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1. 发明申请

WO2013136186A3 READILY ISOLATED BISPECIFIC ANTIBODIES WITH NATIVE IMMUNOGLOBULIN FORMAT 审中-公开
标题翻译：具有本身免疫球蛋白形式的自分离分离抗体
公开(公告)号：WO2013136186A3
公开(公告)日：2014-01-23
申请号：PCT/IB2013000902
申请日：2013-03-13
申请人： NOVIMMUNE SA , FISCHER NICOLAS , MAGISTRELLI GIOVANNI , ROUSSEAU FRANCOIS , MASTERNAK KRZYSZTOF , MALINGE PAULINE
发明人： FISCHER NICOLAS , MAGISTRELLI GIOVANNI , ROUSSEAU FRANCOIS , MASTERNAK KRZYSZTOF , MALINGE PAULINE
IPC分类号： C07K16/24 , C07K16/28
CPC分类号： C07K16/468 , C07K16/244 , C07K16/2809 , C07K2317/31
摘要： The invention relates to antigen-binding proteins or antibodies having heterodimers of heavy chains, i.e., two immunoglobulin heavy chains that differ by at least one or two amino acid(s) that allows for isolation of the antigen-binding protein based on a differential affinity of an immunoglobulin heavy chain and a modified/mutated immunoglobulin heavy chain toward an affinity reagent. The invention also relates antigen-binding proteins, including bispecific antibodies, having IgG CH1 regions with different affinities with respect to affinity reagent(s) that allows rapid isolation by differential binding of the IgG regions to the affinity reagent(s).
摘要翻译：本发明涉及具有重链异源二聚体的抗原结合蛋白或抗体，即两条免疫球蛋白重链之间有差异的至少一个或两个氨基酸，其允许基于差异亲和力分离抗原结合蛋白的免疫球蛋白重链和修饰/突变的免疫球蛋白重链朝向亲和试剂。本发明还涉及包含双特异性抗体的抗原结合蛋白，其具有相对于亲和试剂具有不同亲和力的IgG CH1区域，其允许通过IgG区域与亲和试剂的差异结合快速分离。

2. 发明申请

WO2015033223A3 READILY ISOLATED BISPECIFIC BINDING MOLECULES WITH NATIVE FORMAT HAVING MUTATED CONSTANT REGIONS 审中-公开
标题翻译：准备隔离的双特异性结合分子与本地格式具有变异的恒定区域
公开(公告)号：WO2015033223A3
公开(公告)日：2015-10-29
申请号：PCT/IB2014002388
申请日：2014-09-03
申请人： NOVIMMUNE SA
发明人： FISCHER NICOLAS , MAGISTRELLI GIOVANNI , ROUSSEAU FRANÇOIS , MASTERNAK KRZYSZTOF , MALINGE PAULINE
IPC分类号： C07K16/24 , C07K1/00 , C07K16/28 , C07K16/46
CPC分类号： C07K16/468 , C07K16/244 , C07K16/2809 , C07K2317/21 , C07K2317/31 , C07K2317/50 , C07K2317/522 , C07K2317/526 , C07K2317/622 , C07K2317/94
摘要： The invention provides heterodimer bispecific antigen-binding molecules that include a first polypeptide thai does not include an IgG CH1 domain and a second polypeptide having an immunoglobulin constant region where there is at least one mutation in the IgG CH3 domain that abolishes the ability of the second polypeptide to bind CH3- specific affinity media such that the first and second polypeptides have different affinities with respect to CH1 and CH3 specific affinity reagents that allows rapid isolation by differential binding of the first and second polypeptides to these affinity reagents. The invention also provides bispeeific antibodies that have IgG CH1 and CH3 regions with different affinities with respect to affinity reagents that allows rapid isolation by differential binding of the IgG regions to these affinity reagents. The invention also concerns bispeeific antibodies which are heterodimers of heavy chains, i.e., two immunoglobulin heavy chains that differ by at least two amino acids that allowr for the isolation of the bispeeific antibody based on a differential affinity of one mutated immunoglobulin heavy chain and a second mutated immunoglobulin heavy chain toward two different affinity reagents.
摘要翻译：本发明提供了异二聚体双特异性抗原结合分子，其包括不包含IgG CH1结构域的第一多肽和具有免疫球蛋白恒定区的第二多肽，其中IgG CH3结构域中存在至少一个突变，其消除了第二多肽结合CH3特异性亲和介质，使得第一和第二多肽对于CH1和CH3特异性亲和试剂具有不同的亲和力，其允许通过第一和第二多肽与这些亲和试剂的差异结合来快速分离。本发明还提供具有对于亲和试剂具有不同亲和力的IgG CH1和CH3区的双特异性抗体，其允许通过IgG区与这些亲和试剂的差异结合来快速分离。本发明还涉及作为重链异二聚体的双特异性抗体，即两条免疫球蛋白重链相差至少两个氨基酸，允许基于一种突变的免疫球蛋白重链与第二种突变的免疫球蛋白重链的差异亲和力分离双特异性抗体突变的免疫球蛋白重链朝向两种不同的亲和试剂。

