专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

CA2408767A1 METHOD AND DEVICE FOR PREPAPING POLYNUCLEOTIDE MICROARRAY AND POLYNUCLEOTIDE MICROARRAY 未知
公开(公告)号：CA2408767A1
公开(公告)日：2001-11-15
申请号：CA2408767
申请日：2001-05-10
申请人： NIPPON LASER DENSHI KK , KYOWA HAKKO KOGYO KK , WATANABE SHINYA
发明人： WATANABE SHINYA
IPC分类号： B01J19/00 , C07H21/00 , C07H21/04 , C12Q1/68 , C40B40/06 , C40B60/14 , G01N33/52 , G01N33/543 , G01N33/53 , G01N33/566
摘要： A method of constructing a polynucleotide microarray whereby a sufficient amount of polynucleotide can be immobilized on a support and thus a uniform and strong signal can be obtained in a spot area even in the case of synthet ic oligopolynucleotides which are known as being hardly immobilized via electrostatic bonds because of short chain length. Namely, a method of constructing a polynucleotide microarray characterized in that a solution in which a polynucleotide is dissolved in the step of immobilizing the polynucleotide on a support comprises water or a mixture of water with an organic solvent and is substantially free from any anionic electrolytes, and , in case where the solution comprises a mixture of water with an organic solvent, the content of the organic solvent in the solution is less than 50% by volume.

2. 发明公开

EP1284421A4 METHOD OF CONSTRUCTING POLYNUCLEOTIDE MICROARRAY, APPARATUS FOR THE CONSTRUCTION AND POLYNUCLEOTIDE MICROARRAY 审中-公开
标题翻译：用于生产的生产方法POLYNUKLEOTIDMICROPROTEINANORDNUNGEN，以及设备
公开(公告)号：EP1284421A4
公开(公告)日：2005-12-28
申请号：EP01930028
申请日：2001-05-10
申请人： KYOWA HAKKO KOGYO KK , NIPPON LASER DENSHI KK , WATANABE SHINYA
发明人： WATANABE SHINYA
IPC分类号： B01J19/00 , C07H21/00 , C07H21/04 , C12Q1/68 , C40B40/06 , C40B60/14 , G01N33/52 , G01N33/543 , G01N33/53 , G01N33/566
CPC分类号： C07H21/04 , B01J19/0046 , B01J2219/00382 , B01J2219/00387 , B01J2219/00441 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00659 , B01J2219/00677 , B01J2219/00707 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C07B2200/11 , C07H21/00 , C12Q1/6837 , C12Q2565/518 , C40B40/06 , C40B50/14 , C40B60/14 , G01N33/52 , G01N33/54393
摘要： A method of constructing a polynucleotide microarray whereby a sufficient amount of polynucleotide can be immobilized on a support and thus a uniform and strong signal can be obtained in a spot area even in the case of synthetic oligopolynucleotides which are known as being hardly immobilized via electrostatic bonds because of short chain length. Namely, a method of constructing a polynucleotide microarray characterized in that a solution in which a polynucleotide is dissolved in the step of immobilizing the polynucleotide on a support comprises water or a mixture of water with an organic solvent and is substantially free from any anionic electrolytes, and, in case where the solution comprises a mixture of water with an organic solvent, the content of the organic solvent in the solution is less than 50% by volume.

3. 发明专利

JP2003247983A TARGET SUBSTANCE MASS SPECTROMETRIC SYSTEM 审中-公开
公开(公告)号：JP2003247983A
公开(公告)日：2003-09-05
申请号：JP2002048148
申请日：2002-02-25
申请人： NIPPON LASER DENSHI KK
发明人： TANAKA KOJI , SATO TAKATO , MORIYAMA EMIKO , FUKAO YASUHIRO , YONEDA HIDEKATSU
IPC分类号： G01N27/62 , G01N1/00 , G01N1/28 , G01N27/64 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a target substance mass spectrometric system capable of performing mass spectrometry with respect to many kinds of target substances effectively and at a low cost. SOLUTION: By using a measurement chip made by specifically bonding target substances to a multitude of fixed specimens fixed on a surface of a substrate, electric-field kinetic energy is given to molecular ions of the target substance ionized by irradiating each target substance with laser light thereby performing mass detection to fix the target substance. It is made possible to selectively and communicatingly connect a multitude of suction members, dispensing members, and suction/discharge members, agreeing with the number of fixed specimens fixed on the substrate with a metallic thin film formed thereon. By using the respective suction members, a prescribed amount of each fixed specimen solution is dispensed onto the substrate. After the solution of each target substance is sucked by each suction member into a corresponding suction/ discharge member, with the suction/discharge member communicating with the dispensing member, the suction/discharge member is activated to dispense the target substance solution to the fixed specimen solution fixed on the substrate for specific bonding reaction. COPYRIGHT: (C)2003,JPO

