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1. 发明授权

US4748187A Opioid peptide-degrading enzyme inhibitor with a germanium compound 失效
标题翻译：阿片样肽降解酶抑制剂与锗化合物
公开(公告)号：US4748187A
公开(公告)日：1988-05-31
申请号：US930561
申请日：1986-11-14
申请人： Norihiro Kakimoto , Takashi Katayama , Tadahiko Hazato , Tsutomu Ohnishi
发明人： Norihiro Kakimoto , Takashi Katayama , Tadahiko Hazato , Tsutomu Ohnishi
IPC分类号： C07F7/30 , A61K31/28
CPC分类号： C07F7/30
摘要： The present invention provides (1) a new organogermanium compound of the following general formula: ##STR1## wherein A represents a hydrogen atom, a lower alkyl group such as a methyl or ethyl group or a phenyl group, B represents a hydrogen atom or a lower alkyl group as mentioned above and Z represents a hydroxyl or amino group and (2) an opioid peptide-degrading enzyme inhibitor containing the compound (1) as a principal ingredient.
摘要翻译：本发明提供（1）下述通式的新的有机锗化合物：其中A表示氢原子，低级烷基如甲基或乙基或苯基，B表示氢原子或低级烷基，Z表示羟基或氨基，（2）含有化合物（1）作为主要成分的阿片样肽降解酶抑制剂。

2. 发明授权

US4681960A Organogermanium compound 失效
标题翻译：有机锗化合物
公开(公告)号：US4681960A
公开(公告)日：1987-07-21
申请号：US626787
申请日：1984-07-02
申请人： Norihiro Kakimoto , Takashi Katayama , Tadahiko Hazato , Tsutomu Ohnishi
发明人： Norihiro Kakimoto , Takashi Katayama , Tadahiko Hazato , Tsutomu Ohnishi
IPC分类号： C07F7/30
CPC分类号： C07F7/30
摘要： The present invention provides (1) a new organogermanium compound of the following general formula: ##STR1## wherein A represents a hydrogen atom, a lower alkyl group such as a methyl or ethyl group or a phenyl group, B represents a hydrogen atom or a lower alkyl group as mentioned above and Z represents a hydroxyl or amino group and (2) an opioid peptide-degrading enzyme inhibitor containing the compound (1) as a principal ingredient.
摘要翻译：本发明提供（1）下述通式的新的有机锗化合物：其中A表示氢原子，低级烷基如甲基或乙基或苯基，B表示氢原子或低级烷基，Z表示羟基或氨基，（2）含有化合物（1）作为主要成分的阿片样肽降解酶抑制剂。

3. 发明授权

US5352815A Agent for suppression and interception of mailard reaction 失效
标题翻译：抑制和拦截邮寄员反应的代理人
公开(公告)号：US5352815A
公开(公告)日：1994-10-04
申请号：US031997
申请日：1993-03-16
申请人： Norihiro Kakimoto , Kunie Nakamura
发明人： Norihiro Kakimoto , Kunie Nakamura
IPC分类号： A61K31/28 , A61P3/00 , A61P3/08 , A61P3/10 , A61P43/00 , C07B63/04 , C07F7/30 , C07K14/00
CPC分类号： C07F7/30 , A61K31/28
摘要： The present invention provides an agent for suppression or interception of the Mailard reaction, which comprises, as the active component, an organogermanium compound represented by formula (1): ##STR1## wherein R.sub.1 to R.sub.3 may be the same or different and each of them represents a hydrogen atom, a lower alkyl group, or a phenyl group; and X represents a hydroxyl group, an O-lower alkyl group, an amino group, or a salt represented by OY (Y is a metal or a basic group-containing compound).Said agent can effectively suppress or intercept the Mailard reaction and has high safety even when administered for a long period of time.
摘要翻译：本发明提供了用于抑制或拦截Mailard反应的试剂，其包含作为活性组分的由式（1）表示的有机锗化合物：其中R 1至R 3可以相同或不同，它们各自表示氢原子，低级烷基或苯基; X表示羟基，O-低级烷基，氨基或OY表示的盐（Y表示金属或含碱性化合物）。所述试剂可以有效地抑制或拦截Mailard反应，即使在长时间施用时也具有高安全性。

