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1. 发明申请

WO2009034119A1 IMPROVED DERIVATIVES OF AMYLIN 审中-公开
标题翻译：改良的AMYLIN衍生物
公开(公告)号：WO2009034119A1
公开(公告)日：2009-03-19
申请号：PCT/EP2008062036
申请日：2008-09-11
申请人： NOVO NORDISK AS , SCHAEFFER LAUGE , KRUSE THOMAS , LAU JESPER
发明人： SCHAEFFER LAUGE , KRUSE THOMAS , LAU JESPER
IPC分类号： C07K14/575 , A61K38/00
CPC分类号： C07K14/575 , A61K38/00
摘要： The invention relates to derivatives of human amylin or analogues thereof which bind to the amylin receptor and are linked to an albumin binding compound, pharmaceutical compositions comprising these derivatives and methods for obtaining such.
摘要翻译：本发明涉及与胰岛淀粉样多肽受体结合并与白蛋白结合化合物连接的人胰岛淀粉样多肽或其类似物的衍生物，包含这些衍生物的药物组合物以及获得该衍生物的方法。

2. 发明申请

WO2007104789A2 AMYLIN DERIVATIVES 审中-公开
标题翻译： AMYLIN衍生物
公开(公告)号：WO2007104789A2
公开(公告)日：2007-09-20
申请号：PCT/EP2007052456
申请日：2007-03-15
申请人： NOVO NORDISK AS , HANSEN THOMAS KRUSE , SCHAEFFER LAUGE , LAU JESPER
发明人： HANSEN THOMAS KRUSE , SCHAEFFER LAUGE , LAU JESPER
IPC分类号： C07K14/575
CPC分类号： C07K14/4713 , A61K38/00 , C07K14/5759
摘要： The present invention relates to novel amylin derivatives having a protracted action profile, to pharmaceutical compositions comprising these derivatives and to the use of the derivatives for the treatment of diseases related to obesity, diabetes and other metabolic disorders.
摘要翻译：本发明涉及具有延长作用特征的新型胰淀素衍生物，包含这些衍生物的药物组合物以及该衍生物用于治疗与肥胖，糖尿病和其它代谢紊乱相关疾病的用途。

3. 发明申请

WO2005058958A3 NOVEL GLP-1 ANALOGUES LINKED TO ALBUMIN-LIKE AGENTS 审中-公开
标题翻译：新型GLP-1类似物与ALBUMIN-LIKE AGENTS连接
公开(公告)号：WO2005058958A3
公开(公告)日：2005-11-24
申请号：PCT/DK2004000887
申请日：2004-12-17
申请人： NOVO NORDISK AS , HANSEN THOMAS KRUSE , ZUNDEL MAGALI , MADSEN KJELD , SVENDSEN ANNE , SCHIOEDT CHRISTINE BRUUN , LAU JESPER
发明人： HANSEN THOMAS KRUSE , ZUNDEL MAGALI , MADSEN KJELD , SVENDSEN ANNE , SCHIOEDT CHRISTINE BRUUN , LAU JESPER
IPC分类号： A61K38/00 , A61K38/26 , A61K38/38 , A61K47/48 , C07K14/46 , C07K14/47 , C07K14/575 , C07K14/605 , C07K14/765 , C07K19/00 , A61P3/10
CPC分类号： C07K14/605 , A61K38/00 , A61K47/643 , C07K14/46 , C07K14/4705 , C07K14/57563 , C07K2319/00
摘要： The present invention relates to a compound having the structure of the formula (I) : GLP-1 agonist-L-RR-protraction protein (I) wherein GLP-1 agonist is a polypeptide which is an agonist of the human GLP-1 receptor, L is a linker connecting an amino acid side chain of said GLP-1 agonist with RR, RR is the remains of a reactive residue that has formed a covalent bond with an amino acid residue of the protraction protein, and protraction protein is a protein having a molar weight of at least 5 kDa, having a plasma halflife of at least 24 hours in human plasma , and said protraction protein has been synthesised by a non-mammalian organism or synthetically.
摘要翻译：本发明涉及具有式（I）结构的化合物：GLP-1激动剂-L-RR-延伸蛋白（I），其中GLP-1激动剂是作为人GLP-1受体激动剂的多肽 L是将所述GLP-1激动剂的氨基酸侧链与RR连接的接头，RR是与延伸蛋白质的氨基酸残基形成共价键的反应性残基的残基，延伸蛋白是蛋白质具有至少5kDa的摩尔重量，在人血浆中具有至少24小时的血浆半衰期，并且所述延伸蛋白已经由非哺乳动物生物合成或合成地合成。

