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1. 发明申请

US20050197289A1 System and method for inhibiting cellular proliferation with tachykinins 失效
标题翻译：用速激肽抑制细胞增殖的系统和方法
公开(公告)号：US20050197289A1
公开(公告)日：2005-09-08
申请号：US10994170
申请日：2004-11-19
申请人： Nathan Maier , James Peacock , Amiel Jarstfer
发明人： Nathan Maier , James Peacock , Amiel Jarstfer
IPC分类号： A61K38/04 , A61K38/19 , A61M31/00
CPC分类号： A61K38/046
摘要： Systems and methods are described providing therapeutic preparations of tachykinins, and more specifically sialokinins, for treating various types of abnormal cellular proliferation conditions in regions of tissue associated with the body of a patient. The sialokinins may be isolated and purified from natural or bioengineered sources, or may be synthesized, and may be combined into, with, or on an implant for local elution or otherwise as a powder mixed in a carrier vehicle for injection delivery. Tumors, warts, and restenosis are abnormal cellular proliferation conditions treated by therapeutic doses of sialokinin. Size of the tissue structure to be treated is used to determine the therapeutic dose of sialokinin. The sialokinins are either locally or systemically delivered at therapeutic doses for the desired effect. Implants such as stents are coated with sialokinins for local elution at the site of injury or tissue otherwise vulnerable to harmful conditions treated by the sialokinin.
摘要翻译：描述了系统和方法，其提供速激肽的治疗制剂，更具体地说是用于治疗与患者身体相关的组织区域中的各种类型的异常细胞增殖病症的治疗制剂。可以从天然或生物工程化来源分离和纯化所述sialokinin，或者可以合成，并且可以将它们与植入物组合，或用于局部洗脱或以其它方式混合在用于注射递送的载体载体中的粉末。肿瘤，疣和再狭窄是通过治疗剂量的sialokinin治疗的异常细胞增殖条件。要处理的组织结构的大小用于确定sialokinin的治疗剂量。可以以治疗剂量局部或全身递送sialokinin以获得所需效果。诸如支架的植入物涂覆有唾液酸溶蛋白，以在损伤或组织的部位进行局部洗脱，否则易受由sialokinin处理的有害条件的影响。

2. 发明申请

US20060100695A1 Implantable stent with modified ends 审中-公开
标题翻译：具有修改末端的植入式支架
公开(公告)号：US20060100695A1
公开(公告)日：2006-05-11
申请号：US10529108
申请日：2003-09-29
申请人： James Peacock , Nathan Maier
发明人： James Peacock , Nathan Maier
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/826 , A61F2002/91508 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2230/0013 , A61F2250/0035 , A61F2250/0067
摘要： A stent is provided with modified ends (782, 786) and enhanced drug delivery. The stent assembly also provides for enhanced overlapping between adjacent stents.
摘要翻译：支架具有修改的末端（782,786）和增强的药物递送。支架组件还提供相邻支架之间的增强的重叠。

3. 发明申请

US20070181433A1 METALLIC COMPOSITE COATINGS FOR DELIVERY OF THERAPEUTIC AGENTS FROM THE SURFACE OF IMPLANTABLE DEVICES 审中-公开
标题翻译：用于从可植入设备表面输送治疗剂的金属复合涂层
公开(公告)号：US20070181433A1
公开(公告)日：2007-08-09
申请号：US11735326
申请日：2007-04-13
申请人： Matthew Birdsall , Richard Klein , Nathan Maier
发明人： Matthew Birdsall , Richard Klein , Nathan Maier
IPC分类号： C23C28/00 , B05D3/00 , A61L33/00
CPC分类号： A61L31/16 , A61L31/088 , A61L2300/102 , A61L2300/104 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/42 , A61L2300/608
摘要： A metallic composite coating, and methods for forming same, for an implantable medical device is disclosed. The composite coating comprises at least one metal or metallic tie layer formed on the surface of the device, followed by an electroless electrochemical cladding of one or more additional layers over the tie layer. One or more therapeutic or biologically active agents are co-deposited with at least one of the electroless electrochemical claddings.
摘要翻译：公开了一种用于可植入医疗装置的金属复合涂层及其形成方法。该复合涂层包括形成在该装置的表面上的至少一个金属或金属粘结层，随后是连接层上的一个或多个附加层的化学电化学包层。一种或多种治疗或生物活性剂与至少一种无电化学电化学包层共沉积。

