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1. 发明申请

WO2006074924A8 3,4,(5)-SUBSTITUTED TETRAHVDROPYRIDINES 审中-公开
标题翻译： 3,4，（5）-SUBSTITUTED TETRAHVDRRYRIDINES
公开(公告)号：WO2006074924A8
公开(公告)日：2007-04-19
申请号：PCT/EP2006000216
申请日：2006-01-12
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , MASUYA KEIICHI , IRIE OSAMU , NIHONYANAGI ATSUKO , TOYAO ATSUSHI , KANAZAWA TAKANORI
发明人： MASUYA KEIICHI , IRIE OSAMU , NIHONYANAGI ATSUKO , TOYAO ATSUSHI , KANAZAWA TAKANORI
IPC分类号： C07D211/78 , A61K31/4545 , A61P9/00 , C07D401/10 , C07D401/12 , C07D409/12
CPC分类号： C07D401/12 , C07D211/78 , C07D401/10 , C07D409/12
摘要： Organic Compounds 3,4(,5)-substituted tetrahydropyridine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,4(,5)- substituted tetrahydropyridine compound, and/or a method of treatment comprising administering a 3,4(,5)-substituted tetrahydropyridine compound, a method for the manufacture of a 3,4(,5)- substituted tetrahydropyridine compound, and novel intermediates and partial steps for its synthesis. The 3,4(,5)- substituted tetrahydropyridine compounds have the formula I wherein the substituents and symbols are as described in the specification.
摘要翻译：有机化合物3,4（，5） - 取代的四氢吡啶化合物，用于诊断和治疗温血动物的化合物，特别是用于治疗依赖于肾素活性的疾病; 使用该类化合物制备用于治疗依赖于肾素活性的疾病的药物制剂; 使用该类化合物治疗依赖于肾素活性的疾病; 包含3,4（，5） - 取代的四氢吡啶化合物的药物制剂和/或包括施用3,4（，5） - 取代的四氢吡啶化合物的方法，以及制备3,4（， 5） - 取代的四氢吡啶化合物，以及其合成的新型中间体和部分步骤。 3,4（，5） - 取代的四氢吡啶化合物具有式I，其中取代基和符号如说明书中所述。

2. 发明申请

WO2006128659A3 PIPERAZINE DERIVATIVE RENIN INHIBITORS. 审中-公开
标题翻译：哌嗪衍生物雷宁抑制剂。
公开(公告)号：WO2006128659A3
公开(公告)日：2007-11-29
申请号：PCT/EP2006005107
申请日：2006-05-29
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , NIHONYANAGI ATSUKO , TOYAO ATSUSHI , IWAKI YUKI , MASUYA KEIICHI
发明人： NIHONYANAGI ATSUKO , TOYAO ATSUSHI , IWAKI YUKI , MASUYA KEIICHI
IPC分类号： C07D403/12 , A61K31/496 , C07D417/14
CPC分类号： C07D417/14 , C07D403/12
摘要： The invention relates to substituted 3,4- or higher substituted piperazine compounds, the use thereof for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (= disorder) that depends on activity of renin; pharmaceutical formulations or products comprising said compounds, and/or a method of treatment comprising administering said compounds, a method for the manufacture of said compounds, as well as novel intermediates, starting materials and/or partial steps for their synthesis. The compounds are especially of the formula (I), wherein R1, R2, R11, C, E and D are as defined in the specification.
摘要翻译：本发明涉及取代的3,4-或更高级取代的哌嗪化合物，其用于制备用于治疗依赖于肾素活性的疾病的药物制剂; 使用该类化合物治疗依赖于肾素活性的疾病; 这些化合物用于诊断和治疗温血动物，特别是用于治疗依赖于肾素活性的疾病（=病症）; 药物制剂或包含所述化合物的产品，和/或包括施用所述化合物的方法，所述化合物的制备方法，以及新型中间体，起始材料和/或其合成的部分步骤。化合物特别是式（I），其中R 1，R 2，R 11，C，E和D如说明书中所定义。

