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1. 发明授权

US5654484A Polyamine derivatives as antineoplastic agents 失效
标题翻译：多胺衍生物作为抗肿瘤药
公开(公告)号：US5654484A
公开(公告)日：1997-08-05
申请号：US457247
申请日：1995-06-01
申请人： Nellikunja J. Prakash , David M. Stemerick , Michael L. Edwards
发明人： Nellikunja J. Prakash , David M. Stemerick , Michael L. Edwards
IPC分类号： C07C211/09 , C07C211/14 , C07C211/00
CPC分类号： C07C211/14 , C07C211/09
摘要： The present invention relates to a method for the treatment of patients suffering from certain neoplastic disease states which comprises administering a therapeutically effective amount of a compound of the formula: ##STR1## wherein m is an integer 6 to 9, Z is a saturated (C.sub.2 -C.sub.6) alkylene moiety, each R group independently is hydrogen, methyl, ethyl, or n-propyl except that both R groups cannot be hydrogen when Z is a straight chain; or a pharmaceutically acceptable acid addition salt thereof. Said treatment can optionally comprise conjunctive therapy with a polyamine oxidase inhibitor. The invention also relates to certain novel polyamine derivatives.
摘要翻译：本发明涉及治疗患有某些肿瘤疾病状态的患者的方法，其包括施用治疗有效量的下式化合物：其中m为整数6至9，Z为饱和（C2 -C 6）亚烷基部分，每个R基团独立地为氢，甲基，乙基或正丙基，除了当Z为直链时，两个R基团不能为氢; 或其药学上可接受的酸加成盐。所述治疗可以任选地包括与多胺氧化酶抑制剂的联合治疗。本发明还涉及某些新型多胺衍生物。

2. 发明授权

US4996308A Derivatives with unsaturated substitutions for the 5'-hydroxymethyl group 失效
标题翻译：具有5'-羟甲基不饱和取代基的衍生物
公开(公告)号：US4996308A
公开(公告)日：1991-02-26
申请号：US173782
申请日：1988-03-25
申请人： Michael L. Edwards , James R. McCarthy , Nellikunja J. Prakash
发明人： Michael L. Edwards , James R. McCarthy , Nellikunja J. Prakash
IPC分类号： A61K31/505 , A61K31/52 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7076 , A61P35/00 , C07D473/00 , C07D473/16 , C07D473/34 , C07D473/40 , C07D487/04 , C07H19/04 , C07H19/052 , C07H19/056 , C07H19/06 , C07H19/16
CPC分类号： C07D473/00 , C07H19/04 , C07H19/052 , C07H19/056 , C07H19/06 , C07H19/16
摘要： This invention relates to certain acetylenic, cyano and allenic aristeromycin/adenosine derivatives which are useful in inhibiting AdoMet-dependent transmethylation and in the treatment of patients afflicted with neoplastic or viral disease states.

3. 发明授权

US5500429A Calcium uptake inhibitors 失效
标题翻译：钙吸收抑制剂
公开(公告)号：US5500429A
公开(公告)日：1996-03-19
申请号：US154146
申请日：1993-11-17
申请人： Robert J. Dinerstein , Michael L. Edwards , David M. Stemerick , Keith A. Diekema
发明人： Robert J. Dinerstein , Michael L. Edwards , David M. Stemerick , Keith A. Diekema
IPC分类号： A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/443 , A61K31/4433 , A61P3/14 , A61P7/02 , A61P9/10 , A61P11/00 , A61P13/02 , A61P15/00 , A61P17/00 , A61P19/06 , A61P29/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07D213/50 , C07D213/61 , C07D213/63 , C07D213/70 , C07D213/73 , C07D213/74 , C07D405/06 , C07D409/06 , C07D213/643 , C07D471/04
CPC分类号： C07D405/06 , C07D213/50 , C07D409/06
摘要： This invention relates to 1-aryl-3-pyridinyl-2-propene-1-ones, the use of these compounds as calcium uptake inhibitors in leukocytes and thrombocytes, and pharmaceutical compositions containing these compounds as active ingredients, and the process of their preparation.
摘要翻译：本发明涉及1-芳基-3-吡啶基-2-丙烯-1-酮，这些化合物在白细胞和凝血细胞中作为钙摄取抑制剂的用途，以及含有这些化合物作为活性成分的药物组合物及其制备方法。

