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1. 发明专利

JP2002062255A DETECTOR FOR DETECTING SURFACE PLASMON RESONANCE ANGLE AND FLUORESCENCE CONCURRENTLY 失效
公开(公告)号：JP2002062255A
公开(公告)日：2002-02-28
申请号：JP2000250424
申请日：2000-08-22
申请人： NIPPON LASER DENSHI KK , JAPAN SCIENCE & TECH CORP
发明人： TAKEDA SHIGEKI , HAGA TATSUYA , TANAKA KOJI , YONEDA HIDEKATSU
IPC分类号： G01N21/64 , G01N21/05 , G01N21/27
摘要： PROBLEM TO BE SOLVED: To highly precisely detect a characteristic of a specimen by combining an SPR method and a fluorescence detecting method. SOLUTION: Light from a light source 9 is emitted onto a boundary of a metal thin film in a substrate 17 at a prescribed angle width, and the reflected light from the boundary is formed into the prescribed angle width to be received by the first photoreceiving member 15. A cell block is made to closely contact with the substrate, and a specimen solution labeled with a fluorescent substance is made to flow so as to be supplied to a portion corresponding to an area irradiated with the light. The second photoreceiving member 37 is provided in the cell block 21 corresponding to a substrate portion irradiated with the light to photoreceive the fluorescence from the fluorescent substance labeled to the specimen coupled to a sample probe. The specimen coupled to the sample probe is detected based on a surface plasmon resonance angle detected by the first photoreceiving member, and the fluorescence from the fluorescent substance excited by an evanescent wave generated when the light is brought into total reflection in a boundary of the metal thin film in the substrate.

2. 发明专利

JP2003247983A TARGET SUBSTANCE MASS SPECTROMETRIC SYSTEM 审中-公开
公开(公告)号：JP2003247983A
公开(公告)日：2003-09-05
申请号：JP2002048148
申请日：2002-02-25
申请人： NIPPON LASER DENSHI KK
发明人： TANAKA KOJI , SATO TAKATO , MORIYAMA EMIKO , FUKAO YASUHIRO , YONEDA HIDEKATSU
IPC分类号： G01N27/62 , G01N1/00 , G01N1/28 , G01N27/64 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a target substance mass spectrometric system capable of performing mass spectrometry with respect to many kinds of target substances effectively and at a low cost. SOLUTION: By using a measurement chip made by specifically bonding target substances to a multitude of fixed specimens fixed on a surface of a substrate, electric-field kinetic energy is given to molecular ions of the target substance ionized by irradiating each target substance with laser light thereby performing mass detection to fix the target substance. It is made possible to selectively and communicatingly connect a multitude of suction members, dispensing members, and suction/discharge members, agreeing with the number of fixed specimens fixed on the substrate with a metallic thin film formed thereon. By using the respective suction members, a prescribed amount of each fixed specimen solution is dispensed onto the substrate. After the solution of each target substance is sucked by each suction member into a corresponding suction/ discharge member, with the suction/discharge member communicating with the dispensing member, the suction/discharge member is activated to dispense the target substance solution to the fixed specimen solution fixed on the substrate for specific bonding reaction. COPYRIGHT: (C)2003,JPO

3. 发明专利

JP2002228671A SUCTION AND DISCHARGE-SWITCHING DEVICE FOR SAMPLE SOLUTION SPOTTING APPARATUS 失效
公开(公告)号：JP2002228671A
公开(公告)日：2002-08-14
申请号：JP2001027731
申请日：2001-02-05
申请人： NIPPON LASER DENSHI KK
发明人： TANAKA KOJI
IPC分类号： G01N35/10 , C12M1/00 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide a suction and discharge-switching device for a sample solution spotting device for easily switching a number of channels for connecting a suction member and a dispensing member with a suction and discharge operation member when spotting a sample probe onto a substrate and nearly uniform quantity, for enabling efficient spotting operation to be performed. SOLUTION: A sample solution is spotted onto a substrate in a matrix to manufacture a sample chip. A switching member having a number of suction channels connected to each suction member for sucking sample solution being accumulated at each well section of a container body and a number of discharge channels for connecting the sucked sample solution to each dispensing member is moved to a number of suction discharge channels that suck and accumulate the sample solution being accumulated at each well section of the container body and are connected to each suction discharge operation member for determining and discharging the sample solution to each dispensing member, thus selectively matching each suction channel and discharge channel corresponding to each suction discharge channel for connection.

