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1. 发明授权

US06482806B1 Product of heat treatment of uronic acid, food, drink, or drug including the product 失效
标题翻译：糖醛酸，食品，饮料或药品的热处理产品，包括产品
公开(公告)号：US06482806B1
公开(公告)日：2002-11-19
申请号：US09125397
申请日：1998-08-18
申请人： Nobuto Koyama , Hiroaki Sagawa , Eiji Kobayashi , Tatsuji Enoki , Hua-Kang Wu , Eiji Nishiyama , Suzu Deguchi , Katsushige Ikai , Hiromu Ohnogi , Motoko Ueda , Akihiro Kondo , Ikunoshin Kato
发明人： Nobuto Koyama , Hiroaki Sagawa , Eiji Kobayashi , Tatsuji Enoki , Hua-Kang Wu , Eiji Nishiyama , Suzu Deguchi , Katsushige Ikai , Hiromu Ohnogi , Motoko Ueda , Akihiro Kondo , Ikunoshin Kato
IPC分类号： A61K31727
CPC分类号： C07H7/033 , A61K8/60 , A61Q11/00 , Y10S977/928 , Y10S977/929 , Y10S977/93
摘要： A product obtained by heating at least one substance selected from the following (a), (b) and (c). (a) uronic acid or uronic acid derivative; (b) a saccharide compound containing uronic acid or a saccharide compound containing uronic acid derivative; and (c) a substance containing a saccharide compound containing uronic acid or a substance containing a saccharide compound containing uronic acid derivative; and food, beverage or a pharmaceutical agent which is characterized in containing the above-mentioned heat-treated product.
摘要翻译：通过加热选自以下（a），（b）和（c）中的至少一种物质获得的产物：（a）糖醛酸或糖醛酸衍生物;（b）含有糖醛酸或含有糖醛酸的糖类化合物的糖类化合物酸衍生物; 和（c）含有糖醛酸的糖类化合物或含有糖醛酸衍生物的糖类化合物的物质的物质;以及含有上述热处理物的食品，饮料或药剂。

2. 发明授权

US6087401A Cyclopentenones, process for preparing the same, and the use thereof 失效
标题翻译：环戊烯酮，其制备方法及其用途
公开(公告)号：US6087401A
公开(公告)日：2000-07-11
申请号：US230868
申请日：1999-02-02
申请人： Nobuto Koyama , Hiroaki Sagawa , Eiji Kobayashi , Tatsuji Enoki , Hua-Kang Wu , Eiji Nishiyama , Katsushige Ikai , Ikunoshin Kato
发明人： Nobuto Koyama , Hiroaki Sagawa , Eiji Kobayashi , Tatsuji Enoki , Hua-Kang Wu , Eiji Nishiyama , Katsushige Ikai , Ikunoshin Kato
IPC分类号： A23L1/30 , A61K8/35 , A61K8/60 , A61K31/12 , A61Q5/00 , A61Q11/00 , A61Q19/00 , C07C45/67 , C07C49/707 , C07H7/033
CPC分类号： C07H7/033 , A61K8/35 , A61K8/60 , A61Q17/005 , A61Q19/00 , A61Q11/00 , A61Q19/10 , A61Q5/00
摘要： There is disclosed a method of manufacturing 4,5-dihydroxy-2-cyclopenten-1-one represented by the following formula [1] which is characterized in that at least one substance selected from the following (a), (b) and (c) is heated.(a): uronic acid or uronic acid derivative(s);(b): a saccharide compound which contains uronic acid and/or uronic acid derivative(s); and(c): a substance containing a saccharide compound which contains uronic acid and/or uronic acid derivative(s). ##STR1##
摘要翻译： PCT No.PCT / JP97 / 03052 Sec。 371日期1999年2月2日 102（e）1999年2月2日PCT 1997年9月1日PCT PCT。公开号WO98 / 13328 日期：1998年4月2日公开了由下式[1]表示的4,5-二羟基-2-环戊烯-1-酮的制造方法，其特征在于，选自下述（a），（b）和（c）被加热。（a）：糖醛酸或糖醛酸衍生物; （b）：含有糖醛酸和/或糖醛酸衍生物的糖类化合物; 和（c）：含有糖醛酸和/或糖醛酸衍生物的糖类化合物的物质。

