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1. 发明授权

US08524864B2 Method for producing conjugate of thyroxine and albumin 失效
标题翻译：生产甲状腺素和白蛋白缀合物的方法
公开(公告)号：US08524864B2
公开(公告)日：2013-09-03
申请号：US13213585
申请日：2011-08-19
申请人： Noriyuki Kasagi , Tadahiro Matsuno
发明人： Noriyuki Kasagi , Tadahiro Matsuno
IPC分类号： C07K1/107 , C07K14/76
CPC分类号： A61K47/643
摘要： It is an object of the present invention to provide a method for producing a conjugate of thyroxine and albumin with higher purity. The present invention provides a method for producing a conjugate of thyroxine and albumin which comprises: step (a) of converting a carboxyl group in thyroxine having a carboxyl group to be linked to albumin into an active ester and allowing the thyroxine to react with albumin, so as to prepare a conjugate of thyroxine and albumin; and step (b) of purifying the conjugate with the use of an acidic mixed aqueous solvent in which the thyroxine having a carboxyl group to be linked to albumin is dissolved but albumin is not precipitated.
摘要翻译：本发明的目的是提供一种制备高纯度甲状腺素和白蛋白缀合物的方法。本发明提供了一种生产甲状腺素和白蛋白缀合物的方法，其包括：将具有与白蛋白连接的羧基的甲状腺素中的羧基转化成活性酯的步骤（a），并使甲状腺素与白蛋白反应，以制备甲状腺素和白蛋白的缀合物; 和使用其中与白蛋白连接的具有羧基的甲状腺素溶解但不沉淀白蛋白的酸性混合水性溶剂来纯化缀合物的步骤（b）。

2. 发明授权

US08912010B2 Thyroxine immunoassay using fluorescent particles 有权
标题翻译：使用荧光颗粒进行甲状腺素免疫测定
公开(公告)号：US08912010B2
公开(公告)日：2014-12-16
申请号：US13610497
申请日：2012-09-11
申请人： Noriyuki Kasagi , Junichi Katada , Tadahiro Matsuno
发明人： Noriyuki Kasagi , Junichi Katada , Tadahiro Matsuno
IPC分类号： G01N33/544 , G01N33/53 , C07K1/04 , G01N33/543 , G01N33/78 , G01N33/58
CPC分类号： G01N33/54373 , G01N33/54306 , G01N33/585 , G01N33/78
摘要： Provided are a base plate and a method for thyroxine immunoassay, which are capable of decreasing the signal change rate caused by temperature change in a high-sensitivity immunoassay method for thyroxine. A base plate for thyroxine immunoassay which has a conjugate of thyroxine or a derivative thereof and albumin immobilized thereon, and in which the ratio of the molecule number of thyroxine or a derivative thereof to the molecule number of albumin in the immobilized conjugate, is disclosed.
摘要翻译：本发明提供甲状腺素免疫测定法的基板和甲基荧光素免疫测定方法，能够降低甲状腺素的高灵敏度免疫测定法中的温度变化引起的信号变化率。公开了一种甲状腺素免疫测定的基板，其具有甲状腺素或其衍生物和固定在其上的白蛋白的缀合物，其中甲状腺素或其衍生物的分子数与固定化缀合物中白蛋白的分子数之比。

3. 发明申请

US20120046447A1 METHOD FOR PRODUCING CONJUGATE OF THYROXINE AND ALBUMIN 失效
标题翻译：生产甲状腺素和阿尔伯霉素的方法
公开(公告)号：US20120046447A1
公开(公告)日：2012-02-23
申请号：US13213585
申请日：2011-08-19
申请人： Noriyuki KASAGI , Tadahiro Matsuno
发明人： Noriyuki KASAGI , Tadahiro Matsuno
IPC分类号： C07K1/107 , C07K14/76
CPC分类号： A61K47/643
摘要： It is an object of the present invention to provide a method for producing a conjugate of thyroxine and albumin with higher purity. The present invention provides a method for producing a conjugate of thyroxine and albumin which comprises: step (a) of converting a carboxyl group in thyroxine having a carboxyl group to be linked to albumin into an active ester and allowing the thyroxine to react with albumin, so as to prepare a conjugate of thyroxine and albumin; and step (b) of purifying the conjugate with the use of an acidic mixed aqueous solvent in which the thyroxine having a carboxyl group to be linked to albumin is dissolved but albumin is not precipitated.
摘要翻译：本发明的目的是提供一种制备高纯度甲状腺素和白蛋白缀合物的方法。本发明提供了一种生产甲状腺素和白蛋白缀合物的方法，其包括：将具有与白蛋白连接的羧基的甲状腺素中的羧基转化成活性酯的步骤（a），并使甲状腺素与白蛋白反应，以制备甲状腺素和白蛋白的缀合物; 和使用其中与白蛋白连接的具有羧基的甲状腺素溶解但不沉淀白蛋白的酸性混合水性溶剂来纯化缀合物的步骤（b）。