3. 发明专利

ES2752054T3 Método para optimizar el ensamble y producción de complejos de proteínas heteromultiméricas 未知
公开(公告)号：ES2752054T3
公开(公告)日：2020-04-02
申请号：ES16715820
申请日：2016-03-31
申请人： NOVIMMUNE SA
发明人： MAGISTRELLI GIOVANNI , MALINGE PAULINE , POITEVIN YVES , FISCHER NICOLAS
IPC分类号： C12N15/67 , C07K16/46 , C12P21/02
摘要： Un método para aumentar el rendimiento de producción de un complejo de proteínas que comprende: (a) identificar uno o más polipéptidos en el complejo que se expresan más abundantemente en una célula en comparación con los otros polipéptidos en el complejo; (b) modificar al menos una molécula de ácido nucleico que codifica los polipéptidos más abundantemente expresados en el complejo, en el que las moléculas de ácido nucleico se modifican al alterar la composición de codón de las moléculas de ácido nucleico que resulta en una reducción de la expresión de los polipéptidos que codifica; (c) introducir las moléculas de ácido nucleico en una célula; y (d) cultivar la célula bajo condiciones que permiten la expresión de todos los polipéptidos del complejo de proteínas; en el que dicha reducción de la expresión se logra mediante el reemplazo de ciertos codones con codones que se utilizan con menos frecuencia en la célula, al codificar un cambio en la estructura secundaria del ARNm o codificar un cambio en la tasa de traducción, y en el que el complejo de proteínas es un anticuerpo biespecífico.

4. 发明专利

AU2017279804B2 Readily Isolated Bispecific Antibodies with Native Immunoglobulin Format 未知
公开(公告)号：AU2017279804B2
公开(公告)日：2020-03-12
申请号：AU2017279804
申请日：2017-12-22
申请人： NOVIMMUNE SA
发明人： FISCHER NICOLAS , MAGISTRELLI GIOVANNI , ROUSSEAU FRANCOIS , MASTERNAK KRZYSZTOF , MALINGE PAULINE
IPC分类号： C07K16/24 , C07K16/28
摘要： The invention relates to antigen-binding proteins or antibodies having heterodimers of heavy chains, i.e., two immunoglobulin heavy chains that differ by at least one or two amino acid(s) that allows for isolation of the antigen-binding protein based on a differential affinity of an immunoglobulin heavy chain and a modified/mutated immunoglobulin heavy chain toward an affinity reagent. The invention also relates antigen-binding proteins, including bispecific antibodies, having IgG CH Iregions with different affinities with respect to affinity reagent(s) that allows rapid isolation by differential binding of the IgG regions to the affinity reagent(s).

