专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20110065213A1 METHOD FOR IMMUNOASSAY USING LATEX PARTICLES 审中-公开
标题翻译：使用LATEX颗粒免疫的方法
公开(公告)号：US20110065213A1
公开(公告)日：2011-03-17
申请号：US12879524
申请日：2010-09-10
申请人： Noriyuki KASAGI , Tomoko Kuwabara , Yuya Watanabe
发明人： Noriyuki KASAGI , Tomoko Kuwabara , Yuya Watanabe
IPC分类号： G01N33/543 , C08F20/06 , C08F12/08 , C08F4/30
CPC分类号： G01N33/585 , G01N33/54313 , G01N33/54393
摘要： An object of the present invention is to provide latex particles with high production reproducibility, by which a sufficiently high value of signal ΔS (=value of signal−value of noise) can be realized in immunodiagnosis. The present invention provides a method for assay which comprises steps of (1) causing a substance to be detected to come into contact with or compete with binding substance-labeled fluorescent latex particles which are obtained by causing a binding substance to bind to fluorescent latex particles, and (2) measuring fluorescence from the binding substance-labeled fluorescent latex particles, wherein: (a) the fluorescent latex particles are obtained by adding a fluorescent substance to latex particles characterized in that the amount of COOH groups existing on the surfaces of the latex particles is from 40 μeq/g to 300 μeq/g, or (b) the fluorescent latex particles contain latex particles and a fluorescent substance, which are characterized in that the amount of COOH groups existing on the surfaces of the fluorescent latex particles is from 40 μeq/g to 300 μeq/g.
摘要翻译：本发明的目的是提供具有高生产重现性的胶乳颗粒，通过该乳胶颗粒可以在免疫诊断中实现足够高的信号值Dgr; S（=噪声信号值的值）。本发明提供了一种测定方法，其包括以下步骤：（1）使被检测物质与通过使结合物质结合荧光胶乳颗粒获得的结合物质标记的荧光胶乳颗粒接触或竞争，和（2）测量来自结合物质标记的荧光胶乳颗粒的荧光，其中：（a）通过将荧光物质添加到胶乳颗粒中获得荧光胶乳颗粒，其特征在于存在于表面上的COOH基团的量胶乳粒子为40μeq/ g〜300μeq/ g，或（b）荧光胶乳粒子含有胶乳粒子和荧光物质，其特征在于，存在于荧光胶乳粒子表面的COOH基团的量为从40μeq/ g到300μeq/ g。

2. 发明申请

US20130078739A1 CORTISOL IMMUNOASSAY USING FLUORESCENT PARTICLES 审中-公开
标题翻译： CORTISOL免疫荧光染料使用荧光颗粒
公开(公告)号：US20130078739A1
公开(公告)日：2013-03-28
申请号：US13614817
申请日：2012-09-13
申请人： Noriyuki KASAGI , Yuya WATANABE , Ryo HAMASAKI , Naoyuki NISHIKAWA
发明人： Noriyuki KASAGI , Yuya WATANABE , Ryo HAMASAKI , Naoyuki NISHIKAWA
IPC分类号： G01N21/64 , C07K17/02 , G01N1/00
CPC分类号： G01N33/743 , G01N33/553 , G01N33/582
摘要： Provided are a base plate and a method for cortisol immunoassay, which enable immunoassay of cortisol with high sensitivity particularly in a clinically significant cortisol concentration range (that is, 1 μg/dL to 30 μg/dL). A base plate for cortisol immunoassay which has a cortisol albumin conjugate having a cortisol/albumin ratio of from 12 to 20 immobilized thereon is disclosed.
摘要翻译：提供了一种用于皮质醇免疫测定的底板和方法，其能够以高灵敏度，特别是在临床显着的皮质醇浓度范围（即1μg/ dL至30μg/ dL）中进行皮质醇的免疫测定。公开了一种用于皮质醇免疫测定的底板，其具有固定在其上的皮质醇/白蛋白比例为12至20的皮质醇清蛋白缀合物。

