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1. 发明申请

US20050143427A1 [B]-fused bicyclic proline derivatives and their use for treating arthritic conditions 审中-公开
标题翻译： [B] - 双环脯氨酸衍生物及其用于治疗关节炎病症的用途
公开(公告)号：US20050143427A1
公开(公告)日：2005-06-30
申请号：US10822389
申请日：2004-04-12
申请人： Nicole Barvian , Cleo Connolly , Peter Guzzo , James Hamby , James Hicks , Matthew Johnson , Van-Duc Le , Lorna Mitchell , William Roark
发明人： Nicole Barvian , Cleo Connolly , Peter Guzzo , James Hamby , James Hicks , Matthew Johnson , Van-Duc Le , Lorna Mitchell , William Roark
IPC分类号： A61P19/00 , C07D209/12 , C07D209/14 , C07D403/04 , C07D413/04 , C07D417/02 , C07D495/04 , A61K31/433 , A61K31/4245 , C07D413/02
CPC分类号： C07D495/04 , C07D209/12 , C07D209/14 , C07D403/04 , C07D413/04 , C07D417/02
摘要： This invention relates to a compound which is [b]-fused bicyclic proline derivative, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition comprising the compound or the salt thereof, and methods of treating diseases, including, but not limited to, methods of preventing or inhibiting joint cartilage damage and preventing or treating diseases characterized by joint cartilage damage, joint inflammation, or joint pain. The [b]-fused bicyclic proline derivatives are compounds of Formula I as described above. Diseases characterized by joint cartilage damage or joint pain include, for example, osteoarthritis and rheumatoid arthritis. Rheumatoid arthritis is also characterized by joint inflammation. This invention also relates to methods of synthesizing and preparing the [b]-fused bicyclic proline derivatives, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及[b]双环脯氨酸衍生物或其药学上可接受的盐的化合物; 包含该化合物或其盐的药物组合物和治疗疾病的方法，包括但不限于预防或抑制关节软骨损伤和预防或治疗以关节软骨损伤，关节炎症或关节疼痛为特征的疾病的方法。 [b]引发的双环脯氨酸衍生物是如上所述的式I化合物。以关节软骨损伤或关节疼痛为特征的疾病包括例如骨关节炎和类风湿性关节炎。类风湿性关节炎的特征还在于关节炎。本发明还涉及合成和制备[b] - 双环脯氨酸衍生物或其药学上可接受的盐的方法。

2. 发明申请

US20060040957A1 BICYCLIC PYRIMIDINE MATRIX METALLOPROTEINASE INHIBITORS 审中-公开
标题翻译：双相PYRIMININE MATRIX金属蛋白酶抑制剂
公开(公告)号：US20060040957A1
公开(公告)日：2006-02-23
申请号：US10071032
申请日：2002-02-08
申请人： Richard Dyer , William Harter , James Hicks , Adam Johnson , Jie Li , William Roark , Kevon Shuler
发明人： Richard Dyer , William Harter , James Hicks , Adam Johnson , Jie Li , William Roark , Kevon Shuler
IPC分类号： A61K31/519 , C07D498/04
CPC分类号： C07D487/04 , C07D513/04
摘要： Selective MMP-13 inhibitors are bicyclic pyrimidines of the Formula I or a pharmaceutically acceptable salt thereof, wherein R1 is hydrogen or alkyl; R2, R3, and R4 include hydrogen, halo, alkyl, C≡C(CH2)m aryl, CO2 alkyl, CO2(CH2)m aryl, COHN alkyl, and CONH(CH2)m aryl; and X is O, S, SO, SO2, CH2, C═O, CHOH, NH, or NR5. A compound of Formula I, or a pharmaceutically acceptable salt thereof, is useful for treating cancer or arthritis.
摘要翻译：选择性MMP-13抑制剂是式I的二环嘧啶或其药学上可接受的盐，其中R 1是氢或烷基; R 2，R 3和R 4包括氢，卤素，烷基，C≡C（CH 2）2，）芳基，CO 2烷基，CO 2（CH 2 CH 2）m，芳基，COHN烷基和CONH（CH 2 CH 2）m芳基; X是O，S，SO，SO 2，CH 2，C-O，CHOH，NH或NR 5。式I化合物或其药学上可接受的盐可用于治疗癌症或关节炎。