5. 发明专利

DK3277821T3 FREMGANGSMÅDE TIL OPTIMERING AF SAMLING OG PRODUKTION AF HETERO-MULTIMERE PROTEINKOMPLEKSER 未知
公开(公告)号：DK3277821T3
公开(公告)日：2019-10-28
申请号：DK16715820
申请日：2016-03-31
申请人： NOVIMMUNE SA
发明人： MAGISTRELLI GIOVANNI , MALINGE PAULINE , POITEVIN YVES , FISCHER NICOLAS
IPC分类号： C12N15/67 , C07K16/46 , C12P21/02

6. 发明专利

ES2728301T3 Anticuerpos biespecíficos fácilmente aislados con formato de inmunoglobulina nativa 未知
公开(公告)号：ES2728301T3
公开(公告)日：2019-10-23
申请号：ES13739281
申请日：2013-03-13
申请人： NOVIMMUNE SA
发明人： FISCHER NICOLAS , MAGISTRELLI GIOVANNI , ROUSSEAU FRANÇOIS , MASTERNAK KRZYSZTOF , MALINGE PAULINE
IPC分类号： C07K16/24 , C07K16/28
摘要： Un método para producir un anticuerpo biespecífico aislado que comprende: a) obtener una secuencia de ácido nucleico que codifica una primera cadena pesada de inmunoglobulina que comprende una primera región variable que se une a un primer epítopo, en el que la primera cadena pesada de inmunoglobulina comprende un dominio constante de isotipo IgG1 que comprende la secuencia de aminoácidos de la SEQ ID NO: 1, un dominio constante de isotipo IgG2 que comprende la secuencia de aminoácidos de la SEQ ID NO: 2, un dominio constante de isotipo IgG3 que comprende la secuencia de aminoácidos de la SEQ ID NO: 3, o un dominio constante de isotipo IgG4 que comprende la secuencia de aminoácidos de SEQ ID NO: 4; b) obtener una segunda secuencia de ácido nucleico que codifica una segunda cadena pesada de inmunoglobulina que comprende una segunda región variable que se une a un segundo epítopo, en el que la segunda cadena pesada de inmunoglobulina comprende un dominio constante de isotipos IgG1, IgG2, IgG3 o IgG4 que comprende una modificación en su dominio CH1 que erradica o reduce la unión a un reactivo de afinidad que se dirige al dominio CH1 humano IgG1, IgG2, IgG3 e IgG4, en el que el dominio constante de isotipo IgG1 comprende la secuencia de aminoácidos de la SEQ ID NO: 15, el dominio constante de isotipo IgG2 comprende la secuencia de aminoácidos de la SEQ ID NO: 16, el dominio constante de isotipo IgG3 comprende la secuencia de aminoácidos de la SEQ ID NO: 17, o el dominio constante de isotipo IgG4 comprende la secuencia de aminoácidos de la SEQ ID NO: 18; c) obtener una tercera secuencia de ácido nucleico que codifica una cadena ligera de inmunoglobulina que se empareja con la primera y la segunda cadena pesada de inmunoglobulina; d) introducción de la primera, segunda y tercera secuencias de ácido nucleico en una célula de mamífero in vitro; e) permitir que la célula exprese un anticuerpo biespecífico; y f) aislar el anticuerpo biespecífico en función de la capacidad del anticuerpo biespecífico para unirse al reactivo de afinidad que se dirige a los dominios de IgG1, IgG2, IgG3 e IgG4 humanos.

