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    • 8. 发明专利
    • Lipid metabolism regulant
    • 脂肪代谢REGULANT
    • JP2006282655A
    • 2006-10-19
    • JP2006024516
    • 2006-02-01
    • National Food Research InstituteNof Corp日本油脂株式会社独立行政法人食品総合研究所
    • TANIMIZU KOICHIARAI MOTOHARUIDE TAKASHI
    • A61K31/045A23K1/16A23L1/30A61K9/16A61P1/16A61P3/06A61P3/10A61P9/00A61P19/02A61P43/00
    • PROBLEM TO BE SOLVED: To provide a lipid metabolism regulant useful for preventing or improving obesity and a fatty liver, capable of being widely utilized in pharmaceutical and food industries and, further, in animal feed and other industries, capable of inhibiting expression of a fatty acid synthetic enzyme group in a liver, capable of depressing activity thereof, and capable of decreasing amounts of triacylglycerol and cholesterol.
      SOLUTION: This lipid metabolism regulant contains a 20-36C higher aliphatic alcohol as an active ingredient and depresses expression of a fatty acid synthetic enzyme, wherein a fatty acid synthetic enzyme comprises fatty acid synthase, glucose-6-phosphate dehydrogenase, ATP-citrate-lyase, malic enzyme, pyruvate kinase, and glycerol-3-phosphate acyltransferase. Further, the higher aliphatic alcohol is in a powdered state and has an average particle diameter of 1-150 μm.
      COPYRIGHT: (C)2007,JPO&INPIT
    • 要解决的问题:提供可用于预防或改善肥胖和脂肪肝的脂质代谢调节剂,其能够广泛地用于制药和食品工业,以及能够抑制表达的动物饲料和其它工业中 的肝脏中的脂肪酸合成酶基团,能够抑制其活性,并且能够降低三酰基甘油和胆固醇的量。 解决方案:该脂质代谢调节剂含有20-36℃高级脂肪醇作为活性成分,并抑制脂肪酸合成酶的表达,其中脂肪酸合成酶包括脂肪酸合酶,葡萄糖-6-磷酸脱氢酶,ATP - 柠檬酸裂解酶,苹果酸酶,丙酮酸激酶和甘油-3-磷酸酰基转移酶。 此外,高级脂肪族醇为粉末状,平均粒径为1-150μm。 版权所有(C)2007,JPO&INPIT