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1. 发明授权

US08481039B2 Monoclonal antibody capable of binding to heparin-binding epidermal growth factor-like growth factor 失效
标题翻译：能够结合肝素结合表皮生长因子样生长因子的单克隆抗体
公开(公告)号：US08481039B2
公开(公告)日：2013-07-09
申请号：US13365769
申请日：2012-02-03
申请人： Eisuke Mekada , Ryo Iwamoto , Shingo Miyamoto , Kenya Shitara , Akiko Furuya , Kazuyasu Nakamura , Kumiko Takahashi , Hiroshi Ando , Kazuhiro Masuda , Yuka Sasaki
发明人： Eisuke Mekada , Ryo Iwamoto , Shingo Miyamoto , Kenya Shitara , Akiko Furuya , Kazuyasu Nakamura , Kumiko Takahashi , Hiroshi Ando , Kazuhiro Masuda , Yuka Sasaki
IPC分类号： A61K39/395 , A61K39/00 , C12P21/08 , C07K1/00
CPC分类号： A61K39/39558 , A61K2039/505 , C07K16/22 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76
摘要： Medicaments for treating diseases related to HB-EGF escalation are in demand. The present invention provides a monoclonal antibody or an antibody fragment thereof which binds to a cell membrane-bound HB-EGF, a membrane type HB-EGF and a secretory HB-EGF.
摘要翻译：需要用于治疗与HB-EGF升高有关的疾病的药物。本发明提供了结合细胞膜结合的HB-EGF，膜型HB-EGF和分泌型HB-EGF的单克隆抗体或其抗体片段。

2. 发明授权

US07851601B2 Monoclonal antibody capable of binding to heparin-binding epidermal growth factor-like growth factor 有权
标题翻译：能够结合肝素结合表皮生长因子样生长因子的单克隆抗体
公开(公告)号：US07851601B2
公开(公告)日：2010-12-14
申请号：US12329946
申请日：2008-12-08
申请人： Eisuke Mekada , Ryo Iwamoto , Shingo Miyamoto , Kenya Shitara , Akiko Furuya , Kazuyasu Nakamura , Kumiko Takahashi , Hiroshi Ando , Kazuhiro Masuda , Yuka Sasaki
发明人： Eisuke Mekada , Ryo Iwamoto , Shingo Miyamoto , Kenya Shitara , Akiko Furuya , Kazuyasu Nakamura , Kumiko Takahashi , Hiroshi Ando , Kazuhiro Masuda , Yuka Sasaki
IPC分类号： C12P21/04 , C07K16/00 , A61K39/395 , C07H21/04
CPC分类号： A61K39/39558 , A61K2039/505 , C07K16/22 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76
摘要： Medicaments for treating diseases related to HB-EGF escalation are in demand. The present invention provides a monoclonal antibody or an antibody fragment thereof which binds to a cell membrane-bound HB-EGF, a membrane type HB-EGF and a secretory HB-EGF.
摘要翻译：需要用于治疗与HB-EGF升高有关的疾病的药物。本发明提供了结合细胞膜结合的HB-EGF，膜型HB-EGF和分泌型HB-EGF的单克隆抗体或其抗体片段。

3. 发明申请

US20110052595A1 MONOCLONAL ANTIBODY CAPABLE OF BINDING TO HEPARIN-BINDING EPIDERMAL GROWTH FACTOR-LIKE GROWTH FACTOR 失效
标题翻译：结合抗HEPARIN结合的单克隆抗体抗生长因子生长因子
公开(公告)号：US20110052595A1
公开(公告)日：2011-03-03
申请号：US12494472
申请日：2009-06-30
申请人： Eisuke MEKADA , Ryo Iwamoto , Shingo Miyamoto , Kenya Shitara , Akiko Furuya , Kazuyasu Nakamura , Kumiko Takahashi , Hiroshi Ando , Kazuhiro Masuda , Yuka Sasaki
发明人： Eisuke MEKADA , Ryo Iwamoto , Shingo Miyamoto , Kenya Shitara , Akiko Furuya , Kazuyasu Nakamura , Kumiko Takahashi , Hiroshi Ando , Kazuhiro Masuda , Yuka Sasaki
IPC分类号： A61K39/395 , C07K16/22 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/04 , A61P35/00
CPC分类号： A61K39/39558 , A61K2039/505 , C07K16/22 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76
摘要： Medicaments for treating diseases related to HB-EGF escalation are in demand. The present invention provides a monoclonal antibody or an antibody fragment thereof which binds to a cell membrane-bound HB-EGF, a membrane type HB-EGF and a secretory HB-EGF.
摘要翻译：需要用于治疗与HB-EGF升高有关的疾病的药物。本发明提供了结合细胞膜结合的HB-EGF，膜型HB-EGF和分泌型HB-EGF的单克隆抗体或其抗体片段。

