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1. 发明授权

US07524981B2 Phospholipid derivatives and process for the production there 有权
标题翻译：磷脂衍生物及其生产工艺
公开(公告)号：US07524981B2
公开(公告)日：2009-04-28
申请号：US10541309
申请日：2003-12-12
申请人： Kazuhiro Kubo , Chika Itoh , Syunsuke Ohhashi , Tohru Yasukohchi , Yusuke Ohkawa , Hiroshi Kikuchi , Norio Suzuki , Miho Takahashi , Hitoshi Yamauchi
发明人： Kazuhiro Kubo , Chika Itoh , Syunsuke Ohhashi , Tohru Yasukohchi , Yusuke Ohkawa , Hiroshi Kikuchi , Norio Suzuki , Miho Takahashi , Hitoshi Yamauchi
IPC分类号： C07C9/02
CPC分类号： A61K9/127 , A61K8/14 , A61K8/553 , A61K9/0014 , A61K9/1273 , A61K47/24 , A61Q19/00 , C07F9/10 , C08G65/2609 , C08G65/3353 , C08G2650/34
摘要： A phospholipid derivative represented by the following formula (1): wherein [PG]k represents a residue of polyglycerin having a polymerization degree of k, wherein k is 2 to 50, R1CO and R2CO independently represent an acyl group having 8 to 22 carbon atoms, symbol “a” independently represents an integer of 0 to 5, symbol “b” independently represents 0 or 1, M represents hydrogen atom, an alkali metal atom, an ammonium, or an organic ammonium, and k1, k2, and k3 represent numbers satisfying the following conditions: 1≦k1≦(k+2)/2, 0≦k2, and k1+k2+k3=k+2. The phospholipid derivative is highly safe for living bodies and can be suitably utilized in drug delivery systems such as liposome, and the like.
摘要翻译：由下式（1）表示的磷脂衍生物：其中[PG] k表示聚合度为k的聚甘油的残基，其中k为2〜50，R1CO和R2CO独立地表示碳原子数为8〜22的酰基符号“a”独立地表示0〜5的整数，符号“b”独立地表示0或1，M表示氢原子，碱金属原子，铵或有机铵，k1，k2和k3表示满足以下条件的数字：1 <= k1 <=（k + 2）/ 2,0 <= k2，k1 + k2 + k3 = k + 2。磷脂衍生物对于活体是高度安全的，并且可以适用于药物递送系统如脂质体等。

2. 发明申请

US20060210618A1 Phospholipid derivatives and process for the production there 有权
标题翻译：磷脂衍生物及其生产工艺
公开(公告)号：US20060210618A1
公开(公告)日：2006-09-21
申请号：US10541309
申请日：2003-12-12
申请人： Kazuhiro Kubo , Chika Itoh , Syunsuke Ohhashi , Tohru Yasukohchi , Yusuke Ohkawa , Hiroshi Kikuchi , Norio Suzuki , Miho Takahashi , Hitoshi Yamauchi
发明人： Kazuhiro Kubo , Chika Itoh , Syunsuke Ohhashi , Tohru Yasukohchi , Yusuke Ohkawa , Hiroshi Kikuchi , Norio Suzuki , Miho Takahashi , Hitoshi Yamauchi
IPC分类号： A61K9/127 , C07F9/02 , A61K31/66
CPC分类号： A61K9/127 , A61K8/14 , A61K8/553 , A61K9/0014 , A61K9/1273 , A61K47/24 , A61Q19/00 , C07F9/10 , C08G65/2609 , C08G65/3353 , C08G2650/34
摘要： A phospholipid derivative represented by the following formula (1): wherein [PG]k represents a residue of polyglycerin having a polymerization degree of k, wherein k is 2 to 50, R1CO and R2CO independently represent an acyl group having 8 to 22 carbon atoms, symbol “a” independently represents an integer of 0 to 5, symbol “b” independently represents 0 or 1, M represents hydrogen atom, an alkali metal atom, an ammonium, or an organic ammonium, and k1, k2, and k3 represent numbers satisfying the following conditions: 1≦k1≦(k+2)/2, 0≦k2, and k1+k2+k3=k+2. The phospholipid derivative is highly safe for living bodies and can be suitably utilized in drug delivery systems such as liposome, and the like.
摘要翻译：由下式（1）表示的磷脂衍生物：其中[PG] k表示聚合度为k的聚甘油的残基，其中k为2至50，R 1 CO和R SUP > 2 CO独立地表示具有8至22个碳原子的酰基，符号“a”独立地表示0至5的整数，符号“b”独立地表示0或1，M表示氢原子，碱金属原子，铵或有机铵，k1，k2和k3表示满足以下条件的数：1 <= k1 <=（k + 2）/ 2,0 <= k2，k1 + k2 + k3 = k + 2。磷脂衍生物对于活体是高度安全的，并且可以适用于药物递送系统如脂质体等。

3. 发明授权

US08440726B2 Solubilizing composition 有权
标题翻译：溶解组合物
公开(公告)号：US08440726B2
公开(公告)日：2013-05-14
申请号：US12059029
申请日：2008-03-31
申请人： Yusuke Ohkawa
发明人： Yusuke Ohkawa
IPC分类号： A61K47/12
CPC分类号： A61K9/1075 , A61K9/0095
摘要： A solubilizing composition containing (A) at least one oily component selected from esters of oleic acid with alcohols having 1 to 3 carbon atoms and triglycerides of fatty acids having 6 to 12 carbon atoms, (B) a polyoxyethylenesorbitan fatty acid ester, (C) a polyhydric alcohol which is liquid between 15° C. and 25° C., and (D) one or more acidic phospholipids where the fatty acid constituting an acyl group thereof is selected from saturated fatty acids having 6 to 14 carbon atoms and unsaturated fatty acids having 16 to 18 carbon atoms, which contains 20 to 40% by weight of the component (A), 30 to 45% by weight of the component (B), 15 to 40% by weight of the component (C), and 0.5 to 4% by weight of the component (D), based on 100% by weight of a total amount of the components (A) to (D).
摘要翻译：一种增溶组合物，其含有（A）至少一种选自油酸酯与碳原子数1〜3的油的油性成分和碳原子数6〜12的脂肪酸的甘油三酯，（B）聚氧乙烯脱水山梨糖醇脂肪酸酯，（C）在15℃至25℃之间为液体的多元醇，和（D）一种或多种构成其酰基的脂肪酸的酸性磷脂选自碳原子数为6〜14的饱和脂肪酸和不饱和脂肪酸含有20至40重量％的组分（A），30至45重量％的组分（B），15至40重量％的组分（C）的碳原子数为16至18的酸，以及基于组分（D）的总量的100重量％的组分（D）的0.5至4重量％。

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