4. 发明申请

WO2007125103A3 BENZAMIDE GLUCOKINASE ACTIVATORS 审中-公开
公开(公告)号：WO2007125103A3
公开(公告)日：2008-04-10
申请号：PCT/EP2007054170
申请日：2007-04-27
申请人： NOVO NORDISK AS , MURRAY ANTHONY , LAU JESPER , JEPPESEN LONE , VEDSOE PER
发明人： MURRAY ANTHONY , LAU JESPER , JEPPESEN LONE , VEDSOE PER
IPC分类号： C07D277/46 , A61K31/426 , A61K31/427 , A61P3/10 , C07D277/54 , C07D417/12
CPC分类号： C07D277/54 , C07D277/46 , C07D417/12 , Y02P20/582
摘要： The present invention relates to N-heteroaryl-benzamides of the formula (I), pharmaceutical compositions comprising the same, and methods of using the same. The N-heteroaryl-benzamides are useful as glucokinase activators.
摘要翻译：本发明涉及式（I）的N-杂芳基 - 苯甲酰胺，包含其的药物组合物及其使用方法。 N-杂芳基 - 苯甲酰胺可用作葡糖激酶活化剂。

5. 发明申请

WO2007125105A2 BENZAMIDE GLUCOKINASE ACTIVATORS 审中-公开
公开(公告)号：WO2007125105A2
公开(公告)日：2007-11-08
申请号：PCT/EP2007054173
申请日：2007-04-27
申请人： NOVO NORDISK AS , MURRAY ANTHONY , LAU JESPER , JEPPESEN LONE , VEDSOE PER , POLISETTI DHARMA RAO , GADDAM BAPU REDDY , CHRISTEN DANIEL P , SANTHOSH KALPATHY CHIDAMBARESW , COOPER JEREMY T , ANDREWS ROBERT CARL
发明人： MURRAY ANTHONY , LAU JESPER , JEPPESEN LONE , VEDSOE PER , POLISETTI DHARMA RAO , GADDAM BAPU REDDY , CHRISTEN DANIEL P , SANTHOSH KALPATHY CHIDAMBARESW , COOPER JEREMY T , ANDREWS ROBERT CARL
CPC分类号： C07D277/44 , Y02P20/582
摘要： The present invention relates to N-heteroaryl-benzamides, pharmaceutical compositions comprising the same, and methods of using the same. The N-heteroaryl-benzamides are useful in diseases or medical conditions mediated by glucokinase.
摘要翻译：本发明涉及N-杂芳基 - 苯甲酰胺，包含它们的药物组合物及其使用方法。 N-杂芳基 - 苯甲酰胺可用于由葡糖激酶介导的疾病或医学病症。

6. 发明申请

WO2006097537A3 ACYLATED GLP-1 COMPOUNDS 审中-公开
标题翻译：酰化GLP-1化合物
公开(公告)号：WO2006097537A3
公开(公告)日：2007-01-25
申请号：PCT/EP2006060855
申请日：2006-03-20
申请人： NOVO NORDISK AS , LAU JESPER , DOERWALD FLORENCIO ZARAGOZA , STEPHENSEN HENRIK , BLOCH PAW , HANSEN THOMAS KRUSE , MADSEN KJELD
发明人： LAU JESPER , DOERWALD FLORENCIO ZARAGOZA , STEPHENSEN HENRIK , BLOCH PAW , HANSEN THOMAS KRUSE , MADSEN KJELD
IPC分类号： C07K14/605 , A61K38/26 , A61K47/48
CPC分类号： C07K14/605 , A61K38/00
摘要： Protracted GLP-1 compounds and therapeutic uses thereof.
摘要翻译：延长的GLP-1化合物及其治疗用途。

