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1. 发明授权

US07851601B2 Monoclonal antibody capable of binding to heparin-binding epidermal growth factor-like growth factor 有权
标题翻译：能够结合肝素结合表皮生长因子样生长因子的单克隆抗体
公开(公告)号：US07851601B2
公开(公告)日：2010-12-14
申请号：US12329946
申请日：2008-12-08
申请人： Eisuke Mekada , Ryo Iwamoto , Shingo Miyamoto , Kenya Shitara , Akiko Furuya , Kazuyasu Nakamura , Kumiko Takahashi , Hiroshi Ando , Kazuhiro Masuda , Yuka Sasaki
发明人： Eisuke Mekada , Ryo Iwamoto , Shingo Miyamoto , Kenya Shitara , Akiko Furuya , Kazuyasu Nakamura , Kumiko Takahashi , Hiroshi Ando , Kazuhiro Masuda , Yuka Sasaki
IPC分类号： C12P21/04 , C07K16/00 , A61K39/395 , C07H21/04
CPC分类号： A61K39/39558 , A61K2039/505 , C07K16/22 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76
摘要： Medicaments for treating diseases related to HB-EGF escalation are in demand. The present invention provides a monoclonal antibody or an antibody fragment thereof which binds to a cell membrane-bound HB-EGF, a membrane type HB-EGF and a secretory HB-EGF.
摘要翻译：需要用于治疗与HB-EGF升高有关的疾病的药物。本发明提供了结合细胞膜结合的HB-EGF，膜型HB-EGF和分泌型HB-EGF的单克隆抗体或其抗体片段。

2. 发明授权

US08173781B2 Monoclonal antibody capable of binding to heparin-binding epidermal growth factor-like growth factor 失效
公开(公告)号：US08173781B2
公开(公告)日：2012-05-08
申请号：US12494472
申请日：2009-06-30
申请人： Eisuke Mekada , Ryo Iwamoto , Shingo Miyamoto , Kenya Shitara , Akiko Furuya , Kazuyasu Nakamura , Kumiko Takahashi , Hiroshi Ando , Kazuhiro Masuda , Yuka Sasaki
发明人： Eisuke Mekada , Ryo Iwamoto , Shingo Miyamoto , Kenya Shitara , Akiko Furuya , Kazuyasu Nakamura , Kumiko Takahashi , Hiroshi Ando , Kazuhiro Masuda , Yuka Sasaki
IPC分类号： C07K16/00 , A61K39/395 , C12P21/08
CPC分类号： A61K39/39558 , A61K2039/505 , C07K16/22 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76
摘要： Medicaments for treating diseases related to HB-EGF escalation are in demand. The present invention provides a monoclonal antibody or an antibody fragment thereof which binds to a cell membrane-bound HB-EGF, a membrane type HB-EGF and a secretory HB-EGF.

3. 发明授权

US08163282B2 Monoclonal antibody capable of binding to heparin-binding epidermal growth factor-like growth factor 失效
标题翻译：能够结合肝素结合表皮生长因子样生长因子的单克隆抗体
公开(公告)号：US08163282B2
公开(公告)日：2012-04-24
申请号：US12609434
申请日：2009-10-30
申请人： Eisuke Mekada , Ryo Iwamoto , Shingo Miyamoto , Kenya Shitara , Akiko Furuya , Kazuyasu Nakamura , Kumiko Takahashi , Hiroshi Ando , Kazuhiro Masuda , Yuka Sasaki
发明人： Eisuke Mekada , Ryo Iwamoto , Shingo Miyamoto , Kenya Shitara , Akiko Furuya , Kazuyasu Nakamura , Kumiko Takahashi , Hiroshi Ando , Kazuhiro Masuda , Yuka Sasaki
IPC分类号： C07K16/00
CPC分类号： C07K16/22 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76
摘要： Medicaments for treating diseases related to HB-EGF escalation are in demand. The present invention provides a monoclonal antibody or an antibody fragment thereof which binds to a cell membrane-bound HB-EGF, a membrane type HB-EGF and a secretory HB-EGF.
摘要翻译：需要用于治疗与HB-EGF升高有关的疾病的药物。本发明提供了结合细胞膜结合的HB-EGF，膜型HB-EGF和分泌型HB-EGF的单克隆抗体或其抗体片段。

