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1. 发明授权

US09836226B2 Method of processing input/output in storage device and storage device and non-volatile memory device using the method 有权
公开(公告)号：US09836226B2
公开(公告)日：2017-12-05
申请号：US15000065
申请日：2016-01-19
申请人： Young-Ho Park , Chan-Ik Park , Chul Lee , In-Hwan Doh , Nam-Wook Kang , Kwang-Hun Lee , In-Sung Song
发明人： Young-Ho Park , Chan-Ik Park , Chul Lee , In-Hwan Doh , Nam-Wook Kang , Kwang-Hun Lee , In-Sung Song
IPC分类号： G06F3/06
CPC分类号： G06F3/0611 , G06F3/0659 , G06F3/0679
摘要： A method of processing input/output (I/O) in a storage device includes adjusting a read anticipation time based on a change of a resource management status related to operations of the storage device and performing an I/O processing operation at the storage device based on the adjusted read anticipation time. The I/O processing operation is performed to postpone an operation regarding a program command and perform a read command at higher priority than a write command at the storage device in a period from completion of a read operation at the storage device until the read anticipation time has elapsed.

2. 发明授权

US08703732B2 Composition for enhancing TRAIL sensitivity comprising inhibitors for expression or activity of TIP41 as a target gene of TRAIL sensitizer 有权
标题翻译：用于增强TRAIL灵敏度的组合物，其包含作为TRAIL增敏剂靶标基因的TIP41的表达或活性的抑制剂
公开(公告)号：US08703732B2
公开(公告)日：2014-04-22
申请号：US13579256
申请日：2011-04-01
申请人： Nam-Soon Kim , In-Sung Song , Cheol-Hee Kim , Ga Hee Ha , Hyun-Taek Kim , So-Young Jeong , Jeong-Min Kim , Joo Heon Kim , Jin-Man Kim , Soo Young Jun
发明人： Nam-Soon Kim , In-Sung Song , Cheol-Hee Kim , Ga Hee Ha , Hyun-Taek Kim , So-Young Jeong , Jeong-Min Kim , Joo Heon Kim , Jin-Man Kim , Soo Young Jun
IPC分类号： C12N15/11 , A61K48/00 , C07H21/02 , C07H21/04
CPC分类号： A61K38/16 , A61K31/7105
摘要： The present invention relates to a pharmaceutical composition, including inhibitors for expression or activity of TIP41 protein, for prevention and treatment of cancer. When the liver cancer cell lines, showing resistance to TRAIL, are treated with TIP41 siRNA and TRAIL, apoptosis is induced in cancer cell. The same effect is found in cases of lung cancer and colon cancer with resistance against TRAIL. Moreover, this induction of apoptosis by TIP41 siRNA and TRAIL was confirmed in tumor xenograft, which was injected with Huh7 liver cancer cells and then was subjected to TIP41 siRNA transfection and TRAIL treatment. In addition, it was confirmed through animal experiments in which the tumor size has reduced and apoptosis was induced by treatment with TIP41 siRNA and TRAIL. Of note, MKK7/JNK pathway was confirmed to mediate the apoptosis induced by the application of TIP41 siRNA and TRAIL. The apoptosis were verified to be caused by the activation of MKK7/JNK signaling pathway. Taken together, the present invention provide the strong evidence that the pharmaceutical composition, including inhibitors for TIP41 expression or activity can be used for cancer prevention and treatment as well as an anti-cancer adjuvant. Taken together, the pharmaceutical composition comprising inhibitors for expression or activity of TIP41 protein may be used for prevention and treatment of cancer or as an anti-cancer adjuvant.
摘要翻译：本发明涉及包含用于预防和治疗癌症的TIP41蛋白表达或活性抑制剂的药物组合物。当显示对TRAIL的抗性的肝癌细胞系用TIP41 siRNA和TRAIL处理时，在癌细胞中诱导细胞凋亡。在具有抗TRAIL的肺癌和结肠癌的情况下也发现了相同的效果。此外，在注射Huh7肝癌细胞的肿瘤异种移植物中证实了TIP41 siRNA和TRAIL的这种诱导凋亡，然后进行TIP41 siRNA转染和TRAIL处理。此外，通过用TIP41 siRNA和TRAIL处理诱导肿瘤大小减少并诱导细胞凋亡的动物实验证实。值得注意的是，MKK7 / JNK途径被证实可以介导应用TIP41 siRNA和TRAIL诱导的细胞凋亡。验证细胞凋亡是由MKK7 / JNK信号通路的激活引起的。综合起来，本发明提供了强有力的证据，包括用于TIP41表达或活性的抑制剂的药物组合物可用于癌症预防和治疗以及抗癌辅助剂。总之，包含TIP41蛋白表达或活性抑制剂的药物组合物可用于预防和治疗癌症或作为抗癌辅助剂。