3. 发明申请

US20130078738A1 METHOD FOR MEASURING SUBSTANCE TO BE MEASURED USING FLUORESCENT PARTICLES, TEST SUBSANCE MEASUREMENT CHIP, AND TEST SUBSANCE MEASUREMENT KIT 审中-公开
标题翻译：使用荧光颗粒测量物质的方法，测试接口测量芯片和测试位置测量套件
公开(公告)号：US20130078738A1
公开(公告)日：2013-03-28
申请号：US13614806
申请日：2012-09-13
申请人： Yuya WATANABE , Noriyuki KASAGI
发明人： Yuya WATANABE , Noriyuki KASAGI
IPC分类号： G01N21/64
CPC分类号： G01N33/54366 , G01N33/54313 , G01N33/585
摘要： A method for measuring a test substance including (1) reacting fluorescent particles and a test substance by bringing the test substance and the fluorescent particles into contact with a test area and a control area present on a substrate, (2) removing the unreacted fluorescent particles, (3) measuring the fluorescence of the fluorescent particles of the test area and the control area, and (4) correcting a fluorescence signal value in the test area using a fluorescence signal value in the control area, wherein the fluorescent particles are binding substance-labeling fluorescent particles in which one or more of a first binding substance which can bind to the test substance, and a third binding substance which can bind to a second binding substance and which does not bind to the test substance are bound, and the second binding substance which can bind to the first binding substance is immobilized on the control area.
摘要翻译：一种测试物质的测量方法，包括：（1）通过使测试物质和荧光颗粒与存在于基底上的测试区域和控制区域接触使荧光颗粒和测试物质反应，（2）除去未反应的荧光颗粒，（3）测量测试区域和控制区域的荧光颗粒的荧光，以及（4）使用控制区域中的荧光信号值校正测试区域中的荧光信号值，其中荧光颗粒是结合物质标记荧光颗粒，其中可以结合测试物质的一种或多种第一结合物质和可结合第二结合物质并且不结合测试物质的第三结合物质结合，第二种可以结合第一结合物质的结合物质固定在对照区域上。

4. 发明申请

US20130052666A1 ANTIBODY AGAINST HUMAN TSH AND CANINE TSH 有权
标题翻译：抗人体抗体和人类TSH
公开(公告)号：US20130052666A1
公开(公告)日：2013-02-28
申请号：US13592802
申请日：2012-08-23
申请人： Noriyuki KASAGI , Yuya WATANABE
发明人： Noriyuki KASAGI , Yuya WATANABE
IPC分类号： G01N33/577 , C07K16/26 , G01N21/64 , G01N21/25 , C12N5/12 , C12N9/96
CPC分类号： C07K16/26 , C07K2317/33 , C07K2317/92
摘要： It is an object of the present invention to provide an antibody that recognizes a canine TSH and binds thereto, without obtaining a large amount of canine TSH antigen. The present invention provides a monoclonal antibody produced by a hybridoma having Accession No. FERM BP-11490.
摘要翻译：本发明的目的是提供一种识别犬TSH并与之结合的抗体，而不需要大量的犬TSH抗原。本发明提供由登录号为FERM BP-11490的杂交瘤产生的单克隆抗体。