4. 发明申请

US20090228088A1 APPARATUS HAVING VARIABLE STRUT LENGTH AND METHODS OF USE 有权
标题翻译：具有可变长度的装置和使用方法
公开(公告)号：US20090228088A1
公开(公告)日：2009-09-10
申请号：US12043513
申请日：2008-03-06
申请人： David Lowe , Craig Bonsignore , David W. Snow , Timothy Robinson , Joshua P. Wiesman , Dawn Henderson , Nathan Maier
发明人： David Lowe , Craig Bonsignore , David W. Snow , Timothy Robinson , Joshua P. Wiesman , Dawn Henderson , Nathan Maier
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2/89 , A61F2/91 , A61F2/966 , A61F2002/91508 , A61F2002/91533 , A61F2002/91541 , A61F2002/9155 , A61F2002/91558
摘要： A tubular prosthesis has a plurality of tubular rings that are radially expandable from a contracted configuration to an expanded configuration. Each ring comprises a plurality of axially oriented struts that are interconnected so as to form a circumferential series of at least one high peak and at least one low peak. The high and low peaks have apices that are oriented in the same axial direction. The apices of the high and low peaks are also oriented in the same direction and the apices of the high peaks are axially offset from the apices of the low peaks. A bridge member couples a pair of adjacent tubular rings together. The bridge member has a first end connected to a first low peak in a first tubular ring and a second end connected to either a high or low peak in an adjacent tubular ring.
摘要翻译：管状假体具有多个管状环，其从收缩构型可扩展至扩张构型。每个环包括多个轴向取向的支柱，其互连以形成至少一个高峰值和至少一个低峰值的圆周系列。高低峰具有相同轴向取向的顶点。高峰和低峰的顶点也定向在相同的方向，并且高峰的顶点从低峰的顶点轴向偏移。桥构件将一对相邻的管状环连接在一起。桥构件具有连接到第一管状环中的第一低峰的第一端和连接到相邻管状环中的高峰或低峰的第二端。

5. 发明申请

US20090177205A1 METHODS AND APPARATUS FOR ACCESSING AND TREATING THE FACET JOINT 有权
标题翻译：方法和设备接入和处理FACET接头
公开(公告)号：US20090177205A1
公开(公告)日：2009-07-09
申请号：US12350609
申请日：2009-01-08
申请人： Bruce M. McCormack , Nathan Maier
发明人： Bruce M. McCormack , Nathan Maier
IPC分类号： A61B17/58
CPC分类号： A61F2/4405 , A61B17/00234 , A61B17/1604 , A61B17/1659 , A61B17/1671 , A61B17/3211 , A61B17/7074 , A61B2017/0256 , A61F2/28 , A61F2/441 , A61F2/4455 , A61F2/4601 , A61F2/4611 , A61F2002/30616 , A61F2310/00359
摘要： Methods and systems are disclosed for accessing and treating the interior of the facet joint for vertebral distraction and immobilization. The systems include a number of tools that facilitate access to the facet joint, distraction of the articulating decortication of the articulating surfaces, and delivery of implants and agents into the facet joint for fusion.
摘要翻译：公开了用于进入和处理小关节内部用于椎体牵引和固定的方法和系统。这些系统包括许多便于进入小关节的工具，分散关节表面的关节性脱胶，以及将植入物和试剂输送到小关节以进行融合。

