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1. 发明授权

US08945870B2 DNA encoding an anti-system ASC amino acid transporter 2 (ASCT2) antibody 有权
标题翻译：编码抗系统ASC氨基酸转运蛋白2（ASCT2）抗体的DNA
公开(公告)号：US08945870B2
公开(公告)日：2015-02-03
申请号：US13584478
申请日：2012-08-13
申请人： Norihiko Shiraishi , Akiko Furuya , Hiroe Toki , Hiroshi Ando , Masayo Suzuki , Tsuguo Kubota
发明人： Norihiko Shiraishi , Akiko Furuya , Hiroe Toki , Hiroshi Ando , Masayo Suzuki , Tsuguo Kubota
IPC分类号： C07H21/04 , C12N15/09 , C12N15/12 , C12N15/13 , C12N15/63 , C12N5/07 , C12N5/10 , C12N5/12 , C07K16/28 , G01N33/68 , C07K16/30 , G01N33/574 , A61K39/395 , A61K39/00
CPC分类号： C07K16/28 , A61K39/39533 , A61K2039/505 , C07H21/04 , C07K16/30 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/624 , C07K2317/626 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C12N5/12 , C12N15/09 , C12N15/63 , C12N2800/10 , G01N33/574 , G01N33/6872 , G01N33/6893
摘要： An object of the present invention is to provide a monoclonal antibody which is useful for treating or diagnosing a disease relating to system ASC amino acid transporter 2 (hereinafter, referred to as “ASCT2”) or a method using the antibody. The present invention provides a monoclonal antibody which specifically recognizes a native three-dimensional structure of an extracellular region of ASCT2 and binds to the extracellular region, or an antibody fragment thereof; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which contains the DNA; a transformant obtainable by introducing the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a therapeutic agent using the antibody or the antibody fragment thereof, and a diagnostic agent using the antibody or the antibody fragment thereof.
摘要翻译：本发明的目的是提供一种单克隆抗体，其可用于治疗或诊断与ASC系统ASC氨基酸转运蛋白2有关的疾病（以下称为“ASCT2”）或使用该抗体的方法。本发明提供特异性识别ASCT2细胞外区域的天然三维结构并结合细胞外区域或其抗体片段的单克隆抗体; 产生抗体的杂交瘤; 编码抗体的DNA; 含有DNA的载体; 通过引入载体可获得的转化体; 使用杂交瘤或转化体生产抗体或其抗体片段的方法; 以及使用该抗体或其抗体片段的治疗剂，以及使用该抗体或其抗体片段的诊断剂。

2. 发明授权

US08268592B2 Anti-system ASC amino acid transporter 2 (ASCT2) antibody 有权
标题翻译：抗系统ASC氨基酸转运蛋白2（ASCT2）抗体
公开(公告)号：US08268592B2
公开(公告)日：2012-09-18
申请号：US12505133
申请日：2009-07-17
申请人： Norihiko Shiraishi , Akiko Furuya , Hiroe Toki , Hiroshi Ando , Masayo Suzuki , Tsuguo Kubota
发明人： Norihiko Shiraishi , Akiko Furuya , Hiroe Toki , Hiroshi Ando , Masayo Suzuki , Tsuguo Kubota
IPC分类号： C07K16/00 , C07K16/28 , C12N5/12 , C12P21/08
CPC分类号： C07K16/28 , A61K39/39533 , A61K2039/505 , C07H21/04 , C07K16/30 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/624 , C07K2317/626 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C12N5/12 , C12N15/09 , C12N15/63 , C12N2800/10 , G01N33/574 , G01N33/6872 , G01N33/6893
摘要： An object of the present invention is to provide a monoclonal antibody which is useful for treating or diagnosing a disease relating to system ASC amino acid transporter 2 (hereinafter, referred to as “ASCT2”) or a method using the antibody. The present invention provides a monoclonal antibody which specifically recognizes a native three-dimensional structure of an extracellular region of ASCT2 and binds to the extracellular region, or an antibody fragment thereof; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which contains the DNA; a transformant obtainable by introducing the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a therapeutic agent using the antibody or the antibody fragment thereof, and a diagnostic agent using the antibody or the antibody fragment thereof.
摘要翻译：本发明的目的是提供一种单克隆抗体，其可用于治疗或诊断与ASC系统ASC氨基酸转运蛋白2有关的疾病（以下称为“ASCT2”）或使用该抗体的方法。本发明提供特异性识别ASCT2细胞外区域的天然三维结构并结合细胞外区域或其抗体片段的单克隆抗体; 产生抗体的杂交瘤; 编码抗体的DNA; 含有DNA的载体; 通过引入载体可获得的转化体; 使用杂交瘤或转化体生产抗体或其抗体片段的方法; 以及使用该抗体或其抗体片段的治疗剂，以及使用该抗体或其抗体片段的诊断剂。