4. 发明授权

US5109024A Polyamine derivatives as antineoplastic agents 失效
标题翻译：多胺衍生物作为抗肿瘤药
公开(公告)号：US5109024A
公开(公告)日：1992-04-28
申请号：US652953
申请日：1991-02-08
申请人： Nellikunja Prakash , David M. Stemerick , Michael L. Edwards , Terry L. Bowlin
发明人： Nellikunja Prakash , David M. Stemerick , Michael L. Edwards , Terry L. Bowlin
IPC分类号： C07C211/09 , C07C211/14
CPC分类号： C07C211/14 , C07C211/09
摘要： The present invention relates to certain novel polyamine compounds of the formula: ##STR1## wherein Z is a saturated (C.sub.2 -C.sub.6) alkylene moiety, each R group independently is hydrogen, methyl, ethyl, or n-propyl with the provisos that both R groups cannot be hydrogen and that R is hydrogen or methyl when Z is a branched chain alkylene; or a pharmaceutically acceptable acid addition salt thereof.
摘要翻译：本发明涉及某些新的具有下式的多胺化合物：其中Z是饱和（C 2 -C 6）亚烷基部分，每个R基团独立地是氢，甲基，乙基或正丙基，条件是R 当Z是支链亚烷基时，基团不能是氢并且R是氢或甲基; 或其药学上可接受的酸加成盐。

5. 发明授权

US4753965A Method of treating multiple sclerosis with chalcone derivatives 失效
标题翻译：用查耳酮衍生物治疗多发性硬化症的方法
公开(公告)号：US4753965A
公开(公告)日：1988-06-28
申请号：US36237
申请日：1987-04-09
申请人： David M. Stemerick , Sai P. Sunkara , Michael L. Edwards
发明人： David M. Stemerick , Sai P. Sunkara , Michael L. Edwards
IPC分类号： A61K31/135
CPC分类号： A61K31/135
摘要： Certain chalcone derivatives are reported to inhibit the polymerization of tubulin to form microtubules and are therefore antimitotic agents which can be used to control the growth of tumor tissue and can be used as antigout agents.

6. 发明授权

US4935449A N-2,3-butadienyl tri- and tetraaminoalkane derivatives 失效
标题翻译： N-2,3-丁二烯基三 - 和四氨基烷烃衍生物
公开(公告)号：US4935449A
公开(公告)日：1990-06-19
申请号：US228620
申请日：1988-08-04
申请人： Philippe Bey , David M. Stemerick , Michael L. Edwards , Alan J. Bitonti
发明人： Philippe Bey , David M. Stemerick , Michael L. Edwards , Alan J. Bitonti
IPC分类号： C12N9/99 , A01N33/04 , A61K31/13 , A61K31/16 , A61P33/02 , A61P43/00 , C07C67/00 , C07C209/00 , C07C209/62 , C07C211/21 , C07C211/22 , C07C231/00 , C07C231/12 , C07C233/36 , C07C233/38
CPC分类号： C07C211/21 , A01N33/04 , A61K31/13 , Y10S514/895
摘要： The importance of polyamines in biological systems is discussed as well as the implications of polyamines in the treatment of various diseases. Novel N-substituted-2,3-butadienyl tri- and tetra-aminoalkanes are disclosed as well as their use inthe treatment of diseases and the pharmaceutical compositions.

7. 发明授权

US4863968A Methods of treating gout with chalcone derivatives 失效
标题翻译：用查耳酮衍生物治疗痛风的方法
公开(公告)号：US4863968A
公开(公告)日：1989-09-05
申请号：US285331
申请日：1988-12-14
申请人： Michael L. Edwards , Sai P. Sunkara , David M. Stemerick
发明人： Michael L. Edwards , Sai P. Sunkara , David M. Stemerick
IPC分类号： A61K31/165
CPC分类号： A61K31/165
摘要： Certain chalcone derivatives are reported to inhibit the polymerization of tubulin to form microtubules and are therefore antimitotic agents which can be used as antigout agents. The chalcone derivatives are also reported to inhibit the destruction of the myelin sheath in the central nervous system of multiple sclerosis patients and are thus useful in controlling the progressive nature of the disease.
摘要翻译：据报道某些查耳酮衍生物抑制微管蛋白的聚合形成微管，因此可以用作抗突变剂的抗有丝分裂剂。据报道，查耳酮衍生物可抑制多发性硬化患者的中枢神经系统中的髓鞘的破坏，因此可用于控制疾病的进行性质。

