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1. 发明申请

US20140333929A1 3-D HOLOGRAPHIC IMAGING FLOW CYTOMETRY 审中-公开
标题翻译： 3-D全息成像流程细胞计数
公开(公告)号：US20140333929A1
公开(公告)日：2014-11-13
申请号：US14173804
申请日：2014-02-05
申请人： Yongjin Sung , Niyom Lue , Zahid Yagoob , Ramachandra Dasari , Peter T.C. So
发明人： Yongjin Sung , Niyom Lue , Zahid Yagoob , Ramachandra Dasari , Peter T.C. So
IPC分类号： G01N15/14 , G01N21/64
摘要： Refractive index of biological specimens is a source of intrinsic contrast that can be explored without any concerns of photobleaching or harmful effects caused by extra contrast agents. This feature also contains rich information that can be related to the metabolism of cells at the cellular and subcellular levels. The present invention relates to systems and methods that can provide, without any moving parts, the 3-D refractive index map of continuously flowing biological samples in a micro-fluidic channel, for example.
摘要翻译：生物标本的折射率是内在对比的来源，可以在没有光漂白或额外造影剂引起的有害影响的任何问题的情况下进行探索。该特征还包含可以与细胞和亚细胞水平的细胞代谢相关的丰富信息。本发明涉及可以提供例如在微流体通道中连续流动的生物样品的3-D折射率图的无任何移动部件的系统和方法。

2. 发明授权

US09575015B2 Systems and methods for x-ray phase contrast imaging using arrays of x-ray focusing elements 有权
标题翻译：使用x射线聚焦元件阵列进行X射线相位成像的系统和方法
公开(公告)号：US09575015B2
公开(公告)日：2017-02-21
申请号：US14673304
申请日：2015-03-30
申请人： Yongjin Sung , Rajiv Gupta
发明人： Yongjin Sung , Rajiv Gupta
IPC分类号： G01N23/04 , G21K1/06 , G01N23/20
CPC分类号： G01N23/04 , G01N23/20075 , G01N2223/303 , G21K1/06 , G21K2201/067 , G21K2207/005
摘要： Systems and methods for performing x-ray phase-contrast imaging using a conventional x-ray source and detector are provided. An array of x-ray focusing elements it provided and used to focus x-ray onto a pattern of multiple different focal spots. When an object is introduced into the beam path, the focal spots will be displaced based on the x-rays being refracted by the object. A refraction angle map is produced and used to generate a phase contrast image, such as an image that indicates the electron density distribution in the object. Multi-spectral imaging can be achieved by utilizing the chromatic aberration of the array of x-ray focusing elements and sweeping the detector through different focal planes associated with different x-ray energy levels or sweeping the peak voltage of the x-ray source for a fixed object-to-detector distance.
摘要翻译：提供了使用常规x射线源和检测器执行X射线相位对比成像的系统和方法。它提供并用于将x射线聚焦到多个不同焦点的图案上的x射线聚焦元件阵列。当物体被引入光束路径时，焦斑将基于被物体折射的X射线而移位。产生折射角度图并用于产生相位对比图像，例如指示物体中的电子密度分布的图像。可以通过利用x射线聚焦元件阵列的色差并通过与不同X射线能级相关联的不同焦平面扫描检测器来实现多光谱成像，或扫描X射线源的峰值电压固定的物体到检测器的距离。

3. 发明申请

US20150340113A1 Systems and Methods For X-Ray Phase Contrast Imaging Using Arrays Of X-Ray Focusing Elements 有权
标题翻译：使用X射线聚焦元件阵列进行X射线相位对比成像的系统和方法
公开(公告)号：US20150340113A1
公开(公告)日：2015-11-26
申请号：US14673304
申请日：2015-03-30
申请人： Yongjin Sung , Rajiv Gupta
发明人： Yongjin Sung , Rajiv Gupta
IPC分类号： G21K1/06 , G01N23/04
CPC分类号： G01N23/04 , G01N23/20075 , G01N2223/303 , G21K1/06 , G21K2201/067 , G21K2207/005
摘要： Systems and methods for performing x-ray phase-contrast imaging using a conventional x-ray source and detector are provided. An array of x-ray focusing elements it provided and used to focus x-ray onto a pattern of multiple different focal spots. When an object is introduced into the beam path, the focal spots will be displaced based on the x-rays being refracted by the object. A refraction angle map is produced and used to generate a phase contrast image, such as an image that indicates the electron density distribution in the object. Multi-spectral imaging can be achieved by utilizing the chromatic aberration of the array of x-ray focusing elements and sweeping the detector through different focal planes associated with different x-ray energy levels or sweeping the peak voltage of the x-ray source for a fixed object-to-detector distance.
摘要翻译：提供了使用常规x射线源和检测器执行X射线相位对比成像的系统和方法。它提供并用于将x射线聚焦到多个不同焦点的图案上的x射线聚焦元件阵列。当物体被引入光束路径时，焦斑将基于被物体折射的X射线而移位。产生折射角度图并用于产生相位对比图像，例如指示物体中的电子密度分布的图像。可以通过利用x射线聚焦元件阵列的色差并通过与不同X射线能级相关联的不同焦平面扫描检测器来实现多光谱成像，或扫描X射线源的峰值电压固定的物体到检测器的距离。

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