专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20070238122A1 SYSTEMS AND METHODS FOR EFFICIENT COLLECTION OF SINGLE CELLS AND COLONIES OF CELLS AND FAST GENERATION OF STABLE TRANSFECTANTS 有权
标题翻译：有效收集单细胞和细胞群的系统和方法以及快速生成稳定转录因子
公开(公告)号：US20070238122A1
公开(公告)日：2007-10-11
申请号：US11733053
申请日：2007-04-09
申请人： Nancy Allbritton , Christopher Sims , Yuli Wang , Mark Bachman , Guann-Pyng Li , Eric Stanbridge
发明人： Nancy Allbritton , Christopher Sims , Yuli Wang , Mark Bachman , Guann-Pyng Li , Eric Stanbridge
IPC分类号： C12Q1/68 , C12N1/20
CPC分类号： G01N1/286 , B01L3/5085 , B01L2200/0668 , B01L2300/0829 , C12M23/12 , C12M47/04 , G01N2001/2886
摘要： A plate manufactured to enable samples of cells, micro-organisms, proteins, DNA, biomolecules and other biological media to be positioned at specific locations or sites on the plate for the purpose of performing addressable analyses on the samples. Preferably, some or all of the sites are built from a removable material or as pallets so that a subset of the samples of interest can be readily isolated from the plate for further processing or analysis. The plate can contain structures or chemical treatments that enhance or promote the attachment and/or function of the samples, and that promote or assist in their analyses. Use of the plate advantageously enables the selection and sorting of cells based on dynamic phenomena and the rapid establishment of stable tranfectants.
摘要翻译：制造的板可使细胞，微生物，蛋白质，DNA，生物分子和其他生物培养基的样品定位在板上的特定位置或位点，以便对样品进行可寻址分析。优选地，一些或所有的部位由可移除的材料或托盘构建，使得感兴趣的样品的子集可以容易地与板分离以用于进一步的处理或分析。该板可以包含增强或促进样品的附着和/或功能的结构或化学处理，并且促进或辅助其分析。板的使用有利于基于动态现象和快速建立稳定的转染剂来选择和分选细胞。

2. 发明授权

US07759119B2 Systems and methods for efficient collection of single cells and colonies of cells and fast generation of stable transfectants 有权
标题翻译：有效收集单个细胞和细胞菌落的系统和方法，并快速产生稳定的转染子
公开(公告)号：US07759119B2
公开(公告)日：2010-07-20
申请号：US11733053
申请日：2007-04-09
申请人： Nancy Allbritton , Christopher E. Sims , Yuli Wang , Mark Bachman , Guann-Pyng Li , Eric Stanbridge
发明人： Nancy Allbritton , Christopher E. Sims , Yuli Wang , Mark Bachman , Guann-Pyng Li , Eric Stanbridge
IPC分类号： C12N15/00 , C12N5/02 , C12N5/00 , C12N15/01 , C12N1/02
CPC分类号： G01N1/286 , B01L3/5085 , B01L2200/0668 , B01L2300/0829 , C12M23/12 , C12M47/04 , G01N2001/2886
摘要： A plate manufactured to enable samples of cells, micro-organisms, proteins, DNA, biomolecules and other biological media to be positioned at specific locations or sites on the plate for the purpose of performing addressable analyses on the samples. Preferably, some or all of the sites are built from a removable material or as pallets so that a subset of the samples of interest can be readily isolated from the plate for further processing or analysis. The plate can contain structures or chemical treatments that enhance or promote the attachment and/or function of the samples, and that promote or assist in their analyses. Use of the plate advantageously enables the selection and sorting of cells based on dynamic phenomena and the rapid establishment of stable tranfectants.
摘要翻译：制造的板可使细胞，微生物，蛋白质，DNA，生物分子和其他生物培养基的样品定位在板上的特定位置或位点，以便对样品进行可寻址分析。优选地，一些或所有的部位由可移除的材料或托盘构建，使得感兴趣的样品的子集可以容易地与板分离以用于进一步的处理或分析。该板可以包含增强或促进样品的附着和/或功能的结构或化学处理，并且促进或辅助其分析。板的使用有利于基于动态现象和快速建立稳定的转染剂来选择和分选细胞。

