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1. 发明授权

US08703732B2 Composition for enhancing TRAIL sensitivity comprising inhibitors for expression or activity of TIP41 as a target gene of TRAIL sensitizer 有权
标题翻译：用于增强TRAIL灵敏度的组合物，其包含作为TRAIL增敏剂靶标基因的TIP41的表达或活性的抑制剂
公开(公告)号：US08703732B2
公开(公告)日：2014-04-22
申请号：US13579256
申请日：2011-04-01
申请人： Nam-Soon Kim , In-Sung Song , Cheol-Hee Kim , Ga Hee Ha , Hyun-Taek Kim , So-Young Jeong , Jeong-Min Kim , Joo Heon Kim , Jin-Man Kim , Soo Young Jun
发明人： Nam-Soon Kim , In-Sung Song , Cheol-Hee Kim , Ga Hee Ha , Hyun-Taek Kim , So-Young Jeong , Jeong-Min Kim , Joo Heon Kim , Jin-Man Kim , Soo Young Jun
IPC分类号： C12N15/11 , A61K48/00 , C07H21/02 , C07H21/04
CPC分类号： A61K38/16 , A61K31/7105
摘要： The present invention relates to a pharmaceutical composition, including inhibitors for expression or activity of TIP41 protein, for prevention and treatment of cancer. When the liver cancer cell lines, showing resistance to TRAIL, are treated with TIP41 siRNA and TRAIL, apoptosis is induced in cancer cell. The same effect is found in cases of lung cancer and colon cancer with resistance against TRAIL. Moreover, this induction of apoptosis by TIP41 siRNA and TRAIL was confirmed in tumor xenograft, which was injected with Huh7 liver cancer cells and then was subjected to TIP41 siRNA transfection and TRAIL treatment. In addition, it was confirmed through animal experiments in which the tumor size has reduced and apoptosis was induced by treatment with TIP41 siRNA and TRAIL. Of note, MKK7/JNK pathway was confirmed to mediate the apoptosis induced by the application of TIP41 siRNA and TRAIL. The apoptosis were verified to be caused by the activation of MKK7/JNK signaling pathway. Taken together, the present invention provide the strong evidence that the pharmaceutical composition, including inhibitors for TIP41 expression or activity can be used for cancer prevention and treatment as well as an anti-cancer adjuvant. Taken together, the pharmaceutical composition comprising inhibitors for expression or activity of TIP41 protein may be used for prevention and treatment of cancer or as an anti-cancer adjuvant.
摘要翻译：本发明涉及包含用于预防和治疗癌症的TIP41蛋白表达或活性抑制剂的药物组合物。当显示对TRAIL的抗性的肝癌细胞系用TIP41 siRNA和TRAIL处理时，在癌细胞中诱导细胞凋亡。在具有抗TRAIL的肺癌和结肠癌的情况下也发现了相同的效果。此外，在注射Huh7肝癌细胞的肿瘤异种移植物中证实了TIP41 siRNA和TRAIL的这种诱导凋亡，然后进行TIP41 siRNA转染和TRAIL处理。此外，通过用TIP41 siRNA和TRAIL处理诱导肿瘤大小减少并诱导细胞凋亡的动物实验证实。值得注意的是，MKK7 / JNK途径被证实可以介导应用TIP41 siRNA和TRAIL诱导的细胞凋亡。验证细胞凋亡是由MKK7 / JNK信号通路的激活引起的。综合起来，本发明提供了强有力的证据，包括用于TIP41表达或活性的抑制剂的药物组合物可用于癌症预防和治疗以及抗癌辅助剂。总之，包含TIP41蛋白表达或活性抑制剂的药物组合物可用于预防和治疗癌症或作为抗癌辅助剂。