4. 发明专利

JP2003172701A DEVICE FOR ANALYZING SAMPLE CHIP 审中-公开
公开(公告)号：JP2003172701A
公开(公告)日：2003-06-20
申请号：JP2001374432
申请日：2001-12-07
申请人： NIPPON LASER DENSHI KK
发明人： YONEDA HIDEKATSU , TAKASHIMA NARITSUYO
IPC分类号： G01N21/64 , G01N33/533 , G01N33/536 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a device and a method for analyzing a sample chip capable of improving the efficiency of an analyzing work on an assayed sample by surely and precisely detecting a fluorescence from a fluorescent material labeled to the assayed sample combined with a sample without being affected by an excitation light for the fluorescent material or a disturbing light. SOLUTION: This device is provided with a first and a second moving devices moving a sample chip holding member holding a sample chip with a plurality of samples fixed on a substrate which can guide an incident light in the longitudinal direction and in the longitudinally perpendicular direction of the sample chip respectively, a white light source, a filter member in the output side selecting a light having a wavelength exciting the fluorescent material labeled to the assayed sample reacted to the sample on the sample chip, an optical fiber bundle guiding a transmitted light to each light irradiation member, a filter member in the light reception side arranged facing to the sample chip between a pair of the light irradiation members, selectively transmitting the fluorescence from the excited fluorescent material labeled to the assayed sample reacted with the sample of the sample chip, and a light receiving unit outputting a electrical signal in accordance with the fluorescence by transmitted prescribed area. COPYRIGHT: (C)2003,JPO

5. 发明专利

JP2002228671A SUCTION AND DISCHARGE-SWITCHING DEVICE FOR SAMPLE SOLUTION SPOTTING APPARATUS 失效
公开(公告)号：JP2002228671A
公开(公告)日：2002-08-14
申请号：JP2001027731
申请日：2001-02-05
申请人： NIPPON LASER DENSHI KK
发明人： TANAKA KOJI
IPC分类号： G01N35/10 , C12M1/00 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide a suction and discharge-switching device for a sample solution spotting device for easily switching a number of channels for connecting a suction member and a dispensing member with a suction and discharge operation member when spotting a sample probe onto a substrate and nearly uniform quantity, for enabling efficient spotting operation to be performed. SOLUTION: A sample solution is spotted onto a substrate in a matrix to manufacture a sample chip. A switching member having a number of suction channels connected to each suction member for sucking sample solution being accumulated at each well section of a container body and a number of discharge channels for connecting the sucked sample solution to each dispensing member is moved to a number of suction discharge channels that suck and accumulate the sample solution being accumulated at each well section of the container body and are connected to each suction discharge operation member for determining and discharging the sample solution to each dispensing member, thus selectively matching each suction channel and discharge channel corresponding to each suction discharge channel for connection.

6. 发明专利

JP2002181817A POLYNUCLEOTIDE ARRAY PRODUCTION METHOD 失效
公开(公告)号：JP2002181817A
公开(公告)日：2002-06-26
申请号：JP2000374754
申请日：2000-12-08
申请人： NIPPON LASER DENSHI KK
发明人： HARADA MANABU
IPC分类号： G01N31/22 , C12M1/00 , C12N15/09 , G01N33/53 , G01N33/566 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a polynucleotide array production method of firmly fixing a multiple kinds of polynucleotides spotted on a supporting body at an approximately homogeneous concentration while preventing mutual contamination for effectively and efficiently analyzing a tested nucleotide with sufficient measurement sensitivity. SOLUTION: In the first step, a solution is prepared by dissolving the polynucleotide in a solvent prepared by adding 10 vol.% formamide at least to water. In the second step, the solution is taken into a dispensing needle after its tip part is washed with a washing liquid, an excess of the solution sticking to the tip part is removed by bringing the dispensing needle into contact with a waste injection plate, multiple solutions are spotted by allowing the dispensing needle to about on the supporting body surface, the polynucleotides are immobilized by drying, and the supporting body is immersed into a blocking liquid for blocking the supporting body surface between the polynucleotide spots. According to these processes, the polynucleotide is immobilized on the supporting body surface.

7. 发明专利

JP2002066770A LASER MARKING SYSTEM 失效
公开(公告)号：JP2002066770A
公开(公告)日：2002-03-05
申请号：JP2000258342
申请日：2000-08-29
申请人： NIPPON LASER DENSHI KK
发明人： TAJIMA HARUO
IPC分类号： B23K26/00 , B23K26/064 , B23K26/082 , B23K26/08
摘要： PROBLEM TO BE SOLVED: To provide a laser marking system which can surely print various data while effectively preventing the environment of production line from being polluted and is downsized to replace an traditional inkjet type in the existing production line. SOLUTION: By scanning a laser beam in a two-dimensional direction by laser scanning device 5 which is emitted by pulse output signal from a laser beam source 3, the scheduled mark is printed on the material to be marked. A printer head 7b adjoining to the material to be marked and an incoming head 7a to which a laser beam scanned in a two-dimensional direction is incoming are connected by optical fiber group 17 with the number of optical fibers meeting the number of dots which composes a mark to be printed.