3. 发明申请

US20210103642A9 DETERMINING A PROBABILISTIC DIAGNOSIS OF CANCER BY ANALYSIS OF GENOMIC COPY NUMBER VARIATIONS 有权
公开(公告)号：US20210103642A9
公开(公告)日：2021-04-08
申请号：US15960445
申请日：2018-04-23
申请人： Michael H. Wigler , James Hicks , Alexander Krasnitz , Anders Zetterberg
发明人： Michael H. Wigler , James Hicks , Alexander Krasnitz , Anders Zetterberg
IPC分类号： G06F19/18 , C12Q1/6886 , G16H50/20 , G16H50/30 , G06F19/24 , G06F17/18
摘要： The present invention provides methods and compositions related to genomic profiling, and in particular, to assigning probabilistic measure of clinical outcome for a patient having a disease or a tumor using segmented genomic profiles such as those produced by representational oligonucleotide microarray analysis (ROMA).

4. 发明申请

US20140065609A1 VARIETAL COUNTING OF NUCLEIC ACIDS FOR OBTAINING GENOMIC COPY NUMBER INFORMATION 有权
标题翻译：用于获取基因组复制号码信息的核酸的数量计数
公开(公告)号：US20140065609A1
公开(公告)日：2014-03-06
申请号：US13278333
申请日：2011-10-21
申请人： James Hicks , Nicholas Navin , Jennifer Troge , Zihua Wang , Michael Wigler
发明人： James Hicks , Nicholas Navin , Jennifer Troge , Zihua Wang , Michael Wigler
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q1/683 , C12Q1/6881 , C12Q1/6886 , C12Q2600/156 , G06F19/20 , C12Q2525/155 , C12Q2525/191 , C12Q2535/122 , C12Q2537/159 , C12Q2537/16
摘要： A method for obtaining from genomic material genomic copy number information unaffected by amplification distortion, comprising obtaining segments of the genomic material, tagging the segments with substantially unique tags to generate tagged nucleic acid molecules, such that each tagged nucleic acid molecule comprises one segment of the genomic material and a tag, subjecting the tagged nucleic acid molecules to polymerase chain reaction (PCR) amplification, generating tag associated sequence reads by sequencing the product of the PCR reaction, assigning each tagged nucleic acid molecule to a location on a genome associated with the genomic material by mapping the subsequence of each tag associated sequence read corresponding to a segment of the genomic material to a location on the genome, and counting the number of tagged nucleic acid molecules assigned to the same location on the genome having a different tag, thereby obtaining genomic copy number information unaffected by amplification distortion.
摘要翻译：一种用于从基因组材料获得未受扩增变形影响的基因组拷贝数信息的方法，包括获得所述基因组材料的片段，用基本上唯一的标签标记片段以产生标记的核酸分子，使得每个标记的核酸分子包含基因组材料和标签，对标记的核酸分子进行聚合酶链反应（PCR）扩增，通过对PCR反应的产物进行测序产生标签相关序列读数，将每个标记的核酸分子分配到与基因组材料通过将对应于基因组材料的片段的每个标签相关序列的亚序列映射到基因组上的位置，并计数分配给具有不同标签的基因组上相同位置的标记核酸分子的数目，从而获得不受扩增影响的基因组拷贝数信息扭曲变形。

