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1. 发明授权

US06703422B2 Sulfide and disulfide compounds and compositions for cholesterol management and related uses 失效
标题翻译：硫化物和二硫化物以及用于胆固醇管理和相关用途的组合物
公开(公告)号：US06703422B2
公开(公告)日：2004-03-09
申请号：US09976898
申请日：2001-10-11
申请人： Jean-Louis Henri Dasseux , Carmen Daniela Oniciu
发明人： Jean-Louis Henri Dasseux , Carmen Daniela Oniciu
IPC分类号： A61K31215
CPC分类号： C07F9/2408 , A61K31/194 , A61K31/381 , A61K31/382 , A61K31/4178 , A61K31/42 , A61K31/4743 , A61K31/675 , C07C323/12 , C07C323/16 , C07C323/22 , C07C323/52 , C07C323/56 , C07C323/60 , C07C323/66 , C07F9/091 , C07F9/4407
摘要： The present invention relates to novel sulfide and disulfide compounds, compositions comprising sulfide and disulfide compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
摘要翻译：本发明涉及新型硫化物和二硫化物化合物，包含硫化物和二硫化物的组合物，以及可用于治疗和预防心血管疾病，血脂异常，dysproteinemias和葡萄糖代谢紊乱的方法，包括施用包含醚化合物的组合物。本发明的化合物，组合物和方法还可用于治疗和预防阿尔茨海默病，综合征X，过氧化物酶体增殖物激活受体相关病症，败血症，血栓形成障碍，肥胖症，胰腺炎，高血压，肾脏疾病，癌症，炎症和阳。在某些实施方案中，本发明的化合物，组合物和方法可用于与其它治疗剂如降胆固醇和降血糖药物组合治疗。

2. 发明授权

US06664290B1 Oral or vaginal administration of mesoprostol in third stage labor 失效
标题翻译：口服或阴道管理米索前列醇在第三阶段劳动
公开(公告)号：US06664290B1
公开(公告)日：2003-12-16
申请号：US08809379
申请日：1997-04-15
申请人： Hazem El-Rafaey
发明人： Hazem El-Rafaey
IPC分类号： A61K31215
CPC分类号： A61K31/5575 , Y10S514/935
摘要： This invention relates to a method of limiting postpartum hemorrhage comprising administering orally a single effective dose of misoprostol to a woman during the third stage of labor.
摘要翻译：本发明涉及一种限制产后出血的方法，其包括在第三阶段期间向女性口服单次有效剂量的米索前列醇。

3. 发明授权

US06593364B2 Triterpene derivatives and remedies for liver diseases 失效
标题翻译：三萜衍生物和肝病的补救措施
公开(公告)号：US06593364B2
公开(公告)日：2003-07-15
申请号：US09921983
申请日：2001-08-06
申请人： Kazue Sasaki , Nobuto Minowa , Shoji Nishiyama , Hiroyuki Kuzuhara
发明人： Kazue Sasaki , Nobuto Minowa , Shoji Nishiyama , Hiroyuki Kuzuhara
IPC分类号： A61K31215
CPC分类号： C07J63/008 , C07J63/00 , Y10S514/893 , Y10S514/894
摘要： A triterpene derivative useful for the treatment of hepatic disorders is disclosed. This compound comprises as an active ingredient a triterpene derivative represented by the following formula (I) or a salt thereof: wherein R1 represents a hydroxyl group, arylmethyloxy, lower alkoxy, or lower alkanoyloxy, R2 represents lower alkyl, lower alkenyl, —CH2OR5, formyl, —COOR6, or —CH2N(R7)R8, or R1 and R2 may combine with each other to form —O—C(R9)R10—O—CH2—, R3 and R4, which may be the same or different represent a hydrogen atom, a hydroxyl group, lower alkyl, lower alkenyl, aryl, hydroxymethyl, —N(R11)R12, formyl, —COOR6, or —OR13, or R3 and R4 may combine with each other to form oxo, hydroxyimino, or alkylidene and X represents O, CH2, or NH.
摘要翻译：公开了用于治疗肝脏疾病的三萜衍生物。该化合物包含作为活性成分的下式（I）表示的三萜衍生物或其盐：其中R1表示羟基，芳基甲氧基，低级烷氧基或低级烷酰氧基，R2表示低级烷基，低级烯基，-CH2OR5，甲酰基，-COOR 6或-CH 2 N（R 7）R 8，或R 1和R 2可以彼此结合形成-OC（R 9）R 10 -O-CH 2 - ，R 3和R 4，其可以相同或不同，表示氢原子，羟基，低级烷基，低级烯基，芳基，羟甲基，-N（R 11）R 12，甲酰基，-COOR 6或-OR 13或R 3和R 4可以彼此结合形成氧代，羟基亚氨基或亚烷基， X表示O，CH 2或NH。

