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1. 发明申请

WO2006109191A3 HUMAN ANTI-INTERFERON GAMMA ANTIBODIES AND METHODS OF USE THEREOF 审中-公开
标题翻译：人类抗干扰素GAMMA抗体及其使用方法
公开(公告)号：WO2006109191A3
公开(公告)日：2007-04-26
申请号：PCT/IB2006001514
申请日：2006-01-27
申请人： NOVIMMUNE SA , FERLIN WALTER , FISCHER NICOLAS , ELSON GREG , LEGER OLIVIER
发明人： FERLIN WALTER , FISCHER NICOLAS , ELSON GREG , LEGER OLIVIER
IPC分类号： C07K16/24 , A61K39/395
CPC分类号： C07K16/249 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/54 , C07K2317/21 , C07K2317/33 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： The invention relates to fully human antibodies, and fragments thereof, that bind to human interferon gamma (hlFN?), thereby modulating the interaction between IFN? and its receptor, IFN?-R, and/or modulating the biological activities of IFN?. The invention also relates to the use of such anti-IFN? antibodies in the prevention or treatment of immune- related disorders and in the amelioration of a symptom associated with an immune-related disorder.
摘要翻译：本发明涉及与人类干扰素γ（hIFN1β）结合的完全人抗体及其片段，从而调节IFNα 和其受体IFNγ-R，和/或调节IFNα的生物学活性。本发明还涉及使用这种抗-IFN？抗体在预防或治疗免疫相关疾病和改善与免疫相关病症相关的症状中。

2. 发明申请

WO2005118635A3 ANTI-CD3 ANTIBODIES AND METHODS OF USE THEREOF 审中-公开
标题翻译：抗CD3抗体及其使用方法
公开(公告)号：WO2005118635A3
公开(公告)日：2006-06-15
申请号：PCT/US2005019922
申请日：2005-06-03
申请人： NOVIMMUNE SA , MACH BERNARD , DEAN YANN , KOSCO-VILBOIS MARIE , ELSON GREG CHRISTOPHER ANDREW , FISCHER NICOLAS , LEGER OLIVIER
发明人： MACH BERNARD , DEAN YANN , KOSCO-VILBOIS MARIE , ELSON GREG CHRISTOPHER ANDREW , FISCHER NICOLAS , LEGER OLIVIER
IPC分类号： C07K16/28 , C07K14/47
CPC分类号： C07K16/2809 , A61K39/3955 , A61K45/06 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/74
摘要： The present invention is related to antibodies directed to the antigen CD3 and uses of such antibodies. In particular, the present invention provides fully human monoclonal antibodies directed to CD3. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.
摘要翻译：本发明涉及针对抗原CD3的抗体和这种抗体的用途。特别地，本发明提供了完全针对CD3的人单克隆抗体。编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是包含重链和轻链免疫球蛋白分子的序列，特别是对应于跨越框架区和/或互补决定区的连续重链和轻链序列的序列（CDR ），特别是FR1至FR4或CDR1至CDR3。还提供了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。

3. 发明申请

WO2012023053A3 METHODS FOR THE GENERATION OF MULTISPECIFIC AND MULTIVALENT ANTIBODIES 审中-公开
标题翻译：用于产生多重和多重抗体的方法
公开(公告)号：WO2012023053A3
公开(公告)日：2012-05-24
申请号：PCT/IB2011002664
申请日：2011-08-16
申请人： NOVIMMUNE SA , FISCHER NICOLAS , MAGISTRELLI GIOVANNI , GUENEAU FRANCK , RAVN ULLA , ELSON GREG
发明人： FISCHER NICOLAS , MAGISTRELLI GIOVANNI , GUENEAU FRANCK , RAVN ULLA , ELSON GREG
IPC分类号： C07K16/00 , C07K16/46
CPC分类号： C07K16/468 , C07K16/005 , C07K16/248 , C07K16/249 , C07K16/2866 , C07K2317/31 , C07K2317/32 , C07K2317/622 , C07K2317/92 , C12N15/1037 , C12N15/1075
摘要： The invention provides novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule and methods for producing novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule. The antibodies are composed of a single heavy chain and two different light chains, one containing a Kappa constant domain and the other of a Lambda constant domain. The invention provides methods for the isolation of antibodies of different specificities but sharing a common heavy chain. The invention also provides methods for the controlled co-expression of two light chains and a single heavy chain leading to the assembly of monospecific and bispecific antibodies. The invention provides a mean of producing a fully human bispecific and bivalent antibody that is unaltered in sequence and does not involve the use of linkers or other non-human sequences, as well as antibody mixtures of two monospecific antibodies and one bispecific antibody. The invention also provides the means of efficiently purifying the bispecific antibody.
摘要翻译：本发明提供对免疫球蛋白分子的每个结合位点携带不同特异性的新型双特异性单克隆抗体以及用于产生对免疫球蛋白分子的每个结合位点具有不同特异性的新型双特异性单克隆抗体的方法。抗体由单个重链和两个不同的轻链组成，一个含有κ恒定结构域，另一个是λ恒定结构域。本发明提供了分离不同特异性但共享共同重链的抗体的方法。本发明还提供了两个轻链和单个重链的受控共表达的方法，导致单特异性和双特异性抗体的组装。本发明提供了产生完全人双特异性和二价抗体的平均值，其依次不变，不涉及使用接头或其它非人序列，以及两种单特异性抗体和一种双特异性抗体的抗体混合物。本发明还提供有效纯化双特异性抗体的方法。

