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1. 发明申请

US20190382765A1 NUCLEOSIDE DERIVATIVE OR SALT THEREOF, POLYNUCLEOTIDE SYNTHESIS REAGENT, METHOD FOR PRODUCING POLYNUCLEOTIDE, POLYNUCLEOTIDE, AND METHOD FOR PRODUCING BINDING NUCLEIC ACID MOLECULE 审中-公开
公开(公告)号：US20190382765A1
公开(公告)日：2019-12-19
申请号：US16464057
申请日：2017-10-12
申请人： NEC Solution Innovators, Ltd. , National University Corporation Gunma University
发明人： Hirotaka MINAGAWA , Katsunori HORII , Jou AKITOMI , Naoto KANEKO , Iwao WAGA , Masayasu KUWAHARA
IPC分类号： C12N15/115 , C12N15/10
摘要： The present invention provides a novel nucleoside derivative or a salt thereof, a polynucleotide synthesis reagent, a method for producing a polynucleotide, a polynucleotide, and a method for producing a binding nucleic acid molecule. The nucleoside derivative or a salt thereof of the present invention is represented by the following chemical formula (1). In the chemical formula (1), Su is an atomic group having a sugar skeleton at a nucleoside residue or an atomic group having a sugar phosphate skeleton at a nucleotide residue, and may or may not have a protecting group, L1 and L2 are each independently a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms, X1 is an imino group (—NR1—), an ether group (—O—), or a thioether group (—S—), and R1 is a hydrogen atom or a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms.

2. 发明申请

US20190248826A1 NUCLEOSIDE DERIVATIVE OR SALT THEREOF, POLYNUCLEOTIDE SYNTHESIS REAGENT, METHOD FOR PRODUCING POLYNUCLEOTIDE, POLYNUCLEOTIDE, AND METHOD FOR PRODUCING BINDING NUCLEIC ACID MOLECULE 审中-公开
公开(公告)号：US20190248826A1
公开(公告)日：2019-08-15
申请号：US16333325
申请日：2017-09-14
申请人： NEC Solution Innovators, Ltd. , NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY
发明人： Hirotaka MINAGAWA , Katsunori HORII , Jou AKITOMI , Naoto KANEKO , Iwao WAGA , Masayasu KUWAHARA
IPC分类号： C07H19/10
CPC分类号： C07H19/10 , C07H19/073 , C07H21/00 , C07K16/00 , C12N15/115 , Y02P20/55
摘要： The present invention provides a novel nucleoside derivative or a salt thereof, a polynucleotide synthesis reagent, a method for producing a polynucleotide, a polynucleotide, and a method for producing a binding nucleic acid molecule.The nucleoside derivative or a salt thereof of the present invention is represented by the following chemical formula (1): where in the chemical formula (1), Su is an atomic group having a sugar skeleton at a nucleoside residue or an atomic group having a sugar phosphate skeleton at a nucleotide residue, and may or may not have a protecting group, L1 and L2 are each independently a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms, X1 and X2 are each independently an imino group (—NR1—), an ether group (—O—), or a thioether group (—S—), and the R1 is a hydrogen atom or a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms.

3. 发明申请

US20190241895A1 SECRETORY IMMUNOGLOBULIN A (SIGA)-BINDING NUCLEIC ACID MOLECULE, SIGA ANALYSIS SENSOR, AND SIGA ANALYSIS METHOD 审中-公开
公开(公告)号：US20190241895A1
公开(公告)日：2019-08-08
申请号：US16333293
申请日：2017-04-20
申请人： NEC Solution Innovators, Ltd. , NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY
发明人： Hirotaka MINAGAWA , Katsunori HORII , Jou AKITOMI , Naoto KANEKO , Iwao WAGA , Masayasu KUWAHARA
IPC分类号： C12N15/115
CPC分类号： C12N15/115 , C12N15/09 , C12N2310/16 , C12N2310/333 , C12N2310/335 , C12N2310/336 , C12Q1/68 , G01N33/53
摘要： The present invention provides a novel molecule that can be used for detection of sIgA. The sIgA-binding nucleic acid molecule of the present invention is characterized in that it binds to secretory immunoglobulin A (sIgA) with a dissociation constant of 37.7 nM or less, and preferably includes a polynucleotide consisting of any of base sequences of SEQ ID NOs: 1 to 12 or a partial sequence thereof, for example. According to the sIgA-binding nucleic acid molecule of the present invention, it is possible to detect sIgA in saliva.

