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1. 发明授权

US07837621B2 Computer-aided bone distraction 有权
标题翻译：计算机辅助骨牵引
公开(公告)号：US07837621B2
公开(公告)日：2010-11-23
申请号：US10636052
申请日：2003-08-07
申请人： Norman Krause , Robert W. Mendicino , Kenji Shimada , Lee E. Weiss , Takeo Kanade
发明人： Norman Krause , Robert W. Mendicino , Kenji Shimada , Lee E. Weiss , Takeo Kanade
IPC分类号： A61B5/00 , G06G7/48
CPC分类号： A61B17/025 , A61B2017/0275 , A61B2034/101 , A61B2090/376 , G06T15/20 , G06T17/10 , G06T2210/41
摘要： Systems and methods of generating updated surgical plans are described herein. In one embodiment, a method of generating an updated surgical plan can include generating a three dimensional (3D) model of a bone, generating a surgical plan based on the 3D model, in which the surgical plan can include: locations on the bone upon which to dispose a fixator and settings of struts of the fixator, disposing the fixator on the bone based on the surgical plan, and, based on data associated with the placement of the fixator disposed on the bone, generating an updated surgical plan including updated settings for the struts.
摘要翻译：本文描述了产生更新的手术计划的系统和方法。在一个实施例中，生成更新的手术计划的方法可以包括生成骨骼的三维（3D）模型，基于3D模型生成手术计划，其中手术计划可以包括：骨骼上的位置设置固定器和固定器的支柱设置，基于手术计划将固定器放置在骨骼上，并且基于与放置在骨头上的固定器的放置相关联的数据，生成更新的手术计划，其包括更新的设置，支柱

2. 发明授权

US06711432B1 Computer-aided orthopedic surgery 有权
标题翻译：计算机辅助矫形外科手术
公开(公告)号：US06711432B1
公开(公告)日：2004-03-23
申请号：US09694665
申请日：2000-10-23
申请人： Norman M. Krause , Lee E. Weiss , Kenji Shimada , Takeo Kanade
发明人： Norman M. Krause , Lee E. Weiss , Kenji Shimada , Takeo Kanade
IPC分类号： A61F230
CPC分类号： A61B17/151 , A61B17/15 , A61B17/152 , A61B34/10 , A61B90/36 , A61B2034/101 , G06F19/00 , Y10S128/922
摘要： Devices and methods for implementing computer-aided surgical procedures and more specifically devices and methods for implementing a computer-aided orthopedic surgery utilizing intra-operative feedback. A three-dimensional model of an area of a patient upon which a surgical procedure is to be performed is modeled using software techniques. The software model is used to generate a surgical plan, including placement of multifunctional markers, for performing the surgical procedure. After the markers are placed on the patient, an updated image of the patient is taken and used to calculate a final surgical plan for performing the remainder of the surgical procedure. The three-dimensional modeling, surgical planning, and surgery may all take place remote from each other. The various entities may communicate via an electronic communications network such as the Internet.
摘要翻译：用于实施计算机辅助外科手术的装置和方法，更具体地涉及利用术中反馈来实施计算机辅助整形外科手术的装置和方法。使用软件技术对要进行外科手术的患者区域的三维模型进行建模。软件模型用于产生手术计划，包括放置多功能标记物，用于执行外科手术。在将标记物放置在患者身上之后，拍摄患者的更新图像并用于计算用于执行外科手术的其余部分的最终手术计划。三维建模，手术计划和手术都可能相互远离。各个实体可以通过诸如因特网之类的电子通信网络进行通信。