2. 发明申请

US20120315284A1 COMPOSITION FOR ENHANCING TRAIL SENSITIVITY COMPRISING INHIBITORS FOR EXPRESSION OR ACTIVITY OF TIP41 AS A TARGET GENE OF TRAIL SENSITIZER 有权
标题翻译：用于增强包含抑制剂的TRAIL敏感性的组合物，用于表达或活化TIP41作为TRAIL SENSITIZER的目标基因
公开(公告)号：US20120315284A1
公开(公告)日：2012-12-13
申请号：US13579256
申请日：2011-04-01
申请人： Nam-Soon Kim , In-Sung Song , Cheol-Hee Kim , Ga Hee Ha , Hyun-Taek Kim , So-Young Jeong , Jeong-Min Kim , Joo Heon Kim , Jin-Man Kim , Soo Young Jun
发明人： Nam-Soon Kim , In-Sung Song , Cheol-Hee Kim , Ga Hee Ha , Hyun-Taek Kim , So-Young Jeong , Jeong-Min Kim , Joo Heon Kim , Jin-Man Kim , Soo Young Jun
IPC分类号： A61K39/395 , G01N33/53 , G01N33/566 , A61K38/00 , A61K38/17 , A61K31/7088 , A61P35/00 , A61P29/00 , A61P37/00 , A61P17/00 , A61P37/08 , A61P1/04 , A61P1/00 , A61P19/02 , A61P21/00 , A61P31/14 , A61P25/00 , A61P3/10 , A61P7/06 , C12Q1/68
CPC分类号： A61K38/16 , A61K31/7105
摘要： The present invention relates to a pharmaceutical composition, including inhibitors for expression or activity of TIP41 protein, for prevention and treatment of cancer. When the liver cancer cell lines, showing resistance to TRAIL, are treated with TIP41 siRNA and TRAIL, apoptosis is induced in cancer cell. The same effect is found in cases of lung cancer and colon cancer with resistance against TRAIL. Moreover, this induction of apoptosis by TIP41 siRNA and TRAIL was confirmed in tumor xenograft, which was injected with Huh7 liver cancer cells and then was subjected to TIP41 siRNA transfection and TRAIL treatment. In addition, it was confirmed through animal experiments in which the tumor size has reduced and apoptosis was induced by treatment with TIP41 siRNA and TRAIL. Of note, MKK7/JNK pathway was confirmed to mediate the apoptosis induced by the application of TIP41 siRNA and TRAIL. The apoptosis were verified to be caused by the activation of MKK7/JNK signaling pathway. Taken together, the present invention provide the strong evidence that the pharmaceutical composition, including inhibitors for TIP41 expression or activity can be used for cancer prevention and treatment as well as an anti-cancer adjuvant. Taken together, the pharmaceutical composition comprising inhibitors for expression or activity of TIP41 protein may be used for prevention and treatment of cancer or as an anti-cancer adjuvant.
摘要翻译：本发明涉及包含用于预防和治疗癌症的TIP41蛋白表达或活性抑制剂的药物组合物。当显示对TRAIL的抗性的肝癌细胞系用TIP41 siRNA和TRAIL处理时，在癌细胞中诱导细胞凋亡。在具有抗TRAIL的肺癌和结肠癌的情况下也发现了相同的效果。此外，在注射Huh7肝癌细胞的肿瘤异种移植物中证实了TIP41 siRNA和TRAIL的这种诱导凋亡，然后进行TIP41 siRNA转染和TRAIL处理。此外，通过用TIP41 siRNA和TRAIL处理诱导肿瘤大小减少并诱导细胞凋亡的动物实验证实。值得注意的是，MKK7 / JNK途径被证实可以介导应用TIP41 siRNA和TRAIL诱导的细胞凋亡。验证细胞凋亡是由MKK7 / JNK信号通路的激活引起的。综合起来，本发明提供了强有力的证据，包括用于TIP41表达或活性的抑制剂的药物组合物可用于癌症预防和治疗以及抗癌辅助剂。总之，包含TIP41蛋白表达或活性抑制剂的药物组合物可用于预防和治疗癌症或作为抗癌辅助剂。