5. 发明申请

US20120328607A1 GENETIC MARKERS INDICATIVE OF A CANCER PATIENT RESPONSE TO TRASTUZUMAB (HERCEPTIN) 有权
标题翻译：遗传标记表示患者对TRASTUZUMAB（HERCEPTIN）的反应
公开(公告)号：US20120328607A1
公开(公告)日：2012-12-27
申请号：US13491359
申请日：2012-06-07
申请人： James Hicks , Alexander Krasnitz
发明人： James Hicks , Alexander Krasnitz
IPC分类号： C40B30/04 , A61K39/395 , A61P35/00 , C12Q1/68
CPC分类号： C12Q1/6886 , A61K31/337 , A61K39/39558 , A61K2039/545 , C12Q2600/106 , C12Q2600/156 , A61K2300/00
摘要： The invention relates to the fields of therapeutics and identifying candidates for therapy, in particular to a method of identifying candidates for trastuzumab (Herceptin®) therapy in a patient presenting with breast cancer based on the presence or absence of specific genetic markers in a tumor sample from said patient.
摘要翻译：本发明涉及治疗领域和鉴定治疗候选物，特别是基于肿瘤样品中特异性遗传标记物的存在或不存在，确定呈现乳腺癌患者的曲妥珠单抗（Herceptin？）治疗候选者的方法来自所述患者。

6. 发明申请

US20050219426A1 Automatic convergence for image projection systems 审中-公开
标题翻译：图像投影系统的自动会聚
公开(公告)号：US20050219426A1
公开(公告)日：2005-10-06
申请号：US10837465
申请日：2004-04-29
申请人： Brian Maxson , James Hicks
发明人： Brian Maxson , James Hicks
IPC分类号： H04N3/26 , H04N9/28 , H04N17/00
CPC分类号： H04N9/28
摘要： Systems and methods are provided that facilitate automatic convergence and geometry alignment in projection systems. Preferably, an optical element such as a lens array is coupled to all areas of the projection system's screen and to a detector element such as a photocell array. In operation, each lens of the lens array is adapted to map an individual portion or region of the screen onto the photocell array. A microprocessor, controller or the like uses the data output from the photocells to instruct an alignment controller to center or steer the beams to compensate for convergence error at a particular location. In a center alignment mode, four (4) or more beacon dots located about the periphery of the screen are detected to determine screen size and position, which is used to center the video image and the centers of the mapped regions on the screen.
摘要翻译：提供了有助于投影系统中的自动会聚和几何对准的系统和方法。优选地，诸如透镜阵列的光学元件耦合到投影系统的屏幕的所有区域以及诸如光电池阵列的检测器元件。在操作中，透镜阵列的每个透镜适于将屏幕的单独部分或区域映射到光电晶体阵列上。微处理器，控制器等使用从光电管输出的数据来指示对准控制器使波束中心或转向以补偿特定位置处的收敛误差。在中心对准模式中，检测位于屏幕周边周围的四（4）个或更多个信标点，以确定用于将视频图像和映射区域的中心对准在屏幕上的屏幕尺寸和位置。

7. 发明申请

US20050134006A1 Multi-layer cylinder head gasket with resilient seal 审中-公开
标题翻译：多层气缸盖垫片，弹性密封
公开(公告)号：US20050134006A1
公开(公告)日：2005-06-23
申请号：US10996963
申请日：2004-11-24
申请人： Jeffrey Adams , Mark Whitlow , James Hicks , George Whittier
发明人： Jeffrey Adams , Mark Whitlow , James Hicks , George Whittier
IPC分类号： F02F11/00 , F16J20060101 , F16J15/08
CPC分类号： F16J15/0825 , F16J2015/0856 , F16J2015/0862 , F16J2015/0875
摘要： A head gasket assembly comprising a gasket body comprising a plurality of layers of gasket material a combustion aperture extending through said gasket body, the aperture defined by an inner periphery of the gasket, said periphery adapted to be fitted with a resilient seal element, and a resilient seal element disposed about the inner periphery of the aperture in the gasket body, said seal element being formed of a helically-wound metal wire or metal tube seal at least partially surrounded by a jacket having a flange protruding therefrom and engaging the gasket body.
摘要翻译：一种头垫片组件，包括垫圈主体，其包括多个衬垫材料层，延伸穿过所述垫圈主体的燃烧孔，所述孔由所述垫圈的内周限定，所述周边适于装配弹性密封元件，弹性密封元件围绕垫圈主体中的孔的内周设置，所述密封元件由螺旋缠绕的金属线或金属管密封件形成，金属线或金属管密封件至少部分地由护套所包围，该护套具有从其突出的凸缘并与垫圈本体接合。