8. 发明专利

JP2002062218A OPTICAL ANISOTROPIC SUBSTANCE EVALUATING DEVICE 失效
公开(公告)号：JP2002062218A
公开(公告)日：2002-02-28
申请号：JP2000249145
申请日：2000-08-21
申请人： SEIKO EPSON CORP , NIPPON LASER DENSHI KK
发明人： FUKUSHIMA HITOSHI , TAJIMA HARUO
IPC分类号： G01N21/21 , G01M11/00 , G01N21/27 , G01N21/41 , G02F1/13
摘要： PROBLEM TO BE SOLVED: To provide an optical anisotropic substance evaluating device for macroscopically, microscopically and simultaneously evaluating orientation of an optical anisotropic substance impressed with an electric field of an optical anisotropic substance-sealed cell member such as a liquid crystal cell. SOLUTION: Electrodes are arranged on an inside surface of light transmissive base boards oppositely arranged at a prescribed interval, the optical anisotropic substance-sealed cell member is brought into close contact with the electrodes, the light from one outer peripheral surface side light source is radiated to an optical anisotropic substance interface in the electrodes of the light transmissive base boards positioned on the close contact side, and a surface plasmon resonance angle is detected by a prism for making a light receiving means arranged on the other outer peripheral surface side receive the reflected light from the interface. An image of an orientation state of the optical anisotropic substance of a bulk layer of the cell member is picked up by image pickup means oppositely arranged in the cell member. A control means impresses voltage between a pair of electrodes in a prescribed period, and reads and stores an electric signal from at least the light receiving means in the reading timing in synchronism with the voltage impressing timing, and macroscopically, microscopically and simultaneously evaluates the sealed liquid crystal composition.

9. 发明专利

JP2001147193A ADHESIVE STRENGTH MEASURING DEVICE 失效
公开(公告)号：JP2001147193A
公开(公告)日：2001-05-29
申请号：JP33212499
申请日：1999-11-24
申请人： NIPPON LASER DENSHI KK
发明人： KURIHARA KAZUE , TAJIMA HARUO
IPC分类号： G01N19/00 , G01N19/04
摘要： PROBLEM TO BE SOLVED: To provide an adhesive strength measuring device capable of directly measuring adhesive strength to make measuring work efficient and measuring even micro adhesive strength with high accuracy. SOLUTION: A first holding member fitted to the end part of a movable member movably supported inside a case, is moved by a driving member. An electrostrictive element flexurally deformable relative to the moving direction of the first holding member and having a predetermined spring constant is provided for outputting an electric signal of voltage corresponding to physical distortion, and the electrostrictive member relative to the first holding member is provided with a second holding member. From the mutually abutting state of the surfaces of the first and second holding members whose surfaces are modified with measured substances, the first holding member is moved by the driving of the driving member. The mutual adhesive strength of the substances is measured from the flexure quantity of the electrostrictive element detected on the basis of the electric signal from the electrostrictive element when the first and second holding members are spaced from each other.

10. 发明专利

JP2000123996A ATOMIC RADICAL MEASURING METHOD AND DEVICE 失效
公开(公告)号：JP2000123996A
公开(公告)日：2000-04-28
申请号：JP29550498
申请日：1998-10-16
申请人： GOTO TOSHIO , NIPPON LASER DENSHI KK
发明人： GOTO TOSHIO , KONO AKIHIRO , HORI MASARU , ITO AKIFUMI , YONEDA KATSUMI , TAKASHIMA NARITSUYO
IPC分类号： H01L21/302 , H01L21/205 , H01L21/3065 , H05H1/00 , H05H1/46
摘要： PROBLEM TO BE SOLVED: To easily measure atomic radical density in plasma with high accuracy and high sensitivity by making gas of specified pressure containing atoms in gas, into plasma in a micro hole of a negative electrode plate to generate atomic beams, and irradiating the atomic beams to raw material gas made into plasma. SOLUTION: In the case of making raw material gas into plasma to form a thin film, to etch, and the like, atomic beams are irradiated to the raw material gas made into plasma, and atomic radical density in plasma is measured from the difference of atomic beam intensity before and after penetrating plasma to control plasma. In a hydrogen atomic beam generating device 25 for generating the atomic beams, a negative electrode 37 such as a copper plate with a hole with a micro inner diameter 37a bored, and a positive electrode 39 of tungsten with its tip brought close to the hole 37a are provided in a stainless case 33. A current is applied to both electrodes, and noble gas and gas of a predetermined pressure containing measured atoms are made into plasma in the hole 37a to emit light. Requested atomic beams are therefore generated and irradiated through an optical lens 35.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式