3. 发明授权

US08278285B2 Gastric carcinoma gene ZNF312b, a protein translated from the gene, and a diagnostic kit and a screening method for anticancer agents using the same 有权
标题翻译：胃癌基因ZNF312b是从基因翻译的蛋白质，以及诊断试剂盒和使用其的抗癌剂的筛选方法
公开(公告)号：US08278285B2
公开(公告)日：2012-10-02
申请号：US12594843
申请日：2008-08-06
申请人： Nam-Soon Kim , In-Sung Song , Nang-Su Oh , So-Young Jeong , Ga-Hee Ha , Yeo-Jin Jeon , Jeong-Min Kim , Cheol-Hee Kim , Hyun-Taek Kim
发明人： Nam-Soon Kim , In-Sung Song , Nang-Su Oh , So-Young Jeong , Ga-Hee Ha , Yeo-Jin Jeon , Jeong-Min Kim , Cheol-Hee Kim , Hyun-Taek Kim
IPC分类号： A61K31/70 , C07H21/04
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178
摘要： The present invention relates to a diagnostic marker containing ZNF312b gene and the fragment thereof, a diagnostic method for stomach cancer and a screening method for stomach cancer inducers or inhibitors using the same. ZNF312b gene expression is specifically increased in stomach cancer. And the over-expression or the under-expression of the gene affects activation or inhibition of cell proliferation and tumor formation of a stomach cancer cell line and cell proliferation signal transduction system as well to induce stomach cancer at last. Therefore, ZNF312b marker gene can be effectively used for diagnosis of stomach cancer, construction of a stomach cancer animal model, prevention and treatment of stomach cancer and development of a stomach cancer specific anticancer agent.
摘要翻译：本发明涉及含有ZNF312b基因及其片段的诊断标记物，胃癌的诊断方法以及使用其的胃癌诱导剂或抑制剂的筛选方法。 ZNF312b基因表达在胃癌中特异性增加。并且该基因的过表达或低表达影响胃癌细胞系和细胞增殖信号转导系统的细胞增殖和肿瘤形成的激活或抑制，并最终诱导胃癌。因此，ZNF312b标记基因可以有效地用于胃癌的诊断，胃癌动物模型的建立，胃癌的预防和治疗以及胃癌特异性抗癌剂的开发。

4. 发明申请

US20100162420A1 GASTRIC CARCINOMA GENE ZNF312B, A PROTEIN TRANSLATED FROM THE GENE, AND A DIAGNOSTIC KIT AND A SCREENING METHOD FOR ANTICANCER AGENTS USING THE SAME 有权
标题翻译： GASTRIC CARCINOMA基因ZNF312B，从基因翻译的蛋白质，以及诊断试剂盒和使用其的抗病毒剂的筛选方法
公开(公告)号：US20100162420A1
公开(公告)日：2010-06-24
申请号：US12594843
申请日：2008-08-06
申请人： Nam-Soon Kim , In-Sung Song , Nang-Su Oh , So-Young Jeong , Ga-Hee Ha , Yeo-Jin Jeon , Jeong-Min Kim , Cheol-Hee Kim , Hyun-Taek Kim
发明人： Nam-Soon Kim , In-Sung Song , Nang-Su Oh , So-Young Jeong , Ga-Hee Ha , Yeo-Jin Jeon , Jeong-Min Kim , Cheol-Hee Kim , Hyun-Taek Kim
IPC分类号： A01K67/00 , C12Q1/68 , A61K31/7088
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178
摘要： The present invention relates to a diagnostic marker containing ZNF312b gene and the fragment thereof, a diagnostic method for stomach cancer and a screening method for stomach cancer inducers or inhibitors using the same. ZNF312b gene expression is specifically increased in stomach cancer. And the over-expression or the under-expression of the gene affects activation or inhibition of cell proliferation and tumor formation of a stomach cancer cell line and cell proliferation signal transduction system as well to induce stomach cancer at last. Therefore, ZNF312b marker gene can be effectively used for diagnosis of stomach cancer, construction of a stomach cancer animal model, prevention and treatment of stomach cancer and development of a stomach cancer specific anticancer agent.
摘要翻译：本发明涉及含有ZNF312b基因及其片段的诊断标记物，胃癌的诊断方法以及使用其的胃癌诱导剂或抑制剂的筛选方法。 ZNF312b基因表达在胃癌中特异性增加。并且该基因的过表达或低表达影响胃癌细胞系和细胞增殖信号转导系统的细胞增殖和肿瘤形成的激活或抑制，并最终诱导胃癌。因此，ZNF312b标记基因可以有效地用于胃癌的诊断，胃癌动物模型的建立，胃癌的预防和治疗以及胃癌特异性抗癌剂的开发。