7. 发明专利

CA2922979A1 READILY ISOLATED BISPECIFIC BINDING MOLECULES WITH NATIVE FORMAT HAVING MUTATED CONSTANT REGIONS 未知
公开(公告)号：CA2922979A1
公开(公告)日：2015-03-12
申请号：CA2922979
申请日：2014-09-03
申请人： NOVIMMUNE SA
发明人： FISCHER NICOLAS , MAGISTRELLI GIOVANNI , ROUSSEAU FRANCOIS , MASTERNAK KRZYSZTOF , MALINGE PAULINE
IPC分类号： C07K16/00 , C07K1/00 , C07K16/24 , C07K16/28 , C07K16/46
摘要： The invention provides heterodimer bispecific antigen-binding molecules that include a first polypeptide thai does not include an IgG CH1 domain and a second polypeptide having an immunoglobulin constant region where there is at least one mutation in the IgG CH3 domain that abolishes the ability of the second polypeptide to bind CH3- specific affinity media such that the first and second polypeptides have different affinities with respect to CH1 and CH3 specific affinity reagents that allows rapid isolation by differential binding of the first and second polypeptides to these affinity reagents. The invention also provides bispeeific antibodies that have IgG CH1 and CH3 regions with different affinities with respect to affinity reagents that allows rapid isolation by differential binding of the IgG regions to these affinity reagents. The invention also concerns bispeeific antibodies which are heterodimers of heavy chains, i.e., two immunoglobulin heavy chains that differ by at least two amino acids that allowr for the isolation of the bispeeific antibody based on a differential affinity of one mutated immunoglobulin heavy chain and a second mutated immunoglobulin heavy chain toward two different affinity reagents.

8. 发明专利

CA2867020C READILY ISOLATED BISPECIFIC ANTIBODIES WITH NATIVE IMMUNOGLOBULIN FORMAT 未知
公开(公告)号：CA2867020C
公开(公告)日：2022-11-15
申请号：CA2867020
申请日：2013-03-13
申请人： NOVIMMUNE SA
发明人： FISCHER NICOLAS , MAGISTRELLI GIOVANNI , ROUSSEAU FRANCOIS , MASTERNAK KRZYSZTOF , MALINGE PAULINE
IPC分类号： C07K16/24 , C07K16/28
摘要： The invention relates to antigen-binding proteins or antibodies having heterodimers of heavy chains, i.e., two immunoglobulin heavy chains that differ by at least one or two amino acid(s) that allows for isolation of the antigen-binding protein based on a differential affinity of an immunoglobulin heavy chain and a modified/mutated immunoglobulin heavy chain toward an affinity reagent. The invention also relates antigen-binding proteins, including bispecific antibodies, having IgG CH1 regions with different affinities with respect to affinity reagent(s) that allows rapid isolation by differential binding of the IgG regions to the affinity reagent(s).

9. 发明专利

AU2013234039B2 Readily isolated bispecific antibodies with native immunoglobulin format 未知
公开(公告)号：AU2013234039B2
公开(公告)日：2018-02-01
申请号：AU2013234039
申请日：2013-03-13
申请人： NOVIMMUNE SA
发明人： FISCHER NICOLAS , MAGISTRELLI GIOVANNI , ROUSSEAU FRANCOIS , MASTERNAK KRZYSZTOF , MALINGE PAULINE
IPC分类号： C07K16/24 , C07K16/28
摘要： The invention relates to antigen-binding proteins or antibodies having heterodimers of heavy chains,

10. 发明专利

AU2017279804A1 Readily Isolated Bispecific Antibodies with Native Immunoglobulin Format 未知
公开(公告)号：AU2017279804A1
公开(公告)日：2018-01-25
申请号：AU2017279804
申请日：2017-12-22
申请人： NOVIMMUNE SA
发明人： FISCHER NICOLAS , MAGISTRELLI GIOVANNI , ROUSSEAU FRANCOIS , MASTERNAK KRZYSZTOF , MALINGE PAULINE
IPC分类号： C07K16/24 , C07K16/28
摘要： The invention relates to antigen-binding proteins or antibodies having heterodimers of heavy chains, i.e., two immunoglobulin heavy chains that differ by at least one or two amino acid(s) that allows for isolation of the antigen-binding protein based on a differential affinity of an immunoglobulin heavy chain and a modified/mutated immunoglobulin heavy chain toward an affinity reagent. The invention also relates antigen-binding proteins, including bispecific antibodies, having IgG CHI regions with different affinities with respect to affinity reagent(s) that allows rapid isolation by differential binding of the IgG regions to the affinity reagent(s).

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