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1. 发明申请

US20130289641A1 METHOD AND SYSTEM FOR OPTIMIZING CARDIAC PACING SETTINGS 审中-公开
标题翻译：优化心脏瓣膜设置的方法和系统
公开(公告)号：US20130289641A1
公开(公告)日：2013-10-31
申请号：US13997620
申请日：2010-12-23
申请人： John Gustafsson , Andreas Karlsson , Andreas Blomqvist , Hedberg Sven-Erik , Nils Holmstrom
发明人： John Gustafsson , Andreas Karlsson , Andreas Blomqvist , Hedberg Sven-Erik , Nils Holmstrom
IPC分类号： A61N1/365
CPC分类号： A61N1/36571 , A61B5/02028 , A61B5/0215 , A61B5/028 , A61B5/029 , A61B5/0472 , A61B5/0538 , A61B5/1116 , A61B5/686 , A61B8/06 , A61B2562/0219 , A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36535 , A61N1/36564 , A61N1/36578 , A61N1/36585 , A61N1/3682
摘要： The present invention relates generally to methods and systems for optimizing stimulation of a heart of a patient. Hemodynamical index signals reflecting a mechanical functioning of a heart of a patient are recorded at different hemodynamical states. Corresponding hemodynamical reference signals at corresponding hemodynamical states are recorded. At least one hemodynamical index parameter is extracted from the recorded hemodynamical index signals. The at least one hemodynamical index parameter is a measure of the mechanical functioning of the heart and a hemodynamical index model is created, wherein the hemodynamical index model is based on the at least one hemodynamical index parameter and a comparison between output results from the hemodynamical index model and corresponding hemodynamical reference signals. From this hemodynamical index model, a hemodynamical index can be derived, which then can be used in determining patient customized cardiac pacing settings of the cardiac stimulator.
摘要翻译：本发明一般涉及优化患者心脏的刺激的方法和系统。在不同的血液动力学状态下记录反映患者心脏的机械功能的血液动力学指标信号。记录相应血液动力学状态下的相应血液动力学参考信号。从记录的血液动力学指标信号中提取至少一个血液动力学指标参数。所述至少一个血液动力学指数参数是心脏的机械功能的度量，并且创建血液动力学指标模型，其中所述血液动力学指标模型基于所述至少一个血液动力学指数参数和来自所述血液动力学指标的输出结果之间的比较模型和相应的血液动力学参考信号。从该血液动力学指标模型可以得出血流动力学指标，然后可以用于确定心脏刺激器患者定制的心脏起搏设置。

2. 发明授权

US08620432B2 Identification of pacing site 有权
标题翻译：鉴定起搏部位
公开(公告)号：US08620432B2
公开(公告)日：2013-12-31
申请号：US13171952
申请日：2011-06-29
申请人： Sven-Erik Hedberg , Nils Holmström , John Gustafsson , Andreas Blomqvist , Andreas Karlsson
发明人： Sven-Erik Hedberg , Nils Holmström , John Gustafsson , Andreas Blomqvist , Andreas Karlsson
IPC分类号： A61N1/00
CPC分类号： A61N1/3686 , A61N1/36521
摘要： An implantable medical device applies an electric signal over two electrodes and measures the resulting electric signal over a candidate pair of neighboring electrodes on a lead for a first heart ventricle or over a candidate electrode of the lead and a case electrode. An impedance signal is determined for each candidate pair or electrode based on the applied signal and the measured resulting signal. A time difference between start of contraction in a second ventricle and the timing of local myocardial contraction as identified from the impedance signal at the site of the candidate pair or electrode is determined for each candidate pair or electrode. An optimal pacing electrode is selected to correspond to one of the electrodes of the candidate pair having the largest time difference or the candidate electrode having largest time difference.
摘要翻译：可植入医疗装置在两个电极上施加电信号，并且通过在第一心室的引线上或在引线的候选电极和外壳电极上的相邻电极的候选对测量所得到的电信号。基于所施加的信号和测得的结果信号，为每个候选对或电极确定阻抗信号。针对每个候选对或电极确定从候选对或电极的位置处的阻抗信号识别的第二心室的收缩开始与局部心肌收缩的定时之间的时间差。选择最佳起搏电极以对应于具有最大时间差的候选对的电极之一或具有最大时间差的候选电极。