5. 外观设计

USD632265S1 Remote controller for air conditioner 有权
公开(公告)号：USD632265S1
公开(公告)日：2011-02-08
申请号：US29370206
申请日：2010-06-16
申请人： Eun-Ha Choi , Ji-Hyeoung Lee , Jeong-Min Kim
设计人： Eun-Ha Choi , Ji-Hyeoung Lee , Jeong-Min Kim

6. 发明授权

US07605147B2 Acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same 失效
标题翻译：无环核苷膦酸衍生物，其盐及其制备方法
公开(公告)号：US07605147B2
公开(公告)日：2009-10-20
申请号：US11455679
申请日：2006-06-20
申请人： Dong-Gyu Cho , Jae-Hong Lim , Jae-Taeg Hwang , Woo-Young Cho , Hyun-Sook Jang , Chang-Ho Lee , Tae-Saeng Choi , Chung-Mi Kim , Yong-Zu Kim , Tae-Kyun Kim , Seung-Joo Cho , Gyoung-Won Kim , Jong-Ryoo Choi , Jeong-Min Kim , Kee-Yoon Roh
发明人： Dong-Gyu Cho , Jae-Hong Lim , Jae-Taeg Hwang , Woo-Young Cho , Hyun-Sook Jang , Chang-Ho Lee , Tae-Saeng Choi , Chung-Mi Kim , Yong-Zu Kim , Tae-Kyun Kim , Seung-Joo Cho , Gyoung-Won Kim , Jong-Ryoo Choi , Jeong-Min Kim , Kee-Yoon Roh
IPC分类号： C07F9/6561 , A61K31/675 , A61P31/20 , C07F9/6512 , C07F9/40 , C07F7/18
CPC分类号： C07H19/10 , C07F9/65616 , C07H19/20
摘要： The present invention relates to an acyclic nucleoside phosphonate derivative represented by the following formula (1): in which represents single bond or double bond, R1, R2, R3, R7 and R8 are defined herein, Y represents —O—, —S—, —CH(Z)-, ═C(Z)-, —N(Z)-, ═N—, or —SiH(Z)-, wherein Z represents hydrogen, hydroxy or halogen, or represents C1-C7-alkyl, C1-C5-alkoxy, allyl, hydroxy-C1-C7-alkyl, C1-C7-aminoalkyl or phenyl, Q represents a group having the following formula: wherein X1, and X2 independently of one another represent hydrogen, amino, hydroxy or halogen, or represent C1-C7-alkyl, C1-C5-alkoxy, allyl, hydroxy-C1-C7-alkyl, phenyl or phenoxy each of which is optionally substituted by nitro or C1-C5-alkoxy, or represent C6-C10-arylthio which is optionally substituted by nitro, amino, C1-C6-alkyl or C1-C4-alkoxy, or represent C6-C12-arylamino, C1-C7-alkylamino, di(C1-C7-alkyl)amino, C3-C6-cycloalkylamino or a structure of wherein n denotes an integer of 1 or 2 and Y1 represents O, CH2 or N—R (R represents C1-C7-alkyl or C6-C12-aryl), which is useful as an antiviral agent (particularly, against hepatitis B virus), pharmaceutically acceptable salts, stereoisomers, and a process for the preparation thereof.
摘要翻译：本发明涉及由下式（1）表示的无环核苷膦酸酯衍生物：其中表示单键或双键，R1，R2，R3，R7和R8如本文所定义，Y表示 - O，-S - ， - CH（Z） - ， - C（Z） - ， - N（Z） - ， - -N-或-SiH（Z） - ，其中Z表示氢，羟基或卤素，或表示C 1 -C 7 - 烷基，C 1 -C 5 - 烷氧基，烯丙基，羟基-C 1 -C 7 - 烷基，C 1 -C 7 - 氨基烷基或苯基，Q表示具有下式的基团：其中X 1和X 2彼此独立地表示氢，氨基，羟基或卤素，或表示任选被硝基或C 1 -C 5烷氧基取代的C 1 -C 7 - 烷基，C 1 -C 5 - 烷氧基，烯丙基，羟基-C 1 -C 7 - 烷基，苯基或苯氧基，或表示任选被硝基，氨基，C 1 -C 6 - 烷基或C 1 -C 4 - 烷氧基取代的C 6 -C 10 - 芳硫基，或代表 C 1 -C 12 - 芳基氨基，C 1 -C 7 - 烷基氨基，二（C 1 -C 7 - 烷基）氨基，C 3 -C 6环烷基氨基或其中n表示1或2的整数，Y 1表示O，CH 2或NR（ R表示可用作抗病毒剂（特别是针对乙型肝炎病毒）的药学上可接受的盐，立体异构体及其制备方法的C 1 -C 7 - 烷基或C 6 -C 12 - 芳基）。

