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1. 发明授权

US09138583B2 Method and system for determining pacing settings 有权
标题翻译：确定起搏设置的方法和系统
公开(公告)号：US09138583B2
公开(公告)日：2015-09-22
申请号：US13596585
申请日：2012-08-28
申请人： Nils Holmstrom , Andreas Karlsson
发明人： Nils Holmstrom , Andreas Karlsson
IPC分类号： A61N1/362 , A61N1/365 , A61N1/37 , A61N1/368
CPC分类号： A61N1/36585 , A61N1/365 , A61N1/36514 , A61N1/3682 , A61N1/3704
摘要： Systems and methods for optimizing the stimulation of a heart of a patient are disclosed herein. The method comprises delivering pacing therapy to the patient according to a pacing therapy setting schedule, using specific pacing intervals via specific electrode configurations. Further, sinus rate values are recorded over at least one cardiac cycle at each pacing therapy setting and it is determined whether a sinus rate value satisfies predetermined measurement conditions, wherein sinus rate values are used for trending the sinus rate over time if the measurement conditions are satisfied. The accepted sinus rate values, i.e. values that satisfy the measurement conditions, are trended over time, wherein each trended sinus rate value is created based on recordings from at least one cardiac cycle. A preferred pacing therapy setting is determined to be the pacing therapy setting that provides a lowest sinus rate.
摘要翻译：本文公开了用于优化患者心脏刺激的系统和方法。该方法包括根据起搏治疗设置时间表，通过特定电极配置使用特定的起搏间隔向患者输送起搏治疗。此外，在每个起搏治疗设置中，在至少一个心动周期上记录窦速率值，并且确定窦速率值是否满足预定的测量条件，其中如果测量条件是窦性速率值，则使用窦速率值来随着时间推移窦速率满意。接受的窦速率值，即满足测量条件的值随时间趋势，其中每个趋势窦速率值是基于至少一个心动周期的记录创建的。优选的起搏治疗设置被确定为提供最低窦速率的起搏治疗设置。

2. 发明申请

US20130289641A1 METHOD AND SYSTEM FOR OPTIMIZING CARDIAC PACING SETTINGS 审中-公开
标题翻译：优化心脏瓣膜设置的方法和系统
公开(公告)号：US20130289641A1
公开(公告)日：2013-10-31
申请号：US13997620
申请日：2010-12-23
申请人： John Gustafsson , Andreas Karlsson , Andreas Blomqvist , Hedberg Sven-Erik , Nils Holmstrom
发明人： John Gustafsson , Andreas Karlsson , Andreas Blomqvist , Hedberg Sven-Erik , Nils Holmstrom
IPC分类号： A61N1/365
CPC分类号： A61N1/36571 , A61B5/02028 , A61B5/0215 , A61B5/028 , A61B5/029 , A61B5/0472 , A61B5/0538 , A61B5/1116 , A61B5/686 , A61B8/06 , A61B2562/0219 , A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36535 , A61N1/36564 , A61N1/36578 , A61N1/36585 , A61N1/3682
摘要： The present invention relates generally to methods and systems for optimizing stimulation of a heart of a patient. Hemodynamical index signals reflecting a mechanical functioning of a heart of a patient are recorded at different hemodynamical states. Corresponding hemodynamical reference signals at corresponding hemodynamical states are recorded. At least one hemodynamical index parameter is extracted from the recorded hemodynamical index signals. The at least one hemodynamical index parameter is a measure of the mechanical functioning of the heart and a hemodynamical index model is created, wherein the hemodynamical index model is based on the at least one hemodynamical index parameter and a comparison between output results from the hemodynamical index model and corresponding hemodynamical reference signals. From this hemodynamical index model, a hemodynamical index can be derived, which then can be used in determining patient customized cardiac pacing settings of the cardiac stimulator.
摘要翻译：本发明一般涉及优化患者心脏的刺激的方法和系统。在不同的血液动力学状态下记录反映患者心脏的机械功能的血液动力学指标信号。记录相应血液动力学状态下的相应血液动力学参考信号。从记录的血液动力学指标信号中提取至少一个血液动力学指标参数。所述至少一个血液动力学指数参数是心脏的机械功能的度量，并且创建血液动力学指标模型，其中所述血液动力学指标模型基于所述至少一个血液动力学指数参数和来自所述血液动力学指标的输出结果之间的比较模型和相应的血液动力学参考信号。从该血液动力学指标模型可以得出血流动力学指标，然后可以用于确定心脏刺激器患者定制的心脏起搏设置。