4. 发明授权

US4849236A Method for maintaining freshness of vegetables by increasing germanium content 失效
标题翻译：通过增加锗含量来维持蔬菜新鲜的方法
公开(公告)号：US4849236A
公开(公告)日：1989-07-18
申请号：US002659
申请日：1986-11-14
申请人： Norihiro Kakimoto , Teizou Sakai , Yoshinori Sasaki
发明人： Norihiro Kakimoto , Teizou Sakai , Yoshinori Sasaki
IPC分类号： A01N3/00 , A23B7/154 , A23B7/157
CPC分类号： A01N3/00 , A23B7/154 , A23B7/157
摘要： The present invention relates to a method enabling the freshness of vegetables to be easily maintained by increasing the germanium content of vegetables and is characterized by comprising the treatment of the surfaces and/or inner parts of vegetables with an organic or inorganic germanium compound by a suitable method. In this case, the organogermanium compound is, for example, carboxyethylgermanium sesquioxide, and the inorganic germanium compound is, for example, germanium dioxide. It is possible to treat vegetables with an organic or inorganic compound in the state of an aqueous solution and the methods available include one in which vegetables are impregnated or are sprayed with the aqueous solution so that the germanium compound acts on the surfaces of the vegetables; and another in which the aqueous solution is absorbed by the roots of the vegetables so that the germanium compound acts on their inner parts.
摘要翻译： PCT No.PCT / JP86 / 00130 Sec。一九八六年十一月十四日 102（e）1986年11月14日PCT PCT公布1986年3月14日PCT公布。公开号WO86 / 05354 日期：1986年9月25日本发明涉及通过增加蔬菜的锗含量容易地维持蔬菜新鲜度的方法，其特征在于包括用有机物处理蔬菜的表面和/或内部部分或无机锗化合物。在这种情况下，有机锗化合物是例如羧乙基锗倍半氧化物，无机锗化合物是例如二氧化锗。可以用水溶液状态用有机或无机化合物处理蔬菜，并且可用的方法包括用水溶液浸渍或喷洒蔬菜的方法，使得锗化合物作用在蔬菜的表面上; 其中水溶液被蔬菜的根部吸收，使得锗化合物作用在其内部部分上。

5. 发明授权

US5118679A Agent for preventing and treating opacity of lens 失效
标题翻译：防止和处理镜片透明度的代理
公开(公告)号：US5118679A
公开(公告)日：1992-06-02
申请号：US554724
申请日：1990-07-19
申请人： Susumu Sato , Norihiro Kakimoto , Mikio Miyata , Shigezo Uga , Kunie Nakamura
发明人： Susumu Sato , Norihiro Kakimoto , Mikio Miyata , Shigezo Uga , Kunie Nakamura
IPC分类号： A61K31/28 , A61K31/535 , C07F7/30
CPC分类号： C07F7/30 , A61K31/28 , A61K31/535 , Y10S514/912
摘要： The present invention is to provide a highly effective agent for preventing and treating opacity of lens, containing the organic germanium compound represented by the fornula (1); ##STR1## (wherein R1 to R3 represent hydrogen atoms, lower alkyl groups each of which may be the same or different and selected from the group consisting of methyl group, ethyl group, etc., or phenyl groups substituted or unsubstituted; X represents a hydroxyl group, an O-lower alkyl group, an amino group or O.sup.- Y.sup.+ {Y represents a metal such as sodium, potassium, etc., or a compound having a basic group such as lysozyme and basic amino acid, etc.})or (2) a combination of the organic germanium compound and aminoguanidien, or (3) a combination of the organic germanium compound specifically defined above and the specific phenoxazine derivative.
摘要翻译：本发明提供一种防止和治疗透镜的不透明度的高效试剂，其含有由（1）所表示的有机锗化合物; （1）（其中R 1至R 3表示氢原子，各自可以相同或不同且选自甲基，乙基等的低级烷基或取代或未取代的苯基; X表示羟基，O-低级烷基，氨基或O-Y + {Y表示金属如钠，钾等，或具有碱性基团的化合物如溶菌酶和碱性氨基酸等））或（2）有机锗化合物和氨基胍二烯的组合，或（3）上述具体定义的有机锗化合物与特定吩恶嗪衍生物的组合。