4. 发明专利

JP2002243733A MANUFACTURE OF SAMPLE CHIP, AND METHOD OF ANALYZING REACTION SAMPLE 失效
公开(公告)号：JP2002243733A
公开(公告)日：2002-08-28
申请号：JP2001034138
申请日：2001-02-09
申请人： NIPPON LASER DENSHI KK
发明人： TANAKA KOJI
IPC分类号： G01N33/53 , G01N1/00 , G01N33/566 , G01N35/02 , G01N35/10 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To mass-produce a large number of sample chips by spotting a large number of fixed samples onto a substrate small in an occupied volume at one operation, and to make efficient analytical work by spotting a large number of reaction samples at one operation to react with the fixed samples, using the sample chips. SOLUTION: Suction and delivery operation members 29 are connected to be selectively communicated to a large number of suction members 23 and dispenser members 47 consistent with tire number of the spotted fixed samples, a fixed sample solution sucked and reserved in the each suction and delivery operation member 29 is delivered from the each dispenser member 47 into each hole of a thin film formed coatedly on the substrate 53 to prepare the sample chips, under the condition where the suction and delivery operation members 29 are selectively communicated to the respective suction members 23. A washing liquid is made to pass through insides of the each dispenser member 47, the each operation member 29 and the each suction member 23 to be washed respectively. A reaction sample solution sucked and reserved by the each suction and delivery operation member 29 is dispensed from the each dispenser member 47 onto the each fixed sample on the substrate 53 to react therebetween, under the condition where the suction and delivery operation members 29 are selectively communicated to the respective suction members 23.

5. 发明专利

JP2003156490A PROTEIN CHIP HOLDING TOOL 审中-公开
公开(公告)号：JP2003156490A
公开(公告)日：2003-05-30
申请号：JP2001358678
申请日：2001-11-26
申请人： NIPPON LASER DENSHI KK
发明人： TANAKA KOJI , FUKAO YASUHIRO
IPC分类号： G01N33/53 , B01L3/02 , B01L9/00 , G01N1/28 , G01N35/02 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a protein chip holding device capable of reducing a protein sample to be an extremely small quantity, and preventing denaturation and deactivation thereof. SOLUTION: This protein chip 33 is constituted by sticking an elastic body having a plurality of holes formed in a matrix form thereon on the upper surface of a substrate 35, and by injecting a prescribed quantity of the protein sample solution in each hole. The device is constituted from a substrate holding member 39 having a substrate locking part for holding the substrate provided on its upper surface, an elastic body holding member 45 supported rotatably so as to cover the upper surface of one end of the member, having an elastic body locking part for holding the elastic body 37 on the surface facing to the member, and having opening parts coincident with the holes 37a of the held elastic body, an opening/closing member 53 supported movably on the upper surface of the elastic body holding member, for opening/closing the opening parts, and a locking member 59 for locking the elastic body holding member when the elastic body holding member is rotated relative to the substrate holding member so as cover its upper surface, an allowing the elastic body held by the elastic body holding member to adhere to the substrate held by the substrate holding member by elastic deformation.

6. 发明专利

JP2003146966A METAL COMPLEX FOR CATALYST PRECURSOR FOR DEHYDROGENATION REACTION OF ORGANIC COMPOUND TAKING ADVANTAGE OF OXIDATIVE ACTIVATION OF WATER MOLECULE 审中-公开
公开(公告)号：JP2003146966A
公开(公告)日：2003-05-21
申请号：JP2001344047
申请日：2001-11-09
申请人： JAPAN SCIENCE & TECH CORP
发明人： TANAKA KOJI , WADA TORU , SUGIMOTO HIDEKI
IPC分类号： B01J31/22 , C07C325/02 , C07F11/00 , C07F15/00 , C07F15/06
摘要： PROBLEM TO BE SOLVED: To provide a new catalyst precursor complex accelerating the progress of an oxidative dehydrogenation reaction of an organic substrate by the oxidative activation of water molecule. SOLUTION: The catalyst precursor complex for the dehydrogenation reaction from a carbon-hydrogen bond containing water as a ligand is expressed by general formula A (L1 is a tridentate ligand; R1 and R2 are each an alkyl, an aryl or an aralkyl or together form a (substituted)monocyclic or condensed ring group; M is a metal selected from the metals of the groups 6-9 of the periodic table; and Y is an anion). The precursor complex forms a complex having a function of catalyzing the dehydrogenation from an organic compound by deprotonation and oxidation.

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