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1. 发明授权

US5126529A Method and apparatus for fabrication of three-dimensional articles by thermal spray deposition 失效
标题翻译：通过热喷涂沉积制备三维制品的方法和装置
公开(公告)号：US5126529A
公开(公告)日：1992-06-30
申请号：US620745
申请日：1990-12-03
申请人： Lee E. Weiss , Fritz R. Prinz , E. Levent Gursoz
发明人： Lee E. Weiss , Fritz R. Prinz , E. Levent Gursoz
IPC分类号： C23C4/02 , B22F3/115 , B29C67/00 , C23C4/12 , C23C4/18
CPC分类号： B29C67/0092 , B22F3/115 , B29C67/0074 , G05B2219/49016 , G05B2219/49039 , Y10T29/49986
摘要： A method and apparatus for forming a three-dimensional object by thermal spraying utilizes a plurality of masks positioned and removed over a work surface in accordance with a predetermined sequence. The masks correspond to cross sections normal to a centerline through the workpiece. One set of masks defines all cross sections through the workpiece. A second set of masks contains at least one masks which corresponds to each mask of the first set. Masks from each set are alternatively placed above a work surface and sprayed with either a deposition material from which the workpiece will be made or a complementary material. In this manner, layers of material form a block of deposition material and complementary material. Then, the complementary material which serves as a support structure during forming is removed. Preferably, the complementary material has a lower melting temperature than the deposition material and is removed by heating the block. Alternatively, one could mask only for the deposition material and remove complementary material overlying the deposition material after each spraying of complementary material.
摘要翻译：通过热喷涂形成三维物体的方法和装置利用根据预定顺序在工作表面上定位和移除的多个掩模。掩模对应于垂直于通过工件的中心线的横截面。一组掩模定义了穿过工件的所有横截面。第二组掩模包含至少一个对应于第一组的每个掩模的掩模。每个组的面罩可替换地放置在工作表面上方，并喷涂有将由其制造工件的沉积材料或互补材料。以这种方式，材料层形成沉积材料块和互补材料。然后，去除在成形期间用作支撑结构的互补材料。优选地，互补材料具有比沉积材料更低的熔化温度，并且通过加热块来除去。或者，可以在每次喷涂互补材料之后，仅掩盖沉积材料并除去覆盖沉积材料的互补材料。

2. 发明授权

US08293530B2 Method and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom 有权
标题翻译：用于制造等离子体的塑料和生物塑料的方法和装置
公开(公告)号：US08293530B2
公开(公告)日：2012-10-23
申请号：US11873751
申请日：2007-10-17
申请人： James E. Burgess , Phil G. Campbell , Lee E. Weiss , Jason Smith
发明人： James E. Burgess , Phil G. Campbell , Lee E. Weiss , Jason Smith
IPC分类号： C12N5/078
CPC分类号： A61L27/3616 , A61L27/3834 , A61L27/502 , A61L31/005 , A61L31/141
摘要： A method of making a bioplastic, and a bioplastic produced thereby, by using human plasma in which human plasma is clotted, either dried through its gel phase or dried and powdered, and processed into a bioplastic with the addition of at least one plasticizer followed by forming and heating to form a final bioplastic construct.
摘要翻译：通过使用其中血浆凝结的人血浆，通过其凝胶相干燥或干燥和粉末化，制备生物塑料和生物塑料的方法，并且通过加入至少一种增塑剂加工成生物塑料，然后加入形成和加热以形成最终的生物塑料结构。

3. 发明申请

US20120003193A1 Methods and Apparatus for Manufacturing Plasma Based Plastics and Bioplastics Produced Therefrom 有权
标题翻译：制造等离子体基塑料和生物塑料的方法和装置
公开(公告)号：US20120003193A1
公开(公告)日：2012-01-05
申请号：US13177090
申请日：2011-07-06
申请人： Phil G. Campbell , James E. Burgess , Lee E. Weiss , Jason Smith
发明人： Phil G. Campbell , James E. Burgess , Lee E. Weiss , Jason Smith
IPC分类号： A61K35/16 , A61P19/04 , A61K35/48
CPC分类号： A61K35/16 , A61L27/3604 , A61L27/3616 , A61L27/3834 , A61L27/502 , A61L31/005 , A61L31/141
摘要： Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.
摘要翻译：由包括血液的组合物制备的血液衍生的塑料制品，在一些实施方案中，至少一种交联剂和/或至少一种生物反应调节剂可用于生物应用如伤口修复和组织移植物; 制作和使用方法; 用于评估制品中生物反应调节剂浓度的方法; 并提供用于制备血液源塑料制品的系统。

