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1. 发明申请

WO2012168430A2 POLYPEPTIDES 审中-公开
标题翻译：多肽
公开(公告)号：WO2012168430A2
公开(公告)日：2012-12-13
申请号：PCT/EP2012060897
申请日：2012-06-08
申请人： NOVO NORDISK AS , SCHAEFFER LAUGE , KRUSE THOMAS , THOEGERSEN HENNING
发明人： SCHAEFFER LAUGE , KRUSE THOMAS , THOEGERSEN HENNING
IPC分类号： C07K14/575 , A61K47/48
CPC分类号： C07K14/57527 , A61K38/00 , A61K38/225 , A61K45/06 , A61K47/542 , A61K47/643 , C07K14/575 , Y10S514/909
摘要： The invention relates to polypeptides comprising an amino acid sequence which is an analogue of pramlintide, pharmaceutical compositions comprising these polypeptides, and these polypeptides for use as medicaments.
摘要翻译：本发明涉及包含氨基酸序列的多肽，其是普兰林肽的类似物，包含这些多肽的药物组合物，以及用作药物的这些多肽。

2. 发明申请

WO2012168431A3 POLYPEPTIDES 审中-公开
标题翻译：多肽
公开(公告)号：WO2012168431A3
公开(公告)日：2013-01-31
申请号：PCT/EP2012060899
申请日：2012-06-08
申请人： NOVO NORDISK AS , SCHAEFFER LAUGE , KRUSE THOMAS , THOEGERSEN HENNING
发明人： SCHAEFFER LAUGE , KRUSE THOMAS , THOEGERSEN HENNING
IPC分类号： C07K14/575 , A61K47/48 , C07K14/62
CPC分类号： C07K14/57527 , A61K38/00 , A61K38/225 , A61K45/06 , A61K47/542 , A61K47/643 , C07K14/575 , Y10S514/909
摘要： The invention relates to polypeptides comprising an amino acid sequence which is an analogue of pramlintide, pharmaceutical compositions comprising these polypeptides, and these polypeptides for use as medicaments.
摘要翻译：本发明涉及包含作为普兰林肽类似物的氨基酸序列的多肽，包含这些多肽的药物组合物以及用作药物的这些多肽。

3. 发明申请

WO2009034119A1 IMPROVED DERIVATIVES OF AMYLIN 审中-公开
标题翻译：改良的AMYLIN衍生物
公开(公告)号：WO2009034119A1
公开(公告)日：2009-03-19
申请号：PCT/EP2008062036
申请日：2008-09-11
申请人： NOVO NORDISK AS , SCHAEFFER LAUGE , KRUSE THOMAS , LAU JESPER
发明人： SCHAEFFER LAUGE , KRUSE THOMAS , LAU JESPER
IPC分类号： C07K14/575 , A61K38/00
CPC分类号： C07K14/575 , A61K38/00
摘要： The invention relates to derivatives of human amylin or analogues thereof which bind to the amylin receptor and are linked to an albumin binding compound, pharmaceutical compositions comprising these derivatives and methods for obtaining such.
摘要翻译：本发明涉及与胰岛淀粉样多肽受体结合并与白蛋白结合化合物连接的人胰岛淀粉样多肽或其类似物的衍生物，包含这些衍生物的药物组合物以及获得该衍生物的方法。

4. 发明申请

WO2007104789A2 AMYLIN DERIVATIVES 审中-公开
标题翻译： AMYLIN衍生物
公开(公告)号：WO2007104789A2
公开(公告)日：2007-09-20
申请号：PCT/EP2007052456
申请日：2007-03-15
申请人： NOVO NORDISK AS , HANSEN THOMAS KRUSE , SCHAEFFER LAUGE , LAU JESPER
发明人： HANSEN THOMAS KRUSE , SCHAEFFER LAUGE , LAU JESPER
IPC分类号： C07K14/575
CPC分类号： C07K14/4713 , A61K38/00 , C07K14/5759
摘要： The present invention relates to novel amylin derivatives having a protracted action profile, to pharmaceutical compositions comprising these derivatives and to the use of the derivatives for the treatment of diseases related to obesity, diabetes and other metabolic disorders.
摘要翻译：本发明涉及具有延长作用特征的新型胰淀素衍生物，包含这些衍生物的药物组合物以及该衍生物用于治疗与肥胖，糖尿病和其它代谢紊乱相关疾病的用途。