3. 发明授权

US06548543B1 Remedies or preventives containing cyclopentenone compounds as the active ingredient 失效
标题翻译：含环戊烯酮化合物作为活性成分的补救措施或预防措施
公开(公告)号：US06548543B1
公开(公告)日：2003-04-15
申请号：US09763244
申请日：2001-02-20
申请人： Eiji Kobayashi , Hiromu Ohnogi , Hiroaki Sagawa , Takanari Tominaga , Eiji Nishiyama , Nobuto Koyama , Katsushige Ikai , Ikunoshin Kato
发明人： Eiji Kobayashi , Hiromu Ohnogi , Hiroaki Sagawa , Takanari Tominaga , Eiji Nishiyama , Nobuto Koyama , Katsushige Ikai , Ikunoshin Kato
IPC分类号： A61K31215
CPC分类号： A61K31/215 , A61K31/22 , C07C69/013 , C07C2601/10 , Y02A50/411
摘要： Remedies or preventives for diseases with a need for immunoregulation, diseases with a need for inhibition of inflammation, diseases with a need for regulation of tumor necrosis factor production, diseases with a need for regulation of fungal growth, diseases with a need for regulation of cell adhesion or disease with a deed for induction of heat-shock protein, which contain as the active ingredient at least one compound selected from among cyclopentenone derivatives represented by general formula [I], optically active isomers and salts thereof, wherein R1 and R2 are the same or different and each represents hydrogen, an aliphatic group, an aromatic group or an aromatic aliphatic group.
摘要翻译：需要免疫调节的疾病的治疗或预防措施，需要抑制炎症的疾病，需要调节肿瘤坏死因子产生的疾病，需要调节真菌生长的疾病，需要调节细胞的疾病含有作为活性成分的至少一种选自通式[I]表示的环戊烯酮衍生物的化合物，其光学活性异构体和盐，其中R 1和R 2为相同或不同，各自表示氢，脂族基，芳基或芳族脂族基。

4. 发明授权

US6136854A Cyclopentenone derivative 失效
标题翻译：环戊烯酮衍生物
公开(公告)号：US6136854A
公开(公告)日：2000-10-24
申请号：US359069
申请日：1999-07-21
申请人： Nobuto Koyama , Katsushige Ikai , Eiji Kobayashi , Ikunoshin Kato
发明人： Nobuto Koyama , Katsushige Ikai , Eiji Kobayashi , Ikunoshin Kato
IPC分类号： C07C69/013 , A61K31/235 , C07C69/52 , C07C69/76
CPC分类号： C07C69/013
摘要： Cyclopentenone derivative having a structure of 5-(R.sub.1 COO--)-4-(R.sub.2 COO--)--substituted 2-cyclopenten-1-one (R.sub.1 and R.sub.2 are some or different and each is alkyl group, alkenyl group or aryl group) or an optically active substance thereof; a method for the manufacture of the cyclopentenone derivative by the reaction of 4,5-dihydroxy-2-cyclopenten-1-one with the corresponding carboxylic acid or a reactive derivative thereof; and anticancer agent, apoptosis-inducing agent and antibacterial agent containing said derivative.
摘要翻译：具有5-（R 1 COO - ） - 4-（R 2 COO - ） - 取代的2-环戊烯-1-酮的结构的环戊烯酮衍生物（R 1和R 2有一些或不同，各自为烷基，烯基或芳基）或其光学活性物质; 通过4,5-二羟基-2-环戊烯-1-酮与相应的羧酸或其活性衍生物的反应制备环戊烯酮衍生物的方法; 和抗癌剂，凋亡诱导剂和含有所述衍生物的抗菌剂。

5. 发明申请

US20050202064A1 Product of heat treatment of uronic acid, food, drink or drug including the product 审中-公开
标题翻译：产品的糖醛酸，食品，饮料或药物包括产品的热处理
公开(公告)号：US20050202064A1
公开(公告)日：2005-09-15
申请号：US11114071
申请日：2005-04-26
申请人： Nobuto Koyama , Hiroaki Sagawa , Eiji Kobayashi , Tatsuji Enoki , Hua-Kang Wu , Eiji Nishiyama , Suzu Deguchi , Katsushige Ikai , Hiromu Ohnogi , Motoko Ueda , Akihiro Kondo , Ikunoshin Kato
发明人： Nobuto Koyama , Hiroaki Sagawa , Eiji Kobayashi , Tatsuji Enoki , Hua-Kang Wu , Eiji Nishiyama , Suzu Deguchi , Katsushige Ikai , Hiromu Ohnogi , Motoko Ueda , Akihiro Kondo , Ikunoshin Kato
IPC分类号： A23L3/3562 , A61K8/60 , A61K31/19 , A61K31/70 , A61K31/7012 , A61K31/715 , A61K31/727 , A61K31/728 , A61K31/732 , A61K31/734 , A61K31/737 , A61K35/00 , A61K35/12 , A61K35/74 , A61K36/00 , A61L2/16 , A61P35/00 , A61Q11/00 , C07H7/033 , C08B37/00
CPC分类号： C07H7/033 , A61K8/60 , A61Q11/00 , Y10S977/928 , Y10S977/929 , Y10S977/93
摘要： A product obtained by heating at least one substance selected from the following (a), (b) and (c). (a) uronic acid or uronic acid derivative; (b) a saccharide compound containing uronic acid or a saccharide compound containing uronic acid derivative; and (c) a substance containing a saccharide compound containing uronic acid or a substance containing a saccharide compound containing uronic acid derivative; and food, beverage or a pharmaceutical agent which is characterized in containing the above-mentioned heat-treated product.
摘要翻译：通过加热至少一种选自以下（a），（b）和（c）的物质而得到的产物。（a）糖醛酸或糖醛酸衍生物; （b）含有糖醛酸的糖类化合物或含有糖醛酸衍生物的糖类化合物; 和（c）含有糖醛酸的糖类化合物或含有糖醛酸衍生物的糖类化合物的物质的物质; 以及食品，饮料或药剂，其特征在于含有上述热处理产品。