4. 发明申请

WO2013149111A3 ANTI-TLR4 ANTIBODIES AND USES THEREOF 审中-公开
标题翻译：抗TLR4抗体及其用途
公开(公告)号：WO2013149111A3
公开(公告)日：2014-01-30
申请号：PCT/US2013034543
申请日：2013-03-29
申请人： NOVIMMUNE SA , ROUSSEAU FRANCOIS , LOYAU JEREMY , FISCHER NICOLAS , ELSON GREG , KOSCO-VILBOIS MARIE
发明人： ROUSSEAU FRANCOIS , LOYAU JEREMY , FISCHER NICOLAS , ELSON GREG , KOSCO-VILBOIS MARIE
IPC分类号： C07K16/28
CPC分类号： C07K16/2896 , C07K16/2866 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/92
摘要： Disclosed are antibodies that specifically bind Toll-like Receptor 4 (TLR-4), and to methods of using the anti-TLR4 antibodies as therapeutics and diagnostic agents.
摘要翻译：公开了特异性结合Toll样受体4（TLR-4）的抗体，以及使用抗TLR4抗体作为治疗剂和诊断剂的方法。

5. 发明申请

WO2013088259A3 METHODS OF PURIFYING ANTIBODIES 审中-公开
标题翻译：纯化抗体的方法
公开(公告)号：WO2013088259A3
公开(公告)日：2013-11-14
申请号：PCT/IB2012003028
申请日：2012-10-19
申请人： NOVIMMUNE SA , ELSON GREG , FOUQUE NICOLAS , DEPOISIER JEAN-FRANCOIS , FISCHER NICOLAS , MAGISTRELLI GIOVANNI
发明人： ELSON GREG , FOUQUE NICOLAS , DEPOISIER JEAN-FRANCOIS , FISCHER NICOLAS , MAGISTRELLI GIOVANNI
IPC分类号： C07K16/00 , C07K16/46
CPC分类号： C07K16/00 , C07K16/248 , C07K16/249 , C07K16/2866 , C07K16/468 , C07K2317/32 , C07K2317/52
摘要： The invention provides methods of purifying antibodies using various antibody- specific purification media to rapidly and efficiently separate mixtures of antibodies, antibody fragments and/or antibody components to isolate a desired antibody product from the mixture. The invention relates to the purification of bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule, e.g., antibodies composed of a single heavy chain and two different light chains, one containing Kappa constant domain and the other a Lambda constant domain, including antibodies of different specificities that share a common heavy chain. The invention also provides the methods of efficiently purifying intact antibodies by separating the intact antibody from non-intact antibodies including free light chains.
摘要翻译：本发明提供了使用各种抗体特异性纯化介质来纯化抗体以快速且有效地分离抗体，抗体片段和/或抗体组分的混合物以从混合物中分离出所需抗体产物的方法。本发明涉及纯化对免疫球蛋白分子的每个结合位点具有不同特异性的双特异性单克隆抗体，例如由单一重链和两个不同轻链组成的抗体，一个含有κ恒定结构域，另一个含有λ恒定结构域包括具有共同重链的不同特异性的抗体。本发明还提供了通过将完整抗体与包括游离轻链的非完整抗体分开来有效纯化完整抗体的方法。