4. 发明授权

US08481039B2 Monoclonal antibody capable of binding to heparin-binding epidermal growth factor-like growth factor 失效
标题翻译：能够结合肝素结合表皮生长因子样生长因子的单克隆抗体
公开(公告)号：US08481039B2
公开(公告)日：2013-07-09
申请号：US13365769
申请日：2012-02-03
申请人： Eisuke Mekada , Ryo Iwamoto , Shingo Miyamoto , Kenya Shitara , Akiko Furuya , Kazuyasu Nakamura , Kumiko Takahashi , Hiroshi Ando , Kazuhiro Masuda , Yuka Sasaki
发明人： Eisuke Mekada , Ryo Iwamoto , Shingo Miyamoto , Kenya Shitara , Akiko Furuya , Kazuyasu Nakamura , Kumiko Takahashi , Hiroshi Ando , Kazuhiro Masuda , Yuka Sasaki
IPC分类号： A61K39/395 , A61K39/00 , C12P21/08 , C07K1/00
CPC分类号： A61K39/39558 , A61K2039/505 , C07K16/22 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76
摘要： Medicaments for treating diseases related to HB-EGF escalation are in demand. The present invention provides a monoclonal antibody or an antibody fragment thereof which binds to a cell membrane-bound HB-EGF, a membrane type HB-EGF and a secretory HB-EGF.
摘要翻译：需要用于治疗与HB-EGF升高有关的疾病的药物。本发明提供了结合细胞膜结合的HB-EGF，膜型HB-EGF和分泌型HB-EGF的单克隆抗体或其抗体片段。

5. 发明申请

US20110052595A1 MONOCLONAL ANTIBODY CAPABLE OF BINDING TO HEPARIN-BINDING EPIDERMAL GROWTH FACTOR-LIKE GROWTH FACTOR 失效
标题翻译：结合抗HEPARIN结合的单克隆抗体抗生长因子生长因子
公开(公告)号：US20110052595A1
公开(公告)日：2011-03-03
申请号：US12494472
申请日：2009-06-30
申请人： Eisuke MEKADA , Ryo Iwamoto , Shingo Miyamoto , Kenya Shitara , Akiko Furuya , Kazuyasu Nakamura , Kumiko Takahashi , Hiroshi Ando , Kazuhiro Masuda , Yuka Sasaki
发明人： Eisuke MEKADA , Ryo Iwamoto , Shingo Miyamoto , Kenya Shitara , Akiko Furuya , Kazuyasu Nakamura , Kumiko Takahashi , Hiroshi Ando , Kazuhiro Masuda , Yuka Sasaki
IPC分类号： A61K39/395 , C07K16/22 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/04 , A61P35/00
CPC分类号： A61K39/39558 , A61K2039/505 , C07K16/22 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76
摘要： Medicaments for treating diseases related to HB-EGF escalation are in demand. The present invention provides a monoclonal antibody or an antibody fragment thereof which binds to a cell membrane-bound HB-EGF, a membrane type HB-EGF and a secretory HB-EGF.
摘要翻译：需要用于治疗与HB-EGF升高有关的疾病的药物。本发明提供了结合细胞膜结合的HB-EGF，膜型HB-EGF和分泌型HB-EGF的单克隆抗体或其抗体片段。

6. 发明授权

US08399621B2 Anti-CD4 antibody 有权
标题翻译：抗CD4抗体
公开(公告)号：US08399621B2
公开(公告)日：2013-03-19
申请号：US12647698
申请日：2009-12-28
申请人： Tomoaki Nakagawa , Sayaka Hori , Rinpei Niwa , Tsuguo Kubota , Kazuhiro Masuda , Kazuyasu Nakamura
发明人： Tomoaki Nakagawa , Sayaka Hori , Rinpei Niwa , Tsuguo Kubota , Kazuhiro Masuda , Kazuyasu Nakamura
IPC分类号： C07K16/00
CPC分类号： C07K16/2812 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/92 , C07K2319/30 , G01N2333/70514
摘要： An anti-CD4 antibody which binds to CD4, has a high affinity and has a high effector activity, such as an antibody-dependent cellular cytotoxicity (ADCC activity) or complement-dependent cellular cytotoxicity (CDC activity), is required for a disease relating to a CD4-expressing cell.The present invention can provide a monoclonal antibody or an antibody fragment thereof, which binds to a CD4 extracellular region with high affinity and also exhibits a high ADCC activity or a high CDC activity; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which contains the DNA; a transformant obtainable by introducing the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a therapeutic agent using the antibody or the antibody fragment thereof or a diagnostic agent using the antibody or the antibody fragment thereof.
摘要翻译：与CD4结合的抗CD4抗体具有高亲和力并具有高效应活性，例如抗体依赖性细胞毒性（ADCC活性）或补体依赖性细胞毒性（CDC活性），涉及到疾病到CD4表达细胞。本发明可以提供以高亲和力结合CD4细胞外区域并且也表现出高ADCC活性或高CDC活性的单克隆抗体或其抗体片段; 产生抗体的杂交瘤; 编码抗体的DNA; 含有DNA的载体; 通过引入载体可获得的转化体; 使用杂交瘤或转化体生产抗体或其抗体片段的方法; 以及使用该抗体或其抗体片段的治疗剂或使用该抗体或其抗体片段的诊断剂。