3. 发明申请

US20070292312A1 METHOD OF MANUFACTURE OF A PLATE OF RELEASABLE ELEMENTS AND ITS ASSEMBLY INTO A CASSETTE 审中-公开
标题翻译：可释放元素板的制造方法及其组装于CASSETTE
公开(公告)号：US20070292312A1
公开(公告)日：2007-12-20
申请号：US11742006
申请日：2007-04-30
申请人： Mark Bachman , Yuli Wang , Christopher Sims , Nancy Allbritton , Guann-Pyng Li
发明人： Mark Bachman , Yuli Wang , Christopher Sims , Nancy Allbritton , Guann-Pyng Li
IPC分类号： B01L3/02 , G01N35/00 , G03F7/038
CPC分类号： B01L3/502707 , B01L3/5085 , B01L3/5088 , B01L2200/0647 , B01L2300/0636 , B01L2300/0822 , B01L2300/0829 , B01L2300/089 , B01L2400/0454 , G01N2035/00158
摘要： A plate manufactured to enable samples of cells, micro-organisms, proteins, DNA, biomolecules and other biological media to be positioned at specific locations or sites on the plate for the purpose of performing addressable analyses on the samples. Preferably, some or all of the sites are built from a removable material or as pallets so that a subset of the samples of interest can be readily isolated from the plate for further processing or analysis. The plate can contain structures or chemical treatments that enhance or promote the attachment and/or function of the samples, and that promote or assist in their analyses.
摘要翻译：制造的板可使细胞，微生物，蛋白质，DNA，生物分子和其他生物培养基的样品定位在板上的特定位置或位点，以便对样品进行可寻址分析。优选地，一些或所有的部位由可移除的材料或托盘构建，使得感兴趣的样品的子集可以容易地与板分离以用于进一步的处理或分析。该板可以包含增强或促进样品的附着和/或功能的结构或化学处理，并且促进或辅助其分析。

4. 发明申请

US20070128716A1 MICRO-BUBBLE PLATE FOR PATTERNING BIOLOGICAL AND NON-BIOLOGICAL MATERIALS 有权
标题翻译：用于绘制生物和非生物材料的微孔板
公开(公告)号：US20070128716A1
公开(公告)日：2007-06-07
申请号：US11539695
申请日：2006-10-09
申请人： Yuli Wang , Mark Bachman , Christopher Sims , Guann-Pyng Li , Nancy Allbritton
发明人： Yuli Wang , Mark Bachman , Christopher Sims , Guann-Pyng Li , Nancy Allbritton
IPC分类号： C12M1/22
CPC分类号： B01L3/5085 , B01L3/5088 , B01L2200/0642 , B01L2200/12 , B01L2300/0819 , C12M25/06 , C12M29/20
摘要： Systems and methods are provided for patterning biological and non-biological material at specific sites on a plate, as well as growing three dimensional structures. Preferred embodiments comprise a plate with regions that will trap gas, usually in the form of bubbles, when the plate is submerged in liquid. Other embodiment of the present invention include a method for placing materials on the plate at pre-determined locations through the use of trapped gas to prevent materials from collecting at unwanted regions. The plate has great utility for plating cells and tissues at specific sites, such as on an array. The disclosed method can also be used to coat the surface of a plate with coatings at specific locations for patterned coating applications and to build up materials to produce three dimensional structures, including micro-mechanical structures—where the structures may be formed from living or non-living material, tissue or non-tissue, organic or inorganic, and the like.
摘要翻译：提供了系统和方法，用于在板上的特定位置图案化生物和非生物材料，以及生长三维结构。优选实施例包括具有区域的板，当板被浸没在液体中时，其具有通常以气泡形式捕获气体的区域。本发明的其它实施方案包括通过使用捕获的气体将材料放置在预定位置处的材料的方法，以防止材料在不需要的区域收集。该板对于在特定位置（例如阵列）上的电镀细胞和组织具有很大的用途。所公开的方法还可以用于在具有特定位置的涂层涂覆板的表面以用于图案化涂布应用，并且建立材料以产生三维结构，包括微机械结构，其中结构可以由活的或非 - 生物材料，组织或非组织，有机或无机物等。