5. 发明申请

WO2008145721A3 N-TERMINAL MODIFICATION OF POLYPEPTIDES FOR PROTECTION AGAINST DEGRADATION BY AMINOPEPTIDASES 审中-公开
标题翻译：用于保护抗微生物剂降解的多肽的N-末端修饰
公开(公告)号：WO2008145721A3
公开(公告)日：2009-03-12
申请号：PCT/EP2008056673
申请日：2008-05-30
申请人： NOVO NORDISK AS , SENSFUSS ULRICH , HUBALEK FRANTISEK , SCHAEFFER LAUGE , HOEG-JENSEN THOMAS , KODRA JANOS TIBOR
发明人： SENSFUSS ULRICH , HUBALEK FRANTISEK , SCHAEFFER LAUGE , HOEG-JENSEN THOMAS , KODRA JANOS TIBOR
IPC分类号： C07K14/435 , C07K14/62
CPC分类号： C07K14/62 , C07K1/003 , C07K14/605
摘要： N-terminally modified polypeptides comprising one or more N-terminal modifications consisting of an organic molecular substituent having a MW below 100 g per mol are ob- tained by the invention. Also compositions comprising such and the use thereof are com- prised by the invention.
摘要翻译：包含一个或多个N末端修饰的N-末端修饰的多肽由MW低于100g / mol的有机分子取代基组成，得到本发明。包含该组合物的组合物及其用途也包括本发明。

6. 发明申请

WO2007039606A2 INSULIN RECEPTOR ANTAGONISTS AND RELATED COMPOSITIONS, USES AND METHODS 审中-公开
标题翻译：胰岛素受体拮抗剂及相关组合物，用途和方法
公开(公告)号：WO2007039606A2
公开(公告)日：2007-04-12
申请号：PCT/EP2006066993
申请日：2006-10-03
申请人： NOVO NORDISK AS , SCHAEFFER LAUGE , BRAND CHRISTIAN LEHN , RIBEL ULLA , STURIS JEPPE
发明人： SCHAEFFER LAUGE , BRAND CHRISTIAN LEHN , RIBEL ULLA , STURIS JEPPE
IPC分类号： C07K14/43
CPC分类号： C07K14/62
摘要： Provided are new peptidic insulin receptor antagonists (PIRAs) and related compounds and compositions. Also provided are new uses of PIRAs and methods of obtaining PIRAs.
摘要翻译：提供了新的肽类胰岛素受体拮抗剂（PIRAs）及相关化合物和组合物。还提供了PIRAs的新用途和获得PIRAs的方法。

7. 发明专利

JP2013100315A Amylin derivative 审中-公开
标题翻译： AMYLIN DERIVATIVE
公开(公告)号：JP2013100315A
公开(公告)日：2013-05-23
申请号：JP2013000256
申请日：2013-01-04
申请人： Novo Nordisk As , ノボ・ノルデイスク・エー/エス
发明人： HANSEN THOMAS KRUSE , SCHAEFFER LAUGE , LAU JESPER
IPC分类号： C07K14/575 , A61K38/22 , A61K47/42 , A61K47/48 , A61P1/04 , A61P1/14 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P25/28
CPC分类号： C07K14/4713 , A61K38/00 , C07K14/5759
摘要： PROBLEM TO BE SOLVED: To provide a pharmaceutical composition containing human amylin or its derivative, and a use of the derivative to prepare a pharmaceutical to treat a disease.SOLUTION: The human amylin or its derivative has a delayed action profile in which 2- to 37-position amino acid residues are substituted with a lysine residue or a cysteine residue and the lysine residue or the cysteine residue is bonded to, through a linker in some cases, an albumin bond residue or a polyethylene glycol polymer, or (b) 1-position lysine residues are bonded to, through linkers in some cases, albumin bond residues or polyethylene glycol polymers. There are provided a pharmaceutical composition containing the derivative, and a use of the derivative to treat diseases related to obesity, and diabetes and other metabolic diseases.
摘要翻译：待解决的问题：提供含有人胰岛淀粉样多肽或其衍生物的药物组合物，以及该衍生物用于制备治疗疾病的药物的用途。解决方案：人胰岛淀粉样多肽或其衍生物具有延迟作用特征，其中2至37位氨基酸残基被赖氨酸残基或半胱氨酸残基取代，赖氨酸残基或半胱氨酸残基通过在某些情况下，连接物，白蛋白键残基或聚乙二醇聚合物，或（b）1-位赖氨酸残基通过接头在某些情况下与白蛋白键残基或聚乙二醇聚合物键合。提供含有该衍生物的药物组合物，以及该衍生物用于治疗与肥胖相关的疾病以及糖尿病和其它代谢性疾病的用途。版权所有（C）2013，JPO＆INPIT