6. 发明申请

WO2008106200A3 HUMAN ANTI-IP-10 ANTIBODIES AND USES THEREOF 审中-公开
标题翻译：人类抗体-IP-10抗体及其用途
公开(公告)号：WO2008106200A3
公开(公告)日：2009-04-09
申请号：PCT/US2008002650
申请日：2008-02-28
申请人： NOVIMMUNE SA , FISCHER NICOLAS , KOSCO-VILBOIS MARIE , LEGER OLIVIER
发明人： FISCHER NICOLAS , KOSCO-VILBOIS MARIE , LEGER OLIVIER
IPC分类号： C07K16/24 , A61P37/06
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The invention relates to fully human antibodies, and fragments thereof, that bind to interferon-inducible-protein-10 (IP-IO, CXCLlO), thereby modulating the interaction between IP-IO and its receptor, CXCR3, and/or modulating the biological activities of IP-IO. The invention also relates to the use of such anti-IP- 10 antibodies in the prevention or treatment of immune-related disorders and in the amelioration of one or more symptoms associated with an immune-related disorder.
摘要翻译：本发明涉及与干扰素诱导型蛋白-10（IP-10，CXCL10）结合的完全人抗体及其片段，从而调节IP-10与其受体CXCR3之间的相互作用和/或调节生物学 IP-IO的活动。本发明还涉及这样的抗-IP-10抗体在预防或治疗免疫相关疾病以及改善与免疫相关疾病相关的一种或多种症状中的用途。

7. 发明申请

WO2008106200A9 ANTI-IP-10 ANTIBODIES AND METHODS OF USE THEREOF 审中-公开
标题翻译：抗-IP-10抗体及其使用方法
公开(公告)号：WO2008106200A9
公开(公告)日：2008-12-04
申请号：PCT/US2008002650
申请日：2008-02-28
申请人： NOVIMMUNE SA , FISCHER NICOLAS , KOSCO-VILBOIS MARIE , LEGER OLIVIER
发明人： FISCHER NICOLAS , KOSCO-VILBOIS MARIE , LEGER OLIVIER
IPC分类号： C07K16/24 , A61P37/06
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The invention relates to fully human antibodies, and fragments thereof, that bind to interferon-inducible-protein-10 (IP-IO, CXCLlO), thereby modulating the interaction between IP-IO and its receptor, CXCR3, and/or modulating the biological activities of IP-IO. The invention also relates to the use of such anti-IP- 10 antibodies in the prevention or treatment of immune-related disorders and in the amelioration of one or more symptoms associated with an immune-related disorder.
摘要翻译：本发明涉及与干扰素诱导型蛋白-10（IP-10，CXCL10）结合的完全人抗体及其片段，从而调节IP-10与其受体CXCR3之间的相互作用和/或调节生物学 IP-IO的活动。本发明还涉及这样的抗-IP-10抗体在预防或治疗免疫相关疾病以及改善与免疫相关疾病相关的一种或多种症状中的用途。

8. 发明申请

WO2011084255A3 SYNTHETIC POLYPEPTIDE LIBRARIES AND METHODS FOR GENERATING NATURALLY DIVERSIFIED POLYPEPTIDE VARIANTS 审中-公开
标题翻译：合成多肽文库和产生自然多样化多肽变体的方法
公开(公告)号：WO2011084255A3
公开(公告)日：2011-10-06
申请号：PCT/US2010057780
申请日：2010-11-23
申请人： NOVIMMUNE SA , FISCHER NICOLAS , KOSCO-VILBOIS MARIE , RAVN ULLA , GUENEAU FRANCK , VENET-BONNOT SOPHIE
发明人： FISCHER NICOLAS , KOSCO-VILBOIS MARIE , RAVN ULLA , GUENEAU FRANCK , VENET-BONNOT SOPHIE
IPC分类号： C12N15/13 , C07K16/18 , C12N15/70
CPC分类号： C12N15/70 , C07K16/005 , C07K16/249 , C07K16/42 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12N15/1034
摘要： The invention provides compositions and methods for generating libraries of DNA sequences encoding homologous polypeptides, and uses of the libraries to identify naturally diversified polypeptide variants. The invention also provides compositions and methods for generating collections of synthetic antibody fragments in which one or several complementary determining regions (CDR) are replaced by a collection of the corresponding CDR captured from a natural source. The invention further provides compositions and methods for diversifying a portion of a polypeptide by inserting a diversified sequence of synthetic or natural origin without the need for modification of the original polypeptide coding sequence.
摘要翻译：本发明提供了用于产生编码同源多肽的DNA序列文库的组合物和方法，以及文库用于鉴定天然多样化的多肽变体的用途。本发明还提供了用于产生合成抗体片段集合的组合物和方法，其中一个或多个互补决定区（CDR）被从天然来源捕获的相应CDR的集合所取代。本发明进一步提供了通过插入多样化的合成或天然来源序列而不需要修饰原始多肽编码序列来使多肽的一部分多样化的组合物和方法。