4. 发明授权

US06495563B1 Method and composition for prevention of scar formation in glaucoma filtration bleb and drainage fistula 失效
标题翻译：青光眼过滤泡瘘排瘘预防瘢痕形成的方法和组合物
公开(公告)号：US06495563B1
公开(公告)日：2002-12-17
申请号：US09913849
申请日：2001-11-02
申请人： Johan Stjernschantz , Bahram Resul
发明人： Johan Stjernschantz , Bahram Resul
IPC分类号： A61K31215
CPC分类号： A61K31/5575 , Y10S514/912 , Y10S977/908 , Y10S977/915
摘要： This invention is related to a method whereby scar formation in the drainage fistula and subconjunctival bleb created during and after glaucoma surgery using a prostaglandin subtype A or J.
摘要翻译：本发明涉及一种使用前列腺素亚型A或J.在青光眼手术期间和之后产生的排水瘘和结膜下泡中形成瘢痕的方法。

5. 发明授权

US06458836B1 Treatment of ocular hypertension and glaucoma 有权
标题翻译：治疗眼高压和青光眼
公开(公告)号：US06458836B1
公开(公告)日：2002-10-01
申请号：US09900021
申请日：2001-07-09
申请人： Ryuji Ueno
发明人： Ryuji Ueno
IPC分类号： A61K31215
CPC分类号： A61K31/557 , A61K31/5575 , A61K31/5585 , Y10S514/913
摘要： Disclosed is treatment of ocular hypertension and glaucoma by long-term therapy with a prostaglandin related compound for eliminating or reducing potential iridic pigmentation. Composition useful for the treatment, and use of the prostaglandin related compound for producing the composition are also disclosed.
摘要翻译：公开了通过用前列腺素相关化合物长期治疗眼睛高血压和青光眼来消除或减少潜在的虹膜色素沉着。还公开了可用于治疗的组合物和用于制备组合物的前列腺素相关化合物的用途。

6. 发明授权

US06417229B1 &agr;-sulfonylamino hydroxamic acid inhibitors of matrix metalloproteinases for the treatment of peripheral or central nervous system disorders 失效
标题翻译：用于治疗外周或中枢神经系统疾病的基质金属蛋白酶的α-磺酰氨基异羟肟酸抑制剂
公开(公告)号：US06417229B1
公开(公告)日：2002-07-09
申请号：US09671435
申请日：2000-09-27
申请人： Barbara G. Sahagan , Anabella Villalobos
发明人： Barbara G. Sahagan , Anabella Villalobos
IPC分类号： A61K31215
CPC分类号： A61K45/06 , A61K31/00 , A61K31/195 , A61K31/197 , A61K31/216 , A61K31/351 , A61K31/395 , A61K31/438 , A61K31/4453 , A61K31/4468
摘要： The present invention relates to a method of using a compound of the formula (I): wherein A, X1, X2 and Q are as defined herein, a pharmaceutically acceptable salt thereof, or a pharmaceutical composition thereof, in the treatment of a disease, condition or disorder of the peripheral or central nervous system, including but not limited to Alzheimer's disease, stroke/cerebral ischemia, head trauma, spinal cord injury, multiple sclerosis, amyotrophic lateral sclerosis, Huntington's disease, Parkinson's disease, migraine, cerebral amyloid angiopathy, AIDS, age-related cognitive decline, mild cognitive impairment and prion diseases.
摘要翻译：本发明涉及使用式（I）化合物或其药物组合物的方法：其中A，X1，X2和Q如本文所定义，其用于治疗疾病，包括但不限于阿尔茨海默氏病，脑卒中/脑缺血，头部创伤，脊髓损伤，多发性硬化，肌萎缩性侧索硬化，亨廷顿舞蹈病，帕金森病，偏头痛，脑淀粉样血管病，艾滋病，年龄相关认知衰退，轻度认知障碍和朊病毒疾病。