4. 发明授权

US08173781B2 Monoclonal antibody capable of binding to heparin-binding epidermal growth factor-like growth factor 失效
公开(公告)号：US08173781B2
公开(公告)日：2012-05-08
申请号：US12494472
申请日：2009-06-30
申请人： Eisuke Mekada , Ryo Iwamoto , Shingo Miyamoto , Kenya Shitara , Akiko Furuya , Kazuyasu Nakamura , Kumiko Takahashi , Hiroshi Ando , Kazuhiro Masuda , Yuka Sasaki
发明人： Eisuke Mekada , Ryo Iwamoto , Shingo Miyamoto , Kenya Shitara , Akiko Furuya , Kazuyasu Nakamura , Kumiko Takahashi , Hiroshi Ando , Kazuhiro Masuda , Yuka Sasaki
IPC分类号： C07K16/00 , A61K39/395 , C12P21/08
CPC分类号： A61K39/39558 , A61K2039/505 , C07K16/22 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76
摘要： Medicaments for treating diseases related to HB-EGF escalation are in demand. The present invention provides a monoclonal antibody or an antibody fragment thereof which binds to a cell membrane-bound HB-EGF, a membrane type HB-EGF and a secretory HB-EGF.

5. 发明授权

US08163282B2 Monoclonal antibody capable of binding to heparin-binding epidermal growth factor-like growth factor 失效
标题翻译：能够结合肝素结合表皮生长因子样生长因子的单克隆抗体
公开(公告)号：US08163282B2
公开(公告)日：2012-04-24
申请号：US12609434
申请日：2009-10-30
申请人： Eisuke Mekada , Ryo Iwamoto , Shingo Miyamoto , Kenya Shitara , Akiko Furuya , Kazuyasu Nakamura , Kumiko Takahashi , Hiroshi Ando , Kazuhiro Masuda , Yuka Sasaki
发明人： Eisuke Mekada , Ryo Iwamoto , Shingo Miyamoto , Kenya Shitara , Akiko Furuya , Kazuyasu Nakamura , Kumiko Takahashi , Hiroshi Ando , Kazuhiro Masuda , Yuka Sasaki
IPC分类号： C07K16/00
CPC分类号： C07K16/22 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76
摘要： Medicaments for treating diseases related to HB-EGF escalation are in demand. The present invention provides a monoclonal antibody or an antibody fragment thereof which binds to a cell membrane-bound HB-EGF, a membrane type HB-EGF and a secretory HB-EGF.
摘要翻译：需要用于治疗与HB-EGF升高有关的疾病的药物。本发明提供了结合细胞膜结合的HB-EGF，膜型HB-EGF和分泌型HB-EGF的单克隆抗体或其抗体片段。