3. 发明申请

US20100196392A1 ANTI-SYSTEM ASC AMINO ACID TRANSPORTER 2 (ASCT2) ANTIBODY 有权
标题翻译：抗体系统氨基酸运输2（ASCT2）抗体
公开(公告)号：US20100196392A1
公开(公告)日：2010-08-05
申请号：US12505133
申请日：2009-07-17
申请人： Norihiko SHIRAISHI , Akiko Furuya , Hiroe Toki , Hiroshi Ando , Masayo Suzuki , Tsuguo Kubota
发明人： Norihiko SHIRAISHI , Akiko Furuya , Hiroe Toki , Hiroshi Ando , Masayo Suzuki , Tsuguo Kubota
IPC分类号： A61K39/395 , C07K16/00 , C12N5/00 , C12N15/13 , C12N15/63 , C12N5/07 , C12P21/00 , G01N33/53 , A61P35/00
CPC分类号： C07K16/28 , A61K39/39533 , A61K2039/505 , C07H21/04 , C07K16/30 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/624 , C07K2317/626 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C12N5/12 , C12N15/09 , C12N15/63 , C12N2800/10 , G01N33/574 , G01N33/6872 , G01N33/6893
摘要： An object of the present invention is to provide a monoclonal antibody which is useful for treating or diagnosing a disease relating to system ASC amino acid transporter 2 (hereinafter, referred to as “ASCT2”) or a method using the antibody. The present invention provides a monoclonal antibody which specifically recognizes a native three-dimensional structure of an extracellular region of ASCT2 and binds to the extracellular region, or an antibody fragment thereof; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which contains the DNA; a transformant obtainable by introducing the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a therapeutic agent using the antibody or the antibody fragment thereof, and a diagnostic agent using the antibody or the antibody fragment thereof.
摘要翻译：本发明的目的是提供一种单克隆抗体，其可用于治疗或诊断与ASC系统ASC氨基酸转运蛋白2有关的疾病（以下称为“ASCT2”）或使用该抗体的方法。本发明提供特异性识别ASCT2细胞外区域的天然三维结构并结合细胞外区域或其抗体片段的单克隆抗体; 产生抗体的杂交瘤; 编码抗体的DNA; 含有DNA的载体; 通过引入载体可获得的转化体; 使用杂交瘤或转化体生产抗体或其抗体片段的方法; 以及使用该抗体或其抗体片段的治疗剂，以及使用该抗体或其抗体片段的诊断剂。

4. 发明申请

US20110052595A1 MONOCLONAL ANTIBODY CAPABLE OF BINDING TO HEPARIN-BINDING EPIDERMAL GROWTH FACTOR-LIKE GROWTH FACTOR 失效
标题翻译：结合抗HEPARIN结合的单克隆抗体抗生长因子生长因子
公开(公告)号：US20110052595A1
公开(公告)日：2011-03-03
申请号：US12494472
申请日：2009-06-30
申请人： Eisuke MEKADA , Ryo Iwamoto , Shingo Miyamoto , Kenya Shitara , Akiko Furuya , Kazuyasu Nakamura , Kumiko Takahashi , Hiroshi Ando , Kazuhiro Masuda , Yuka Sasaki
发明人： Eisuke MEKADA , Ryo Iwamoto , Shingo Miyamoto , Kenya Shitara , Akiko Furuya , Kazuyasu Nakamura , Kumiko Takahashi , Hiroshi Ando , Kazuhiro Masuda , Yuka Sasaki
IPC分类号： A61K39/395 , C07K16/22 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/04 , A61P35/00
CPC分类号： A61K39/39558 , A61K2039/505 , C07K16/22 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76
摘要： Medicaments for treating diseases related to HB-EGF escalation are in demand. The present invention provides a monoclonal antibody or an antibody fragment thereof which binds to a cell membrane-bound HB-EGF, a membrane type HB-EGF and a secretory HB-EGF.
摘要翻译：需要用于治疗与HB-EGF升高有关的疾病的药物。本发明提供了结合细胞膜结合的HB-EGF，膜型HB-EGF和分泌型HB-EGF的单克隆抗体或其抗体片段。

5. 发明授权

US08173781B2 Monoclonal antibody capable of binding to heparin-binding epidermal growth factor-like growth factor 失效
公开(公告)号：US08173781B2
公开(公告)日：2012-05-08
申请号：US12494472
申请日：2009-06-30
申请人： Eisuke Mekada , Ryo Iwamoto , Shingo Miyamoto , Kenya Shitara , Akiko Furuya , Kazuyasu Nakamura , Kumiko Takahashi , Hiroshi Ando , Kazuhiro Masuda , Yuka Sasaki
发明人： Eisuke Mekada , Ryo Iwamoto , Shingo Miyamoto , Kenya Shitara , Akiko Furuya , Kazuyasu Nakamura , Kumiko Takahashi , Hiroshi Ando , Kazuhiro Masuda , Yuka Sasaki
IPC分类号： C07K16/00 , A61K39/395 , C12P21/08
CPC分类号： A61K39/39558 , A61K2039/505 , C07K16/22 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76
摘要： Medicaments for treating diseases related to HB-EGF escalation are in demand. The present invention provides a monoclonal antibody or an antibody fragment thereof which binds to a cell membrane-bound HB-EGF, a membrane type HB-EGF and a secretory HB-EGF.