4. 发明申请

US20190211048A1 NUCLEOSIDE DERIVATIVE OR SALT THEREOF, POLYNUCLEOTIDE SYNTHESIS REAGENT, METHOD FOR PRODUCING POLYNUCLEOTIDE, POLYNUCLEOTIDE, AND METHOD FOR PRODUCING BINDING NUCLEIC ACID MOLECULE 审中-公开
公开(公告)号：US20190211048A1
公开(公告)日：2019-07-11
申请号：US16333333
申请日：2017-09-14
申请人： NEC Solution Innovators, Ltd. , NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY
发明人： Hirotaka MINAGAWA , Katsunori HORII , Jou AKITOMI , Naoto KANEKO , Iwao WAGA , Masayasu KUWAHARA
IPC分类号： C07H19/20 , C07H21/04 , C07H21/02
摘要： The present invention provides a novel nucleoside derivative or a salt thereof, a polynucleotide synthesis reagent, a method for producing a polynucleotide, a polynucleotide, and a method for producing a binding nucleic acid molecule. The nucleoside derivative or a salt thereof of the present invention is represented by the following chemical formula (1): where in the chemical formula (1), Su is an atomic group having a sugar skeleton at a nucleoside residue or an atomic group having a sugar phosphate skeleton at a nucleotide residue, and may or may not have a protecting group, L1 and L2 are each independently a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms, X1 and X2 are each independently an imino group (—NR1—), an ether group (—O—), or a thioether group (—S—), and the R1 is a hydrogen atom or a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms.

5. 发明申请

US20210187499A1 TARGET ANALYSIS KIT AND TARGET ANALYSIS METHOD 有权
公开(公告)号：US20210187499A1
公开(公告)日：2021-06-24
申请号：US16318951
申请日：2017-03-23
申请人： NEC SOLUTION INNOVATORS LTD.
发明人： Yoshihito YOSHIDA , Katsunori HORII , Iwao WAGA , Jou AKITOMI , Naoto KANEKO
IPC分类号： B01L3/00 , C12Q1/6813 , G01N33/543
摘要： A target analysis kit includes: a sample holder including: a reagent chamber containing a first reagent; a sample holding portion; and a liquid transfer portion; and an analysis container including: a first chamber containing a second reagent; and a second chamber with a labeling substance contained in the first or second reagent to be detected. A combination of the first and second reagents is any of the combinations (1) to (3) and (4): (1) first reagent is the immobilized second binding substance and second reagent is the labeled first binding substance; (2) first reagent is the labeled first binding substance and second reagent is the immobilized second binding substance; (3) first reagent is the immobilized first binding substance and second reagent is the labeled second binding substance; and (4) first reagent is the labeled second binding substance and second reagent is the immobilized first binding substance.