7. 发明申请

WO9901423A8 GLUCAGON ANTAGONISTS/INVERSE AGONISTS 审中-公开
标题翻译： GLUCAGON ANTAGONISTS / INVERSE AGONISTS
公开(公告)号：WO9901423A8
公开(公告)日：2001-05-17
申请号：PCT/DK9800287
申请日：1998-06-30
申请人： NOVO NORDISK AS , ALANEX CORP , LING ANTHONY , GREGOR VLAD , GONZALES JAVIER , HONG YUFENG , KIEL DAN , KUKI ATSUO , SHI SHENGHUA , NAERUM LARS , MADSEN PETER , SAMS CHRISTIAN , LAU JESPER , PLEWE MICHAEL BRUNO , FENG JUN , TENG MIN , JOHNSON MICHAEL DAVID , TESTON KIMBERLY ANN , SIDELMANN ULLA GROVE , KNUDSEN LOTTE BJERRE
发明人： LING ANTHONY , GREGOR VLAD , GONZALES JAVIER , HONG YUFENG , KIEL DAN , KUKI ATSUO , SHI SHENGHUA , NAERUM LARS , MADSEN PETER , SAMS CHRISTIAN , LAU JESPER , PLEWE MICHAEL BRUNO , FENG JUN , TENG MIN , JOHNSON MICHAEL DAVID , TESTON KIMBERLY ANN , SIDELMANN ULLA GROVE , KNUDSEN LOTTE BJERRE
IPC分类号： C07C251/86 , C07C255/29 , C07C309/65 , C07C311/49 , C07C317/28 , C07C323/45 , C07D209/48 , C07D209/86 , C07D213/30 , C07D213/80 , C07D215/12 , C07D231/12 , C07D295/185 , C07D307/12 , C07D307/52 , C07D309/06 , C07D317/58 , C07C243/18 , A61K31/15 , A61K31/40 , C07D209/04
CPC分类号： C07D209/48 , C07C251/86 , C07C255/29 , C07C309/65 , C07C311/49 , C07C317/28 , C07C323/45 , C07C2601/02 , C07C2601/14 , C07D209/86 , C07D213/30 , C07D213/80 , C07D215/12 , C07D231/12 , C07D295/185 , C07D307/12 , C07D307/52 , C07D309/06 , C07D317/58
摘要： Non-peptide compounds comprising a central hydrazide motif and methods for the synthesis thereof. The compounds act to antagonize the action of the glucagon peptide hormone.
摘要翻译：包含中心酰肼基序的非肽化合物及其合成方法。该化合物起拮抗胰高血糖素肽激素的作用。

8. 发明申请

WO2008119571A3 NUCLEIC ACID MYOSTATIN ANTAGONIST APTAMERS OBTAINED BY (MIRROR- IMAGE) SELEX 审中-公开
标题翻译：（MIRROR-IMAGE）SELEX获得的核酸肌营养肽
公开(公告)号：WO2008119571A3
公开(公告)日：2009-07-23
申请号：PCT/EP2008050046
申请日：2008-01-03
申请人： NOVO NORDISK AS , DAUGAARD JENS ROSENGREN , THOEGERSEN HENNING , JEPPESEN CLAUS BEKKER , LAU JESPER
发明人： DAUGAARD JENS ROSENGREN , THOEGERSEN HENNING , JEPPESEN CLAUS BEKKER , LAU JESPER
IPC分类号： A61K31/7088 , A61P3/04 , A61P3/10 , A61P21/00 , C12N15/10 , C12N15/115 , C12Q1/68
CPC分类号： A61K31/7088 , C12N15/115 , C12N2310/16
摘要： Myostatin antagonists are used to treat muscular generative disorders, type 2 diabetes or obesity. The antanogists are nucleic acid molecules capable of binding to myostatin.
摘要翻译：肌生成抑制素拮抗剂用于治疗肌肉发育障碍，2型糖尿病或肥胖。抗神经学家是能够结合肌生成抑制素的核酸分子。

9. 发明申请

WO2006037810A3 PROTRACTED GLP-1 COMPOUNDS 审中-公开
标题翻译：提炼的GLP-1化合物
公开(公告)号：WO2006037810A3
公开(公告)日：2006-09-08
申请号：PCT/EP2005055101
申请日：2005-10-07
申请人： NOVO NORDISK AS , LAU JESPER , HANSEN THOMAS KRUSE
发明人： LAU JESPER , HANSEN THOMAS KRUSE
IPC分类号： C07K14/605 , A61K38/26
CPC分类号： C07K14/605 , A61K38/00
摘要： Novel protracted GLP-1 compounds and therapeutic uses thereof.
摘要翻译：新颖的长效GLP-1化合物及其治疗用途。