3. 发明授权

US08293530B2 Method and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom 有权
标题翻译：用于制造等离子体的塑料和生物塑料的方法和装置
公开(公告)号：US08293530B2
公开(公告)日：2012-10-23
申请号：US11873751
申请日：2007-10-17
申请人： James E. Burgess , Phil G. Campbell , Lee E. Weiss , Jason Smith
发明人： James E. Burgess , Phil G. Campbell , Lee E. Weiss , Jason Smith
IPC分类号： C12N5/078
CPC分类号： A61L27/3616 , A61L27/3834 , A61L27/502 , A61L31/005 , A61L31/141
摘要： A method of making a bioplastic, and a bioplastic produced thereby, by using human plasma in which human plasma is clotted, either dried through its gel phase or dried and powdered, and processed into a bioplastic with the addition of at least one plasticizer followed by forming and heating to form a final bioplastic construct.
摘要翻译：通过使用其中血浆凝结的人血浆，通过其凝胶相干燥或干燥和粉末化，制备生物塑料和生物塑料的方法，并且通过加入至少一种增塑剂加工成生物塑料，然后加入形成和加热以形成最终的生物塑料结构。

4. 发明申请

US20120003193A1 Methods and Apparatus for Manufacturing Plasma Based Plastics and Bioplastics Produced Therefrom 有权
标题翻译：制造等离子体基塑料和生物塑料的方法和装置
公开(公告)号：US20120003193A1
公开(公告)日：2012-01-05
申请号：US13177090
申请日：2011-07-06
申请人： Phil G. Campbell , James E. Burgess , Lee E. Weiss , Jason Smith
发明人： Phil G. Campbell , James E. Burgess , Lee E. Weiss , Jason Smith
IPC分类号： A61K35/16 , A61P19/04 , A61K35/48
CPC分类号： A61K35/16 , A61L27/3604 , A61L27/3616 , A61L27/3834 , A61L27/502 , A61L31/005 , A61L31/141
摘要： Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.
摘要翻译：由包括血液的组合物制备的血液衍生的塑料制品，在一些实施方案中，至少一种交联剂和/或至少一种生物反应调节剂可用于生物应用如伤口修复和组织移植物; 制作和使用方法; 用于评估制品中生物反应调节剂浓度的方法; 并提供用于制备血液源塑料制品的系统。

5. 发明申请

US20100254900A1 Biocompatible polymers and Methods of use 审中-公开
标题翻译：生物相容性聚合物和使用方法
公开(公告)号：US20100254900A1
公开(公告)日：2010-10-07
申请号：US11495115
申请日：2006-07-28
申请人： Phil G. Campbell , Lee E. Weiss , Jason Smith
发明人： Phil G. Campbell , Lee E. Weiss , Jason Smith
IPC分类号： A61K51/00 , A61K38/20 , A61K38/21 , A61K49/06 , A61K49/04 , A61K49/00 , A61K38/36 , A61K38/38 , A61K38/39 , A61K9/00 , A61K39/395 , A61K38/18 , A61K38/19 , A61P31/12 , A61P29/00 , A61P31/00
CPC分类号： C12N5/0068 , A61L27/18 , A61L27/502 , A61L27/54 , A61L2300/252 , A61L2300/406 , A61L2300/41 , A61L2300/414 , C12N2533/56 , C12N2533/90 , C12N2535/10 , C08L89/00
摘要： Compositions and methods for manufacturing polymers are disclosed. Compositions include novel plastics, including films and shaped forms comprising polymer matrices that are biologically compatible and biodegradable. Such plastics may comprise polymers derived from natural sources. Further, such plastics are useful in biological systems for wound repair, implants, stents, drug encapsulation and delivery, and other applications. The disclosed methods comprise mild manufacturing processes such that various additives, such as biologically active proteins, sugars, lipids, and the like may be incorporated into the polymer matrix without subsequent loss of bioactivity during processing. Additionally, methods of manufacture for controlling mechanical properties, such as elasticity, pliancy, and the porosity of such plastics are disclosed.
摘要翻译：公开了制备聚合物的组合物和方法。组合物包括新型塑料，包括膜和成形形式，其包含生物相容性和可生物降解的聚合物基质。这种塑料可以包含衍生自天然来源的聚合物。此外，这种塑料可用于伤口修复，植入物，支架，药物包封和递送以及其它应用的生物系统中。所公开的方法包括温和的制备方法，使得可以将各种添加剂，例如生物活性蛋白质，糖，脂质等掺入聚合物基质中，而不会在加工过程中随后丧失生物活性。此外，公开了用于控制这种塑料的机械性能如弹性，柔软度和孔隙率的制造方法。