3. 发明申请

US20130053915A1 METHOD AND SYSTEM FOR DETERMINING PACING SETTINGS 有权
公开(公告)号：US20130053915A1
公开(公告)日：2013-02-28
申请号：US13596585
申请日：2012-08-28
申请人： Nils Holmstrom , Andreas Karlsson
发明人： Nils Holmstrom , Andreas Karlsson
IPC分类号： A61N1/365
CPC分类号： A61N1/36585 , A61N1/365 , A61N1/36514 , A61N1/3682 , A61N1/3704
摘要： Systems and methods for optimizing the stimulation of a heart of a patient are disclosed herein. The method comprises delivering pacing therapy to the patient according to a pacing therapy setting schedule, using specific pacing intervals via specific electrode configurations. Further, sinus rate values are recorded over at least one cardiac cycle at each pacing therapy setting and it is determined whether a sinus rate value satisfies predetermined measurement conditions, wherein sinus rate values are used for trending the sinus rate over time if the measurement conditions are satisfied. The accepted sinus rate values, i.e. values that satisfy the measurement conditions, are trended over time, wherein each trended sinus rate value is created based on recordings from at least one cardiac cycle. A preferred pacing therapy setting is determined to be the pacing therapy setting that provides a lowest sinus rate.

4. 外观设计

USD678213S1 Cable and pipe penetration seal 有权
公开(公告)号：USD678213S1
公开(公告)日：2013-03-19
申请号：US29378436
申请日：2010-11-04
申请人： Andreas Karlsson
设计人： Andreas Karlsson

5. 发明授权

US08030320B2 Derivatives of 1-OXO-1,2-dihydroisoquinoline-5-carboxamides and of 4-OXO-3,4-dihydroquinazoline-8-carboxamides, preparation thereof and application thereof in therapeutics 失效
标题翻译： 1-OXO-1,2-二氢异喹啉-5-甲酰胺和4-OXO-3,4-二氢喹唑啉-8-甲酰胺的衍生物，其制备及其在治疗中的应用
公开(公告)号：US08030320B2
公开(公告)日：2011-10-04
申请号：US12693598
申请日：2010-01-26
申请人： Michel Evers , Arielle Genevois-Borella , Andreas Karlsson , Jean-Luc Malleron
发明人： Michel Evers , Arielle Genevois-Borella , Andreas Karlsson , Jean-Luc Malleron
IPC分类号： A61K31/517
CPC分类号： C07D217/24 , C07D239/88
摘要： The present invention relates to compounds of formula I, to the preparation thereof and to the therapeutic use thereof.
摘要翻译：本发明涉及式I化合物及其制备及其治疗用途。

6. 外观设计

USD632656S1 Frame for cable lead-through 有权
公开(公告)号：USD632656S1
公开(公告)日：2011-02-15
申请号：US29294625
申请日：2008-01-18
申请人： Andreas Karlsson
设计人： Andreas Karlsson

7. 发明申请

US20060153435A1 Method and means for 2d-gel-image segmentation 审中-公开
标题翻译：二维凝胶图像分割的方法和手段
公开(公告)号：US20060153435A1
公开(公告)日：2006-07-13
申请号：US10516800
申请日：2003-06-19
申请人： Gustav Wallmark , Anders Heyden , Andreas Karlsson , Ola Frosstrom-Olsson
发明人： Gustav Wallmark , Anders Heyden , Andreas Karlsson , Ola Frosstrom-Olsson
IPC分类号： G06E3/00
CPC分类号： G06T7/0012 , G06K9/0014 , G06K9/34 , G06T7/11 , G06T7/187 , G06T7/64 , G06T2207/10056 , G06T2207/30024
摘要： The present invention relates to the segmentation of two-dimensional gel electrophoresis images (2D images). The method according to the invention associates an initial protein seed candidate with an interface circumscribing said seed and thereafter brings said interface to evolve in accordance with a defined speed function F(x, y). The evolution of the interface is halted by a stopping criterion, C. According to the invention, the speed function can depend on a wide variety of parameters such as the pixel intensity, the curvature of the pixel intensity, the distance to the initial seed, the curvature and/or shape and/or normal direction and/or position of the evolving interface. The stopping criterion depends e.g. on the speed function F and/or the time of arrival T(x, y) and/or the departure time Td for said interface. The invention provides criteria for a specific treatment of saturated spots and to mike sure that interfaces never overlap.
摘要翻译：本发明涉及二维凝胶电泳图像（2D图像）的分割。根据本发明的方法将初始蛋白质种子候选物与限定所述种子的界面相关联，然后使所述界面根据定义的速度函数F（x，y）进行演化。接口的演变由停止标准C停止。根据本发明，速度函数可以取决于各种各样的参数，例如像素强度，像素强度的曲率，到初始种子的距离，演变界面的曲率和/或形状和/或法线方向和/或位置。停止标准取决于对于所述接口，速度函数F和/或到达时间T（x，y）和/或出发时间T 。本发明提供了对饱和斑点的具体处理的标准，并确保界面不重叠。