7. 发明授权

US08877913B2 Anti-CD4 antibody 有权
标题翻译：抗CD4抗体
公开(公告)号：US08877913B2
公开(公告)日：2014-11-04
申请号：US13755472
申请日：2013-01-31
申请人： Tomoaki Nakagawa , Sayaka Hori , Rinpei Niwa , Tsuguo Kubota , Kazuhiro Masuda , Kazuyasu Nakamura
发明人： Tomoaki Nakagawa , Sayaka Hori , Rinpei Niwa , Tsuguo Kubota , Kazuhiro Masuda , Kazuyasu Nakamura
IPC分类号： C07H21/04
CPC分类号： C07K16/2812 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/92 , C07K2319/30 , G01N2333/70514
摘要： An anti-CD4 antibody which binds to CD4, has a high affinity and has a high effector activity, such as an antibody-dependent cellular cytotoxicity (ADCC activity) or complement-dependent cellular cytotoxicity (CDC activity), is required for a disease relating to a CD4-expressing cell.The present invention can provide a monoclonal antibody or an antibody fragment thereof, which binds to a CD4 extracellular region with high affinity and also exhibits a high ADCC activity or a high CDC activity; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which contains the DNA; a transformant obtainable by introducing the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a therapeutic agent using the antibody or the antibody fragment thereof or a diagnostic agent using the antibody or the antibody fragment thereof.
摘要翻译：与CD4结合的抗CD4抗体具有高亲和力并具有高效应活性，例如抗体依赖性细胞毒性（ADCC活性）或补体依赖性细胞毒性（CDC活性），涉及到疾病到CD4表达细胞。本发明可以提供以高亲和力结合CD4细胞外区域并且也表现出高ADCC活性或高CDC活性的单克隆抗体或其抗体片段; 产生抗体的杂交瘤; 编码抗体的DNA; 含有DNA的载体; 通过引入载体可获得的转化体; 使用杂交瘤或转化体生产抗体或其抗体片段的方法; 以及使用该抗体或其抗体片段的治疗剂或使用该抗体或其抗体片段的诊断剂。

8. 发明授权

US07955655B2 Coating compositions and method of forming coating film 失效
标题翻译：涂料组合物和形成涂膜的方法
公开(公告)号：US07955655B2
公开(公告)日：2011-06-07
申请号：US10503127
申请日：2003-02-18
申请人： Kazutoshi Sugiura , Kazuhiro Masuda , Hiromi Katoh , Kenichi Nagai , Yoshizumi Matsuno
发明人： Kazutoshi Sugiura , Kazuhiro Masuda , Hiromi Katoh , Kenichi Nagai , Yoshizumi Matsuno
IPC分类号： C08F2/46 , B05D1/36 , C09D167/00
CPC分类号： C09D175/16 , B05D3/067 , B05D7/16 , B05D7/53 , C08G18/3206 , C08G18/8175 , C08K5/0025 , C08K5/34922 , C08L33/06 , C08L63/10 , C08L67/00 , C08L67/06 , C08L101/02 , C09D4/00 , C09D4/06 , C09D167/00 , C09D167/06 , C09D175/06 , Y10T428/31786 , C08G18/62 , C08F283/02 , C08L2666/22 , C08L2666/02 , C08L2666/04 , C08L2666/18
摘要： The present invention provides a thermosetting and photocurable coating composition comprising: (A) at least one compound selected from the group consisting of radical-polymerizable unsaturated monomers, resins containing radical-polymerizable unsaturated groups, and resins containing radical-polymerizable unsaturated groups and thermosetting functional groups; (B) a hydroxyl-containing polyester resin produced by esterifying a polybasic acid (a) and a polyhydric alcohol (b), wherein an alicyclic polybasic acid (a1) and/or an alicyclic polyhydric alcohol (b1) are included in a ratio of 20% or more based on the total weight of polybasic acid (a) and polyhydric alcohol (b); (C) a crosslinking agent; and (D) a photopolymerization initiator; and a method of forming a coating film using the coating composition.
摘要翻译：本发明提供一种热固性和光固化性涂料组合物，其包含：（A）至少一种选自可自由基聚合的不饱和单体，含有可自由基聚合的不饱和基团的树脂和含有可自由基聚合的不饱和基团的树脂和热固性官能团团体（B）通过酯化多元酸（a）和多元醇（b）而制备的含羟基的聚酯树脂，其中脂环族多元酸（a1）和/或脂环族多元醇（b1）的比例为基于多元酸（a）和多元醇（b）的总重量为20％以上。（C）交联剂; 和（D）光聚合引发剂; 以及使用该涂料组合物形成涂膜的方法。