7. 发明申请

US20100165007A1 DISPLAY DEVICE AND SOURCE LINE DRIVING METHOD THEREOF 审中-公开
标题翻译：显示设备及其线路驱动方法
公开(公告)号：US20100165007A1
公开(公告)日：2010-07-01
申请号：US12649189
申请日：2009-12-29
申请人： Jeong-Min Kim
发明人： Jeong-Min Kim
IPC分类号： G09G5/10
CPC分类号： G09G3/2011 , G09G5/02 , G09G2320/0276 , G09G2330/028
摘要： A display device for generating gamma voltages for driving source lines and a source line driving method thereof are disclosed. The display device includes a plurality of gamma generation units configured to generate gamma voltages corresponding to respective colors, a selection unit configured to select gamma voltages corresponding to any one color from among the gamma voltages generated by the plurality of gamma generation units and to output the gamma voltages to a common line, a decoding unit configured to decode the gamma voltages output to the common line, and an output unit configured to buffer the signals decoded by the decoding unit and to output source line driving signals. Thus, it is possible to reduce the number of lines for transferring the gamma voltages.
摘要翻译：公开了一种用于产生用于驱动源极线的伽马电压的显示装置及其源极线驱动方法。显示装置包括：多个伽马生成单元，被配置为产生与各颜色相对应的伽马电压;选择单元，被配置为从多个伽马生成单元生成的伽马电压中选择与任意一种颜色相对应的伽马电压，并输出伽马电压到公共线，解码单元，被配置为解码输出到公共线的伽马电压;以及输出单元，被配置为缓冲由解码单元解码的信号并输出源极线驱动信号。因此，可以减少用于传送伽马电压的行数。

8. 发明申请

US20070163711A1 Apparatus for treating substrate 有权
标题翻译：用于处理基材的设备
公开(公告)号：US20070163711A1
公开(公告)日：2007-07-19
申请号：US11524320
申请日：2006-09-21
申请人： Kyo-Woog Koo , Jeong-Min Kim
发明人： Kyo-Woog Koo , Jeong-Min Kim
IPC分类号： H01L21/306
CPC分类号： H01L21/67051 , H01L21/6708
摘要： There is provided an apparatus for treating a substrate using a plurality of treatment solutions in sequence. The apparatus includes treatment liquid collecting vessels for separately collecting used treatment solutions, and an exhaust member for separately discharging pollutant gases generated during a process.
摘要翻译：提供了使用多个处理液依次处理基板的装置。该设备包括用于分别收集使用的处理溶液的处理液收集容器和用于分别排出在处理过程中产生的污染气体的排气构件。

