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1. 发明申请

US20130024336A1 Systems and Methods for Providing Controls for Aggregated Weather-Based Work 有权
标题翻译：提供总体天气工作控制系统和方法
公开(公告)号：US20130024336A1
公开(公告)日：2013-01-24
申请号：US13187364
申请日：2011-07-20
申请人： Raymond P. Jones, JR. , Gregory G. Gonzales , Michael L. Edwards , Douglas S., II Haymore
发明人： Raymond P. Jones, JR. , Gregory G. Gonzales , Michael L. Edwards , Douglas S., II Haymore
IPC分类号： G06Q10/00 , G06F17/00
CPC分类号： G06Q30/0202 , G06Q30/06 , G06Q50/188
摘要： Systems, methods, non-transitory computer-readable media storing computer program instructions for causing a computer device to implement methods, and the like utilize weather information from one or a variety of locations to estimate costs for providing weather-dependent work, and to provide financial controls for weather-dependent work allegedly performed. One method includes utilizing historical weather information relating to performance of weather-dependent work at a work location to generate an estimate of an anticipated frequency with which weather-dependent work will be necessary, utilizing information to estimate an anticipated cost per incident for performing weather-dependent work at the selected work location, and using such information at a plurality of locations to generate an aggregate bid for performing weather-dependent work at the locations. Weather information is also used to audit weather-dependent work allegedly performed at the work locations to provide financial controls to the aggregated weather-dependent work in compliance with law and regulation.
摘要翻译：存储用于使计算机设备实现方法的计算机程序指令的系统，方法，非暂时计算机可读介质等利用来自一个或多个位置的天气信息来估计用于提供与天气有关的工作的成本，并提供涉及天气依赖的工作的财务控制。一种方法包括利用与在工作场所执行天气依赖性工作相关的历史天气信息来产生对于天气依赖性工作将是必要的预期频率的估计，利用信息来估计每个事件的预期成本，并且在多个位置处使用这些信息来生成用于在该位置执行与天气有关的工作的总出价。天气信息也用于审计据称在工作地点执行的天气依赖工作，以便根据法律和法规为天气依赖的工作提供财务控制。

2. 发明授权

US08288425B2 Benzimidazoles 有权
标题翻译：苯并咪唑
公开(公告)号：US08288425B2
公开(公告)日：2012-10-16
申请号：US11029064
申请日：2005-01-04
申请人： Michael L. Edwards , Paul J. Cox , Shelley Amendola , Stephanie D. Deprets , Timothy A. Gillespy , Christopher D. Edlin , Andrew D. Morley , Charles J. Gardner , Brian Pedgrift , Herve Bouchard , Didier Babin , Laurence Gauzy , Alain Le-Brun , Tahir N. Majid , John C. Reader , Lloyd J. Payne , Nawaz M. Khan , Michael Cherry
发明人： Michael L. Edwards , Paul J. Cox , Shelley Amendola , Stephanie D. Deprets , Timothy A. Gillespy , Christopher D. Edlin , Andrew D. Morley , Charles J. Gardner , Brian Pedgrift , Herve Bouchard , Didier Babin , Laurence Gauzy , Alain Le-Brun , Tahir N. Majid , John C. Reader , Lloyd J. Payne , Nawaz M. Khan , Michael Cherry
IPC分类号： A61K31/4184 , C07D235/18
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D471/04 , C07D487/04 , C07D491/04
摘要： The invention is directed to physiologically active compounds of the general formula (Ix) and compositions containing such compounds, and their prodrugs, and pharmaceutically acceptable salts and solvates of such compounds and their prodrugs, as well as to novel compounds within the scope of formula (Ix), and to processes for their preparation. Such compounds and compositions have valuable pharmaceutical properties, in particular the ability to inhibit kinases.
摘要翻译：本发明涉及通式（Ix）的生理活性化合物和含有这些化合物及其前药以及这些化合物及其前药的药学上可接受的盐和溶剂合物的组合物，以及式（Ix）范围内的新化合物 Ix），以及它们的制备过程。这些化合物和组合物具有有价值的药物特性，特别是抑制激酶的能力。

