组分分离复合物。然后将至少一个复杂的或未结合的组件引入第二个“维度”。第二维能够基于第二结合特征分离组分。然后，然后将具有所需结合特征的配体洗脱出来。

10. 发明申请

US20100057368A1 Biological Systems Analysis 审中-公开
标题翻译：生物系统分析
公开(公告)号：US20100057368A1
公开(公告)日：2010-03-04
申请号：US11791400
申请日：2005-11-30
申请人： Noubar Afeyan , Aram Adourian , Robert McBurney
发明人： Noubar Afeyan , Aram Adourian , Robert McBurney
IPC分类号： G06F19/00 , G06G7/60
CPC分类号： A61K49/0004 , G16B40/00 , G16B45/00 , G16H10/20
摘要： Disclosed are methods for the practice of systems pharmacology, systems toxicology, and systems pathology using patterns, such as images, reflective of the biological state of subjects such as humans or experimental mammals. The patterns are generated from data obtained from one or more samples from one or more subjects by applying certain data treatment techniques, and are reflective of the biochemistry of the subjects. The patterns are used in drug selection and discovery, assessment of toxicity and drug efficacy, segmentation of populations, discovery of disease subtypes, as surrogate end points, in the assessment of therapeutic options, and for diagnosis and prognosis of disease.
摘要翻译：公开了使用诸如图像的图案来系统药理学，系统毒理学和系统病理学的方法，其反映诸如人类或实验哺乳动物的受试者的生物学状态。通过应用某些数据处理技术，从一个或多个受试者的一个或多个样本获得的数据生成图案，并且反映了受试者的生物化学。这些模式用于药物选择和发现，评估毒性和药物功效，人群分割，发现疾病亚型，作为替代终点，评估治疗选择，以及疾病诊断和预后。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式