10. 发明申请

WO2005058845A3 NOVEL GLUCAGON ANTAGONISTS/INVERSE AGONISTS 审中-公开
标题翻译：新的GLUCAGON ANTAGONISTS / INVERSE AGONISTS
公开(公告)号：WO2005058845A3
公开(公告)日：2005-10-20
申请号：PCT/EP2004053580
申请日：2004-12-17
申请人： NOVO NORDISK AS , MADSEN PETER , LAU JESPER , KODRA JANOS TIBOR , CHRISTENSEN INGE THOEGER
发明人： MADSEN PETER , LAU JESPER , KODRA JANOS TIBOR , CHRISTENSEN INGE THOEGER
IPC分类号： A61K31/198 , A61K31/275 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/50 , C07C235/84 , C07C237/12 , C07D207/32 , C07D207/323 , C07D233/70 , C07D233/96 , C07D237/02 , C07D237/08 , C07D261/02 , C07D261/08 , C07D261/18 , C07D413/12 , A61P3/04 , A61P3/06 , A61P3/10
CPC分类号： C07D207/323 , C07C235/84 , C07C2601/02 , C07C2601/14 , C07D233/96 , C07D237/08 , C07D261/18
摘要： Novel compounds that act to antagonize the action of the glucagon peptide hormone on the glucagon receptor. More particularly, it relates to glucagon antagonists or inverse agonists. (I) wherein A is (II), (III) or (IV), Y is a valence bond, >C=O, =CR -, -(CR R )m-, -NR -,=N-, E is: C1-10-alkyl or C2-10-alkenyl; C3-10-cycloalkyl, C3-10-cycloalkenyl, C7-10-bicycloalkyl, C3-10-cycloakyl-C1-6-alkyl, C3-10-cycloalkenyl-C1-6-alkyl or C7-10-bicycloalkyl-C1-6-alkyl, wherein the rings may optionally be substituted with one or more substituents selected from halogen, C1-6-alkyl, C2-6-alkenyl, C1-6-alkoxy, C1-6-thioalkyl, -CF3, -OCF3, -SCF3, -OCHF2 and -SCHF2; aryl, aryloxy, arylthio, heteroaryl, aryl-C1-6-alkyl, aryloxy-C1-6-alkyl, arylthio-C1-6-alkyl, heteroaryl-C1-6-alkyl, diaryl-C1-6-alkyl or (C1-6 -alkyl)(aryl)-C1-7-alkyl, wherein the non-aromatic and aromatic rings may optinally be substituted with one or more substituents selected from halogen, C1-6-alkyl, C2-6-alkenyl, C1-6 -alkoxy, C1-6-thioalkyl, -CF3, -OCF3, -SCF3, -OCHF2, SCHF2, C3-10-cycloalkyl and C3-10-cycloalkenyl, or with two substituents on adjacent positions which are combined to form a bridge C1-6-alkylene, C2-6-alkenylene or -O-C1-6-alkylene-O-; (V) represents a phenyl, C3-8-cycloalkyl, or a 4-, 5-, 6- or 7-membered heterocycle, D is aryl or heteroaryl.
摘要翻译：用于拮抗胰高血糖素肽激素对胰高血糖素受体的作用的新型化合物。更具体地，涉及胰高血糖素拮抗剂或反向激动剂。（I）其中A是（II），（III）或（IV），Y是价键，C = O，= CR 1 - ， - （CR 1 R 2）m - ，-NR 1 - ，= N-，E是：C 1-10 - 烷基或C 2-10 - 烯基; C 3-10 - 环烷基，C 3-10 - 环烯基，C 7-10 - 双环烷基，C 3-10 - 环烷基-C 1-6 - 烷基，C 3-10 - 环烯基-C 1-6 - 烷基或C 3-10 - 双环烷基-C 其中所述环可以任选地被一个或多个选自卤素，C 1-6 - 烷基，C 2-6 - 烯基，C 1-6 - 烷氧基，C 1-6 - 硫代烷基，-CF 3，-OCF 3， -SCF 3，-OCHF 2和-SCHF 2; 芳基，芳氧基，芳硫基，杂芳基，芳基-C 1-6 - 烷基，芳氧基-C 1-6 - 烷基，芳硫基-C 1-6 - 烷基，杂芳基-C 1-6 - 烷基，二芳基-C 1-6 - 烷基或（C 1 （芳基）-C 1-7 - 烷基，其中非芳族和芳族环可以选择性地被一个或多个选自卤素，C 1-6 - 烷基，C 2-6 - 烯基，C 1 -C 6 - 6-烷氧基，C 1-6 - 硫代烷基，-CF 3，-OCF 3，-SCF 3，-OCHF 2，SCHF 2，C 3-10 - 环烷基和C 3-10 - 环烯基，或与相邻位置上的两个取代基组合形成桥 C 1-6亚烷基，C 2-6亚烯基或-O-C 1-6 - 亚烷基-O-; （V）代表苯基，C 3-8 - 环烷基或4-，5-，6-或7-元杂环，D是芳基或杂芳基。

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