3. 发明授权

US6114394A Polyamine derivatives as radioprotective agents 失效
标题翻译：聚胺衍生物作为放射防护剂
公开(公告)号：US6114394A
公开(公告)日：2000-09-05
申请号：US949536
申请日：1997-10-14
申请人： Michael L. Edwards , Ronald D. Snyder
发明人： Michael L. Edwards , Ronald D. Snyder
IPC分类号： A61K31/13 , A61K31/785 , A61K47/18 , A61K47/34 , A61P43/00 , C07C211/14 , C07C211/27 , C07C211/48 , C07C211/53 , C07C211/57 , C07C211/58 , A61K31/135 , C07C211/00
CPC分类号： C07C211/58 , A61K31/785 , C07C211/14 , C07C211/27 , C07C211/48
摘要： The present invention relates to polyamine derivatives of the formula RHN-(CH.sub.2).sub.m -NH-(CH.sub.2).sub.n -NHR wherein m is an integer from 2 to 4, n is an integer from 3 to 10 and R is C.sub.2 -C.sub.6 alkyl or --(CH.sub.2).sub.p -Ar wherein Ar is phenyl or naphthyl and p is an integer from 0 to 2; and the pharmaceutically acceptable addition salts thereof which are useful as radioprotective agents. It relates also to the use of polyamines of the formula RHN-(CH.sub.2).sub.m -NH-(CH.sub.2).sub.n -NH-(CH.sub.2).sub.m -NHR wherein m is an integer from 2 to 4, n is an integer from 3 to 10 and R is C.sub.2 -C.sub.6 alkyl or --(CH.sub.2).sub.p -Ar wherein Ar is phenyl or naphthyl and p is an integer from 0 to 2; and the pharmaceutically acceptable addition salts thereof as radioprotective agents.
摘要翻译：本发明涉及式RHN-（CH2）m-NH-（CH2）n-NHR的多胺衍生物，其中m为2至4的整数，n为3至10的整数，R为C 2 -C 6烷基或 - （CH 2）p-Ar，其中Ar为苯基或萘基，p为0至2的整数; 和其药学上可接受的加成盐，其可用作放射防护剂。它还涉及式RHN-（CH2）m-NH-（CH2）n-NH-（CH2）m-NHR的多胺的用途，其中m是2至4的整数，n是3至 10和R是C 2 -C 6烷基或 - （CH 2）p-Ar，其中Ar是苯基或萘基，p是0-2的整数; 和其药学上可接受的加成盐作为放射防护剂。

4. 发明授权

US5011859A Di- and tetra-fluoro analogs of squalene as inhibitors of squalene epoxidase 失效
标题翻译：角鲨烯的二氟和四氟类似物作为角鲨烯环氧酶的抑制剂
公开(公告)号：US5011859A
公开(公告)日：1991-04-30
申请号：US502203
申请日：1990-03-30
申请人： Esa T. Jarvi , Michael L. Edwards , James R. McCarthy
发明人： Esa T. Jarvi , Michael L. Edwards , James R. McCarthy
IPC分类号： A61K31/035 , A61K31/045 , A61P3/06 , A61P9/10 , A61P43/00 , C07C21/215 , C07C33/42
CPC分类号： C07C21/215
摘要： This invention relates to certain novel di- and tetra-fluoro analogs of squalene and to their methods of use in lowering plasma cholesterol and in inhibiting squalene epoxidase in patients in need thereof.

5. 发明授权

US4996308A Derivatives with unsaturated substitutions for the 5'-hydroxymethyl group 失效
标题翻译：具有5'-羟甲基不饱和取代基的衍生物
公开(公告)号：US4996308A
公开(公告)日：1991-02-26
申请号：US173782
申请日：1988-03-25
申请人： Michael L. Edwards , James R. McCarthy , Nellikunja J. Prakash
发明人： Michael L. Edwards , James R. McCarthy , Nellikunja J. Prakash
IPC分类号： A61K31/505 , A61K31/52 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7076 , A61P35/00 , C07D473/00 , C07D473/16 , C07D473/34 , C07D473/40 , C07D487/04 , C07H19/04 , C07H19/052 , C07H19/056 , C07H19/06 , C07H19/16
CPC分类号： C07D473/00 , C07H19/04 , C07H19/052 , C07H19/056 , C07H19/06 , C07H19/16
摘要： This invention relates to certain acetylenic, cyano and allenic aristeromycin/adenosine derivatives which are useful in inhibiting AdoMet-dependent transmethylation and in the treatment of patients afflicted with neoplastic or viral disease states.