6. 发明授权

US06197013B1 Method and apparatus for drug and gene delivery 失效
公开(公告)号：US06197013B1
公开(公告)日：2001-03-06
申请号：US08743902
申请日：1996-11-06
申请人： Michael L. Reed , Lee E. Weiss , Clarence C. Wu , Marc D. Feldman
发明人： Michael L. Reed , Lee E. Weiss , Clarence C. Wu , Marc D. Feldman
IPC分类号： A61M3100
CPC分类号： A61F2/86 , A61F2/848 , A61F2220/005 , A61F2220/0058 , A61F2250/0067 , A61M25/10 , A61M37/0015 , A61M2025/105 , A61M2037/0023 , A61M2037/0046
摘要： An apparatus for treating a patient. The apparatus includes a deployment mechanism having a surface. The apparatus also includes at least one probe disposed on the deployment mechanism surface. The probe extends between 25 microns and 1000 microns from the surface of the deployment mechanism. The apparatus also includes material coated on the probe. A method for treating a patient. The method includes the steps of placing a material with a probe which extends less than 1000 microns from a surface of a deployment mechanism. Next, there is the step of inserting the probe into preferably a blood vessel of a patient. Then, there is the step of penetrating the interior wall of the vessel from the interior of the vessel with the probe by activating the deployment mechanism so the material can contact the vessel.

7. 发明授权

US6143293A Assembled scaffolds for three dimensional cell culturing and tissue generation 失效
标题翻译：组装支架用于三维细胞培养和组织生成
公开(公告)号：US6143293A
公开(公告)日：2000-11-07
申请号：US48944
申请日：1998-03-26
申请人： Lee E. Weiss , Jay Wynn Calvert
发明人： Lee E. Weiss , Jay Wynn Calvert
IPC分类号： A61F2/00 , A61F2/02 , A61L27/38 , C12N5/00 , A61K35/12 , C12N11/08 , C12N11/14 , C12N11/16
CPC分类号： A61L27/3625 , A61L27/18 , A61L27/38 , C12N5/0062 , A61F2/0059 , A61F2/022 , A61L2430/22
摘要： A three-dimensional scaffold for tissue generation. Mechanical fasteners allow layered and volumetric scaffold sections, which may be pre-seeded with cells and/or growth factors, to be assembled into a heterogeneous generated tissue for implantation.
摘要翻译：用于组织生成的三维支架。机械紧固件允许可以将细胞和/或生长因子预先接种的分层和体积的支架部分组装成用于植入的异质生成的组织。

8. 发明授权

US5278442A Electronic packages and smart structures formed by thermal spray deposition 失效
标题翻译：通过热喷涂沉积形成的电子封装和智能结构
公开(公告)号：US5278442A
公开(公告)日：1994-01-11
申请号：US730226
申请日：1991-07-15
申请人： Fritz B. Prinz , Lee E. Weiss , Daniel P. Siewiorek
发明人： Fritz B. Prinz , Lee E. Weiss , Daniel P. Siewiorek
IPC分类号： H01L21/56 , B22F3/115 , B29C67/00 , H01L21/00 , H01L23/08 , H05K3/14 , H05K3/46 , H01L23/02
CPC分类号： H01L21/67121 , B22F3/115 , B29C67/0074 , B29C67/0092 , H05K3/14 , H05K3/4644 , Y10T29/49986
摘要： A smart structure or an electronic package is formed by thermal spraying utilizing a plurality of masks positioned and removed over a work surface in accordance with a predetermined sequence. The masks correspond to cross sections normal to a centerline through the structure. Masks are placed above a work surface and sprayed with either at least one primary material to form at least one electronic component and a complementary material. In this manner, layers of material form a block of deposition material and complementary material. Then, the complementary material which serves as a support structure during forming may be removed.
摘要翻译：智能结构或电子封装通过使用根据预定顺序在工作表面上定位和移除的多个掩模的热喷涂形成。掩模对应于通过结构垂直于中心线的横截面。将掩模放置在工作表面上方并用至少一种初级材料喷涂以形成至少一种电子部件和互补材料。以这种方式，材料层形成沉积材料块和互补材料。然后，可以除去在成形期间用作支撑结构的互补材料。