5. 发明授权

US08748085B2 Use of photosensitized Epon epoxy resin 1002F for MEMS and bioMEMS applications 有权
标题翻译：光敏Epon环氧树脂1002F用于MEMS和bioMEMS应用
公开(公告)号：US08748085B2
公开(公告)日：2014-06-10
申请号：US12670349
申请日：2008-07-25
申请人： Jeng-Hao Pai , Yuli Wang , Christopher E. Sims , Mark Bachman , Nancy Allbritton , Guann-Pyng Li
发明人： Jeng-Hao Pai , Yuli Wang , Christopher E. Sims , Mark Bachman , Nancy Allbritton , Guann-Pyng Li
IPC分类号： G03F7/26
CPC分类号： G03F7/40 , B01L3/502707 , G03F1/50 , G03F7/0037 , G03F7/038 , G03F7/095
摘要： Systems and methods directed to the use 1002F to build microdevices and biomedical devices. Through the addition of a photosensitizing agent, Epon epoxy resin 1002F can be linked in the presence of UV light, making it useful as a photoresist or as a micropatternable structural material. One embodiment comprises combining 1002F monomer resin with a solvent and a photoinitiator, placing the monomer solution on a surface, exposing the monomer solution to UV light through a mask to initiate linking, and stripping the unlinked polymer away. In another embodiment, 3-D structures are built using two or more layers of sensitized monomer films, each having different sensitivity to light, and the use of a mask containing opaque and semi-opaque regions.
摘要翻译：针对使用1002F构建微型设备和生物医学设备的系统和方法。通过添加光敏剂，Epon环氧树脂1002F可以在UV光的存在下连接，使其可用作光致抗蚀剂或作为微图案化的结构材料。一个实施方案包括将1002F单体树脂与溶剂和光引发剂组合，将单体溶液置于表面上，通过掩模将单体溶液暴露于UV光以引发连接，并将未连接的聚合物剥离。在另一个实施方案中，使用两层或更多层敏化单体膜来构建3-D结构，每层具有不同的光敏感性，以及使用含有不透明区域和半不透明区域的掩模。

6. 发明授权

US08383378B2 Micro-bubble plate for patterning biological and non-biological materials 有权
标题翻译：用于生物和非生物材料图案的微泡板
公开(公告)号：US08383378B2
公开(公告)日：2013-02-26
申请号：US11539695
申请日：2006-10-09
申请人： Yuli Wang , Mark Bachman , Christopher E. Sims , Guann-Pyng Li , Nancy Allbritton
发明人： Yuli Wang , Mark Bachman , Christopher E. Sims , Guann-Pyng Li , Nancy Allbritton
IPC分类号： C12N11/02 , C12Q1/68 , C12M1/34
CPC分类号： B01L3/5085 , B01L3/5088 , B01L2200/0642 , B01L2200/12 , B01L2300/0819 , C12M25/06 , C12M29/20
摘要： Systems and methods are provided for patterning biological and non-biological material at specific sites on a plate, as well as growing three dimensional structures. Preferred embodiments comprise a plate with regions that will trap gas, usually in the form of bubbles, when the plate is submerged in liquid. Other embodiment of the present invention include a method for placing materials on the plate at pre-determined locations through the use of trapped gas to prevent materials from collecting at unwanted regions. The plate has great utility for plating cells and tissues at specific sites, such as on an array. The disclosed method can also be used to coat the surface of a plate with coatings at specific locations for patterned coating applications and to build up materials to produce three dimensional structures, including micro-mechanical structures—where the structures may be formed from living or non-living material, tissue or non-tissue, organic or inorganic, and the like.
摘要翻译：提供了系统和方法，用于在板上的特定位置图案化生物和非生物材料，以及生长三维结构。优选实施例包括具有区域的板，当板被浸没在液体中时，其具有通常以气泡形式捕获气体的区域。本发明的其它实施方案包括通过使用捕获的气体将材料放置在预定位置处的材料的方法，以防止材料在不需要的区域收集。该板对于在特定位置（例如阵列）上的电镀细胞和组织具有很大的用途。所公开的方法还可以用于在具有特定位置的涂层涂覆板的表面以用于图案化涂布应用，并且建立材料以产生三维结构，包括微机械结构，其中结构可以由活的或非 - 生物材料，组织或非组织，有机或无机物等。