3. 发明申请

WO2006094763A8 3,4,5-SUBSTITUTED PIPERIDINE COMPOUNDS 审中-公开
标题翻译： 3,4,5-取代的哌啶化合物
公开(公告)号：WO2006094763A8
公开(公告)日：2007-10-11
申请号：PCT/EP2006002083
申请日：2006-03-07
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , MASUYA KEIICHI , YOKOKAWA FUMIAKI , IRIE OSAMU , NIHONYANAGI ATSUKO , TOYAO ATSUSHI , EHARA TAKERU , KONISHI KAZUHIDE , KANAZAWA TAKANORI , SUZUKI MASAKI
发明人： MASUYA KEIICHI , YOKOKAWA FUMIAKI , IRIE OSAMU , NIHONYANAGI ATSUKO , TOYAO ATSUSHI , EHARA TAKERU , KONISHI KAZUHIDE , KANAZAWA TAKANORI , SUZUKI MASAKI
IPC分类号： C07D211/60 , A61K31/4545 , A61P9/00 , C07D401/12 , C07D413/12
CPC分类号： C07D401/12 , C07D211/60 , C07D413/12
摘要： 3,4,5-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (= disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,4,5-substituted piperidine compound, and/or a method of treatment comprising administering a 3,4,5-substituted piperidine compound, a method for the manufacture of a 3,4,5-substituted piperidine compound, and novel intermediates and partial steps for its synthesis. The compounds are of the formula (I), wherein the substitutents are as defined in the specification.
摘要翻译： 3,4,5-取代的哌啶化合物，这些化合物用于诊断和治疗温血动物，特别是用于治疗依赖于肾素活性的疾病（=病症）; 使用该类化合物制备用于治疗依赖于肾素活性的疾病的药物制剂; 使用该类化合物治疗依赖于肾素活性的疾病; 包含3,4,5-取代的哌啶化合物的药物制剂和/或治疗方法，包括给予3,4,5-取代的哌啶化合物，制备3,4,5-取代哌啶化合物的方法，以及其合成的新型中间体和部分步骤。化合物是式（I），其中取代基如说明书中所定义。

4. 发明专利

DE602005017665D1 未知
公开(公告)号：DE602005017665D1
公开(公告)日：2009-12-24
申请号：DE602005017665
申请日：2005-12-28
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH
发明人： BREITENSTEIN WERNER , EHARA TAKERU , EHRHARDT CLAUS , GROSCHE PHILIPP , HITOMI YUKO , IWAKI YUKI , KANAZAWA TAKANORI , KONISHI KAZUHIDE , MAIBAUM JUERGEN KLAUS , MASUYA KEIICHI , NIHONYANAGI ATSUKO , OSTERMANN NILS , SUZUKI MASAKI , TOYAO ATSUSHI , YOKOKAWA FUMIAKI
IPC分类号： C07D401/10 , A61K31/4545 , C07D211/60 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/10 , C07D409/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
摘要： 3,4-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (= disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,4-substituted piperidine compound, and/or a method of treatment comprising administering a 3,4-substituted piperidine compound, a method for the manufacture of a 3,4-substituted piperidine compound, and novel intermediates and partial steps for their synthesis are disclosed. The 3,4-disubstituted piperidine compounds have the formula I, wherein the symbols have the meanings defined in the specification.

5. 发明专利

AT448217T 未知
公开(公告)号：AT448217T
公开(公告)日：2009-11-15
申请号：AT05820552
申请日：2005-12-28
申请人： NOVARTIS PHARMA GMBH
发明人： BREITENSTEIN WERNER , EHARA TAKERU , EHRHARDT CLAUS , GROSCHE PHILIPP , HITOMI YUKO , IWAKI YUKI , KANAZAWA TAKANORI , KONISHI KAZUHIDE , MAIBAUM JUERGEN , MASUYA KEIICHI , NIHONYANAGI ATSUKO , OSTERMANN NILS , SUZUKI MASAKI , TOYAO ATSUSHI , YOKOKAWA FUMIAKI
IPC分类号： C07D401/10 , C07D211/60 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/10 , C07D409/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
摘要： 3,4-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (= disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,4-substituted piperidine compound, and/or a method of treatment comprising administering a 3,4-substituted piperidine compound, a method for the manufacture of a 3,4-substituted piperidine compound, and novel intermediates and partial steps for their synthesis are disclosed. The 3,4-disubstituted piperidine compounds have the formula I, wherein the symbols have the meanings defined in the specification.

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