6. 发明授权

US06809091B1 Substances capable of inducing apoptosis 失效
标题翻译：能诱导细胞凋亡的物质
公开(公告)号：US06809091B1
公开(公告)日：2004-10-26
申请号：US09582554
申请日：2000-06-28
申请人： Yoko Tatsumi , Hiroaki Sagawa , Hiromu Ohnogi , Eiji Kobayashi , Hua-Kang Wu , Nobuto Koyama , Katsushige Ikai , Ikunoshin Kato
发明人： Yoko Tatsumi , Hiroaki Sagawa , Hiromu Ohnogi , Eiji Kobayashi , Hua-Kang Wu , Nobuto Koyama , Katsushige Ikai , Ikunoshin Kato
IPC分类号： A61K31555
CPC分类号： A61K31/7004 , A23L33/10 , A23L33/105 , A23V2002/00 , A61K31/11 , A61K31/122 , A61K31/198 , A61K31/351 , A61K31/357 , A61K31/52 , A61K31/522 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/7105 , A61K31/711 , C07C323/22 , C07C323/60 , C07C2601/08 , C07D473/00 , A23V2250/60 , A23V2250/638 , A23V2250/626
摘要： A method for the manufacture of a substance having an apoptosis-inducing ability characterized in including a step of subjecting at least one compound selected from the following (a), (b), (c) and (d) [excluding uronic acid and/or uronic acid derivatives; and compounds which contain uronic acid and/or uronic acid derivatives] to a heating treatment: (a) pentose; (b) pentose derivatives; (c) compounds containing pentose; (d) compounds containing pentose derivatives.
摘要翻译：一种制备具有细胞凋亡诱导能力的物质的方法，其特征在于包括使至少一种选自以下（a），（b），（c）和（d）的化合物（不包括糖醛酸和/ 或糖醛酸衍生物; （a）戊糖;（b）戊糖衍生物;（c）含有戊糖的化合物;（d）含有戊糖衍生物的化合物。

7. 发明授权

US06380262B1 5-membered ring compounds 失效
标题翻译： 5元环化合物
公开(公告)号：US06380262B1
公开(公告)日：2002-04-30
申请号：US09762265
申请日：2001-02-06
申请人： Eiji Kobayashi , Hiromu Ohnogi , Nobuto Koyama , Katsushige Ikai , Hiroaki Sagawa , Ikunoshin Kato
发明人： Eiji Kobayashi , Hiromu Ohnogi , Nobuto Koyama , Katsushige Ikai , Hiroaki Sagawa , Ikunoshin Kato
IPC分类号： A61K3112
CPC分类号： C07K5/0215 , A61K38/00
摘要： 5-Membered ring compounds represented by general formula (I), optically active isomers thereof or salts of the same. These compounds have physiological activities including a carcinostatic effect. In said formula the bond shown by the dotted line in the 5-membered ring represents that this 5-membered ring may be either a cyclopentene ring having a double bond or a saturated cyclopentane ring, and when the 5-membered ring is a cyclopentene ring, X is OR1, Y is ═O and Z is H, and when it is a cyclopentane ring, X is ═O, Y is OR2 and Z is OR3, (wherein R1 is R4 or —(CO)—R5; R2 is H, —R6 or —(CO)—R7; and R3 is H, R8 or (CO)—R9 (wherein R4, R5, R6, R7, R8 and R9 are the same or different and each represents an aliphatic, aromatic or aliphatic aromatic group, and R5, R7 and R9 may be each H), provided that the case where R2═R3═H is excluded); and W represents a residue obtained by eliminating SH from an SH-containing compound.
摘要翻译：由通式（I）表示的5-元环化合物，其旋光异构体或其盐。这些化合物具有包括致癌作用的生理活性。在所述式中，五元环中虚线所示的键表示该5元环可以是具有双键或饱和环戊烷环的环戊烯环，当5元环为环戊烯环时 X为OR 1，Y为= O且Z为H，当为环戊烷环时，X为= O，Y为OR 2，Z为OR 3，（其中R1为R4或 - （CO）-R5; R2为 H，-R6或 - （CO）-R7; R3为H，R8或（CO）-R9（其中R4，R5，R6，R7，R8和R9相同或不同，各自表示脂族，芳族或脂族芳族基团，R 5，R 7和R 9可以各自为H），条件是排除R2 = R3 = H的情况）; W表示通过从含SH化合物中除去SH而得到的残基。