7. 发明授权

US09068155B2 Array of micromolded structures for sorting adherent cells 有权
标题翻译：用于分类贴壁细胞的微复合结构阵列
公开(公告)号：US09068155B2
公开(公告)日：2015-06-30
申请号：US13513310
申请日：2012-06-01
申请人： Nancy Allbritton , Christopher Sims , Yuli Wang , Pavak Kirit Shah
发明人： Nancy Allbritton , Christopher Sims , Yuli Wang , Pavak Kirit Shah
IPC分类号： C40B50/06 , C40B60/14 , C12M1/32 , C12M1/12
CPC分类号： C12M23/12 , B01J19/0046 , B01J2219/00452 , B01J2219/00743 , C12M23/20 , C12M23/22 , C12M25/04 , C12M25/16 , C12M47/02 , C12M47/04
摘要： An apparatus for collecting or culturing cells or cell colonies includes: a common substrate formed from a flexible resilient polymeric material and having a plurality of wells formed therein; and a plurality of rigid cell carriers releasably connected to said common substrate, with said carriers arranged in the form of an array, and with each of the carriers resiliently received in one of the wells. A method of collecting or culturing cells or cell colonies with such an apparatus is carried out by depositing a liquid media carrying cells on the apparatus so that said cells settle on or adhere to said the carriers; and then (c) releasing at least one selected carrier having said cells thereon by gradual application of release energy to each carrier from the cavity in which it is received (e.g., by pushing with a probe).
摘要翻译：用于收集或培养细胞或细胞集落的装置包括：由柔性弹性聚合物材料形成且在其中形成有多个孔的共同基底; 以及可释放地连接到所述公共衬底的多个刚性电池载体，所述载体以阵列的形式布置，并且每个载体弹性地容纳在其中一个孔中。使用这种装置收集或培养细胞或细胞集落的方法是通过在装置上沉积携带细胞的液体培养基进行的，以使所述细胞沉降或粘附到所述载体上; 然后（c）通过从其被接收的空腔（例如通过用探针推动）逐渐地向每个载体施加释放能量，从而释放至少一个具有所述细胞的选定载体。

8. 发明申请

US20130065795A1 ARRAY OF MICROMOLDED STRUCTURES FOR SORTING ADHERENT CELLS 有权
公开(公告)号：US20130065795A1
公开(公告)日：2013-03-14
申请号：US13513310
申请日：2012-06-01
申请人： Nancy Allbritton , Christopher Sims , Yuli Wang , Pavak Kirit Shah
发明人： Nancy Allbritton , Christopher Sims , Yuli Wang , Pavak Kirit Shah
IPC分类号： C40B50/06 , C40B60/14
CPC分类号： C12M23/12 , B01J19/0046 , B01J2219/00452 , B01J2219/00743 , C12M23/20 , C12M23/22 , C12M25/04 , C12M25/16 , C12M47/02 , C12M47/04
摘要： An apparatus for collecting or culturing cells or cell colonies includes: a common substrate formed from a flexible resilient polymeric material and having a plurality of wells formed therein; and a plurality of rigid cell carriers releasably connected to said common substrate, with said carriers arranged in the form of an array, and with each of the carriers resiliently received in one of the wells. A method of collecting or culturing cells or cell colonies with such an apparatus is carried out by depositing a liquid media carrying cells on the apparatus so that said cells settle on or adhere to said the carriers; and then (c) releasing at least one selected carrier having said cells thereon by gradual application of release energy to each carrier from the cavity in which it is received (e.g., by pushing with a probe).