6. 发明授权

US08163282B2 Monoclonal antibody capable of binding to heparin-binding epidermal growth factor-like growth factor 失效
标题翻译：能够结合肝素结合表皮生长因子样生长因子的单克隆抗体
公开(公告)号：US08163282B2
公开(公告)日：2012-04-24
申请号：US12609434
申请日：2009-10-30
申请人： Eisuke Mekada , Ryo Iwamoto , Shingo Miyamoto , Kenya Shitara , Akiko Furuya , Kazuyasu Nakamura , Kumiko Takahashi , Hiroshi Ando , Kazuhiro Masuda , Yuka Sasaki
发明人： Eisuke Mekada , Ryo Iwamoto , Shingo Miyamoto , Kenya Shitara , Akiko Furuya , Kazuyasu Nakamura , Kumiko Takahashi , Hiroshi Ando , Kazuhiro Masuda , Yuka Sasaki
IPC分类号： C07K16/00
CPC分类号： C07K16/22 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76
摘要： Medicaments for treating diseases related to HB-EGF escalation are in demand. The present invention provides a monoclonal antibody or an antibody fragment thereof which binds to a cell membrane-bound HB-EGF, a membrane type HB-EGF and a secretory HB-EGF.
摘要翻译：需要用于治疗与HB-EGF升高有关的疾病的药物。本发明提供了结合细胞膜结合的HB-EGF，膜型HB-EGF和分泌型HB-EGF的单克隆抗体或其抗体片段。

7. 发明授权

US07851601B2 Monoclonal antibody capable of binding to heparin-binding epidermal growth factor-like growth factor 有权
标题翻译：能够结合肝素结合表皮生长因子样生长因子的单克隆抗体
公开(公告)号：US07851601B2
公开(公告)日：2010-12-14
申请号：US12329946
申请日：2008-12-08
申请人： Eisuke Mekada , Ryo Iwamoto , Shingo Miyamoto , Kenya Shitara , Akiko Furuya , Kazuyasu Nakamura , Kumiko Takahashi , Hiroshi Ando , Kazuhiro Masuda , Yuka Sasaki
发明人： Eisuke Mekada , Ryo Iwamoto , Shingo Miyamoto , Kenya Shitara , Akiko Furuya , Kazuyasu Nakamura , Kumiko Takahashi , Hiroshi Ando , Kazuhiro Masuda , Yuka Sasaki
IPC分类号： C12P21/04 , C07K16/00 , A61K39/395 , C07H21/04
CPC分类号： A61K39/39558 , A61K2039/505 , C07K16/22 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76
摘要： Medicaments for treating diseases related to HB-EGF escalation are in demand. The present invention provides a monoclonal antibody or an antibody fragment thereof which binds to a cell membrane-bound HB-EGF, a membrane type HB-EGF and a secretory HB-EGF.
摘要翻译：需要用于治疗与HB-EGF升高有关的疾病的药物。本发明提供了结合细胞膜结合的HB-EGF，膜型HB-EGF和分泌型HB-EGF的单克隆抗体或其抗体片段。

8. 发明授权

US08481039B2 Monoclonal antibody capable of binding to heparin-binding epidermal growth factor-like growth factor 失效
标题翻译：能够结合肝素结合表皮生长因子样生长因子的单克隆抗体
公开(公告)号：US08481039B2
公开(公告)日：2013-07-09
申请号：US13365769
申请日：2012-02-03
申请人： Eisuke Mekada , Ryo Iwamoto , Shingo Miyamoto , Kenya Shitara , Akiko Furuya , Kazuyasu Nakamura , Kumiko Takahashi , Hiroshi Ando , Kazuhiro Masuda , Yuka Sasaki
发明人： Eisuke Mekada , Ryo Iwamoto , Shingo Miyamoto , Kenya Shitara , Akiko Furuya , Kazuyasu Nakamura , Kumiko Takahashi , Hiroshi Ando , Kazuhiro Masuda , Yuka Sasaki
IPC分类号： A61K39/395 , A61K39/00 , C12P21/08 , C07K1/00
CPC分类号： A61K39/39558 , A61K2039/505 , C07K16/22 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76
摘要： Medicaments for treating diseases related to HB-EGF escalation are in demand. The present invention provides a monoclonal antibody or an antibody fragment thereof which binds to a cell membrane-bound HB-EGF, a membrane type HB-EGF and a secretory HB-EGF.
摘要翻译：需要用于治疗与HB-EGF升高有关的疾病的药物。本发明提供了结合细胞膜结合的HB-EGF，膜型HB-EGF和分泌型HB-EGF的单克隆抗体或其抗体片段。