9. 发明申请

WO2013136186A3 READILY ISOLATED BISPECIFIC ANTIBODIES WITH NATIVE IMMUNOGLOBULIN FORMAT 审中-公开
标题翻译：具有本身免疫球蛋白形式的自分离分离抗体
公开(公告)号：WO2013136186A3
公开(公告)日：2014-01-23
申请号：PCT/IB2013000902
申请日：2013-03-13
申请人： NOVIMMUNE SA , FISCHER NICOLAS , MAGISTRELLI GIOVANNI , ROUSSEAU FRANCOIS , MASTERNAK KRZYSZTOF , MALINGE PAULINE
发明人： FISCHER NICOLAS , MAGISTRELLI GIOVANNI , ROUSSEAU FRANCOIS , MASTERNAK KRZYSZTOF , MALINGE PAULINE
IPC分类号： C07K16/24 , C07K16/28
CPC分类号： C07K16/468 , C07K16/244 , C07K16/2809 , C07K2317/31
摘要： The invention relates to antigen-binding proteins or antibodies having heterodimers of heavy chains, i.e., two immunoglobulin heavy chains that differ by at least one or two amino acid(s) that allows for isolation of the antigen-binding protein based on a differential affinity of an immunoglobulin heavy chain and a modified/mutated immunoglobulin heavy chain toward an affinity reagent. The invention also relates antigen-binding proteins, including bispecific antibodies, having IgG CH1 regions with different affinities with respect to affinity reagent(s) that allows rapid isolation by differential binding of the IgG regions to the affinity reagent(s).
摘要翻译：本发明涉及具有重链异源二聚体的抗原结合蛋白或抗体，即两条免疫球蛋白重链之间有差异的至少一个或两个氨基酸，其允许基于差异亲和力分离抗原结合蛋白的免疫球蛋白重链和修饰/突变的免疫球蛋白重链朝向亲和试剂。本发明还涉及包含双特异性抗体的抗原结合蛋白，其具有相对于亲和试剂具有不同亲和力的IgG CH1区域，其允许通过IgG区域与亲和试剂的差异结合快速分离。

10. 发明申请

WO2009054873A9 ANTI-RANTES ANTIBODIES AND METHODS OF USE THEREOF 审中-公开
标题翻译：抗RANTES抗体及其使用方法
公开(公告)号：WO2009054873A9
公开(公告)日：2009-06-25
申请号：PCT/US2008009382
申请日：2008-08-04
申请人： NOVIMMUNE SA , FISCHER NICOLAS , KOSCO-VILBOIS MARIE , MACH FRANCOIS
发明人： FISCHER NICOLAS , KOSCO-VILBOIS MARIE , MACH FRANCOIS
IPC分类号： C07K2/00 , A61K39/395 , C07H21/00 , C07K16/18
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/21 , C07K2317/30 , C07K2317/33 , C07K2317/52 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： The invention relates to fully human monoclonal antibodies, and fragments thereof, that bind to the chemokine Regulated upon Activation, Normal T-cell Expressed, and Secreted (RANTES, CCL5), thereby modulating the interaction between RANTES and one of more of its receptors, such as, e.g., CCR1, CCR3, CCR4 and CCR5, and/or modulating the biological activities of RANTES. The invention also relates to the use of these or any anti-RANTES antibodies in the prevention or treatment of immune-related disorders and in the amelioration of one or more symptoms associated with an immune-related disorder.
摘要翻译：本发明涉及与活化，正常T细胞表达和分泌后调节的趋化因子（RANTES，CCL5）结合的完全人单克隆抗体及其片段，从而调节RANTES与其一种或多种受体之间的相互作用，例如CCR1，CCR3，CCR4和CCR5，和/或调节RANTES的生物活性。本发明还涉及这些或任何抗RANTES抗体在预防或治疗免疫相关病症和改善与免疫相关病症相关的一种或多种症状中的用途。

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