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    • 9. 发明申请
    • Phospholipid derivative
    • 磷脂衍生物
    • US20060110436A1
    • 2006-05-25
    • US10529692
    • 2003-09-30
    • Syunsuke OhhashiKazuhiro KuboChika ItohTohru YasukohchiHiroshi KikuchiNorio SuzukiMiho KurosawaHitoshi Yamauchi
    • Syunsuke OhhashiKazuhiro KuboChika ItohTohru YasukohchiHiroshi KikuchiNorio SuzukiMiho KurosawaHitoshi Yamauchi
    • A61K31/795C08F291/00A61K9/127
    • C08F8/40A61K8/14A61K8/8164A61K9/127A61K9/1271A61K9/1278A61K31/795A61Q19/00C08F220/28C08F222/06C08L53/00C08F222/04C08L2666/02
    • A phospholipid derivative, utilizable for modification of liposomes and the like, which is a copolymer containing, as essential component units, a component unit A represented by the formula (1), a component unit B represented by the formula (2A) and/or the formula (2B), and a component unit C represented by the formula (3) [R1 and R2 represent hydrogen atom or methyl group, provided that R1 and R2 do not simultaneously represent methyl group; R3 represents a divalent hydrocarbon group having 1 to 3 carbon atoms; AO represents an oxyalkylene group having 2 to 4 carbon atoms; m represents an average molar number of the added oxyalkylene groups and is a number in the range represented as 4≦m≦100; R4 represents hydrogen atom, a hydrocarbon group or acyl group having 1 to 20 carbon atoms; R5CO and R6CO represent an acyl group having 8 to 24 carbon atoms; R7 represents a divalent hydrocarbon group having 2 to 4 carbon atoms; and X and Y represent hydrogen atom, an alkali metal atom, ammonium or an organic ammonium] wherein a molar ratio of the component unit A relative to a total of the component unit B and the component unit C is from 7/3 to 3/7, and the component unit C is contained at a ratio of from 1 to 4 moles per 1 mole of the copolymer.
    • 可用于脂质体改性的磷脂衍生物等,其是以式(1)表示的成分单元A,式(2A)表示的成分单元B和/或式 式(2B)和式(3)表示的成分单元C [R 1和R 2]表示氢原子或甲基,条件是R 0 > 1 和R 2不同时表示甲基; R 3表示具有1至3个碳原子的二价烃基; AO表示碳原子数2〜4的氧化烯基, m表示加成的氧化烯基的平均摩尔数,是在4≤M≤100的范围内的数字; R 4表示氢原子,碳原子数为1〜20的烃基或酰基, R 5 CO和R 6 CO表示具有8至24个碳原子的酰基; R 7表示具有2至4个碳原子的二价烃基; 并且X和Y表示氢原子,碱金属原子,铵或有机铵],其中组分单元A相对于组分单元B和组分单元C的总量的摩尔比为7/3至3 / 7,组分单元C的含量相对于1摩尔共聚物为1〜4摩尔。