6. 发明申请

US20160202154A1 METHOD FOR PRODUCING SAMPLE AND METHOD FOR ANALYZING TARGET 审中-公开
标题翻译：生产样本的方法和分析目标的方法
公开(公告)号：US20160202154A1
公开(公告)日：2016-07-14
申请号：US14916942
申请日：2014-06-27
申请人： NEC SOLUTION INNOVATORS, LTD.
发明人： Katsunori HORII , Jou AKITOMI , Naoto KANEKO , Iwao WAGA
IPC分类号： G01N1/30 , G01N33/538 , G01N33/04 , G01N33/53
CPC分类号： G01N1/30 , C12N15/113 , C12N15/115 , C12N2310/127 , C12N2310/16 , C12N2310/3519 , C12Q1/6806 , G01N30/88 , G01N30/96 , G01N33/04 , G01N33/5308 , G01N33/538 , G01N33/566 , G01N2030/8813 , C12Q2527/125
摘要： The present invention is intended to provide a novel sensor for target analysis and a target analysis method using the same.The sensor for target analysis according to the present invention includes a single-stranded nucleic acid molecule. The single-stranded nucleic acid molecule includes a first catalytic nucleic acid region (D1), a second catalytic nucleic acid region (D2), and a binding nucleic acid region (Ap) that binds to a target. The single-stranded nucleic acid molecule includes the first catalytic nucleic acid region (D1) at one end of the binding nucleic acid region (Ap) and the second catalytic nucleic acid region (D2) at the other end of the binding nucleic acid (Ap). In the absence of a target, the catalytic function by the first catalytic nucleic acid region (D1) and the second catalytic nucleic acid region (D2) is inhibited. In the presence of a target, the catalytic function is generated owing to formation of a G-quartet of the first catalytic nucleic acid region (D1) and the second catalytic nucleic acid region (D2) due to the contact between the target and the binding nucleic acid region (Ap).
摘要翻译：本发明旨在提供一种用于目标分析的新型传感器和使用其的目标分析方法。根据本发明的用于靶分析的传感器包括单链核酸分子。单链核酸分子包括与靶标结合的第一催化核酸区域（D1），第二催化核酸区域（D2）和结合核酸区域（Ap）。单链核酸分子包括在结合核酸区（Ap）一端的第一催化核酸区（D1）和结合核酸另一端的第二催化核酸区（D2））。在没有靶的情况下，抑制了第一催化核酸区（D1）和第二催化核酸区（D2）的催化功能。在靶的存在下，由于靶和结合物之间的接触，由于形成第一催化核酸区域（D1）和第二催化核酸区域（D2）的G四重奏，产生催化功能核酸区（Ap）。

7. 发明申请

US20160146772A1 FLUORESCENSE SENSOR FOR TARGET ANALYSIS, KIT FOR TARGET ANALYSIS, AND TARGET ANALYSIS METHOD USING SAME 有权
标题翻译：用于目标分析的荧光传感器，目标分析工具箱和使用相同目标的目标分析方法
公开(公告)号：US20160146772A1
公开(公告)日：2016-05-26
申请号：US14906897
申请日：2014-06-27
申请人： NEC SOLUTION INNOVATORS, LTD.
发明人： Naoto KANEKO , Ikuo SHIRATORI , Katsunori HORII , Jou AKITOMI , Iwao WAGA
IPC分类号： G01N33/04 , C12N15/11 , C12N15/115
CPC分类号： G01N33/04 , C12N15/11 , C12N15/115 , C12N2310/127 , C12N2310/151 , C12N2310/16 , C12N2310/3519 , C12Q1/6825 , G01N33/542 , C12Q2521/345 , C12Q2563/107
摘要： The present invention is intended to provide a novel fluorescence sensor for target analysis, a kit for target analysis, and a target analysis method using the same.The fluorescence sensor for target analysis according to the present invention includes a nucleic acid molecule that includes a G-quartet-forming nucleic acid region (D) that forms a G-quartet and a binding nucleic acid region (A) that binds to a target. In the absence of a target, formation of a G-quartet in the G-quartet-forming nucleic acid region (D) is inhibited. In the presence of a target, the target comes into contact with the binding nucleic acid region (A), the G-quartet is formed in the G-quartet-forming nucleic acid region (D) due to the contact, the G-quartet-forming region (D) and porphyrin forms a complex, and the complex generates fluorescence.
摘要翻译：本发明旨在提供一种用于目标分析的新型荧光传感器，用于目标分析的试剂盒和使用该荧光传感器的目标分析方法。根据本发明的用于靶分析的荧光传感器包括核酸分子，其包括形成G-四重态的G-四重峰形成核酸区（D）和与靶标结合的结合核酸区（A）。在不存在目标的情况下，G-四重峰形成核酸区（D）中的G四重奏的形成被抑制。在靶的存在下，目标与结合核酸区域（A）接触，G-四重峰由于接触而在G-四重峰形成核酸区域（D）中形成，G-四重峰形成区域（D）和卟啉形成复合物，并且复合物产生荧光。