6. 发明授权

US09005288B2 Methods and apparatus for accessing and treating the facet joint 有权
标题翻译：用于接近和处理小关节的方法和装置
公开(公告)号：US09005288B2
公开(公告)日：2015-04-14
申请号：US12350609
申请日：2009-01-08
申请人： Bruce M. McCormack , Nathan Maier
发明人： Bruce M. McCormack , Nathan Maier
IPC分类号： A61F2/46 , A61B17/16 , A61F2/44 , A61B17/02 , A61F2/28 , A61F2/30
CPC分类号： A61F2/4405 , A61B17/00234 , A61B17/1604 , A61B17/1659 , A61B17/1671 , A61B17/3211 , A61B17/7074 , A61B2017/0256 , A61F2/28 , A61F2/441 , A61F2/4455 , A61F2/4601 , A61F2/4611 , A61F2002/30616 , A61F2310/00359
摘要： Methods and systems are disclosed for accessing and treating the interior of the facet joint for vertebral distraction and immobilization. The systems include a number of tools that facilitate access to the facet joint, distraction of the articulating decortication of the articulating surfaces, and delivery of implants and agents into the facet joint for fusion.
摘要翻译：公开了用于进入和处理小关节内部用于椎体牵引和固定的方法和系统。这些系统包括许多便于进入小关节的工具，分散关节表面的关节性脱胶，以及将植入物和试剂输送到小关节以进行融合。

7. 发明申请

US20060062820A1 Metallic structures incorporating bioactive materials and methods for creating the same 有权
标题翻译：包含生物活性材料的金属结构及其制造方法
公开(公告)号：US20060062820A1
公开(公告)日：2006-03-23
申请号：US11203083
申请日：2005-08-12
申请人： Michael Gertner , Nazila Dadvand , Richard Klein , Nathan Maier
发明人： Michael Gertner , Nazila Dadvand , Richard Klein , Nathan Maier
IPC分类号： A61L33/00 , B05D3/00
CPC分类号： A61L31/088 , A61F2/82 , A61F2250/0067 , A61L27/30 , A61L27/42 , A61L27/54 , A61L31/082 , A61L31/121 , A61L31/146 , A61L31/16 , A61L2300/416 , A61L2300/434 , A61L2300/606 , B82Y30/00 , C23C18/1605 , C23C18/1651 , C23C18/1653 , C23C18/1662 , C23C18/1689 , C23C18/1831 , C25D5/022 , C25D5/10 , C25D5/48 , C25D15/00
摘要： Disclosed herein are methods to create medical devices and medical devices including bioactive composite structures. The methods include using template-assisted electro- or electroless deposition or codeposition methods for providing implantable medical devices coated with bioactive composite structures and also include layering deposited or codeposited metal layers with layers of bioactive materials. In one use, the implantable medical devices of the present invention include stents with bioactive composite structure coatings.
摘要翻译：本文公开了创建包括生物活性复合结构的医疗装置和医疗装置的方法。所述方法包括使用模板辅助的电沉积或无电沉积或共沉积方法来提供涂覆有生物活性复合结构的可植入医疗装置，并且还包括用生物活性材料层分层沉积或共沉积的金属层。在一个用途中，本发明的可植入医疗装置包括具有生物活性复合结构涂层的支架。