8. 发明授权

US5753714A Polyamine derivatives 失效
标题翻译：多胺衍生物
公开(公告)号：US5753714A
公开(公告)日：1998-05-19
申请号：US213386
申请日：1994-03-15
申请人： David M. Stemerick , Alan J. Bitonti , Michael L. Edwards , Peter P. McCann , Albert Sjoerdsma
发明人： David M. Stemerick , Alan J. Bitonti , Michael L. Edwards , Peter P. McCann , Albert Sjoerdsma
IPC分类号： C07C211/09 , C07C211/14 , A61K31/135 , C07C211/43
CPC分类号： C07C211/09 , C07C211/14
摘要： This invention relates to certain polyamine derivatives, to the methods and intermediates useful for their preparation, and to their use in treating diseases caused by infestation with a variety of parasitic protozoa.
摘要翻译：本发明涉及某些多胺衍生物，对其制备有用的方法和中间体及其用于治疗由多种寄生原虫感染引起的疾病的用途。

9. 发明授权

US4904697A Controlling the growth of certain tumor tissue with chalcone derivatives 失效
标题翻译：用查耳酮衍生物控制某些肿瘤组织的生长
公开(公告)号：US4904697A
公开(公告)日：1990-02-27
申请号：US36227
申请日：1987-04-09
申请人： Sai P. Sunkara , Michael L. Edwards , David M. Stemerick
发明人： Sai P. Sunkara , Michael L. Edwards , David M. Stemerick
IPC分类号： A61K31/135 , A61K31/165
CPC分类号： A61K31/165 , A61K31/135
摘要： Certain chalcone derivatives are reported to inhibit the polymerization of tubulin to form microtubules and are therefore antimitotic agents which can be used to control the growth of tumor tissue and can be used as antigout agents.

10. 发明申请

US20130024336A1 Systems and Methods for Providing Controls for Aggregated Weather-Based Work 有权
标题翻译：提供总体天气工作控制系统和方法
公开(公告)号：US20130024336A1
公开(公告)日：2013-01-24
申请号：US13187364
申请日：2011-07-20
申请人： Raymond P. Jones, JR. , Gregory G. Gonzales , Michael L. Edwards , Douglas S., II Haymore
发明人： Raymond P. Jones, JR. , Gregory G. Gonzales , Michael L. Edwards , Douglas S., II Haymore
IPC分类号： G06Q10/00 , G06F17/00
CPC分类号： G06Q30/0202 , G06Q30/06 , G06Q50/188
摘要： Systems, methods, non-transitory computer-readable media storing computer program instructions for causing a computer device to implement methods, and the like utilize weather information from one or a variety of locations to estimate costs for providing weather-dependent work, and to provide financial controls for weather-dependent work allegedly performed. One method includes utilizing historical weather information relating to performance of weather-dependent work at a work location to generate an estimate of an anticipated frequency with which weather-dependent work will be necessary, utilizing information to estimate an anticipated cost per incident for performing weather-dependent work at the selected work location, and using such information at a plurality of locations to generate an aggregate bid for performing weather-dependent work at the locations. Weather information is also used to audit weather-dependent work allegedly performed at the work locations to provide financial controls to the aggregated weather-dependent work in compliance with law and regulation.
摘要翻译：存储用于使计算机设备实现方法的计算机程序指令的系统，方法，非暂时计算机可读介质等利用来自一个或多个位置的天气信息来估计用于提供与天气有关的工作的成本，并提供涉及天气依赖的工作的财务控制。一种方法包括利用与在工作场所执行天气依赖性工作相关的历史天气信息来产生对于天气依赖性工作将是必要的预期频率的估计，利用信息来估计每个事件的预期成本，并且在多个位置处使用这些信息来生成用于在该位置执行与天气有关的工作的总出价。天气信息也用于审计据称在工作地点执行的天气依赖工作，以便根据法律和法规为天气依赖的工作提供财务控制。

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