9. 发明申请

US20130066031A1 MICROMOLDING OF POLYSTYRENE BY SOFT LITHOGRAPHY 审中-公开
标题翻译：通过软平台对聚苯乙烯进行微型化
公开(公告)号：US20130066031A1
公开(公告)日：2013-03-14
申请号：US13596603
申请日：2012-08-28
申请人： Nancy Allbritton , Christopher Sims , Yuli Wang
发明人： Nancy Allbritton , Christopher Sims , Yuli Wang
IPC分类号： B28B11/08 , C08F120/10 , C08G63/08 , C08F112/08
CPC分类号： B01L3/502707 , B01L3/5085 , B01L2200/0689 , B01L2200/12 , B01L2300/0819 , B01L2300/0893 , B29C65/02 , B29C66/53461 , B29C66/71 , B29C66/8122 , B29C66/91945 , B29L2031/756 , B82Y10/00 , B82Y40/00 , G03F7/0002 , B29K2025/06 , B29K2909/08
摘要： A method of making such is carried out by (a) providing a reverse template for said article, said template comprising an elastomeric polymer such as PDMS; (b) providing a solution comprising a polymer dissolved in a first solvent; wherein said polymer is selected from the group consisting of polystyrene, poly(methyl methacrylate), epoxy, and aliphatic polyesters; and wherein said solvent comprises a lactone; (c) depositing said solution on said template; (e) removing said solvent from said template to form said article from said polymer on said template; and then (f) separating said template from said article.
摘要翻译：通过（a）为所述制品提供反向模板来进行制造方法，所述模板包括弹性聚合物如PDMS; （b）提供包含溶解在第一溶剂中的聚合物的溶液; 其中所述聚合物选自聚苯乙烯，聚（甲基丙烯酸甲酯），环氧树脂和脂族聚酯; 并且其中所述溶剂包含内酯; （c）将所述溶液沉积在所述模板上; （e）从所述模板中除去所述溶剂以在所述模板上从所述聚合物形成所述制品; 然后（f）从所述制品中分离所述模板。

10. 发明申请

US20100285992A1 MICRO-PATTERNED PLATE COMPOSED OF AN ARRAY OF RELEASABLE ELEMENTS SURROUNDED WITH SOLID OR GEL WALLS 有权
标题翻译：由固体或凝胶墙组成的可释放元素阵列的微型板
公开(公告)号：US20100285992A1
公开(公告)日：2010-11-11
申请号：US12670365
申请日：2008-07-25
申请人： Yuli Wang , Nancy Allbritton
发明人： Yuli Wang , Nancy Allbritton
IPC分类号： C40B40/00 , C40B50/14
CPC分类号： C12M1/20 , C12M3/00 , C12M23/12 , C12M23/20 , C12M23/22 , C12M23/44 , C12M25/06 , C12N1/02 , C12N5/00 , C12N11/02 , C12N11/14
摘要： A micro-patterned plate composed of an array of releasable elements surrounded by a gel or solid wall and methods of manufacture of the micropatterned plate. The surface properties of walls can be tailored if needed to be repellent or attracting to proteins. The walls can also inhibit cell attachment. The walls enable cells or other materials to be localized to the tops of the releasable elements. The individual element in the array of releasable elements can be released from the array by a mechanical force.
摘要翻译：由由凝胶或固体壁围绕的可释放元件的阵列组成的微图案板和微图案化板的制造方法。如果需要排斥或吸引蛋白质，则可以调整壁的表面性质。壁也可以抑制细胞附着。壁可使细胞或其他材料定位于可释放元件的顶部。可释放元件阵列中的单个元件可以通过机械力从阵列释放。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式