4. 发明申请

US20100254900A1 Biocompatible polymers and Methods of use 审中-公开
标题翻译：生物相容性聚合物和使用方法
公开(公告)号：US20100254900A1
公开(公告)日：2010-10-07
申请号：US11495115
申请日：2006-07-28
申请人： Phil G. Campbell , Lee E. Weiss , Jason Smith
发明人： Phil G. Campbell , Lee E. Weiss , Jason Smith
IPC分类号： A61K51/00 , A61K38/20 , A61K38/21 , A61K49/06 , A61K49/04 , A61K49/00 , A61K38/36 , A61K38/38 , A61K38/39 , A61K9/00 , A61K39/395 , A61K38/18 , A61K38/19 , A61P31/12 , A61P29/00 , A61P31/00
CPC分类号： C12N5/0068 , A61L27/18 , A61L27/502 , A61L27/54 , A61L2300/252 , A61L2300/406 , A61L2300/41 , A61L2300/414 , C12N2533/56 , C12N2533/90 , C12N2535/10 , C08L89/00
摘要： Compositions and methods for manufacturing polymers are disclosed. Compositions include novel plastics, including films and shaped forms comprising polymer matrices that are biologically compatible and biodegradable. Such plastics may comprise polymers derived from natural sources. Further, such plastics are useful in biological systems for wound repair, implants, stents, drug encapsulation and delivery, and other applications. The disclosed methods comprise mild manufacturing processes such that various additives, such as biologically active proteins, sugars, lipids, and the like may be incorporated into the polymer matrix without subsequent loss of bioactivity during processing. Additionally, methods of manufacture for controlling mechanical properties, such as elasticity, pliancy, and the porosity of such plastics are disclosed.
摘要翻译：公开了制备聚合物的组合物和方法。组合物包括新型塑料，包括膜和成形形式，其包含生物相容性和可生物降解的聚合物基质。这种塑料可以包含衍生自天然来源的聚合物。此外，这种塑料可用于伤口修复，植入物，支架，药物包封和递送以及其它应用的生物系统中。所公开的方法包括温和的制备方法，使得可以将各种添加剂，例如生物活性蛋白质，糖，脂质等掺入聚合物基质中，而不会在加工过程中随后丧失生物活性。此外，公开了用于控制这种塑料的机械性能如弹性，柔软度和孔隙率的制造方法。

5. 发明授权

US06197013B1 Method and apparatus for drug and gene delivery 失效
公开(公告)号：US06197013B1
公开(公告)日：2001-03-06
申请号：US08743902
申请日：1996-11-06
申请人： Michael L. Reed , Lee E. Weiss , Clarence C. Wu , Marc D. Feldman
发明人： Michael L. Reed , Lee E. Weiss , Clarence C. Wu , Marc D. Feldman
IPC分类号： A61M3100
CPC分类号： A61F2/86 , A61F2/848 , A61F2220/005 , A61F2220/0058 , A61F2250/0067 , A61M25/10 , A61M37/0015 , A61M2025/105 , A61M2037/0023 , A61M2037/0046
摘要： An apparatus for treating a patient. The apparatus includes a deployment mechanism having a surface. The apparatus also includes at least one probe disposed on the deployment mechanism surface. The probe extends between 25 microns and 1000 microns from the surface of the deployment mechanism. The apparatus also includes material coated on the probe. A method for treating a patient. The method includes the steps of placing a material with a probe which extends less than 1000 microns from a surface of a deployment mechanism. Next, there is the step of inserting the probe into preferably a blood vessel of a patient. Then, there is the step of penetrating the interior wall of the vessel from the interior of the vessel with the probe by activating the deployment mechanism so the material can contact the vessel.

6. 发明授权

US6143293A Assembled scaffolds for three dimensional cell culturing and tissue generation 失效
标题翻译：组装支架用于三维细胞培养和组织生成
公开(公告)号：US6143293A
公开(公告)日：2000-11-07
申请号：US48944
申请日：1998-03-26
申请人： Lee E. Weiss , Jay Wynn Calvert
发明人： Lee E. Weiss , Jay Wynn Calvert
IPC分类号： A61F2/00 , A61F2/02 , A61L27/38 , C12N5/00 , A61K35/12 , C12N11/08 , C12N11/14 , C12N11/16
CPC分类号： A61L27/3625 , A61L27/18 , A61L27/38 , C12N5/0062 , A61F2/0059 , A61F2/022 , A61L2430/22
摘要： A three-dimensional scaffold for tissue generation. Mechanical fasteners allow layered and volumetric scaffold sections, which may be pre-seeded with cells and/or growth factors, to be assembled into a heterogeneous generated tissue for implantation.
摘要翻译：用于组织生成的三维支架。机械紧固件允许可以将细胞和/或生长因子预先接种的分层和体积的支架部分组装成用于植入的异质生成的组织。

