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1. 发明申请

US20120302892A1 PORTABLE OPTICAL FIBER PROBE-BASED SPECTROSCOPIC SCANNER FOR RAPID CANCER DIAGNOSIS 审中-公开
标题翻译：便携式光纤基于探针的光谱扫描仪用于快速诊断
公开(公告)号：US20120302892A1
公开(公告)日：2012-11-29
申请号：US13338920
申请日：2011-12-28
申请人： Niyom Lue , Michael Feld , Ishan Barman , Narahara Chari Dingari , Ramachandra Dasari , David Feld , Alison Hearn , Jonathan Feld
发明人： Niyom Lue , Michael Feld , Ishan Barman , Narahara Chari Dingari , Ramachandra Dasari , David Feld , Alison Hearn , Jonathan Feld
IPC分类号： A61B6/00
CPC分类号： A61B5/0091 , A61B5/0068 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/42 , A61B5/4312 , G01N21/64 , G01N2021/4742 , G01N2021/656 , G01N2201/0639
摘要： A multimodal probe system for spectroscopic scanning of tissue for disease diagnosis. The system can use diffuse reflectance spectroscopy, fluorescence spectroscopy and Raman spectroscopy for the detection of cancerous tissue, such as tissue margin assessment.
摘要翻译：用于疾病诊断的组织光谱扫描的多模式探针系统。该系统可以使用漫反射光谱，荧光光谱和拉曼光谱法检测癌组织，如组织边缘评估。

2. 发明申请

US20140333929A1 3-D HOLOGRAPHIC IMAGING FLOW CYTOMETRY 审中-公开
标题翻译： 3-D全息成像流程细胞计数
公开(公告)号：US20140333929A1
公开(公告)日：2014-11-13
申请号：US14173804
申请日：2014-02-05
申请人： Yongjin Sung , Niyom Lue , Zahid Yagoob , Ramachandra Dasari , Peter T.C. So
发明人： Yongjin Sung , Niyom Lue , Zahid Yagoob , Ramachandra Dasari , Peter T.C. So
IPC分类号： G01N15/14 , G01N21/64
摘要： Refractive index of biological specimens is a source of intrinsic contrast that can be explored without any concerns of photobleaching or harmful effects caused by extra contrast agents. This feature also contains rich information that can be related to the metabolism of cells at the cellular and subcellular levels. The present invention relates to systems and methods that can provide, without any moving parts, the 3-D refractive index map of continuously flowing biological samples in a micro-fluidic channel, for example.
摘要翻译：生物标本的折射率是内在对比的来源，可以在没有光漂白或额外造影剂引起的有害影响的任何问题的情况下进行探索。该特征还包含可以与细胞和亚细胞水平的细胞代谢相关的丰富信息。本发明涉及可以提供例如在微流体通道中连续流动的生物样品的3-D折射率图的无任何移动部件的系统和方法。

3. 发明申请

US20120101390A1 Multi-Modal Imaging for Diagnosis of Early Stage Epithelial Cancers 审中-公开
标题翻译：多模态成像诊断早期上皮癌
公开(公告)号：US20120101390A1
公开(公告)日：2012-04-26
申请号：US13277481
申请日：2011-10-20
申请人： Nicusor V. Iftimia , Niyom Lue , Daniel X. Hammer , Mircea Mujat , R. Daniel Ferguson
发明人： Nicusor V. Iftimia , Niyom Lue , Daniel X. Hammer , Mircea Mujat , R. Daniel Ferguson
IPC分类号： A61B6/00 , A61K49/00 , B82Y15/00
CPC分类号： A61K49/0093 , A61B5/0035 , A61B5/0066 , A61B5/0071 , A61B5/0084 , A61B2560/0406 , A61K49/0056 , A61K49/0091 , B82Y5/00 , B82Y30/00
摘要： Epithelial cancer screening can include a staining tissue with a cancer targeting agent, identifying a potentially cancerous lesion using fluorescence imaging, and imaging the potentially cancerous lesion for a cancer diagnosis using optical coherence tomography.
摘要翻译：上皮癌筛选可以包括具有癌症靶向剂的染色组织，使用荧光成像识别潜在的癌性病变，并使用光学相干断层扫描来成像癌症诊断的潜在癌性病变。

4. 发明申请

US20080218732A1 Infrared Scanner for Biological Applications 审中-公开
标题翻译：红外线扫描仪用于生物应用
公开(公告)号：US20080218732A1
公开(公告)日：2008-09-11
申请号：US11996103
申请日：2006-07-24
申请人： Samson Mil'shtein , Niyom Lue
发明人： Samson Mil'shtein , Niyom Lue
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B6/508 , G01J3/10 , G01J3/45 , G01N21/274 , G01N21/359
摘要： Methods and systems for generating near-infrared (NIR) images of biological targets are discussed. In one aspect, one or more radiation sources illuminate a target, with one or more detectors receiving the transmitted radiation. Such equipment can be used to generate a plurality of NIR images of a target. The images can be converted into frequency space, combined using chosen weighting factors, and deconvoluted into the spatial domain to provide a composite image. The composite image can have enhanced quality relative to the individual images, allowing for a richer set of information to be displayed. Other aspects such as scanning, background illumination correction, the use of filters, and additional techniques are also discussed.
摘要翻译：讨论了用于生成生物目标的近红外（NIR）图像的方法和系统。在一个方面，一个或多个辐射源照射目标，一个或多个检测器接收所发射的辐射。这样的设备可以用于产生目标的多个NIR图像。可以将图像转换成频率空间，使用选择的加权因子组合，并解卷积到空间域中以提供合成图像。合成图像可以相对于各个图像具有增强的质量，允许显示更丰富的信息。还讨论了诸如扫描，背景照明校正，滤波器的使用以及附加技术的其他方面。

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