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1. 发明授权

US06529777B1 Electrode for tissue stimulation 失效
标题翻译：电极组织刺激
公开(公告)号：US06529777B1
公开(公告)日：2003-03-04
申请号：US09622817
申请日：2000-08-23
申请人： Nils Holmström , Sven-Erik Hedberg , Kenth Nilsson
发明人： Nils Holmström , Sven-Erik Hedberg , Kenth Nilsson
IPC分类号： A61N105
CPC分类号： A61N1/371 , A61N1/0565 , A61N1/362 , A61N1/36585
摘要： In an implantable electrode for an electrode lead for a stimulation device for stimulating tissue, the electrode is formed as a biocompatible piezoelectric electrode which is adapted to be in direct electrical contact with tissue for electrically and mechanically stimulating the tissue and for detecting electrical and mechanical evoked response of the stimulated tissue. The stimulation device can include circuitry for making a diagnosis of a heart condition using signals received from the implantable electrode.
摘要翻译：在用于刺激组织的刺激装置的电极引线的可植入电极中，电极形成为生物相容性压电电极，其适于与组织直接电接触，用于电和机械刺激组织并检测电和机械诱发刺激组织的反应。刺激装置可以包括使用从可植入电极接收的信号进行心脏状况诊断的电路。

2. 发明申请

US20100099994A1 IMPLANTABLE HEART ANALYZING DEVICE, SYSTEM AND METHOD 审中-公开
标题翻译：可植入心脏分析装置，系统和方法
公开(公告)号：US20100099994A1
公开(公告)日：2010-04-22
申请号：US12528160
申请日：2007-02-28
申请人： Nils Holmström , Andreas Blomqvist , Berit Larsson , Karin Järverud , Sven-Erik Hedberg
发明人： Nils Holmström , Andreas Blomqvist , Berit Larsson , Karin Järverud , Sven-Erik Hedberg
IPC分类号： A61B5/02
CPC分类号： A61B5/1107 , A61B5/0051 , A61B5/4519 , A61B5/6869 , A61N1/36578
摘要： An implantable heart analyzing device has a housing and a control circuit located within said housing. The control circuit generates an output signal adapted to actuate an activator, which is able to make a wall of the heart deflect or vibrate. The control circuit also communicates with a sensor, which can be identical with the activator, with which the movement of the heart wall can be sensed. The control circuit executes a procedure that involves the generation of an output signal and sensing a corresponding sensor signal, and to be able to derive information concerning the tension of the heart wall. An implantable heart analyzing includes the aforementioned heart analyzing device, as well as the activator and the sensor. The heart analyzing device and the system implement a method that results in generation of the aforementioned information concerning the tension of the heart wall.
摘要翻译：可植入心脏分析装置具有壳体和位于所述壳体内的控制电路。控制电路产生适于致动激活器的输出信号，其能够使心脏的壁发生偏转或振动。控制电路还与传感器通信，传感器可以与激活器相同，通过该传感器可以感测心脏壁的移动。控制电路执行涉及生成输出信号并感测相应的传感器信号的过程，并且能够得出关于心壁的张力的信息。可植入心脏分析包括上述心脏分析装置，以及活化剂和传感器。心脏分析装置和系统实施导致产生上述关于心脏壁张力的信息的方法。

3. 发明申请

US20100041970A1 IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：可植入医疗器械
公开(公告)号：US20100041970A1
公开(公告)日：2010-02-18
申请号：US12532186
申请日：2007-11-27
申请人： Sven-Erik Hedberg , Andreas Blomqvist , Karin Järverud , Karin Ljungström , Leif Lindkvist , Urban Lönn , Nils Holmström
发明人： Sven-Erik Hedberg , Andreas Blomqvist , Karin Järverud , Karin Ljungström , Leif Lindkvist , Urban Lönn , Nils Holmström
IPC分类号： A61B5/1459
CPC分类号： A61N1/3702 , A61B5/14542 , A61B5/1459 , A61N1/056 , A61N1/36557
摘要： An implantable medical device has an oxygen sensor adapted to measure the level of oxygen in oxygenized blood, and to generate an oxygen measurement signal in dependence of the level of oxygen. The oxygen sensor is adapted to perform measurements inside the heart, of blood entering the left atrium of a patient's heart. The obtained oxygen measurement signal is compared to a predetermined threshold level and an indication signal is generated in dependence of the comparison. The, indication signal is indicative of the lung functionality of the patient.
摘要翻译：可植入医疗装置具有适于测量氧合血液中的氧气水平的氧传感器，并且根据氧气水平产生氧测量信号。氧传感器适于在心脏内进行血液进入患者心脏左心房的血液。将获得的氧测量信号与预定阈值电平进行比较，并根据比较产生指示信号。该指示信号表示患者的肺功能。