8. 发明授权

US06326405B1 Anticancer agent 失效
标题翻译：抗癌剂
公开(公告)号：US06326405B1
公开(公告)日：2001-12-04
申请号：US09443089
申请日：1999-11-18
申请人： Eiji Kobayashi , Nobuto Koyama , Ikunoshin Kato
发明人： Eiji Kobayashi , Nobuto Koyama , Ikunoshin Kato
IPC分类号： A61K3112
CPC分类号： C07C45/60 , A61K31/12 , A61K31/122 , C07C45/71 , C07C49/707 , C07C49/753
摘要： An anticancer agent in which 4-cyclopentene-1,3-dione represented by the following formula [I] and/or 4-hydroxy-2-cyclopentenone represented by the following formula [II] are/is effective component(s).
摘要翻译：由下式[I]表示的4-环戊烯-1,3-二酮和/或下式[II]表示的4-羟基-2-环戊烯酮的抗癌剂为有效成分。

9. 发明申请

US20070077563A1 Method of searching for functional nucleotide molecule 审中-公开
标题翻译：搜索功能核苷酸分子的方法
公开(公告)号：US20070077563A1
公开(公告)日：2007-04-05
申请号：US10569814
申请日：2004-08-25
申请人： Takashi Ueno , Masashige Tanabe , Risa Sumioka , Eiji Kobayashi , Nobuto Koyama , Hiroaki Sagawa , Junichi Mineno , Ikunoshin Kato
发明人： Takashi Ueno , Masashige Tanabe , Risa Sumioka , Eiji Kobayashi , Nobuto Koyama , Hiroaki Sagawa , Junichi Mineno , Ikunoshin Kato
IPC分类号： C12Q1/68 , C07H21/02
CPC分类号： C12N15/63
摘要： A universal method of searching for a nucleic acid capable of effectively inhibiting gene expression; a nucleic acid construct to be used in this method; a vector; and a kit for the above method. This method is characterized in that a nucleic acid construct, which is a nucleic acid construct having a promoter sequence, at least two gene sequences and a poly A signal sequence and in which the above-described at least two gene sequences are transcribed as a single molecule RNA and at least one gene sequence is in the translatable state while at least one gene sequence is encoded in the substantially untranslatable state, is constructed.
摘要翻译：搜索能够有效抑制基因表达的核酸的通用方法; 在该方法中使用的核酸构建体; 一个矢量和上述方法的试剂盒。该方法的特征在于，具有启动子序列，至少两个基因序列和多聚A信号序列的核酸构建体的核酸构建体，其中上述至少两个基因序列被转录为单个分子RNA和至少一个基因序列处于可翻译状态，而至少一个基因序列被编码为基本上不可翻译的状态。

10. 发明授权

US6111145A Cyclopentenone derivative 失效
标题翻译：环戊烯酮衍生物
公开(公告)号：US6111145A
公开(公告)日：2000-08-29
申请号：US419221
申请日：1999-10-15
申请人： Eiji Kobayashi , Nobuto Koyama , Ikunoshin Kato , Kaoru Inami , Tetsuo Shiba
发明人： Eiji Kobayashi , Nobuto Koyama , Ikunoshin Kato , Kaoru Inami , Tetsuo Shiba
IPC分类号： C07C45/71 , C07C49/753 , C07C49/105 , A61K31/12
CPC分类号： C07C49/753 , C07C45/71
摘要： A cyclopentenone derivative represented by the following formula [I] or an optically active substance or a salt thereof. ##STR1## (In the formula, R.sub.1 and R.sub.2 are same or different and each of them is straight or branched alkyl group, straight or branched alkenyl group, aromatic group, aromatic-aliphatic group or H with a proviso that the case where R.sub.1 =R.sub.2 =H, or R.sub.1 =benzyl group and R.sub.2 =H is excluded.)
摘要翻译：由下式[I]表示的环戊烯酮衍生物或光学活性物质或其盐。（式中，R 1，R 2相同或不同，分别为直链或支链烷基，直链或支链烯基，芳香族基，芳香族 - 脂肪族基或H，条件是R1 = R2 = H ，或R 1 =苄基，并且R 2 = H被排除。

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