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1. 发明授权

US4919917A Agent for reducing nephrotoxicity caused by cyclosporin administration 失效
标题翻译：降低环孢菌素给药引起的肾毒性的药剂
公开(公告)号：US4919917A
公开(公告)日：1990-04-24
申请号：US261406
申请日：1988-10-24
申请人： Norihiro Kakimoto , Kazuo Kumano , Kunie Nakamura
发明人： Norihiro Kakimoto , Kazuo Kumano , Kunie Nakamura
IPC分类号： A61K31/28 , A61K38/00 , A61P13/02 , A61P15/00 , A61P37/06 , A61P43/00 , C07F7/30
CPC分类号： C07F7/30 , Y10S514/922
摘要： The present invention provides (1) an agent for reducing the nephrotoxicity caused by cyclosporin administration, characterized by containing, as an effective component, an organogermanium compound represented by the formula (I) ##STR1## wherein R.sub.1 to R.sub.3 are each a hydrogen atom, a lower alkyl group such as methyl, ethyl or the like which may be the same or different, or a substituted or unsubstituted phenyl group, and X is a hydroxyl group, an O-lower alkyl group, an amino group or O.sup.- Y.sup.+ (Y is a metal such as sodium, potassium or the like, or a basic group-containing compound such as lysozyme, basic amino acid or the like), and (2) a method for reducing the nephrotoxicity caused by cyclosporin administration, characterized by administering, in need of such treatment, an effective amount of an organogermanium compound represented by the above formula (I).
摘要翻译：本发明提供（1）一种降低由环孢菌素给药引起的肾毒性的药剂，其特征在于，含有式（I）表示的有机锗化合物作为有效成分，其中R1〜R3各自为氢原子，可以相同或不同的甲基，乙基等的低级烷基或取代或未取代的苯基，X是羟基，O-低级烷基，氨基或O -Y +（Y是钠，钾等金属或溶菌酶，碱性氨基酸等碱性化合物），（2）降低环孢菌素给药引起的肾毒性的方法，其特征在于，在需要这种治疗的情况下施用有效量的由上式（I）表示的有机锗化合物。

2. 发明授权

US4956272A Organogermanium containing solution for washing and storing separated organs 失效
标题翻译：含有机硅的溶液用于洗涤和储存分离的器官
公开(公告)号：US4956272A
公开(公告)日：1990-09-11
申请号：US261628
申请日：1988-10-24
申请人： Norihiro Kakimoto , Kazuo Kumano , Kunie Nakamura
发明人： Norihiro Kakimoto , Kazuo Kumano , Kunie Nakamura
IPC分类号： A01N1/02 , A01N55/02
CPC分类号： A01N55/02 , A01N1/02 , A01N1/0226
摘要： The present invention provides (1) a solution for washing and storing separated organs, characterized by containing, as an effective component, an organogermanium compound represented by the formula (I) ##STR1## wherein R.sub.1 to R.sub.3 are each a hydrogen atom, a lower alkyl group such as methyl, ethyl or the like which may be the same or different, or a substituted or unsubstituted phenyl group, and X is a hydroxyl group, an O-lower alkyl group, an amino group or O.sup.- Y.sup.+ (Y is a metal such as sodium, potassium or the like, or a basic group-containing compound such as lysozyme, basic amino acid or the like), and (2) a method for washing and storing separated organs with a solution containing, as an effective component, an organogermanium compound represented by the formula (I).
摘要翻译：本发明提供（1）洗涤和储存分离的器官的溶液，其特征在于含有式（I）表示的有机锗化合物作为有效成分，其中R1至R3各自为氢原子，可以相同或不同的甲基，乙基等的低级烷基或取代或未取代的苯基，X是羟基，O-低级烷基，氨基或O-Y + （Y是钠，钾等金属或溶菌酶，碱性氨基酸等含碱性化合物的化合物），和（2）将分离的器官与含有作为有效成分，由式（I）表示的有机锗化合物。