4. 发明申请

US20100075435A1 BIOTINYLATED THYROXINE 审中-公开
标题翻译：生物素化噻吩
公开(公告)号：US20100075435A1
公开(公告)日：2010-03-25
申请号：US12509736
申请日：2009-07-27
申请人： Noriyuki KASAGI , Tadahiro Matsuno
发明人： Noriyuki KASAGI , Tadahiro Matsuno
IPC分类号： G01N33/53 , C07D495/04 , C07K14/77
CPC分类号： G01N33/78 , A61K47/557 , A61K47/60 , C07D495/04 , G01N33/54313 , G01N33/583
摘要： A means for conveniently and accurately measuring thyroxine or thyronine present in the blood or the like is provided: a compound represented by general formula (I) below: wherein L represents a linear or branched-chain linker having 5 to 50 total atoms; X represents one or more thyroxines, thyronines, or residues of derivatives thereof, bound to the main chain and/or side chain of the linker represented by L, a conjugate in the form of the above compound bonded to an avidin protein, and an aqueous dispersion including a microparticles the surface of which is modified with the above conjugate.
摘要翻译：提供用于方便，准确地测量存在于血液中的甲状腺素或甲状腺素的方法等：下列通式（I）表示的化合物：其中L表示具有5至50个总原子的直链或支链接头; X表示与由L表示的连接物的主链和/或侧链结合的一种或多种甲状腺素，甲状腺素或其衍生物的残基，与抗生物素蛋白蛋白结合的上述化合物形式的缀合物，以及水性包括其表面用上述缀合物修饰的微粒的分散体。

5. 发明申请

US20080145869A1 Immunoassay method 审中-公开
标题翻译：免疫测定法
公开(公告)号：US20080145869A1
公开(公告)日：2008-06-19
申请号：US12000108
申请日：2007-12-10
申请人： Katsuhisa Ohzeki , Tadahiro Matsuno
发明人： Katsuhisa Ohzeki , Tadahiro Matsuno
IPC分类号： G01N33/53
CPC分类号： G01N33/582
摘要： The present invention provides a method for immunoassaying an object to be analyzed including: causing to act, on a specimen or a sample including the specimen, a first protein (Y), which can specifically recognize the object to be analyzed in the specimen and is modified by a labeling substance, so as to form a complex including the object to be analyzed and Y; and measuring the labeling substance contained in the complex or the labeling substance contained in the free protein (Y), wherein the measurement of the labeling substance is performed by a chemiluminescent method which includes sensing the light generated by chemiluminescence using a photothermographic material including at least an organic silver salt, a reducing agent for silver ions and a photosensitive silver halide to form a latent image, and making the latent image visible by thermal development. An easy, quick, and highly precise immunoassay method is provided.
摘要翻译：本发明提供一种免疫测定待分析对象的方法，包括：使样品或包含样本的样品作用于能够特异性识别样品中待分析对象的第一蛋白质（Y），并且是由标记物修饰，以形成包括待分析对象和Y的复合物; 测定包含在游离蛋白质（Y）中的复合物或标记物质中的标记物质，其中，所述标记物质的测定是通过化学发光法进行的，所述化学发光方法包括使用光热敏成像材料检测由化学发光产生的光，所述光热敏成像材料至少包括有机银盐，银离子还原剂和感光卤化银以形成潜像，并通过热显影使潜像可见。提供了一种简单，快速，高精度的免疫测定方法。

6. 发明授权

US08110403B2 Immunoassay method 失效
标题翻译：免疫测定法
公开(公告)号：US08110403B2
公开(公告)日：2012-02-07
申请号：US12369547
申请日：2009-02-11
申请人： Tadahiro Matsuno , Kentaro Nakamura
发明人： Tadahiro Matsuno , Kentaro Nakamura
IPC分类号： G01N30/02 , G01N21/75 , C12M3/00
CPC分类号： G01N33/54346 , G01N33/54386 , Y10T436/25375 , Y10T436/255
摘要： It is an object of the present invention to provide an immunoassay method which is capable of simultaneous quantification of a plurality of test substances under a same analysis condition, through adjustment of the measurement sensitivity/range by simply varying the size of particles for use as labels, without changing the spectra of these particles. The present invention provides an immunoassay method which comprises: simultaneously or step-by step developing respective of the plurality of the test substances and respective of labeling substance particles labeled with first binding substance against the respective of the plurality of the test substances on an insoluble carrier; capturing the test substances and the labeling substance particles in reaction portions on the insoluble carrier that has been immobilized with the respective of second binding substances against the respective of the plurality of the test substances at different positions; and measuring optical characteristic of the labeling substance particles, so as to simultaneously detect the plurality of the test substances, wherein the plurality of the test substances having different detection concentration ranges are simultaneously detected with use of the labeling substance particles which are different in the particle size corresponding to the test substances.
摘要翻译：本发明的目的是提供一种免疫测定方法，其能够在相同的分析条件下同时量化多种测试物质，通过简单地改变用作标签的颗粒的尺寸来调节测量灵敏度/范围，而不改变这些颗粒的光谱。本发明提供了一种免疫测定方法，其包括：在不溶性载体上同时或逐步地将多个测试物质和相应于第一结合物质标记的标记物质颗粒相对于多种测试物质分别显影 ; 在不溶性载体上的反应部分中捕获被测物质和标记物质颗粒，所述不溶性载体已经被固定有相应的第二结合物质，而不同于多种测试物质在不同位置; 并测量标记物质颗粒的光学特性，以便同时检测多个测试物质，其中使用不同颗粒的标记物质颗粒同时检测多个具有不同检测浓度范围的检测物质尺寸对应于测试物质。

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