6. 发明授权

US5633035A Thin-film resistor and process for producing the same 失效
标题翻译：薄膜电阻及其制造方法
公开(公告)号：US5633035A
公开(公告)日：1997-05-27
申请号：US428835
申请日：1995-04-25
申请人： Kazuo Baba , Yoshiyuki Shiratsuki , Kumiko Takahashi
发明人： Kazuo Baba , Yoshiyuki Shiratsuki , Kumiko Takahashi
IPC分类号： B41J2/335 , H01B1/22 , H01C7/00 , H01C17/06 , H01C17/075 , H01C17/20 , H01C17/30 , B05D5/12
CPC分类号： H01C7/006 , H01C17/075 , H01C17/20 , H01C7/003
摘要： A thin-film resistor comprising a mixture of rhodium (Rh) oxide as a resistive material, and at least one element M selected from the group consisting of silicon (Si), lead (Pb), bismuth (Bi), zirconium (Zr), barium (Ba), aluminium (Al), boron (B), tin (Sn), and titanium (Ti), wherein M/Rh, or the ratio of the number of element M atoms to that of rhodium (Rh) atoms is in the range of 0.3 to 3.0. Thin-film resistor is formed from the process of preparing a solution of an organometallic material, coating the material on a substrate, drying and then firing the material at a peak temperature not less than 500.degree. C.
摘要翻译：一种薄膜电阻器，其包含作为电阻材料的铑（Rh）氧化物的混合物，以及选自由硅（Si），铅（Pb），铋（Bi），锆（Zr），钡（Ba），铝（Al），硼（B），锡（Sn）和钛（Ti），其中M / Rh或元素M原子数与铑（Rh）原子数的比例在0.3〜3.0的范围内。由制备有机金属材料溶液的方法形成薄膜电阻体，将该材料涂覆在基板上，干燥然后在不低于500℃的峰值温度下烧制。

7. 发明申请

US20130045402A1 FLAT-TYPE BATTERY 有权
标题翻译：平板式电池
公开(公告)号：US20130045402A1
公开(公告)日：2013-02-21
申请号：US13643657
申请日：2011-04-19
申请人： Kumiko Takahashi
发明人： Kumiko Takahashi
IPC分类号： H01M2/08 , H01M10/48
CPC分类号： H01M2/30 , H01M2/0212
摘要： Disclosed is a flat battery which includes power generating element 18 accommodated in an inner space formed by sealing outer peripheral edges of package members 16 and 17, collector 11a, 13a connected to an electrode plate of power generating element 18 and an electrode tab 14, 15 taken out from the outer peripheral edges of package members 16 and 17. Electrode tab 14, 15 has conducting portion 151 overlapping and joined to collector 11a, 13a and stress relieving portion 152 formed of a material having higher elasticity than that of conducting portion 151. It is thus possible to prevent the occurrence of wrinkles in collector 11a, 13a or electrode tab 14, 15 and separations in weld joints due to a difference in expansion/contraction rate between collector 11a, 13a and electrode tab 14, 15.
摘要翻译：公开了一种扁平电池，其包括容纳在通过密封封装构件16和17的外周边缘而形成的内部空间中的发电元件18，连接到发电元件18的电极板的集电体11a，13a和电极接头14,15 从封装构件16和17的外周边缘取出。电极接头14,15具有重叠并连接到集电体11a，13a和由具有比导电部分151的弹性高的材料形成的应力消除部分152的导电部分151。因此，可以防止集电体11a，13a或电极片14,15的褶皱的发生，以及由于集电体11a，13a和电极片14,15之间的膨胀/收缩率的差异导致的焊缝的分离。

8. 发明授权

US5189284A Resistor, process for producing the same, and thermal head using the same 失效
标题翻译：电阻器，制造过程，以及使用其的热敏头
公开(公告)号：US5189284A
公开(公告)日：1993-02-23
申请号：US315665
申请日：1989-02-27
申请人： Kumiko Takahashi , Kazuo Baba , Yoshiyuki Shiratsuki
发明人： Kumiko Takahashi , Kazuo Baba , Yoshiyuki Shiratsuki
IPC分类号： B41J2/335 , G01D15/10 , H01C7/00 , H01C17/06 , H01C17/065 , H01C17/20 , H01C17/30 , H05B3/14
CPC分类号： B41J2/33515 , B41J2/33545 , B41J2/3355 , B41J2/3357 , B41J2/3359 , G01D15/10 , H01C17/0654 , H05B3/141
摘要： A resistor comprises iridium and at least one metal selected from the group consisting of silicon, bismuth, lead, tin, aluminum, boron, titanium, zirconium, calcium and barium. A process for producing the resistor comprises the steps of coating a solution of an iridium containing organometallic material onto a substrate and subsequently firing the coated solution. The resistor is used as a heating resistor of a thermal head.
摘要翻译：电阻器包括铱和至少一种选自硅，铋，铅，锡，铝，硼，钛，锆，钙和钡的金属。制造电阻器的方法包括以下步骤：将含有铱的有机金属材料的溶液涂布到基材上，随后烧制涂布的溶液。该电阻用作热敏头的加热电阻。