9. 发明申请

US20050142297A1 Coating compositions and method of forming coating film 失效
标题翻译：涂料组合物和形成涂膜的方法
公开(公告)号：US20050142297A1
公开(公告)日：2005-06-30
申请号：US10503127
申请日：2003-02-18
申请人： Kazutoshi Sugiura , Kazuhiro Masuda , Hiromi Katoh , Kenichi Nagai , Yoshizumi Matsuno
发明人： Kazutoshi Sugiura , Kazuhiro Masuda , Hiromi Katoh , Kenichi Nagai , Yoshizumi Matsuno
IPC分类号： B05D3/06 , B05D7/00 , B05D7/16 , C08G18/32 , C08G18/81 , C08K5/00 , C08K5/3492 , C08L33/06 , C08L63/10 , C08L67/00 , C08L67/06 , C08L101/02 , C09D4/00 , C09D4/06 , C09D167/00 , C09D167/06 , C09D175/06 , C09D175/16 , C08F2/46 , B05D1/36
CPC分类号： C09D175/16 , B05D3/067 , B05D7/16 , B05D7/53 , C08G18/3206 , C08G18/8175 , C08K5/0025 , C08K5/34922 , C08L33/06 , C08L63/10 , C08L67/00 , C08L67/06 , C08L101/02 , C09D4/00 , C09D4/06 , C09D167/00 , C09D167/06 , C09D175/06 , Y10T428/31786 , C08G18/62 , C08F283/02 , C08L2666/22 , C08L2666/02 , C08L2666/04 , C08L2666/18
摘要： The present invention provides a thermosetting and photocurable coating composition comprising: (A) at least one compound selected from the group consisting of radical-polymerizable unsaturated monomers, resins containing radical-polymerizable unsaturated groups, and resins containing radical-polymerizable unsaturated groups and thermosetting functional groups; (B) a hydroxyl-containing polyester resin produced by esterifying a polybasic acid (a) and a polyhydric alcohol (b), wherein an alicyclic polybasic acid (a1) and/or an alicyclic polyhydric alcohol (b1) are included in a ratio of 20% or more based on the total weight of polybasic acid (a) and polyhydric alcohol (b); (C) a crosslinking agent; and (D) a photopolymerization initiator; and a method of forming a coating film using the coating composition.
摘要翻译：本发明提供一种热固性和光固化性涂料组合物，其包含：（A）至少一种选自可自由基聚合的不饱和单体，含有可自由基聚合的不饱和基团的树脂和含有可自由基聚合的不饱和基团的树脂和热固性官能团团体（B）通过酯化多元酸（a）和多元醇（b）而制备的含羟基的聚酯树脂，其中脂环族多元酸（a1）和/或脂环族多元醇（b1）的比例为基于多元酸（a）和多元醇（b）的总重量计为20％以上。（C）交联剂; 和（D）光聚合引发剂; 以及使用该涂料组合物形成涂膜的方法。

10. 发明授权

US08295875B2 Apparatus and method for mobile communication by using non-volatile memory device 有权
标题翻译：使用非易失性存储器件进行移动通信的装置和方法
公开(公告)号：US08295875B2
公开(公告)日：2012-10-23
申请号：US11941230
申请日：2007-11-16
申请人： Kazuhiro Masuda
发明人： Kazuhiro Masuda
IPC分类号： H04M1/00
CPC分类号： H04M19/04 , G06F12/0246
摘要： A mobile communication apparatus configured to communicate with an opposite communication device is provided. The mobile communication apparatus includes a transceiver configured to receive an incoming signal sent from the opposite communication device. The transceiver is configured to produce an interrupt signal upon receiving the incoming signal. The mobile communication apparatus includes a first memory device and a non-volatile second memory device. The mobile communication apparatus includes a controller connected to the transceiver, the first memory device and the second memory device. The controller is configured to perform garbage collection of the second memory device, to load data stored in one of the first memory device and the second memory device into another of the first memory device and the second memory device, to access the first memory device if the transceiver produces the interrupt signal.
摘要翻译：提供了一种被配置为与相对的通信设备通信的移动通信设备。移动通信装置包括：收发器，被配置为接收从相对的通信设备发送的输入信号。收发器被配置为在接收到输入信号时产生中断信号。移动通信装置包括第一存储装置和非易失性第二存储装置。移动通信设备包括连接到收发器，第一存储器设备和第二存储器设备的控制器。控制器被配置为执行第二存储器设备的垃圾收集，将存储在第一存储器设备和第二存储器设备之一中的数据加载到第一存储器设备和第二存储器设备中的另一个中以访问第一存储器设备，如果收发器产生中断信号。

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