5. 发明申请

US20120046447A1 METHOD FOR PRODUCING CONJUGATE OF THYROXINE AND ALBUMIN 失效
标题翻译：生产甲状腺素和阿尔伯霉素的方法
公开(公告)号：US20120046447A1
公开(公告)日：2012-02-23
申请号：US13213585
申请日：2011-08-19
申请人： Noriyuki KASAGI , Tadahiro Matsuno
发明人： Noriyuki KASAGI , Tadahiro Matsuno
IPC分类号： C07K1/107 , C07K14/76
CPC分类号： A61K47/643
摘要： It is an object of the present invention to provide a method for producing a conjugate of thyroxine and albumin with higher purity. The present invention provides a method for producing a conjugate of thyroxine and albumin which comprises: step (a) of converting a carboxyl group in thyroxine having a carboxyl group to be linked to albumin into an active ester and allowing the thyroxine to react with albumin, so as to prepare a conjugate of thyroxine and albumin; and step (b) of purifying the conjugate with the use of an acidic mixed aqueous solvent in which the thyroxine having a carboxyl group to be linked to albumin is dissolved but albumin is not precipitated.
摘要翻译：本发明的目的是提供一种制备高纯度甲状腺素和白蛋白缀合物的方法。本发明提供了一种生产甲状腺素和白蛋白缀合物的方法，其包括：将具有与白蛋白连接的羧基的甲状腺素中的羧基转化成活性酯的步骤（a），并使甲状腺素与白蛋白反应，以制备甲状腺素和白蛋白的缀合物; 和使用其中与白蛋白连接的具有羧基的甲状腺素溶解但不沉淀白蛋白的酸性混合水性溶剂来纯化缀合物的步骤（b）。

6. 发明申请

US20130078737A1 THYROXINE IMMUNOASSAY USING FLUORESCENT PARTICLES 有权
标题翻译：使用荧光颗粒进行甲状腺素免疫
公开(公告)号：US20130078737A1
公开(公告)日：2013-03-28
申请号：US13610497
申请日：2012-09-11
申请人： Noriyuki KASAGI , Junichi KATADA , Tadahiro MATSUNO
发明人： Noriyuki KASAGI , Junichi KATADA , Tadahiro MATSUNO
IPC分类号： G01N33/78 , G01N21/64
CPC分类号： G01N33/54373 , G01N33/54306 , G01N33/585 , G01N33/78
摘要： Provided are a base plate and a method for thyroxine immunoassay, which are capable of decreasing the signal change rate caused by temperature change in a high-sensitivity immunoassay method for thyroxine. A base plate for thyroxine immunoassay which has a conjugate of thyroxine or a derivative thereof and albumin immobilized thereon, and in which the ratio of the molecule number of thyroxine or a derivative thereof to the molecule number of albumin in the immobilized conjugate, is disclosed.
摘要翻译：本发明提供甲状腺素免疫测定法的基板和甲基荧光素免疫测定方法，能够降低甲状腺素的高灵敏度免疫测定法中的温度变化引起的信号变化率。公开了一种甲状腺素免疫测定的基板，其具有甲状腺素或其衍生物和固定在其上的白蛋白的缀合物，其中甲状腺素或其衍生物的分子数与固定化缀合物中白蛋白的分子数之比。

7. 发明申请

US20100075435A1 BIOTINYLATED THYROXINE 审中-公开
标题翻译：生物素化噻吩
公开(公告)号：US20100075435A1
公开(公告)日：2010-03-25
申请号：US12509736
申请日：2009-07-27
申请人： Noriyuki KASAGI , Tadahiro Matsuno
发明人： Noriyuki KASAGI , Tadahiro Matsuno
IPC分类号： G01N33/53 , C07D495/04 , C07K14/77
CPC分类号： G01N33/78 , A61K47/557 , A61K47/60 , C07D495/04 , G01N33/54313 , G01N33/583
摘要： A means for conveniently and accurately measuring thyroxine or thyronine present in the blood or the like is provided: a compound represented by general formula (I) below: wherein L represents a linear or branched-chain linker having 5 to 50 total atoms; X represents one or more thyroxines, thyronines, or residues of derivatives thereof, bound to the main chain and/or side chain of the linker represented by L, a conjugate in the form of the above compound bonded to an avidin protein, and an aqueous dispersion including a microparticles the surface of which is modified with the above conjugate.
摘要翻译：提供用于方便，准确地测量存在于血液中的甲状腺素或甲状腺素的方法等：下列通式（I）表示的化合物：其中L表示具有5至50个总原子的直链或支链接头; X表示与由L表示的连接物的主链和/或侧链结合的一种或多种甲状腺素，甲状腺素或其衍生物的残基，与抗生物素蛋白蛋白结合的上述化合物形式的缀合物，以及水性包括其表面用上述缀合物修饰的微粒的分散体。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式