9. 发明授权

US08076458B2 Anti-claudin-4 antibody 失效
标题翻译：抗紧密连蛋白-4抗体
公开(公告)号：US08076458B2
公开(公告)日：2011-12-13
申请号：US12049581
申请日：2008-03-17
申请人： So Ohta , Hiroshi Ando , Masayo Suzuki , Shinobu Kawamoto , Mariko Nakano , Kazuyasu Nakamura
发明人： So Ohta , Hiroshi Ando , Masayo Suzuki , Shinobu Kawamoto , Mariko Nakano , Kazuyasu Nakamura
IPC分类号： C07K16/00 , G01N33/53
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76
摘要： An object of the present invention is to provide a monoclonal antibody which is useful as a diagnostic agent or a therapeutic agent for a disease relating to a polypeptide encoded by Claudin-4 (hereinafter referred to as “CLDN4”) gene or a polypeptide encoded by a Claudin-3 (hereinafter referred to as “CLDN3”) gene, or a method for using the same. Accordingly, the present invention provides a monoclonal antibody or an antibody fragment thereof, which specifically recognizes three-dimensional structure of an extracellular region of CLDN4 and binds to the extracellular region; a monoclonal antibody or an antibody fragment thereof, which specifically recognizes three-dimensional structure of both of extracellular regions of CLDN3 and CLDN4 and binds to the extracellular regions; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which comprises the DNA; a transformant obtained by transforming the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a diagnostic agent or a therapeutic agent for a disease relating to a polypeptide encoded by CLDN4 gene and/or CLDN3 gene using the antibody or the antibody fragment.
摘要翻译：本发明的目的是提供一种单克隆抗体，其可用作与由紧密连接蛋白-4（以下称为“CLDN4”）基因编码的多肽相关的疾病的诊断剂或治疗剂，或者由紧密连接蛋白-3（以下称为“CLDN3”）基因或其使用方法。因此，本发明提供特异性识别CLDN4的细胞外区域的三维结构并结合细胞外区域的单克隆抗体或其抗体片段; 单克隆抗体或其抗体片段，其特异性识别CLDN3和CLDN4的细胞外区域的三维结构并结合细胞外区域; 产生抗体的杂交瘤; 编码抗体的DNA; 包含DNA的载体; 通过转化载体获得的转化体; 使用杂交瘤或转化体生产抗体或其抗体片段的方法; 以及使用抗体或抗体片段的与CLDN4基因和/或CLDN3基因编码的多肽有关的疾病的诊断剂或治疗剂。

10. 发明授权

US08842262B2 Radar apparatus and light scan apparatus 有权
标题翻译：雷达装置和光扫描装置
公开(公告)号：US08842262B2
公开(公告)日：2014-09-23
申请号：US13477197
申请日：2012-05-22
申请人： Narihiro Haneda , Hiroshi Ando
发明人： Narihiro Haneda , Hiroshi Ando
IPC分类号： G01S7/499 , G01S17/42 , G01S7/481
CPC分类号： G01S7/499 , G01S7/4815 , G01S7/4817 , G01S17/42
摘要： A radar apparatus for detecting a distance to an object by receiving an electromagnetic wave reflected by the object is disclosed. The radar apparatus comprises a scan part and an electromagnetic wave emitter. The scan part includes a polarized light separation member configured to pass a preset first component of the electromagnetic wave and reflect a preset second component of the electromagnetic wave. The first and second components, respectively, are polarized lights having first and second polarization directions, which are perpendicular to each other. The scan part scans the second component of the electromagnetic wave in a predetermine scan angle range by rotating the polarized light separation member around a predetermined rotation axis. The electromagnetic wave emitter emits the electromagnetic wave toward the polarized light separation member of the scan part.
摘要翻译：公开了一种用于通过接收由物体反射的电磁波来检测到物体的距离的雷达装置。雷达装置包括扫描部分和电磁波发射器。扫描部分包括偏振光分离构件，其被配置为使预定的电磁波的第一分量通过并且反映电磁波的预设的第二分量。第一和第二分量分别是具有彼此垂直的第一和第二偏振方向的偏振光。扫描部件通过使偏振光分离部件围绕预定的旋转轴线旋转而以预定的扫描角度范围扫描电磁波的第二分量。电磁波发射器向扫描部分的偏振光分离部件发射电磁波。

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