9. 发明授权

US09257692B2 Flat-type battery 有权
标题翻译：扁平式电池
公开(公告)号：US09257692B2
公开(公告)日：2016-02-09
申请号：US13643657
申请日：2011-04-19
申请人： Kumiko Takahashi
发明人： Kumiko Takahashi
IPC分类号： H01M10/48 , H01M2/30 , H01M2/02
CPC分类号： H01M2/30 , H01M2/0212
摘要： Disclosed is a flat battery which includes power generating element 18 accommodated in an inner space formed by sealing outer peripheral edges of package members 16 and 17, collector 11a, 13a connected to an electrode plate of power generating element 18 and an electrode tab 14, 15 taken out from the outer peripheral edges of package members 16 and 17. Electrode tab 14, 15 has conducting portion 151 overlapping and joined to collector 11a, 13a and stress relieving portion 152 formed of a material having higher elasticity than that of conducting portion 151. It is thus possible to prevent the occurrence of wrinkles in collector 11a, 13a or electrode tab 14, 15 and separations in weld joints due to a difference in expansion/contraction rate between collector 11a, 13a and electrode tab 14, 15.
摘要翻译：公开了一种扁平电池，其包括容纳在通过密封封装构件16和17的外周边缘而形成的内部空间中的发电元件18，连接到发电元件18的电极板的集电体11a，13a和电极接头14,15 从封装构件16和17的外周边缘取出。电极接头14,15具有重叠并连接到集电体11a，13a和由具有比导电部分151的弹性高的材料形成的应力消除部分152的导电部分151。因此，可以防止集电体11a，13a或电极片14,15的褶皱的发生，以及由于集电体11a，13a和电极片14,15之间的膨胀/收缩率的差异导致的焊缝的分离。

10. 发明申请

US20060008928A1 Process for producing fine particles of bismuth titanate 有权
标题翻译：生产钛酸铋微粒的方法
公开(公告)号：US20060008928A1
公开(公告)日：2006-01-12
申请号：US11223984
申请日：2005-09-13
申请人： Yoshihisa Beppu , Kazuo Sunahara , Hiroyuki Tomonaga , Kumiko Takahashi
发明人： Yoshihisa Beppu , Kazuo Sunahara , Hiroyuki Tomonaga , Kumiko Takahashi
IPC分类号： H01L21/00
CPC分类号： C01G29/00 , B82Y30/00 , C01P2004/10 , C01P2004/20 , C01P2004/52 , C01P2004/54 , C01P2004/62 , C01P2004/64 , Y10S977/775 , Y10S977/776 , Y10S977/90
摘要： It is an object to provide fine particles of bismuth titanate having excellent dielectric characteristics, high crystallinity and a small particle diameter, and a process for their production. The object is accomplished by a process which comprises a step of obtaining a melt comprising, as represented by mol % based on oxides, from 23 to 72% of Bi2O3, from 4 to 64% of TiO2 and from 6 to 50% of B2O3, a step of quickly quenching this melt to obtain an amorphous material, a step of crystallization of bismuth titanate crystals from the above amorphous material, and a step of separating the bismuth titanate crystals from the obtained crystallized material, in this order.
摘要翻译：本发明的目的是提供具有优异的介电特性，高结晶度和小粒径的钛酸铋微粒及其生产方法。该目的通过一种方法来实现，该方法包括获得熔体的步骤，其包含以氧化物计的摩尔％表示的23％至72％的Bi 2 O 3 ，4〜64％的TiO 2和6〜50％的B 2 O 3 3，将该熔体迅速骤冷至获得无定形材料，从上述无定形材料中结晶钛酸铋晶体的步骤，以及从获得的结晶材料中依次分离钛酸铋晶体的步骤。

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