3. 发明申请

US20080111480A1 ORGANIC LIGHT-EMITTING DEVICE 有权
标题翻译：有机发光装置
公开(公告)号：US20080111480A1
公开(公告)日：2008-05-15
申请号：US11868625
申请日：2007-10-08
申请人： Young-gu LEE , In-seo KEE , In-sung SONG , Euk-che HWANG , Hong-shik SHIM
发明人： Young-gu LEE , In-seo KEE , In-sung SONG , Euk-che HWANG , Hong-shik SHIM
IPC分类号： H01J1/63
CPC分类号： H01L51/5048 , H01L51/0042 , H01L51/0059 , H01L51/0073 , H01L51/0081 , H01L51/5012
摘要： Provided is an organic light-emitting device exhibiting lower driving voltages and improved lifetime characteristics and emission efficiency. The organic light-emitting device includes a cathode; an anode; and a light-emitting layer interposed between the cathode and the anode, wherein a buffer layer is disposed on at least one surface of the light-emitting layer.
摘要翻译：提供了具有较低驱动电压和改善的寿命特性和发射效率的有机发光器件。有机发光装置包括阴极; 阳极; 以及插入在所述阴极和所述阳极之间的发光层，其中缓冲层设置在所述发光层的至少一个表面上。

4. 发明授权

US06124046A Organic electroluminescent polymer for light emitting diode 有权
标题翻译：用于发光二极管的有机电致发光聚合物
公开(公告)号：US06124046A
公开(公告)日：2000-09-26
申请号：US133181
申请日：1998-08-12
申请人： Sung-Ho Jin , Woo-Hong Kim , Byung-Hee Son , In-Sung Song , Eun-Mi Han
发明人： Sung-Ho Jin , Woo-Hong Kim , Byung-Hee Son , In-Sung Song , Eun-Mi Han
IPC分类号： H01L51/50 , C08G61/00 , C08G61/12 , C08L65/00 , C09K11/06 , B32B9/00
CPC分类号： C08G61/00 , Y10S428/917
摘要： An organic electroluminescent (EL) polymer for a light emitting diode in accordance with the present invention is PDPCVz which is prepared by combining a dialkyl substituted phenylene moiety and a carbazole moiety. Another organic EL polymer is PPOPPD which is prepared by combining an oxadiazole moiety and a phenylene moiety. In the present invention, a polymer blend of said PDPCVz and PPDPPO is used for an organic EL polymer. The organic EL polymer according to the present invention is applied to a light emitting layer of a light emitting diode having a cathode/light emitting layer/anode structure, a cathode/buffer layer/light emitting layer/anode structure, or a cathode/hole transporting layer/light emitting layer/electron transporting layer/anode structure. Each of said PDPCVz and PPDPPO can be blended with conventional polymers such as polystyrene, polycarbonate, polyacrylate, polymethylmethacrylate, polyvinylcarbazole, polyimide, liquid crystalline polymer, etc. The EL polymers according to the present invention can be blended with a lower molecular fluorescent dye.
摘要翻译：根据本发明的用于发光二极管的有机电致发光（EL）聚合物是通过组合二烷基取代的亚苯基部分和咔唑部分制备的PDPCVz。另一种有机EL聚合物是通过结合恶二唑部分和亚苯基部分制备的PPOPPD。在本发明中，将所述PDPCVz和PPDPPO的聚合物共混物用于有机EL聚合物。根据本发明的有机EL聚合物被应用于具有阴极/发光层/阳极结构，阴极/缓冲层/发光层/阳极结构或阴极/孔的发光二极管的发光层传输层/发光层/电子传输层/阳极结构。所述PDPCVz和PPDPPO中的每一种可与常规聚合物如聚苯乙烯，聚碳酸酯，聚丙烯酸酯，聚甲基丙烯酸甲酯，聚乙烯基咔唑，聚酰亚胺，液晶聚合物等共混。根据本发明的EL聚合物可与较低分子荧光染料共混。