8. 发明申请

US20220148696A1 LIFESTYLE HABIT RECOMMENDATION APPARATUS, LIFESTYLE HABIT RECOMMENDATION METHOD, PROGRAM, AND RECORDING MEDIUM 有权
公开(公告)号：US20220148696A1
公开(公告)日：2022-05-12
申请号：US17435812
申请日：2020-03-12
申请人： NEC Solution Innovators, Ltd.
发明人： Jou AKITOMI , Mineko YAMAYUCHI
IPC分类号： G16H20/00 , A61B5/00 , A61B5/11
摘要： An apparatus (10) for lifestyle habit recommendation, comprising at least one processor configured to: acquire execution information executed for each item serving as an indicator of a lifestyle habit and a vitality level of a sample user in association with a date; set a scheduled date on which a vitality level of a target user is required to be a predetermined value; set a given period up to the scheduled date as an output period of recommended lifestyle habit information; acquire a date on which the associated vitality level of the sample user is the predetermined value, and determines the execution information corresponding to the number of days of the output period up to the date as the recommended information in the output period; and output the recommended information to the target user.

9. 发明申请

US20210201649A1 CONTINUAL ENGAGEMENT SUPPORT DEVICE, PORTABLE TERMINAL, CONTINUAL ENGAGEMENT SUPPORT METHOD, AND PROGRAM 有权
公开(公告)号：US20210201649A1
公开(公告)日：2021-07-01
申请号：US17273349
申请日：2019-06-26
申请人： NEC Solution Innovators, Ltd.
发明人： Ikuo KAJIYAMA , Jou AKITOMI , Miho ISHII
IPC分类号： G08B21/18 , G08B25/01 , G08B27/00
摘要： The continual engagement support device 600 includes: the performance data storage means 601 that stores performance data including time data indicating the time of performance and sensor data of the time of performance or the surrounding time obtained from the sensors mounted on the portable terminal when the target action is performed via the portable terminal possessed by the target user; the timing detection means 602 that detects the performance timing, which is the timing at which the target user is likely to perform the target action during the predetermined cycle, on the basis of the performance data; and the notification means 603 provides a notification to prompt the performance of the target action at the detected performance timing when the target action is not performed for a predetermined period of time or longer.

10. 发明申请

US20160298117A1 PEANUT-BINDING NUCLEIC ACID MOLECULE AND USE THEREOF 有权
标题翻译： PEANUT-BINDIN NUCLEIC ACID MOLECULLE及其用途
公开(公告)号：US20160298117A1
公开(公告)日：2016-10-13
申请号：US15100833
申请日：2014-06-26
申请人： NEC SOLUTION INNOVATORS, LTD.
发明人： Tomoko MURATA , Katsunori HORII , Ikuo SHIRATORI , Jou AKITOMI , Naoto KANEKO , Iwao WAGA
IPC分类号： C12N15/115 , C12Q1/68
CPC分类号： C12N15/115 , C12N2310/16 , C12Q1/6895
摘要： The present invention provides a novel nucleic acid molecule that can be used for detection of peanuts. The peanut-binding nucleic acid molecule of the present invention is characterized in that it binds to a peanut allergen with a dissociation constant of 10 nM or less, and preferably contains a polynucleotide consisting of any of base sequences of SEQ ID NOs: 1 to 15, for example. It is also preferable that, for example, the peanut-binding nucleic acid molecule of the present invention binds with significant specificity to the peanut allergen rather than to a soybean protein.
摘要翻译：本发明提供了可用于检测花生的新型核酸分子。本发明的花生结合核酸分子的特征在于其以10nM以下的解离常数结合花生过敏原，优选含有由SEQ ID NO：1〜15的碱基序列中的任一种组成的多核苷酸，例如。还优选的是，例如，本发明的花生结合核酸分子对花生过敏原而不是大豆蛋白具有显着特异性的结合。

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