4. 发明申请

US20100010600A1 PIEZOELECTRIC SENSOR, A METHOD FOR MANUFACTURING A PIEZOELECTRIC SENSOR AND A MEDICAL IMPLANTABLE LEAD COMPRISING SUCH A PIEZOELECTRIC SENSOR 有权
标题翻译：压电传感器，制造压电传感器的方法和包含这种压电传感器的医用可植入引线
公开(公告)号：US20100010600A1
公开(公告)日：2010-01-14
申请号：US12298218
申请日：2006-04-25
申请人： Tom Eriksson , Kenth Nilsson , Sven-Erik Hedberg
发明人： Tom Eriksson , Kenth Nilsson , Sven-Erik Hedberg
IPC分类号： A61N1/05 , H01L41/22 , G01L9/08
CPC分类号： A61N1/056 , A61B5/0215 , A61N1/0565 , A61N1/36542 , A61N1/36564 , G01L9/0026 , G01L9/08 , H01L41/087 , H01L41/1132
摘要： In a piezoelectric sensor, a method for the manufacture thereof, and an implantable lead embodying such a piezoelectric sensor, a layer of piezoelectric material, having aligned, polarized dipoles, is applied to a tubular supporting substrate, the layer of piezoelectric material having at least one electrode at an outer surface thereof and at least one electrode at an inner surface thereof. The piezoelectric material is applied on the inner circumference of the tubular supporting substrate.
摘要翻译：在压电传感器中，其制造方法以及体现这种压电传感器的可植入引线，具有排列的极化偶极子的压电材料层被施加到管状支撑衬底，压电材料层至少具有一个电极在其外表面和至少一个电极在其内表面。压电材料被施加在管状支撑衬底的内圆周上。

5. 发明授权

US08321016B2 Implantable medical device and a method comprising means for detecting and classifying ventricular tachyarrhythmias 有权
标题翻译：植入式医疗装置和包括用于检测和分类室性快速性心律失常的装置的方法
公开(公告)号：US08321016B2
公开(公告)日：2012-11-27
申请号：US12602533
申请日：2007-06-13
申请人： Nils Holmström , Andreas Blomqvist , Sven-Erik Hedberg , Malin Öhlander
发明人： Nils Holmström , Andreas Blomqvist , Sven-Erik Hedberg , Malin Öhlander
IPC分类号： A61N1/365 , A61N1/37
CPC分类号： A61N1/3702 , A61B5/0464 , A61B5/053 , A61B5/7264
摘要： In a method and implantable medical device for ventricular tachyarrhythmia detection and classification, upon detection of a ventricular tachyarrhythmia based on an electrocardiogram signal, cardiogenic impedance data representative of ventricular volume dynamics are collected and used for classifying the detected tachyarrhythmia as stable or unstable. In the latter case but typically not in the former case, defibrillation shocks or other forms of therapy are applied to combat the unstable ventricular tachyarrhythmia.
摘要翻译：在用于室性快速性心律失常检测和分类的方法和可植入医疗装置中，在基于心电图信号检测到心室快速性心律失常时，收集表示心室容积动力学的心源阻抗数据，并用于将检测到的心律失常分类为稳定或不稳定。在后一种情况下，但通常不是在前一种情况下，应用除颤电击或其他形式的治疗来对抗不稳定性室性快速性心律失常。