3. 发明授权

US5006553A Agent for improving reduced functions of organs caused by inhibited blood circulation 失效
标题翻译：改善由血液循环受阻引起的器官功能降低的药剂
公开(公告)号：US5006553A
公开(公告)日：1991-04-09
申请号：US555829
申请日：1990-07-23
申请人： Norihiro Kakimoto , Kazuo Kumano , Kunie Nakamura
发明人： Norihiro Kakimoto , Kazuo Kumano , Kunie Nakamura
IPC分类号： C07F7/30
CPC分类号： C07F7/30
摘要： The present invention provides (1) an agent for improving the reduced functions of organs caused by inhibited blood circulation, characterized by containing, as an effective component, an organogermanium compound represented by the formula (I) ##STR1## wherein R.sub.1 to R.sub.3 are each a hydrogen atom, a lower alkyl group such as methyl, ethyl or the like which may be the same or different, or a substituted or unsubstituted phenyl group, and X is a hydroxyl group, an O-lower alkyl group, an amino group or O.sup.- Y.sup.+ (Y is a metal such as sodium, potassium or the like, or a basic group-containing compound such as lysozyme, basic amino acid or the like), and (2) a method for improving the reduced functions of organs caused by inhibited blood circulation, characterized by administering, in need of such treatment, an effective amount of an organogermanium compound represented by the above formula (I).
摘要翻译：本发明提供（1）一种用于改善由抑制血液循环引起的功能降低的药剂，其特征在于，含有式（I）表示的有机锗化合物作为有效成分，其中R1至 R3各自为氢原子，低级烷基如甲基，乙基等可以相同或不同，或取代或未取代的苯基，X为羟基，O-低级烷基，氨基或O-Y +（Y是金属如钠，钾等，或含碱性基团的化合物如溶菌酶，碱性氨基酸等），和（2）一种改善功能降低的方法其特征在于，在需要这种治疗的情况下施用有效量的由上述式（I）表示的有机锗化合物。

4. 发明授权

US4977287A Organogermanium compounds and process for producing the same 失效
标题翻译：有机锗化合物及其制备方法
公开(公告)号：US4977287A
公开(公告)日：1990-12-11
申请号：US400062
申请日：1989-08-29
申请人： Norihiro Kakimoto , Kunie Nakamura , Toru Yoshihara
发明人： Norihiro Kakimoto , Kunie Nakamura , Toru Yoshihara
IPC分类号： A61K31/28 , A61P3/08 , A61P27/02 , A61P27/12 , A61P43/00 , C07F7/30
CPC分类号： C07F7/30
摘要： The present invention provides (A) an organogermanium compound represented by the general formula (1) ##STR1## wherein X is a halogen atom and R is a hydrogen atom, a lower alkyl group or a phenyl group, or by the general formula (2) ##STR2## wherein X and Y are each a halogen atom and R is a hydrogen atom, a lower alkyl group or a phenyl group, or by the general formula (3-O), ##STR3## wherein R is a hydrogen atom, a lower alkyl group or a phenyl group, or by the general formula (3-S), ##STR4## wherein R is a hydrogen atom, a lower alkyl group or a phenyl group, or by the general formula (4-O), ##STR5## wherein R is a hydrogen atom, a lower alkyl group or a phenyl group, or by the general formula (4-S), ##STR6## wherein R is a hydrogen atom, a lower alkyl group or a phenyl group, and (B) a process for producing an organogermanium compound represented by each of the formulas (3-O), (3-S), (4-O) and (4-S).
摘要翻译：本发明提供（A）由通式（1）表示的有机锗化合物，其中X是卤原子，R是氢原子，低级烷基或苯基，或由通式式（2）其中X和Y各自为卤素原子，R为氢原子，低级烷基或苯基，或由通式（3-O），（IMA） 3-O），其中R是氢原子，低级烷基或苯基，或通式（3-S），其中R是氢原子，低级烷基或通式（4-O），其中R是氢原子，低级烷基或苯基，或通式（4-S）的通式（4-O）（3-O），（3）表示的有机锗化合物的制造方法，其中R为氢原子，低级烷基或苯基，（B） -S），（4-O）和（4-S）。