9. 发明授权

US5126529A Method and apparatus for fabrication of three-dimensional articles by thermal spray deposition 失效
标题翻译：通过热喷涂沉积制备三维制品的方法和装置
公开(公告)号：US5126529A
公开(公告)日：1992-06-30
申请号：US620745
申请日：1990-12-03
申请人： Lee E. Weiss , Fritz R. Prinz , E. Levent Gursoz
发明人： Lee E. Weiss , Fritz R. Prinz , E. Levent Gursoz
IPC分类号： C23C4/02 , B22F3/115 , B29C67/00 , C23C4/12 , C23C4/18
CPC分类号： B29C67/0092 , B22F3/115 , B29C67/0074 , G05B2219/49016 , G05B2219/49039 , Y10T29/49986
摘要： A method and apparatus for forming a three-dimensional object by thermal spraying utilizes a plurality of masks positioned and removed over a work surface in accordance with a predetermined sequence. The masks correspond to cross sections normal to a centerline through the workpiece. One set of masks defines all cross sections through the workpiece. A second set of masks contains at least one masks which corresponds to each mask of the first set. Masks from each set are alternatively placed above a work surface and sprayed with either a deposition material from which the workpiece will be made or a complementary material. In this manner, layers of material form a block of deposition material and complementary material. Then, the complementary material which serves as a support structure during forming is removed. Preferably, the complementary material has a lower melting temperature than the deposition material and is removed by heating the block. Alternatively, one could mask only for the deposition material and remove complementary material overlying the deposition material after each spraying of complementary material.
摘要翻译：通过热喷涂形成三维物体的方法和装置利用根据预定顺序在工作表面上定位和移除的多个掩模。掩模对应于垂直于通过工件的中心线的横截面。一组掩模定义了穿过工件的所有横截面。第二组掩模包含至少一个对应于第一组的每个掩模的掩模。每个组的面罩可替换地放置在工作表面上方，并喷涂有将由其制造工件的沉积材料或互补材料。以这种方式，材料层形成沉积材料块和互补材料。然后，去除在成形期间用作支撑结构的互补材料。优选地，互补材料具有比沉积材料更低的熔化温度，并且通过加热块来除去。或者，可以在每次喷涂互补材料之后，仅掩盖沉积材料并除去覆盖沉积材料的互补材料。

10. 发明授权

US08529956B2 Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom 有权
标题翻译：用于制造等离子体的塑料和生物塑料的方法和装置
公开(公告)号：US08529956B2
公开(公告)日：2013-09-10
申请号：US12104728
申请日：2008-04-17
申请人： Phil G. Campbell , James E. Burgess , Lee E. Weiss , Jason Smith
发明人： Phil G. Campbell , James E. Burgess , Lee E. Weiss , Jason Smith
IPC分类号： A61K35/16
CPC分类号： A61K35/16 , A61L27/3604 , A61L27/3616 , A61L27/3834 , A61L27/502 , A61L31/005 , A61L31/141
摘要： Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.
摘要翻译：由包括血液的组合物制备的血液衍生的塑料制品，在一些实施方案中，至少一种交联剂和/或至少一种生物反应调节剂可用于生物应用如伤口修复和组织移植物; 制作和使用方法; 用于评估制品中生物反应调节剂浓度的方法; 并提供用于制备血液源塑料制品的系统。

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