5. 发明申请

US20120315284A1 COMPOSITION FOR ENHANCING TRAIL SENSITIVITY COMPRISING INHIBITORS FOR EXPRESSION OR ACTIVITY OF TIP41 AS A TARGET GENE OF TRAIL SENSITIZER 有权
标题翻译：用于增强包含抑制剂的TRAIL敏感性的组合物，用于表达或活化TIP41作为TRAIL SENSITIZER的目标基因
公开(公告)号：US20120315284A1
公开(公告)日：2012-12-13
申请号：US13579256
申请日：2011-04-01
申请人： Nam-Soon Kim , In-Sung Song , Cheol-Hee Kim , Ga Hee Ha , Hyun-Taek Kim , So-Young Jeong , Jeong-Min Kim , Joo Heon Kim , Jin-Man Kim , Soo Young Jun
发明人： Nam-Soon Kim , In-Sung Song , Cheol-Hee Kim , Ga Hee Ha , Hyun-Taek Kim , So-Young Jeong , Jeong-Min Kim , Joo Heon Kim , Jin-Man Kim , Soo Young Jun
IPC分类号： A61K39/395 , G01N33/53 , G01N33/566 , A61K38/00 , A61K38/17 , A61K31/7088 , A61P35/00 , A61P29/00 , A61P37/00 , A61P17/00 , A61P37/08 , A61P1/04 , A61P1/00 , A61P19/02 , A61P21/00 , A61P31/14 , A61P25/00 , A61P3/10 , A61P7/06 , C12Q1/68
CPC分类号： A61K38/16 , A61K31/7105
摘要： The present invention relates to a pharmaceutical composition, including inhibitors for expression or activity of TIP41 protein, for prevention and treatment of cancer. When the liver cancer cell lines, showing resistance to TRAIL, are treated with TIP41 siRNA and TRAIL, apoptosis is induced in cancer cell. The same effect is found in cases of lung cancer and colon cancer with resistance against TRAIL. Moreover, this induction of apoptosis by TIP41 siRNA and TRAIL was confirmed in tumor xenograft, which was injected with Huh7 liver cancer cells and then was subjected to TIP41 siRNA transfection and TRAIL treatment. In addition, it was confirmed through animal experiments in which the tumor size has reduced and apoptosis was induced by treatment with TIP41 siRNA and TRAIL. Of note, MKK7/JNK pathway was confirmed to mediate the apoptosis induced by the application of TIP41 siRNA and TRAIL. The apoptosis were verified to be caused by the activation of MKK7/JNK signaling pathway. Taken together, the present invention provide the strong evidence that the pharmaceutical composition, including inhibitors for TIP41 expression or activity can be used for cancer prevention and treatment as well as an anti-cancer adjuvant. Taken together, the pharmaceutical composition comprising inhibitors for expression or activity of TIP41 protein may be used for prevention and treatment of cancer or as an anti-cancer adjuvant.
摘要翻译：本发明涉及包含用于预防和治疗癌症的TIP41蛋白表达或活性抑制剂的药物组合物。当显示对TRAIL的抗性的肝癌细胞系用TIP41 siRNA和TRAIL处理时，在癌细胞中诱导细胞凋亡。在具有抗TRAIL的肺癌和结肠癌的情况下也发现了相同的效果。此外，在注射Huh7肝癌细胞的肿瘤异种移植物中证实了TIP41 siRNA和TRAIL的这种诱导凋亡，然后进行TIP41 siRNA转染和TRAIL处理。此外，通过用TIP41 siRNA和TRAIL处理诱导肿瘤大小减少并诱导细胞凋亡的动物实验证实。值得注意的是，MKK7 / JNK途径被证实可以介导应用TIP41 siRNA和TRAIL诱导的细胞凋亡。验证细胞凋亡是由MKK7 / JNK信号通路的激活引起的。综合起来，本发明提供了强有力的证据，包括用于TIP41表达或活性的抑制剂的药物组合物可用于癌症预防和治疗以及抗癌辅助剂。总之，包含TIP41蛋白表达或活性抑制剂的药物组合物可用于预防和治疗癌症或作为抗癌辅助剂。