6. 发明授权

US5071873A Antioxidant 失效
标题翻译：抗氧化剂
公开(公告)号：US5071873A
公开(公告)日：1991-12-10
申请号：US348129
申请日：1989-05-03
申请人： Norihiro Kakimoto , Mitsuo Namiki , Toshihiko Osawa , Kohei Miyao
发明人： Norihiro Kakimoto , Mitsuo Namiki , Toshihiko Osawa , Kohei Miyao
IPC分类号： C09K15/32 , C07F7/30
CPC分类号： C07F7/30
摘要： A new synthetic antioxidant comprising an organogermanium compound represented by the formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are one of a hydrogen atom, a substituted or unsubstituted phenyl group or an alkyl group, Y is a hydroxyl or amino group and Z is an oxygen or sulfur atom, is particularly effective in inhibiting auto-oxidation in living organisms.

7. 发明授权

US5006553A Agent for improving reduced functions of organs caused by inhibited blood circulation 失效
标题翻译：改善由血液循环受阻引起的器官功能降低的药剂
公开(公告)号：US5006553A
公开(公告)日：1991-04-09
申请号：US555829
申请日：1990-07-23
申请人： Norihiro Kakimoto , Kazuo Kumano , Kunie Nakamura
发明人： Norihiro Kakimoto , Kazuo Kumano , Kunie Nakamura
IPC分类号： C07F7/30
CPC分类号： C07F7/30
摘要： The present invention provides (1) an agent for improving the reduced functions of organs caused by inhibited blood circulation, characterized by containing, as an effective component, an organogermanium compound represented by the formula (I) ##STR1## wherein R.sub.1 to R.sub.3 are each a hydrogen atom, a lower alkyl group such as methyl, ethyl or the like which may be the same or different, or a substituted or unsubstituted phenyl group, and X is a hydroxyl group, an O-lower alkyl group, an amino group or O.sup.- Y.sup.+ (Y is a metal such as sodium, potassium or the like, or a basic group-containing compound such as lysozyme, basic amino acid or the like), and (2) a method for improving the reduced functions of organs caused by inhibited blood circulation, characterized by administering, in need of such treatment, an effective amount of an organogermanium compound represented by the above formula (I).
摘要翻译：本发明提供（1）一种用于改善由抑制血液循环引起的功能降低的药剂，其特征在于，含有式（I）表示的有机锗化合物作为有效成分，其中R1至 R3各自为氢原子，低级烷基如甲基，乙基等可以相同或不同，或取代或未取代的苯基，X为羟基，O-低级烷基，氨基或O-Y +（Y是金属如钠，钾等，或含碱性基团的化合物如溶菌酶，碱性氨基酸等），和（2）一种改善功能降低的方法其特征在于，在需要这种治疗的情况下施用有效量的由上述式（I）表示的有机锗化合物。

8. 发明授权

US06323038B1 Diagnostic reagent for complications associated with diabetes or renal failure 失效
标题翻译：与糖尿病或肾衰竭相关的并发症的诊断试剂
公开(公告)号：US06323038B1
公开(公告)日：2001-11-27
申请号：US09482927
申请日：2000-01-14
申请人： Tomoko Oya , Hiroyuki Kobayashi , Mitsuo Akiba , Norihiro Kakimoto , Yasujiro Morimitsu , Toshihiko Osawa
发明人： Tomoko Oya , Hiroyuki Kobayashi , Mitsuo Akiba , Norihiro Kakimoto , Yasujiro Morimitsu , Toshihiko Osawa
IPC分类号： G01N2175
CPC分类号： A61K49/0004 , G01N33/66 , Y10S436/811 , Y10T436/17 , Y10T436/18 , Y10T436/20
摘要： In view of the situation of the prior art, the present invention specifies the structure of a late-stage product of Mailard reaction in vivo having a close relation with various tissue disorders, and provides a diagnostic reagent for complications associated with diabetes or renal failure, containing the above compound as a main component. The diagnostic reagent of the present invention for complications associated with diabetes or renal failure contains a pyridinium compound represented by the following formula as a main component:
摘要翻译：鉴于现有技术的情况，本发明规定了与各种组织紊乱密切相关的Mailard反应体系的后期产物的结构，并提供了与糖尿病或肾衰竭相关的并发症的诊断试剂，含有上述化合物作为主要成分。本发明涉及糖尿病或肾功能衰竭并发症的诊断试剂含有以下式表示的吡啶鎓化合物作为主要成分：