9. 发明申请

US20060111324A1 (+)-Ttrans-isomers of (1-phosphonomethoxy-2-alkylcyclopropyl)methyl nucleoside derivatives, process for the preparation of stereoisomers thereof, and use of antiviral agents thereof 审中-公开
标题翻译：（1-膦酰甲氧基-2-烷基环丙基）甲基核苷衍生物的（+） - Ttrans-异构体，其制备立体异构体的方法及其抗病毒剂的用途
公开(公告)号：US20060111324A1
公开(公告)日：2006-05-25
申请号：US10528336
申请日：2003-09-22
申请人： Jong-Ryoo Choi , Jae-Taeg Hwang , Dong-Gyu Cho , Kee-Yoon Roh , Chung-Hyung Kim , Chung-Mi Kim , Min-Joon Han , Jeong-Min Kim , Woo-Young Cho , Gyoung-Won Kim , Sin-Byoung Ahn
发明人： Jong-Ryoo Choi , Jae-Taeg Hwang , Dong-Gyu Cho , Kee-Yoon Roh , Chung-Hyung Kim , Chung-Mi Kim , Min-Joon Han , Jeong-Min Kim , Woo-Young Cho , Gyoung-Won Kim , Sin-Byoung Ahn
IPC分类号： A61K31/675 , C07F9/6512
CPC分类号： C07F9/65616 , C07F9/4006 , C07F9/6512
摘要： The present invention relates to (+)-trans-isomers of (1-phosphonomethoxy-2-alkylcyclopropyl)methyl nucleoside derivatives of the formula (1) which are useful as an antiviral agent (particularly, against hepatitis B virus), pharmaceutically acceptable saltss, hydrates, or solvates thereof, and processes for the preparation of stereoisomers of the compounds of the formula (1), and a composition for the treatment of viral diseases (particularly, against hepatitis B virus) comprising (+)-trans-isomer of the compound of the formula (1), pharmaceutically acceptable salt, hydrate, or solvate thereof as an active substance.
摘要翻译：本发明涉及可用作抗病毒剂（特别是针对乙型肝炎病毒）的式（1）的（1-膦酰基甲氧基-2-烷基环丙基）甲基核苷衍生物的（+） - 反式异构体，其药学上可接受的盐，其水合物或溶剂化物，以及制备式（1）化合物的立体异构体的方法和用于治疗病毒性疾病（特别是针对乙型肝炎病毒）的组合物，其包含（+） - 反式异构体式（1）的化合物，其药学上可接受的盐，水合物或溶剂合物作为活性物质。

10. 发明授权

US07771970B2 Process for preparation of polypeptides of interest from fusion polypeptides 有权
标题翻译：从融合多肽制备目的多肽的方法
公开(公告)号：US07771970B2
公开(公告)日：2010-08-10
申请号：US10484478
申请日：2002-07-26
申请人： Woo-Jong Lee , Heung-Bok Park , Tae-Hoon Cho , Jeong-Min Kim , Yeon-Sung Park
发明人： Woo-Jong Lee , Heung-Bok Park , Tae-Hoon Cho , Jeong-Min Kim , Yeon-Sung Park
IPC分类号： C12P21/00
CPC分类号： C07K14/00 , C07K19/00 , C07K2319/00
摘要： The present invention relates to a process of separation a protein of interest comprising expressing the protein of interest fused with a fusion partner, selectively adsorbing on matrix, and performing efficient cleavage reaction on the fusion protein adsorbed on matrix or separated from the matrix, and recovering the protein of interest. Also, the present invention provides a fusion protein comprising a protein of interest and a fusion partner, wherein the fusion partner comprises an amino acid sequence which can be cleaved by ubiquitin cleavage enzyme at its C-terminus, and which has a difference in isoelectric point of 1 or more from the protein of interest. According to the present invention, the proteins of interest can be purified in high yield and purity. In addition, complicated separating processes required in the production of recombinant proteins can be eliminated so as to cut down the production cost.
摘要翻译：本发明涉及分离感兴趣的蛋白质的方法，包括表达与融合配偶体融合的目的蛋白质，选择性吸附于基质上，并对吸附在基质上或与基质分离的融合蛋白进行有效的切割反应，并回收感兴趣的蛋白质此外，本发明提供了包含目标蛋白质和融合配偶体的融合蛋白质，其中融合配偶体包含可在其C末端被泛素切割酶切割的氨基酸序列，并且其等电点从感兴趣的蛋白质1或更多。根据本发明，可以高产率和纯度纯化目的蛋白质。此外，可以消除生产重组蛋白质所需的复杂分离过程，从而降低生产成本。

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