8. 发明授权

US09101503B2 Apparatus having variable strut length and methods of use 有权
标题翻译：具有可变支柱长度和使用方法的装置
公开(公告)号：US09101503B2
公开(公告)日：2015-08-11
申请号：US12043513
申请日：2008-03-06
申请人： David Lowe , Craig Bonsignore , David W. Snow , Timothy Robinson , Joshua P. Wiesman , Dawn Henderson , Nathan Maier
发明人： David Lowe , Craig Bonsignore , David W. Snow , Timothy Robinson , Joshua P. Wiesman , Dawn Henderson , Nathan Maier
IPC分类号： A61F2/06 , A61F2/915 , A61F2/91 , A61F2/966 , A61F2/89
CPC分类号： A61F2/915 , A61F2/89 , A61F2/91 , A61F2/966 , A61F2002/91508 , A61F2002/91533 , A61F2002/91541 , A61F2002/9155 , A61F2002/91558
摘要： A tubular prosthesis has a plurality of tubular rings that are radially expandable from a contracted configuration to an expanded configuration. Each ring comprises a plurality of axially oriented struts that are interconnected so as to form a circumferential series of at least one high peak and at least one low peak. The high and low peaks have apices that are oriented in the same axial direction. The apices of the high and low peaks are also oriented in the same direction and the apices of the high peaks are axially offset from the apices of the low peaks. A bridge member couples a pair of adjacent tubular rings together. The bridge member has a first end connected to a first low peak in a first tubular ring and a second end connected to either a high or low peak in an adjacent tubular ring.
摘要翻译：管状假体具有多个管状环，其从收缩构型可扩展至扩张构型。每个环包括多个轴向取向的支柱，其互连以形成至少一个高峰值和至少一个低峰值的圆周系列。高低峰具有相同轴向取向的顶点。高峰和低峰的顶点也定向在相同的方向，并且高峰的顶点从低峰的顶点轴向偏移。桥构件将一对相邻的管状环连接在一起。桥构件具有连接到第一管状环中的第一低峰的第一端和连接到相邻管状环中的高峰或低峰的第二端。

9. 发明授权

US07208172B2 Metallic composite coating for delivery of therapeutic agents from the surface of implantable devices 失效
标题翻译：金属复合涂层，用于从可植入装置的表面输送治疗剂
公开(公告)号：US07208172B2
公开(公告)日：2007-04-24
申请号：US10701262
申请日：2003-11-03
申请人： Matthew J. Birdsall , Richard L. Klein , Nathan Maier
发明人： Matthew J. Birdsall , Richard L. Klein , Nathan Maier
IPC分类号： A61F2/02
CPC分类号： A61L31/16 , A61L31/088 , A61L2300/102 , A61L2300/104 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/42 , A61L2300/608
摘要： A metallic composite coating, and methods for forming same, for an implantable medical device is disclosed. The composite coating comprises at least one metal or metallic tie layer formed on the surface of the device, followed by an electroless electrochemical cladding of one or more additional layers over the tie layer. One or more therapeutic or biologically active agents are co-deposited with at least one of the electroless electrochemical claddings.
摘要翻译：公开了一种用于可植入医疗装置的金属复合涂层及其形成方法。该复合涂层包括形成在该装置的表面上的至少一个金属或金属粘结层，随后是连接层上的一个或多个附加层的化学电化学包层。一种或多种治疗或生物活性剂与至少一种无电化学电化学包层共沉积。

10. 发明申请

US20060051397A1 Metallic structures incorporating bioactive materials and methods for creating the same 审中-公开
标题翻译：包含生物活性材料的金属结构及其制造方法
公开(公告)号：US20060051397A1
公开(公告)日：2006-03-09
申请号：US11220328
申请日：2005-09-06
申请人： Nathan Maier , Richard Klein
发明人： Nathan Maier , Richard Klein
IPC分类号： A61F2/00 , C25D3/46
CPC分类号： A61L31/16 , A61L31/088 , A61L2300/102 , A61L2300/104 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/42 , A61L2300/608
摘要： Disclosed herein are methods to create medical devices and medical devices including bioactive composite structures. The methods include using electroless and electrophoretic deposition and codeposition methods for providing implantable medical devices coated with bioactive composite structures. In one use, the implantable medical devices of the present invention include stents with bioactive composite structures.
摘要翻译：本文公开了创建包括生物活性复合结构的医疗装置和医疗装置的方法。所述方法包括使用无电泳和电泳沉积和共沉积方法来提供涂覆有生物活性复合结构的可植入医疗装置。在一个用途中，本发明的可植入医疗装置包括具有生物活性复合结构的支架。

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