8. 发明申请

WO0172771A3 INSULIN AND IGF-1 RECEPTOR AGONISTS AND ANTAGONISTS 审中-公开
标题翻译：胰岛素和IGF-1受体激动剂和拮抗剂
公开(公告)号：WO0172771A3
公开(公告)日：2003-12-04
申请号：PCT/US0008528
申请日：2000-03-29
申请人： DGI BIOTECHNOLOGIES L L C , NOVO NORDISK AS
发明人： BEASLEY JAMES , BLUME ARTHUR J , SCHAEFFER LAUGE , PILLUTLA RENUKA , BRANDT JAKOB , BRISSETTE RENEE , SPETZLER JANE , CHENG WEIQING , OESTERGAARD SOEREN , MANDECKI WLODEK S , HANSEN PER HERTZ , RAVERA MARK , HSIAO KU-CHUAN
IPC分类号： G01N33/50 , A61K35/76 , A61K38/00 , A61K48/00 , A61P3/10 , A61P35/00 , A61P43/00 , C07K1/04 , C07K7/08 , C07K14/00 , C12N5/10 , C12N15/09 , C40B30/00 , C40B40/02 , C40B50/06 , G01N33/15 , A61K38/10 , A61K38/16 , C12N5/12 , C12N15/11 , G01N33/68
CPC分类号： G01N33/74 , A61K38/00 , C07K1/047 , C07K7/08 , C07K14/001 , C07K2319/00 , G01N2333/65 , G01N2333/71 , G01N2500/02 , G01N2500/04
摘要： Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites which are present on insulin and insulin-like growth factor receptors which selectively bind the peptides of this invention. As agonists, certain of the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonists may also be developed as therapeutics.
摘要翻译：公开了能够以激动剂或拮抗剂活性结合胰岛素和/或胰岛素样生长因子受体并由各种肽文库鉴定的肽序列。本发明还鉴定存在于选择性结合本发明的肽的胰岛素和胰岛素样生长因子受体上的至少两个不同的结合位点。作为激动剂，本发明的某些肽可用于开发作为补充或代替内源肽激素的治疗剂。拮抗剂也可以作为治疗剂开发。

9. 发明公开

EP1496935A4 INSULIN AND IGF-1 RECEPTOR AGONISTS AND ANTAGONISTS 审中-公开
标题翻译：胰岛素和IGF-1受体激动剂和拮抗剂
公开(公告)号：EP1496935A4
公开(公告)日：2006-06-07
申请号：EP02806867
申请日：2002-09-24
申请人： NOVO NORDISK AS , DGI BIOTECHNOLOGIES INC
发明人： PILLUTLA RENUKA , BRISSETTE RENEE , BLUME ARTHUR J , SCHAEFFER LAUGE , BRANDT JAKOB , GOLDSTEIN NEIL I , SPETZLER JANE , OSTERGAARD SOREN , HERTZ HANSEN PER
IPC分类号： G01N33/50 , A61K38/00 , A61K48/00 , A61P3/10 , A61P43/00 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/62 , C07K14/65 , C12N5/06 , C12N15/09 , G01N33/15 , A61K38/28
CPC分类号： C07K14/65 , C07K14/62
摘要： Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, certain of the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonists may also be developed as therapeutics.

10. 发明专利

DE69722397T2 未知
公开(公告)号：DE69722397T2
公开(公告)日：2004-04-01
申请号：DE69722397
申请日：1997-02-21
申请人： NOVO NORDISK AS
发明人： SCHAEFFER LAUGE , BALSCHMIDT PER
IPC分类号： C07K14/62 , A61K38/28
摘要： The present invention relates to derivatives of insulin and insulin analogues wherein the N-terminal amino group of the B-chain and/or the epsilon-amino group of Lys in position B28, B29 or B30 has a substituent of the formula -CO-W-COOH wherein W is a divalent long chain hydrocarbon group having from 12 to 22 carbon atoms and zinc complexes thereof are soluble at physiological pH values and exhibit a long disappearance half-life from the injection site after subcutaneous injection.

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