8. 发明申请

US20050045142A1 Oil pressure control system and method for engines with hydraulic cylinder deactivation 失效
标题翻译：液压缸停用发动机油压控制系统及方法
公开(公告)号：US20050045142A1
公开(公告)日：2005-03-03
申请号：US10802196
申请日：2004-03-17
申请人： Frederick Rozario , William Albertson , James Hicks
发明人： Frederick Rozario , William Albertson , James Hicks
IPC分类号： F01L1/14 , F01L1/245 , F01L1/34 , F01L13/00 , F01M1/00
CPC分类号： F01L1/146 , F01L13/0005 , F01L2001/0476 , F01L2001/054 , F01L2001/2427 , F01L2105/00 , F01L2810/02
摘要： An oil lubrication and control system, for an engine having cylinder deactivation switching lifters operated at the pressure of the full oil system, is provided with an auxiliary pressure relief valve which opens to control maximum oil pressure in the system whenever the engine speed and temperature conditions lie beyond the ability of the oil pump pressure control unit to maintain the maximum pressure limit. Addition of the auxiliary pressure relief valve allows extended operation of the switching lifters, which are limited by their construction to operation below a prescribed pressure limit. In a preferred embodiment, the auxiliary pressure relief valve is mounted in the engine crankcase in a bore connected directly with the main oil gallery to provide mounting and actuation of the auxiliary pressure relief valve with a minimum of modifications to the engine oil system design.
摘要翻译：一种油润滑和控制系统，用于具有在全油系统的压力下操作的气缸停用切换升降器的发动机，设置有辅助压力释放阀，其在发动机速度和温度条件下打开以控制系统中的最大油压超出了油泵压力控制单元维持最大压力极限的能力。辅助减压阀的添加允许开关升降器的延长操作，其由其结构限制在低于规定压力极限的操作。在优选实施例中，辅助减压阀安装在发动机曲轴箱中的直接与主油道相连接的孔中，以提供对发动机机油系统设计的最小修改的辅助减压阀的安装和致动。

9. 发明授权

US09677139B2 Genetic markers indicative of a cancer patient response to trastuzumab (herceptin) 有权
公开(公告)号：US09677139B2
公开(公告)日：2017-06-13
申请号：US13491359
申请日：2012-06-07
申请人： James Hicks , Alexander Krasnitz
发明人： James Hicks , Alexander Krasnitz
IPC分类号： C12Q1/68 , A61K39/395 , A61K31/337 , A61K39/00
CPC分类号： C12Q1/6886 , A61K31/337 , A61K39/39558 , A61K2039/545 , C12Q2600/106 , C12Q2600/156 , A61K2300/00
摘要： The invention relates to the fields of therapeutics and identifying candidates for therapy, in particular to a method of identifying candidates for trastuzumab (Herceptin®) therapy in a patient presenting with breast cancer based on the presence or absence of specific genetic markers in a tumor sample from said patient.

10. 发明授权

US09370941B2 Housing for ink curing apparatus 有权
标题翻译：油墨固化设备外壳
公开(公告)号：US09370941B2
公开(公告)日：2016-06-21
申请号：US14237140
申请日：2012-08-06
申请人： Malcolm Rae , James Hicks
发明人： Malcolm Rae , James Hicks
IPC分类号： B41J11/00 , B41F23/04
CPC分类号： B41J11/0015 , B41F23/04 , B41F23/0409 , B41F23/0483
摘要： A double-walled housing (3) for an ultra-violet ink curing apparatus (1), comprising an inner skin (5) and an outer wall (7) secured together by at least one locking means (9), wherein the locking means (9) is adapted to secure the inner skin (5) and the outer wall (7) together while permitting relative movement of the inner skin (5) along the length of the outer wall (7).
摘要翻译：一种用于紫外线油墨固化装置（1）的双壁壳体（3），包括通过至少一个锁定装置（9）固定在一起的内表皮（5）和外壁（7），其中锁定装置（9）适于将内皮（5）和外壁（7）固定在一起，同时允许内皮（5）沿着外壁（7）的长度相对运动。

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