6. 发明申请

US20100162420A1 GASTRIC CARCINOMA GENE ZNF312B, A PROTEIN TRANSLATED FROM THE GENE, AND A DIAGNOSTIC KIT AND A SCREENING METHOD FOR ANTICANCER AGENTS USING THE SAME 有权
标题翻译： GASTRIC CARCINOMA基因ZNF312B，从基因翻译的蛋白质，以及诊断试剂盒和使用其的抗病毒剂的筛选方法
公开(公告)号：US20100162420A1
公开(公告)日：2010-06-24
申请号：US12594843
申请日：2008-08-06
申请人： Nam-Soon Kim , In-Sung Song , Nang-Su Oh , So-Young Jeong , Ga-Hee Ha , Yeo-Jin Jeon , Jeong-Min Kim , Cheol-Hee Kim , Hyun-Taek Kim
发明人： Nam-Soon Kim , In-Sung Song , Nang-Su Oh , So-Young Jeong , Ga-Hee Ha , Yeo-Jin Jeon , Jeong-Min Kim , Cheol-Hee Kim , Hyun-Taek Kim
IPC分类号： A01K67/00 , C12Q1/68 , A61K31/7088
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178
摘要： The present invention relates to a diagnostic marker containing ZNF312b gene and the fragment thereof, a diagnostic method for stomach cancer and a screening method for stomach cancer inducers or inhibitors using the same. ZNF312b gene expression is specifically increased in stomach cancer. And the over-expression or the under-expression of the gene affects activation or inhibition of cell proliferation and tumor formation of a stomach cancer cell line and cell proliferation signal transduction system as well to induce stomach cancer at last. Therefore, ZNF312b marker gene can be effectively used for diagnosis of stomach cancer, construction of a stomach cancer animal model, prevention and treatment of stomach cancer and development of a stomach cancer specific anticancer agent.
摘要翻译：本发明涉及含有ZNF312b基因及其片段的诊断标记物，胃癌的诊断方法以及使用其的胃癌诱导剂或抑制剂的筛选方法。 ZNF312b基因表达在胃癌中特异性增加。并且该基因的过表达或低表达影响胃癌细胞系和细胞增殖信号转导系统的细胞增殖和肿瘤形成的激活或抑制，并最终诱导胃癌。因此，ZNF312b标记基因可以有效地用于胃癌的诊断，胃癌动物模型的建立，胃癌的预防和治疗以及胃癌特异性抗癌剂的开发。

7. 发明申请

US20050158583A1 Spirocyclopentaphenanthrenefluorene-based compound and organoelectroluminescent device using the same 有权
标题翻译：螺环苯并菲芴基化合物和使用其的有机电致发光器件
公开(公告)号：US20050158583A1
公开(公告)日：2005-07-21
申请号：US11033887
申请日：2005-01-13
申请人： Kyu-Sik Kim , Woon-Jung Paek , Lyong-Sun Pu , In-Sung Song , Jong-Seob Kim , Ouck Han
发明人： Kyu-Sik Kim , Woon-Jung Paek , Lyong-Sun Pu , In-Sung Song , Jong-Seob Kim , Ouck Han
IPC分类号： H01L51/50 , C07C13/72 , C08G61/00 , C08G61/02 , C08G61/12 , C08G73/06 , C08G73/08 , C09B69/10 , C09K11/06 , H01L51/00 , H05B33/14 , H05B33/22
CPC分类号： C09K11/06 , C08G61/00 , C08G61/02 , C08G61/122 , C08G61/124 , C08G73/0605 , C08G73/0611 , C08G73/08 , C09K2211/1416 , C09K2211/1466 , C09K2211/1475 , C09K2211/1483 , H01L51/0039 , H01L51/0043 , H01L51/0052 , H01L51/0059 , H01L51/0062 , H01L51/5012 , H01L51/5048 , H01L2251/308 , H05B33/14 , Y10S428/917
摘要： A spiro-based compound containing cyclopentaphenanthrene and fluorene, which is used for an organoelectroluminescent device and an organoelectroluminescent device having the spiro-based compound. The spiro-based compound containing cyclopentaphenanthrene and fluorene can be easily manufactured to have high solubility, high color purity, and good thermal stability. The spiro-based compound containing cyclopentaphenanthrene and fluorene is suitable as a substance for an organic film, in particular, an emission layer of an organoelectroluminescent device. Further, the spiro-based compound containing cyclopentaphenanthrene and fluorene can be used as an organic dye, or an electron material such as a non-linear optical material.
摘要翻译：含有环戊二烯和芴的螺基化合物，其用于有机电致发光器件和具有螺基化合物的有机电致发光器件。含有环戊二烯和芴的螺基化合物可以容易地制造成具有高溶解度，高纯度和良好的热稳定性。含有环戊菲和芴的螺基化合物适合用作有机膜的物质，特别是有机电致发光器件的发射层。此外，含有环戊菲和芴的螺基化合物可以用作有机染料或诸如非线性光学材料的电子材料。