8. 发明授权

US08863524B2 Burner 有权
标题翻译：刻录机
公开(公告)号：US08863524B2
公开(公告)日：2014-10-21
申请号：US12935919
申请日：2009-03-26
申请人： Andreas Karlsson , Vladimir Milosavljevic
发明人： Andreas Karlsson , Vladimir Milosavljevic
IPC分类号： F23R3/14 , F23R3/28 , F23R3/34
CPC分类号： F23R3/286 , F23D2900/00014 , F23R3/343 , F23R3/346
摘要： A burner for a gas turbine including a burner housing is provided. Provided is a lean-rich partially premixed low emission burner for a gas turbine combustor providing stable ignition and combustion process at all engine load conditions. At the upstream end of that burner a pilot combustor creates a flow of an unquenched concentration of radicals and heat. Respectively provided is a plurality of quarl sections surrounding the exit of the pilot combustor, a main combustion room defined downstream the pilot combustor and at least a first channel defined as an annular space between an upstream quarl section and the closest downstream quarl section providing air and fuel to a main flame in the combustion room.
摘要翻译：提供一种用于包括燃烧器壳体的燃气轮机的燃烧器。提供了一种用于燃气轮机燃烧器的富稀薄部分预混合的低排放燃烧器，其在所有发动机负载条件下提供稳定的点火和燃烧过程。在该燃烧器的上游端，导向燃烧室产生不消退的自由基和热量的流动。分别设置有围绕导向燃烧室的出口的多个岔区，在主燃烧室下游定义的主燃烧室和至少一个第一通道，其被定义为在上游岔区与最近的下游quar区之间的环形空间，燃烧到燃烧室中的主要火焰。

9. 发明授权

US08761883B2 Physiologically adapted cardiac resynchronization therapy 有权
标题翻译：生理适应性心脏再同步治疗
公开(公告)号：US08761883B2
公开(公告)日：2014-06-24
申请号：US13578553
申请日：2011-08-31
申请人： Tomas Svensson , Andreas Blomqvist , Andreas Karlsson , Michael Broome
发明人： Tomas Svensson , Andreas Blomqvist , Andreas Karlsson , Michael Broome
IPC分类号： A61N1/37
CPC分类号： A61N1/368 , A61N1/36507 , A61N1/36585 , A61N1/3684 , A61N1/3702 , A61N1/371
摘要： An implantable medical device is connectable to an epicardial left ventricular lead having at least one epicardial electrode and a myocardium penetrating catheter with at least one endocardial electrode and present in a lumen of the lead. The device comprises a pulse generator controller that controls a ventricular pulse generator to generate pulses to be applied to the epicardial and endocardial electrodes. The controller uses an endocardial-to-epicardial time interval or epicardial-to-endocardial time interval to coordinate endocardial and epicardial activation of the left ventricle to thereby achieve cardiac pacing that closely mimics the natural electrical activation pattern of a healthy heart.
摘要翻译：可植入医疗装置可连接到具有至少一个心外膜电极的心外膜左心室引线和具有至少一个心内膜电极并存在于引流管腔中的心肌穿透导管。该装置包括脉冲发生器控制器，其控制心室脉冲发生器以产生要施加到心外膜和心内膜电极的脉冲。控制器使用心内膜至心外膜时间间隔或心外膜至心内膜时间间隔来协调左心室的心内膜和心外膜激活，从而实现紧密模拟健康心脏的天然电活化模式的心脏起搏。

10. 发明申请

US20140026579A1 BURNER FOR A GAS TURBINE 审中-公开
标题翻译：燃气轮机
公开(公告)号：US20140026579A1
公开(公告)日：2014-01-30
申请号：US13876594
申请日：2011-09-27
申请人： Andreas Karlsson , Magnus Persson
发明人： Andreas Karlsson , Vladimir Dusan Milosavljevic , Magnus Persson
IPC分类号： F23R3/34
CPC分类号： F23R3/343 , F23D2900/00014 , F23D2900/00015 , F23R3/20 , F23R3/286
摘要： A burner for a gas turbine includes a burner housing, and a pilot combustor having a supply module providing pilot fuel and pilot air into a pilot combustion room being enclosed by a pilot combustor housing having a tapered exit with a throat of a defined length into the resulting main flow direction. The throat discharges a concentration of radicals are and heat generated in the pilot combustion room into a main combustion room enclosed by the burner housing. The interior cross section area of the throat deviates from a circle by means of flow guiding elements provided as protrusions with a defined radial height or as recesses with a defined depth extending longitudinally along the direction of the burner axis to give the discharging flow a defined velocity distribution with regard to a circumferential direction.
摘要翻译：一种用于燃气轮机的燃烧器包括燃烧器壳体和引燃燃烧器，其具有向导向燃烧室提供引燃燃料和先导空气的供给模块，该引燃燃烧室由具有限定长度的喉部的具有锥形出口的先导燃烧器壳体包围，主要流向。喉部将先导燃烧室中产生的自由基浓度和热量排放到由燃烧器壳体包围的主燃烧室中。喉部的内部横截面区域通过作为具有限定的径向高度的突起的流动引导元件而偏离圆形，或者具有沿着燃烧器轴线的方向纵向延伸的限定深度的凹部，以使排出流具有限定的速度关于圆周方向的分布。

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