7. 发明授权

US06417228B1 13-Aza prostaglandins for the treatment of glaucoma and ocular hypertension 有权
标题翻译：用于治疗青光眼和高眼压症的13-Aza前列腺素
公开(公告)号：US06417228B1
公开(公告)日：2002-07-09
申请号：US09430513
申请日：1999-10-29
申请人： Peter G. Klimko
发明人： Peter G. Klimko
IPC分类号： A61K31215
CPC分类号： A61K31/5575 , A61K9/0048 , C07C215/44 , C07C235/22 , C07C405/0041 , C07C2601/08
摘要： 13-Aza analogs of PGF2&agr; and methods of their use in treating glaucoma and ocular hypertension are disclosed.
摘要翻译：公开了PGF2α的13-Aza类似物及其用于治疗青光眼和高眼压症的方法。

8. 发明授权

US06329426B1 Method for treating ocular hypertension of glaucoma 有权
标题翻译：治疗青光眼高眼压症的方法
公开(公告)号：US06329426B1
公开(公告)日：2001-12-11
申请号：US09220847
申请日：1998-12-28
申请人： Ryuji Ueno
发明人： Ryuji Ueno
IPC分类号： A61K31215
CPC分类号： A61K31/557 , Y10S514/913 , A61K31/19 , A61K2300/00
摘要： By combined administration of a non-FP receptor agonist type prostaglandin compound, for example isopropyl unoprostone, and a FP-receptor type prostaglandin compound, for example Latanoprost, the ocular hypotensive effect of the prostaglandin compounds is enhanced synergistically.
摘要翻译：通过联合施用非FP受体激动剂型前列腺素化合物，例如异丙基异佛石碱和FP-受体型前列腺素化合物，例如拉坦前列素，前列腺素化合物的眼低血压作用协同增强。

9. 发明授权

US06703423B2 Inhibition of TNF&agr;-initiated neutrophil response 失效
标题翻译：抑制TNFα引发的嗜中性粒细胞反应
公开(公告)号：US06703423B2
公开(公告)日：2004-03-09
申请号：US10044499
申请日：2002-01-11
申请人： Charles N. Serhan
发明人： Charles N. Serhan
IPC分类号： A61K31215
CPC分类号： A61K31/232 , A61K31/216 , A61K31/23 , A61K31/557
摘要： The impact of lipoxin A4 (LXA4) and aspirin-triggered-lipoxins (ATL) was investigated in tumor necrosis factor (TNF&agr;)-initiated neutrophil (PMN) responses in vitro and in vivo using metabolically stable LX analogs. At concentrations as low as 1-10 nM, the LXA4 and ATL analogs each inhibited TNF&agr;-stimulated superoxide anion generation and IL-1&bgr; release by human PMN.
摘要翻译：在体外和体内使用代谢稳定的LX类似物在肿瘤坏死因子（TNFalpha）诱导的嗜中性粒细胞（PMN）反应中研究了脂氧素A4（LXA4）和阿司匹林引发的脂氧素（ATL）的影响。在低至1-10nM的浓度下，LXA4和ATL类似物各自抑制TNFα刺激的超氧化物阴离子产生和人PMN释放的IL-1beta。

10. 发明授权

US06649655B2 11&bgr;-fluoro 15&bgr;-hydroxy PGF2&agr; analogs as FP receptor antagonists 有权
公开(公告)号：US06649655B2
公开(公告)日：2003-11-18
申请号：US10202230
申请日：2002-07-24
申请人： Najam A. Sharif , Brenda W. Griffin
发明人： Najam A. Sharif , Brenda W. Griffin
IPC分类号： A61K31215
CPC分类号： A61K31/5575 , A61K31/00 , A61K31/192 , A61K31/216
摘要： Methods and compositions for the antagonism of FP receptor-mediated biological responses are disclosed.

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