3. 发明申请

US20120004700A1 IDENTIFICATION OF PACING SITE 有权
标题翻译：鉴定场地
公开(公告)号：US20120004700A1
公开(公告)日：2012-01-05
申请号：US13171952
申请日：2011-06-29
申请人： Sven-Erik Hedberg , Nils Holmström , John Gustafsson , Andreas Blomqvist , Andreas Karlsson
发明人： Sven-Erik Hedberg , Nils Holmström , John Gustafsson , Andreas Blomqvist , Andreas Karlsson
IPC分类号： A61N1/368
CPC分类号： A61N1/3686 , A61N1/36521
摘要： An implantable medical device applies an electric signal over two electrodes and measures the resulting electric signal over a candidate pair of neighboring electrodes on a lead for a first heart ventricle or over a candidate electrode of the lead and a case electrode. An impedance signal is determined for each candidate pair or electrode based on the applied signal and the measured resulting signal. A time difference between start of contraction in a second ventricle and the timing of local myocardial contraction as identified from the impedance signal at the site of the candidate pair or electrode is determined for each candidate pair or electrode. An optimal pacing electrode is selected to correspond to one of the electrodes of the candidate pair having the largest time difference or the candidate electrode having largest time difference.
摘要翻译：可植入医疗装置在两个电极上施加电信号，并且通过在第一心室的引线上或在引线的候选电极和外壳电极上的相邻电极的候选对测量所得到的电信号。基于所施加的信号和测得的结果信号，为每个候选对或电极确定阻抗信号。针对每个候选对或电极确定从候选对或电极的位置处的阻抗信号识别的第二心室的收缩开始与局部心肌收缩的定时之间的时间差。选择最佳起搏电极以对应于具有最大时间差的候选对的电极之一或具有最大时间差的候选电极。

4. 发明申请

US20120239102A1 IMPLANTABLE MEDICAL DEVICE FOR CARDIAC THERAPY 有权
标题翻译：用于心脏治疗的可植入医疗器械
公开(公告)号：US20120239102A1
公开(公告)日：2012-09-20
申请号：US13510873
申请日：2009-12-08
申请人： Nils Holmstrom , John Gustafsson , Michael Broome
发明人： Nils Holmstrom , John Gustafsson , Michael Broome
IPC分类号： A61N1/365 , A61N1/05 , A61N1/362
CPC分类号： A61N1/368 , A61N1/3627 , A61N1/3684 , A61N2001/0585
摘要： An implantable medical device, IMD, (100) is connectable to at least one ventricular lead (210) having a ventricular basal electrode (214) and a ventricular apical electrode (212). The IMD (100) comprises a pulse generator (120) for generating pacing pulses applied to a heart (10) through the ventricular lead (210). The operation of this pulse generator (120) is controlled by a controller (130) that is configured to control the pulse generator to first deliver a pacing pulse to the ventricular basal electrode (214) to stimulate the basal portion of the ventricle (12, 14) before a pacing pulse is delivered to the apical portion of the ventricle (12, 14) by the ventricular apical electrode (212). This pulse sequence achieves a biologically more correct cardiac stimulation and a contraction pattern that reduces the risk for valvular regurgitation.
摘要翻译：植入式医疗装置IMD（100）可连接到至少一个具有心室基底电极（214）和心室顶端电极（212）的心室引线（210）。 IMD（100）包括用于产生通过心室引线（210）施加到心脏（10）的起搏脉冲的脉冲发生器（120）。该脉冲发生器（120）的操作由控制器（130）控制，控制器（130）被配置为控制脉冲发生器首先将起搏脉冲递送至心室基底电极（214）以刺激心室的基部（12， 14）在通过心室顶端电极（212）将起搏脉冲输送到心室（12,14）的顶端部分之前。该脉冲序列实现了生物学更正确的心脏刺激和减少瓣膜反流风险的收缩模式。