9. 发明授权

US5041577A Organogermanium compounds, processes for producing the same, and agent for inhibiting the activity of opioid peptide-degrading enzyme 失效
标题翻译：有机锗化合物，其制备方法和抑制阿片样肽降解酶活性的试剂
公开(公告)号：US5041577A
公开(公告)日：1991-08-20
申请号：US468670
申请日：1990-01-23
申请人： Norihiro Kakimoto , Toru Yoshihara
发明人： Norihiro Kakimoto , Toru Yoshihara
IPC分类号： C07F7/30
CPC分类号： C07F7/30
摘要： The present invention relates to (a) novel organogermanium compounds represented by the general formula (1) ##STR1## (R.sub.1 to R.sub.6 are independently a hydrogen atom or a lower alkyl group; X is a halogen atom; and Y.sub.1 and Y.sub.2 are independently a hydroxyl group or a group chemically equivalent thereto) or by the general formula (2) ##STR2## (R.sub.1 to R.sub.6 are independently a hydrogen atom or a lower alkyl group, and Z is an oxygen atom or a sulfur atom), (b) processes for producing the above organogermanium compounds, and (c) an agent for inhibiting the activity of opioid peptide-degrading enzyme, containing the above organogermanium compounds as an active ingredient.
摘要翻译：本发明涉及（a）由通式（1）表示的新型有机锗化合物（R1至R6独立地为氢原子或低级烷基; X为卤素原子; Y1和Y2独立地为羟基或与其化学等价的基团）或通式（2）的化合物（R 2 -R 6独立地为氢原子或低级烷基，Z为氧原子或硫原子），（b）制备上述有机锗化合物的方法，和（c）含有上述有机锗化合物作为活性成分的用于抑制阿片样肽降解酶活性的试剂。

10. 发明授权

US5002968A Activator for osteoblasts 失效
标题翻译：成骨细胞激活剂
公开(公告)号：US5002968A
公开(公告)日：1991-03-26
申请号：US276666
申请日：1988-11-28
申请人： Hajime Orimo , Hiroshi Satoh , Kohei Miyao , Norihiro Kakimoto
发明人： Hajime Orimo , Hiroshi Satoh , Kohei Miyao , Norihiro Kakimoto
IPC分类号： A61K31/80 , A61K31/28 , A61P3/00 , A61P19/10 , A61P43/00 , C07F7/30
CPC分类号： C07F7/30
摘要： The present invention provides (a) an activator for osteoblast comprising, as an active ingredient, a salt between (1) an organogermanium compound represented by the formula (I) ##STR1## [in the above formula (I), R.sub.1, R.sub.2 and R.sub.3 which may be the same or different, are independently a hydrogen atom, a lower alkyl group such as methyl, ethyl or the like, or an aryl group] and (2) a basic group-containing compound, and (b) a method for activating osteoblasts, which comprises administering in need of such treatment an effective amount of a salt between an organogermanium compound represented by the above formula (I) and a basic group-containing compound.
摘要翻译：本发明提供（a）成骨细胞活化剂，其包含作为活性成分的（1）由式（I）表示的有机锗化合物（I）[在上述式（I）中的R 1 ，R2和R3可以相同或不同，独立地为氢原子，低级烷基如甲基，乙基等或芳基]和（2）含碱性基团的化合物，和（b ）一种激活成骨细胞的方法，其包括在上述式（I）表示的有机锗化合物和含碱性基团的化合物之间施用有效量的盐。

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