5. 发明授权

US5352815A Agent for suppression and interception of mailard reaction 失效
标题翻译：抑制和拦截邮寄员反应的代理人
公开(公告)号：US5352815A
公开(公告)日：1994-10-04
申请号：US031997
申请日：1993-03-16
申请人： Norihiro Kakimoto , Kunie Nakamura
发明人： Norihiro Kakimoto , Kunie Nakamura
IPC分类号： A61K31/28 , A61P3/00 , A61P3/08 , A61P3/10 , A61P43/00 , C07B63/04 , C07F7/30 , C07K14/00
CPC分类号： C07F7/30 , A61K31/28
摘要： The present invention provides an agent for suppression or interception of the Mailard reaction, which comprises, as the active component, an organogermanium compound represented by formula (1): ##STR1## wherein R.sub.1 to R.sub.3 may be the same or different and each of them represents a hydrogen atom, a lower alkyl group, or a phenyl group; and X represents a hydroxyl group, an O-lower alkyl group, an amino group, or a salt represented by OY (Y is a metal or a basic group-containing compound).Said agent can effectively suppress or intercept the Mailard reaction and has high safety even when administered for a long period of time.
摘要翻译：本发明提供了用于抑制或拦截Mailard反应的试剂，其包含作为活性组分的由式（1）表示的有机锗化合物：其中R 1至R 3可以相同或不同，它们各自表示氢原子，低级烷基或苯基; X表示羟基，O-低级烷基，氨基或OY表示的盐（Y表示金属或含碱性化合物）。所述试剂可以有效地抑制或拦截Mailard反应，即使在长时间施用时也具有高安全性。

6. 发明授权

US5118679A Agent for preventing and treating opacity of lens 失效
标题翻译：防止和处理镜片透明度的代理
公开(公告)号：US5118679A
公开(公告)日：1992-06-02
申请号：US554724
申请日：1990-07-19
申请人： Susumu Sato , Norihiro Kakimoto , Mikio Miyata , Shigezo Uga , Kunie Nakamura
发明人： Susumu Sato , Norihiro Kakimoto , Mikio Miyata , Shigezo Uga , Kunie Nakamura
IPC分类号： A61K31/28 , A61K31/535 , C07F7/30
CPC分类号： C07F7/30 , A61K31/28 , A61K31/535 , Y10S514/912
摘要： The present invention is to provide a highly effective agent for preventing and treating opacity of lens, containing the organic germanium compound represented by the fornula (1); ##STR1## (wherein R1 to R3 represent hydrogen atoms, lower alkyl groups each of which may be the same or different and selected from the group consisting of methyl group, ethyl group, etc., or phenyl groups substituted or unsubstituted; X represents a hydroxyl group, an O-lower alkyl group, an amino group or O.sup.- Y.sup.+ {Y represents a metal such as sodium, potassium, etc., or a compound having a basic group such as lysozyme and basic amino acid, etc.})or (2) a combination of the organic germanium compound and aminoguanidien, or (3) a combination of the organic germanium compound specifically defined above and the specific phenoxazine derivative.
摘要翻译：本发明提供一种防止和治疗透镜的不透明度的高效试剂，其含有由（1）所表示的有机锗化合物; （1）（其中R 1至R 3表示氢原子，各自可以相同或不同且选自甲基，乙基等的低级烷基或取代或未取代的苯基; X表示羟基，O-低级烷基，氨基或O-Y + {Y表示金属如钠，钾等，或具有碱性基团的化合物如溶菌酶和碱性氨基酸等））或（2）有机锗化合物和氨基胍二烯的组合，或（3）上述具体定义的有机锗化合物与特定吩恶嗪衍生物的组合。

7. 发明授权

US4710460A Diagnostic applications of phosphofructokinase 失效
标题翻译：磷酸果糖激酶的诊断应用
公开(公告)号：US4710460A
公开(公告)日：1987-12-01
申请号：US620822
申请日：1984-06-15
申请人： Kunie Nakamura
发明人： Kunie Nakamura
IPC分类号： G01N33/50 , C12Q1/48
CPC分类号： C12Q1/48
摘要： An enzyme, phosphofructokinase is now found to be applicable to detection of a phosphofructokinase-inhibitor possibly present in supravital serum sample or other body fluid sample as collected from human person. When an abnormally high content or potency of the phosphofructokinase-inhibitor is detected in the body fluid samples such as serum by means of the phosphofructokinase, it indicates probability of presence of malignant neoplasms in the donor for the samples, usefully for diagnosis of the neoplasms.
摘要翻译：现在发现一种酶，磷酸果糖激酶可用于检测可能存在于从人体中收集的上清液血清样品或其他体液样品中的磷酸果糖激酶抑制剂。当通过磷酸果糖激酶在体液样品如血清中检测到异常含量高的磷酸果糖激酶抑制剂的含量或效力时，表明供体对于样品存在恶性肿瘤的可能性，有助于诊断赘生物。

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