6. 发明授权

US08121971B2 Intelligent drilling advisor 有权
标题翻译：智能钻井顾问
公开(公告)号：US08121971B2
公开(公告)日：2012-02-21
申请号：US12261198
申请日：2008-10-30
申请人： Michael L. Edwards , Cesar A. Gongora , Ganesh Iyer , David McGriffy , John McNeill , Donald F. Shafer , Chris Tolleson , David Wight
发明人： Michael L. Edwards , Cesar A. Gongora , Ganesh Iyer , David McGriffy , John McNeill , Donald F. Shafer , Chris Tolleson , David Wight
IPC分类号： G06N5/02
CPC分类号： E21B44/00 , G06N5/025
摘要： An information integration environment identifies the current drilling sites, and drilling equipment and processes at those current drilling sites. Based upon that identification, and upon data received from the drilling sites, servers access and configure software agents that are sent to a host client system at the drilling site; these software agents operate at the host client system to acquire data from sensors at the drilling site, to transmit that data to the information integration environment, and to derive the drilling state and drilling recommendations for the driller at the drilling site. These software agents include one or more rules, heuristics, or calibrations derived by the inference engine, and called by the information integration environment. In addition, the software agents sent from the information integration environment to the host client system operate to display values, trends, and reliability estimates for various drilling parameters, whether measured or calculated.
摘要翻译：信息集成环境识别当前的钻井现场，以及当前钻井现场的钻井设备和流程。基于该识别，并且根据从钻井站收到的数据，服务器访问并配置在钻井现场发送到主机客户端系统的软件代理; 这些软件代理在主机客户端系统上运行，以从钻井现场的传感器获取数据，将数据传输到信息集成环境，并为钻井现场的钻机推导钻井状态和钻井建议。这些软件代理包括一个或多个由推理机导出的规则，启发式或校准，并由信息集成环境调用。此外，从信息集成环境发送到主机客户端系统的软件代理操作，以显示各种钻探参数的值，趋势和可靠性估计，无论是测量还是计算。

7. 发明授权

US07013004B1 Systems and methods to compare operational statuses of switch feature packages 失效
标题翻译：比较交换机功能包的运行状态的系统和方法
公开(公告)号：US07013004B1
公开(公告)日：2006-03-14
申请号：US09960318
申请日：2001-09-24
申请人： Michael L. Edwards
发明人： Michael L. Edwards
IPC分类号： H04M7/00 , H04M3/42
CPC分类号： H04M3/42136 , H04M2201/42
摘要： Embodiment of the present invention relates to systems and methods for comparing feature package operational statuses of two or more switches. In an embodiment, the system includes a first switch and a second switch. The first switch includes a first set of features packages, and the second switch includes a second set of feature packages. The system also includes a computer coupled to the first switch and to the second switch. The computer is to receive a first set of feature package information and a second set of feature package information. The first set of feature package information corresponds to the first set of feature packages, and the second set of feature package information corresponds to the second set of feature packages. The computer is to compare the first set of feature package information and the second set of feature package information.
摘要翻译：本发明的实施例涉及用于比较两个或更多个交换机的特征包操作状态的系统和方法。在一个实施例中，系统包括第一开关和第二开关。第一开关包括第一组特征包，并且第二开关包括第二组特征包。该系统还包括耦合到第一开关和第二开关的计算机。计算机将接收第一组特征包信息和第二组特征包信息。第一组特征包信息对应于第一组特征包，并且第二组特征包信息对应于第二组特征包。计算机将比较第一组功能包信息和第二组功能包信息。