6. 发明申请

US20100298904A1 IMPLANTABLE HEART STIMULATOR FOR MEASURING DYSSYNCHRONY USING IMPEDANCE 有权
标题翻译：用于测量使用阻抗的DYSSYNCHRONY的可植入心脏刺激仪
公开(公告)号：US20100298904A1
公开(公告)日：2010-11-25
申请号：US12863381
申请日：2008-01-28
申请人： Andreas Blomqvist , Nils Holmström , Malin Öhlander , Sven-Erik Hedberg
发明人： Andreas Blomqvist , Nils Holmström , Malin Öhlander , Sven-Erik Hedberg
IPC分类号： A61N1/365
CPC分类号： A61N1/36521 , A61B5/053 , A61B5/0538 , A61N1/3684
摘要： Implantable heart stimulator connectable to an electrode arrangement has a pulse generator adapted to deliver stimulation pulses to a heart of a subject; an impedance measurement unit adapted monitor at least one heart chamber of the heart of the subject to measure the impedance in the at least one monitored heart chamber for generating an impedance signal corresponding to the measured impedance. The impedance signal is applied to a processor where the signal is processed, according to specified criteria, and a fractionation index value is determined represented by the curve length of the impedance signal during a predetermined measurement period. The fractionation index value is a measure of different degrees of mechanical dyssynchrony of the heart.
摘要翻译：可连接到电极装置的可植入心脏刺激器具有适于将刺激脉冲输送到受试者心脏的脉冲发生器; 阻抗测量单元适于监测所述受试者心脏的至少一个心室，以测量所述至少一个监测的心室中的阻抗，以产生对应于所测量的阻抗的阻抗信号。根据规定的标准，将阻抗信号施加到处理器，信号被处理，并且在预定测量期间由阻抗信号的曲线长度确定分数指数值。分离指数值是心脏不同程度的机械不同步的度量。

7. 发明授权

US07085602B2 Implantable bi-ventricular stimulation device and system, and bi-ventricular stimulation and sensing method 有权
标题翻译：可植入双心室刺激装置和系统，以及双心室刺激和感测方法
公开(公告)号：US07085602B2
公开(公告)日：2006-08-01
申请号：US10720449
申请日：2003-11-24
申请人： Sven-Erik Hedberg , Asa Uhrenius , Karin Jarverud , Hans Strandberg , Nils Holmström , Anders Björling , Göran Budgifvars
发明人： Sven-Erik Hedberg , Asa Uhrenius , Karin Jarverud , Hans Strandberg , Nils Holmström , Anders Björling , Göran Budgifvars
IPC分类号： A61N1/365
CPC分类号： A61N1/368 , A61N1/056 , A61N1/3684 , A61N2001/0585
摘要： An implantable bi-ventricular heart stimulating device (10) has a control circuit with first and second sensing circuits for respectively sensing in the two ventricles and first and second stimulation circuits for respectively stimulating the two ventricles. The control circuit determines whether a signal, sensed by said second sensing circuit, occurs essentially simultaneously with a signal sensed by the first sensing circuit. Furthermore, the control circuit determines whether a further signal is sensed by said second sensing circuit within a predetermined time interval which follows after the signal sensed by the second sensing circuit but within the same time cycle as that signal. If this occurs, the control circuit determines whether the sensed signals represent actual cardiac events, or are likely the result of far field detection.
摘要翻译：可植入式双心室心脏刺激装置（10）具有控制电路，该控制电路具有用于分别感测两个心室的第一和第二感测电路以及分别刺激两个脑室的第一和第二刺激电路。控制电路确定由所述第二感测电路检测到的信号是否基本上与由第一感测电路感测的信号同时发生。此外，控制电路确定在由第二感测电路感测到的信号之后但在与该信号相同的时间周期内的预定时间间隔内，所述第二感测电路是否感测到另外的信号。如果发生这种情况，则控制电路确定感测到的信号是否代表实际的心脏事件，或者很可能是远场检测的结果。