8. 发明授权

US06849870B2 Organic gate insulating film and organic thin film transistor using the same 有权
标题翻译：有机栅极绝缘膜和使用其的有机薄膜晶体管
公开(公告)号：US06849870B2
公开(公告)日：2005-02-01
申请号：US10657191
申请日：2003-09-09
申请人： Bon Won Koo , In Sung Song , In Seo Kee , Hwan Jae Choi , Eun Jeong Jeong , In Nam Kang
发明人： Bon Won Koo , In Sung Song , In Seo Kee , Hwan Jae Choi , Eun Jeong Jeong , In Nam Kang
IPC分类号： C08F222/40 , G03F7/038 , H01L21/31 , H01L21/312 , H01L29/786 , H01L35/24 , H01L51/00 , H01L51/05 , H01L51/30
CPC分类号： H01L51/0516 , H01L51/0036 , H01L51/0052
摘要： Disclosed is an organic gate insulating film and an organic thin film transistor using the same, in which a photo-alignment group is introduced into an organic insulating polymer, so that an organic active film has superior alignment, thereby increasing mobility. Further, the organic active film has a larger grain size, enhancing transistor characteristics.
摘要翻译：公开了一种有机栅极绝缘膜和使用该有机栅极绝缘膜的有机薄膜晶体管，其中将光取向基团引入到有机绝缘聚合物中，使得有机活性膜具有优异的取向，从而增加迁移率。此外，有机活性膜具有更大的晶粒尺寸，增加晶体管特性。

9. 发明授权

US07777408B2 Organic light-emitting device 有权
标题翻译：有机发光装置
公开(公告)号：US07777408B2
公开(公告)日：2010-08-17
申请号：US11868625
申请日：2007-10-08
申请人： Young-gu Lee , In-seo Kee , In-sung Song , Euk-che Hwang , Hong-shik Shim
发明人： Young-gu Lee , In-seo Kee , In-sung Song , Euk-che Hwang , Hong-shik Shim
IPC分类号： H01J63/04 , H01J1/62
CPC分类号： H01L51/5048 , H01L51/0042 , H01L51/0059 , H01L51/0073 , H01L51/0081 , H01L51/5012
摘要： Provided is an organic light-emitting device exhibiting lower driving voltages and improved lifetime characteristics and emission efficiency. The organic light-emitting device includes a cathode; an anode; and a light-emitting layer interposed between the cathode and the anode, wherein a buffer layer is disposed on at least one surface of the light-emitting layer.
摘要翻译：提供了具有较低驱动电压和改善的寿命特性和发射效率的有机发光器件。有机发光装置包括阴极; 阳极; 以及插入在所述阴极和所述阳极之间的发光层，其中缓冲层设置在所述发光层的至少一个表面上。

10. 发明申请

US20160224255A1 METHOD OF PROCESSING INPUT/OUTPUT IN STORAGE DEVICE AND STORAGE DEVICE AND NON-VOLATILE MEMORY DEVICE USING THE METHOD 有权
标题翻译：处理存储设备中的输入/输出和存储设备的方法以及使用该方法的非易失性存储器件
公开(公告)号：US20160224255A1
公开(公告)日：2016-08-04
申请号：US15000065
申请日：2016-01-19
申请人： YOUNG-HO PARK , CHAN-IK PARK , CHUL LEE , IN-HWAN DOH , NAM-WOOK KANG , KWANG-HUN LEE , IN-SUNG SONG
发明人： YOUNG-HO PARK , CHAN-IK PARK , CHUL LEE , IN-HWAN DOH , NAM-WOOK KANG , KWANG-HUN LEE , IN-SUNG SONG
IPC分类号： G06F3/06
CPC分类号： G06F3/0611 , G06F3/0659 , G06F3/0679
摘要： A method of processing input/output (I/O) in a storage device includes adjusting a read anticipation time based on a change of a resource management status related to operations of the storage device and performing an I/O processing operation at the storage device based on the adjusted read anticipation time. The I/O processing operation is performed to postpone an operation regarding a program command and perform a read command at higher priority than a write command at the storage device in a period from completion of a read operation at the storage device until the read anticipation time has elapsed.
摘要翻译：一种处理存储装置中的输入/输出（I / O）的方法包括：根据与存储装置的操作相关的资源管理状态的改变来调整读预期时间，并在存储装置处执行I / O处理操作基于调整后的预期时间。执行I / O处理操作以在从存储装置的读取操作完成直到读取预期时间的时间段内推迟关于程序命令的操作并且执行比存储装置处的写入命令更高优先级的读取命令已经过去了

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