8. 发明授权

US6121463A Alkyl-4-silylheterocyclic phenols and thiophenols useful as antioxidant agents 失效
标题翻译：烷基-4-甲硅烷基杂环苯酚和可用作抗氧化剂的苯硫酚
公开(公告)号：US6121463A
公开(公告)日：2000-09-19
申请号：US102869
申请日：1998-06-23
申请人： Roger A. Parker , Michael L. Edwards , Mark J. Vaal , James E. Matt , Kim S. Chen , Mark T. Yates , Paul S. Wright , Steven J. Busch
发明人： Roger A. Parker , Michael L. Edwards , Mark J. Vaal , James E. Matt , Kim S. Chen , Mark T. Yates , Paul S. Wright , Steven J. Busch
IPC分类号： C07F7/08 , C07D327/00 , C07D305/00 , C07D307/02 , C07D333/22
CPC分类号： C07F7/0814
摘要： The present invention provides compounds of the formula ##STR1## wherein R is hydrogen or --C(O)--(CH.sub.2).sub.m --Q wherein Q is hydrogen or --COOH and m is an integer 1, 2, 3 or 4;R.sub.1, R.sub.5 and R.sub.6 are independently a C.sub.1 -C.sub.6 alkyl group;R.sub.2, R.sub.3 and R.sub.4 are independently hydrogen or a C.sub.1 -C.sub.6 alkyl group;Z is thio, oxy or a methylene group;A is a C.sub.1 -C.sub.4 alkylene group;X is thio or oxy; andG.sub.1 and G.sub.2 are independently hydrogen, C.sub.1 -C.sub.6 alkyl or --C(O)--(CH.sub.2).sub.n --CH.sub.3 and n is an integer 0, 1, 2 or 3;or a pharmaceutically acceptable salt thereof; useful for the treatment of atherosclerosis and chronic inflammatory disorders; for inhibiting cytokine-induced expression of VCAM-1 and/or ICAM-1; for inhibiting the peroxidation of LDL lipid; for lowering plasma cholesterol; and as anti-oxidant chemical additives useful for preventing oxidative deterioration in organic materials.
摘要翻译：本发明提供下式的化合物其中R是氢或-C（O） - （CH 2）m-Q，其中Q是氢或-COOH，m是整数1,2,3或4; R1，R5和R6独立地为C1-C6烷基; R2，R3和R4独立地是氢或C1-C6烷基; Z是硫代，氧基或亚甲基; A是C1-C4亚烷基; X是硫或氧; 且G 1和G 2独立地为氢，C 1 -C 6烷基或-C（O） - （CH 2）n -CH 3，n为整数0,1,2或3; 或其药学上可接受的盐; 可用于治疗动脉粥样硬化和慢性炎症性疾病; 用于抑制VCAM-1和/或ICAM-1的细胞因子诱导的表达; 用于抑制LDL脂质的过氧化; 用于降低血浆胆固醇; 以及用作防止有机材料氧化变质的抗氧化剂。

9. 发明授权

US5616702A 2-'-ethenylidene cytidine, uridine and guanosine derivatives 失效
标题翻译： 2-乙烯基胞苷，尿苷和鸟苷衍生物
公开(公告)号：US5616702A
公开(公告)日：1997-04-01
申请号：US362366
申请日：1994-12-22
申请人： Michael L. Edwards , Donald P. Matthews , James R. McCarthy
发明人： Michael L. Edwards , Donald P. Matthews , James R. McCarthy
IPC分类号： C07H19/06 , C07H19/073 , C07H19/16 , C07H19/173 , C07H19/73
CPC分类号： C07H19/06 , C07H19/16
摘要： This invention relates to certain novel 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl cytidine, uridine and guanosine derivatives, and compositions thereof, which are useful in the treatment of patients afflicted with neoplastic or viral disease states.
摘要翻译：本发明涉及某些新的2'-卤代亚甲基，2'-亚乙基和2'-乙炔基胞苷，尿苷和鸟苷衍生物及其组合物，其可用于治疗患有肿瘤或病毒疾病状态的患者。

10. 发明授权

US5378693A 2'-halomethylidene cytidine, uridine and guanosine compounds and their pharmaceutical compositions 失效
标题翻译： 2'-卤代亚甲基胞苷，尿苷和鸟苷化合物及其药物组合物
公开(公告)号：US5378693A
公开(公告)日：1995-01-03
申请号：US113505
申请日：1993-08-27
申请人： James R. McCarthy , Michael L. Edwards , Donald P. Matthews
发明人： James R. McCarthy , Michael L. Edwards , Donald P. Matthews
IPC分类号： A61K31/513 , A61K31/519 , A61K31/522 , A61K31/7072 , A61K31/7076 , C07D473/04 , C07D473/18 , C07D487/02 , C07H19/06 , C07H19/16 , C07H19/073 , C07H19/173
CPC分类号： C07H19/06 , C07H19/16
摘要： This invention relates to certain novel 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl cytidine, uridine and guanosine derivatives, and compositions thereof, which are useful in the treatment of patients afflicted with neoplastic or viral disease states.
摘要翻译：本发明涉及某些新的2'-卤代亚甲基，2'-亚乙基和2'-乙炔基胞苷，尿苷和鸟苷衍生物及其组合物，其可用于治疗患有肿瘤或病毒疾病状态的患者。

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