8. 发明授权

US08068908B2 Implantable cardiac stimulator, system, device and method for monitoring cardiac synchrony 有权
标题翻译：可植入式心脏刺激器，系统，装置和监测心脏同步的方法
公开(公告)号：US08068908B2
公开(公告)日：2011-11-29
申请号：US12094543
申请日：2005-11-30
申请人： Karin Järverud , Kenth Nilsson , Sven-Erik Hedberg
发明人： Karin Järverud , Kenth Nilsson , Sven-Erik Hedberg
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61B5/1107 , A61B5/6869 , A61B2562/0219 , A61N1/36514 , A61N1/36578
摘要： In a system and method for monitoring cardiac synchrony in a human heart, a first sensor is positioned at a first cardiac wall location of a heart that is subject to movements related to longitudinal valve plane movements along the longitudinal axis of the heart, and the first sensor measures said cardiac wall movements at the first cardiac wall location and emits a first sensor output signal corresponding thereto, a second sensor is positioned at a second cardiac wall location of the heart that is subject to movements related to longitudinal valve plane movements along the longitudinal axis of the heart, and the second sensor measures the cardiac wall movements at the second cardiac wall location and emits a second sensor output signal corresponding thereto. A lead arrangement is electrically connected to the first and second sensors and conducts the first and second sensor output signals therefrom to processing circuitry that processes the first and second sensor output signals to produce a synchronization signal therefrom indicative of synchrony in the respective valve plane movements at the first and second cardiac wall locations.
摘要翻译：在用于监测人心脏心脏同步的系统和方法中，第一传感器位于心脏的第一心脏壁位置处，该第一心脏壁位置受到与沿着心脏的纵向轴线的纵向瓣膜平面运动有关的运动，第一传感器传感器测量在第一心脏壁位置处的心脏壁运动，并且发射与其对应的第一传感器输出信号，第二传感器定位在心脏的第二心脏壁位置处，该第二心脏壁位置受到与沿着纵向的纵向瓣膜平面运动相关的运动并且第二传感器测量第二心脏壁位置处的心脏壁移动，并且发出与其对应的第二传感器输出信号。引线装置电连接到第一和第二传感器，并将第一和第二传感器输出信号传送到处理电路，处理电路处理第一和第二传感器输出信号以产生同步信号，表示在各个阀平面运动中同步的同步信号第一和第二心脏壁位置。

9. 发明授权

US06915162B2 Implantable medical device for measuring ventricular pressure 有权
标题翻译：用于测量心室压力的可植入医疗器械
公开(公告)号：US06915162B2
公开(公告)日：2005-07-05
申请号：US10002496
申请日：2001-11-15
申请人： Kjell Noren , Charlotte Kjellmann , Kenth Nilsson , Sven-Erik Hedberg
发明人： Kjell Noren , Charlotte Kjellmann , Kenth Nilsson , Sven-Erik Hedberg
IPC分类号： A61B5/0215 , A61N1/365 , A61B5/04
CPC分类号： A61N1/36564 , A61B5/0215 , A61B5/7239
摘要： An implantable medical device has a pressure sensing arrangement to measure right ventricular pressure of a heart including a pressure sensor adapted to be positioned in the right ventricle of the heart, to measure the pressure and to generate a pressure signal in response to the measured pressure. The pressure sensing arrangement also has a pressure signal processor and a timing unit. The processor determines from the pressure signal, using diastolic timing signals from the timing unit based on the pressure signal identifying the diastolic phase, a diastolic pressure signal representing the ventricular pressure only during the diastolic phase of the heart cycle.
摘要翻译：可植入医疗装置具有用于测量心脏的右心室压力的压力感测装置，包括适于定位在心脏右心室的压力传感器，以测量压力并响应于测量的压力产生压力信号。压力感测装置还具有压力信号处理器和定时单元。处理器根据压力信号，基于识别舒张期的压力信号使用来自定时单元的舒张定时信号，仅在心脏周期舒张期期间表示心室压力的舒张压信号。

10. 发明授权

US5935158A Electrode lead and device for tissue stimulation and/or detection of tissue response 失效
标题翻译：用于组织刺激和/或检测组织反应的电极引线和装置
公开(公告)号：US5935158A
公开(公告)日：1999-08-10
申请号：US915756
申请日：1997-08-21
申请人： Nils Holmstrom , Sven-Erik Hedberg , Kenth Nilsson
发明人： Nils Holmstrom , Sven-Erik Hedberg , Kenth Nilsson
IPC分类号： A61N1/05 , A61N1/362 , A61N1/39 , A61N1/04
CPC分类号： A61N1/0565
摘要： An implantable electrode for stimulating tissue has a piezoelectric electrode for electrically and mechanically stimulating tissue and for detecting electrical and mechanical evoked response of the stimulated tissue. An implantable lead and an implantable stimulation device employing such an electrode are described including diagnostic circuitry for making a diagnosis of the heart condition using such an electrode.
摘要翻译：用于刺激组织的可植入电极具有用于电和机械刺激组织并用于检测受刺激组织的电和机械诱发反应的压电电极。描述了使用这种电极的可植入引线和可植入刺激装置，其包括使用这种电极进行心脏病症诊断的诊断电路。

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