7. 发明授权

US5278442A Electronic packages and smart structures formed by thermal spray deposition 失效
标题翻译：通过热喷涂沉积形成的电子封装和智能结构
公开(公告)号：US5278442A
公开(公告)日：1994-01-11
申请号：US730226
申请日：1991-07-15
申请人： Fritz B. Prinz , Lee E. Weiss , Daniel P. Siewiorek
发明人： Fritz B. Prinz , Lee E. Weiss , Daniel P. Siewiorek
IPC分类号： H01L21/56 , B22F3/115 , B29C67/00 , H01L21/00 , H01L23/08 , H05K3/14 , H05K3/46 , H01L23/02
CPC分类号： H01L21/67121 , B22F3/115 , B29C67/0074 , B29C67/0092 , H05K3/14 , H05K3/4644 , Y10T29/49986
摘要： A smart structure or an electronic package is formed by thermal spraying utilizing a plurality of masks positioned and removed over a work surface in accordance with a predetermined sequence. The masks correspond to cross sections normal to a centerline through the structure. Masks are placed above a work surface and sprayed with either at least one primary material to form at least one electronic component and a complementary material. In this manner, layers of material form a block of deposition material and complementary material. Then, the complementary material which serves as a support structure during forming may be removed.
摘要翻译：智能结构或电子封装通过使用根据预定顺序在工作表面上定位和移除的多个掩模的热喷涂形成。掩模对应于通过结构垂直于中心线的横截面。将掩模放置在工作表面上方并用至少一种初级材料喷涂以形成至少一种电子部件和互补材料。以这种方式，材料层形成沉积材料块和互补材料。然后，可以除去在成形期间用作支撑结构的互补材料。

8. 发明授权

US08529956B2 Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom 有权
标题翻译：用于制造等离子体的塑料和生物塑料的方法和装置
公开(公告)号：US08529956B2
公开(公告)日：2013-09-10
申请号：US12104728
申请日：2008-04-17
申请人： Phil G. Campbell , James E. Burgess , Lee E. Weiss , Jason Smith
发明人： Phil G. Campbell , James E. Burgess , Lee E. Weiss , Jason Smith
IPC分类号： A61K35/16
CPC分类号： A61K35/16 , A61L27/3604 , A61L27/3616 , A61L27/3834 , A61L27/502 , A61L31/005 , A61L31/141
摘要： Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.
摘要翻译：由包括血液的组合物制备的血液衍生的塑料制品，在一些实施方案中，至少一种交联剂和/或至少一种生物反应调节剂可用于生物应用如伤口修复和组织移植物; 制作和使用方法; 用于评估制品中生物反应调节剂浓度的方法; 并提供用于制备血液源塑料制品的系统。

9. 发明申请

US20130197468A1 Device for Intramyocardial Delivery 审中-公开
标题翻译：心肌内输送装置
公开(公告)号：US20130197468A1
公开(公告)日：2013-08-01
申请号：US13751414
申请日：2013-01-28
申请人： David SCHWARTZMAN , Lee E. Weiss , Phil Gordon Campbell , Gary K. Fedder
发明人： David SCHWARTZMAN , Lee E. Weiss , Phil Gordon Campbell , Gary K. Fedder
IPC分类号： A61M5/00
CPC分类号： A61M5/00 , A61B5/0215 , A61B5/14503 , A61B5/14532 , A61B5/14539 , A61B17/068 , A61B2017/00004 , A61B2017/00022 , A61B2017/00243 , A61B2017/00893 , A61B2017/0648 , A61L27/3633 , A61L27/54
摘要： Methods and apparatuses for delivery of biologically active material and/or sensors to a target organ or system. The apparatuses allow for specific, controlled delivery of the biologically active material and targeted placement of sensors. The apparatuses may be fabricated from cellular and/or acellular biological active components to promote integration of sensors into tissue and achieve appropriate release of biologically active molecules. The apparatuses may be fabricated from plasma-containing materials or other biopolymers such that the apparatus will resorbed into the tissue following insertion. The biologically active cellular or acellular component may be incorporated into that material may then serve as the source of the therapeutic biologically active component. The apparatus may take the form of a screw, though numerous shapes arc contemplated. The delivery methods and apparatuses of the present invention may be employed in a wide variety of physiological and medical situations, with cardiac implementations being particularly appropriate.
摘要翻译：用于将生物活性物质和/或传感器递送至靶器官或系统的方法和装置。这些装置允许生物活性材料的特定的，受控的输送和传感器的目标放置。这些装置可以由细胞和/或细胞生物活性成分制成，以促进传感器集成到组织中并实现生物活性分子的适当释放。这些装置可以由含等离子体的材料或其他生物聚合物制成，使得装置在插入后将被吸收到组织中。可以将生物活性细胞或非细胞成分掺入，然后该物质可以用作治疗性生物活性成分的来源。该装置可以采用螺钉的形式，尽管预期了许多形状。本发明的递送方法和装置可以用于各种生理和医学情况，其中心脏实施是特别合适的。

10. 发明申请

US20120177694A1 Methods and Apparatus for Manufacturing Plasma Based Plastics and Bioplastics Produced Therefrom 有权
公开(公告)号：US20120177694A1
公开(公告)日：2012-07-12
申请号：US13177147
申请日：2011-07-06
申请人： Phil G. Campbell , James E. Burgess , Lee E. Weiss , Jason Smith
发明人： Phil G. Campbell , James E. Burgess , Lee E. Weiss , Jason Smith
IPC分类号： A61K9/00 , A61P29/00 , A61P31/00 , A61P35/00 , A61P17/00 , A61P5/00 , A61P37/02 , A61P37/06 , A61P27/02 , A61P11/00 , A61K35/16 , A61P9/00
CPC分类号： A61K35/16 , A61K38/18 , A61K38/19 , A61K38/22 , A61K38/37 , A61L27/3616 , A61L27/365 , A61L27/54
摘要： Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.

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