5. 发明授权

US08781579B2 Implantable medical device for cardiac therapy 有权
标题翻译：用于心脏治疗的可植入医疗器械
公开(公告)号：US08781579B2
公开(公告)日：2014-07-15
申请号：US13510873
申请日：2009-12-08
申请人： Nils Holmstrom , John Gustafsson , Michael Broome
发明人： Nils Holmstrom , John Gustafsson , Michael Broome
IPC分类号： A61N1/368 , A61N1/362 , A61N1/05
CPC分类号： A61N1/368 , A61N1/3627 , A61N1/3684 , A61N2001/0585
摘要： An implantable medical device, IMD, (100) is connectable to at least one ventricular lead (210) having a ventricular basal electrode (214) and a ventricular apical electrode (212). The IMD (100) comprises a pulse generator (120) for generating pacing pulses applied to a heart (10) through the ventricular lead (210). The operation of this pulse generator (120) is controlled by a controller (130) that is configured to control the pulse generator to first deliver a pacing pulse to the ventricular basal electrode (214) to stimulate the basal portion of the ventricle (12, 14) before a pacing pulse is delivered to the apical portion of the ventricle (12, 14) by the ventricular apical electrode (212). This pulse sequence achieves a biologically more correct cardiac stimulation and a contraction pattern that reduces the risk for valvular regurgitation.
摘要翻译：植入式医疗装置IMD（100）可连接到至少一个具有心室基底电极（214）和心室顶端电极（212）的心室引线（210）。 IMD（100）包括用于产生通过心室引线（210）施加到心脏（10）的起搏脉冲的脉冲发生器（120）。该脉冲发生器（120）的操作由控制器（130）控制，控制器（130）被配置为控制脉冲发生器首先将起搏脉冲递送至心室基底电极（214）以刺激心室的基部（12， 14）在通过心室顶端电极（212）将起搏脉冲输送到心室（12,14）的顶端部分之前。该脉冲序列实现了生物学更正确的心脏刺激和减少瓣膜反流风险的收缩模式。

6. 发明申请

US20130289650A1 Neuromodulation for Hypertension Control 审中-公开
标题翻译：高血压控制神经调节
公开(公告)号：US20130289650A1
公开(公告)日：2013-10-31
申请号：US13456140
申请日：2012-04-25
申请人： Andreas Karlsson , Stuart Rosenberg , John Gustafsson
发明人： Andreas Karlsson , Stuart Rosenberg , John Gustafsson
IPC分类号： A61N1/36
CPC分类号： A61N1/36117
摘要： Neuromodulation for controlling hypertension and other cardio-renal disorders of a patient is disclosed. A neuromodulation device is configured to be delivered to a patient's body and to apply an electric activation to decrease renal sympathetic hyperactivity of the patient based on monitored blood pressure of the patient, substantially without thermal energization of the patient's body by applying the electric activation. The electric activation may also depend on monitored blood volume of the patient. A feedback control module may be used to provide feedback control information for adjusting the electric activation based on the monitored blood pressure and volume of the patient.
摘要翻译：公开了用于控制患者的高血压和其它心脏 - 肾脏疾病的神经调节。神经调节装置被配置为被输送到患者的身体并施加电激活以基于患者的监测的血压来降低患者的肾交感神经活动，基本上通过施加电激活而不能对患者身体进行热激发。电激活也可以取决于患者的监测血容量。可以使用反馈控制模块来提供用于基于所监测的患者的血压和体积来调节电激活的反馈控制信息。

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