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    • 2. 发明申请
    • METHOD FOR PRODUCING SAMPLE AND METHOD FOR ANALYZING TARGET
    • 生产样本的方法和分析目标的方法
    • US20160202154A1
    • 2016-07-14
    • US14916942
    • 2014-06-27
    • NEC SOLUTION INNOVATORS, LTD.
    • Katsunori HORIIJou AKITOMINaoto KANEKOIwao WAGA
    • G01N1/30G01N33/538G01N33/04G01N33/53
    • G01N1/30C12N15/113C12N15/115C12N2310/127C12N2310/16C12N2310/3519C12Q1/6806G01N30/88G01N30/96G01N33/04G01N33/5308G01N33/538G01N33/566G01N2030/8813C12Q2527/125
    • The present invention is intended to provide a novel sensor for target analysis and a target analysis method using the same.The sensor for target analysis according to the present invention includes a single-stranded nucleic acid molecule. The single-stranded nucleic acid molecule includes a first catalytic nucleic acid region (D1), a second catalytic nucleic acid region (D2), and a binding nucleic acid region (Ap) that binds to a target. The single-stranded nucleic acid molecule includes the first catalytic nucleic acid region (D1) at one end of the binding nucleic acid region (Ap) and the second catalytic nucleic acid region (D2) at the other end of the binding nucleic acid (Ap). In the absence of a target, the catalytic function by the first catalytic nucleic acid region (D1) and the second catalytic nucleic acid region (D2) is inhibited. In the presence of a target, the catalytic function is generated owing to formation of a G-quartet of the first catalytic nucleic acid region (D1) and the second catalytic nucleic acid region (D2) due to the contact between the target and the binding nucleic acid region (Ap).
    • 本发明旨在提供一种用于目标分析的新型传感器和使用其的目标分析方法。 根据本发明的用于靶分析的传感器包括单链核酸分子。 单链核酸分子包括与靶标结合的第一催化核酸区域(D1),第二催化核酸区域(D2)和结合核酸区域(Ap)。 单链核酸分子包括在结合核酸区(Ap)一端的第一催化核酸区(D1)和结合核酸另一端的第二催化核酸区(D2) )。 在没有靶的情况下,抑制了第一催化核酸区(D1)和第二催化核酸区(D2)的催化功能。 在靶的存在下,由于靶和结合物之间的接触,由于形成第一催化核酸区域(D1)和第二催化核酸区域(D2)的G四重奏,产生催化功能 核酸区(Ap)。