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1. 发明申请

US20060024397A9 Dietary food supplement containing natural cyclooxygenase inhibitors and methods for inhibiting pain and inflammation 失效
标题翻译：含有天然环氧合酶抑制剂的膳食补充剂和抑制疼痛和炎症的方法
公开(公告)号：US20060024397A9
公开(公告)日：2006-02-02
申请号：US10945609
申请日：2004-09-21
申请人： Muraleedharan Nair , David Dewitt , Haibo Wang , David Krempin , Dipak Mody , David Groh , Mary Murray , Marc Lemay , Yong Qian , Audra Davies , Robin Dykhouse
发明人： Muraleedharan Nair , David Dewitt , Haibo Wang , David Krempin , Dipak Mody , David Groh , Mary Murray , Marc Lemay , Yong Qian , Audra Davies , Robin Dykhouse
IPC分类号： A61K31/7048 , A61K31/353 , A61K35/78
CPC分类号： A61K36/736 , A23L33/105 , A23V2002/00 , A61K36/185 , A61K36/29 , A61K36/35 , A61K36/45 , A23V2250/2104 , A61K2300/00
摘要： The present invention describes food supplements that contain one or more fruit extracts useful for pain relief and anti-inflammation. The food supplements may be used to inhibit inflammation mediated by cyclooxygenase and more particularly by cyclooxygenase-2.
摘要翻译：本发明描述了含有一种或多种可用于缓解疼痛和抗炎的水果提取物的食品添加剂。食物补充剂可用于抑制由环加氧酶介导的炎症，更特别地通过环氧合酶-2。

2. 发明申请

US20050100622A1 Dietary food supplement containing natural cyclooxygenase inhibitors and methods for inhibiting pain and inflammation 失效
标题翻译：含有天然环氧合酶抑制剂的膳食补充剂和抑制疼痛和炎症的方法
公开(公告)号：US20050100622A1
公开(公告)日：2005-05-12
申请号：US10945609
申请日：2005-01-10
申请人： Muraleedharan Nair , David Dewitt , Haibo Wang , David Krempin , Dipak Mody , David Groh , Mary Murray , Marc Lemay , Yong Qian , Audra Davies , Robin Dykhouse
发明人： Muraleedharan Nair , David Dewitt , Haibo Wang , David Krempin , Dipak Mody , David Groh , Mary Murray , Marc Lemay , Yong Qian , Audra Davies , Robin Dykhouse
IPC分类号： A23L1/30 , A61K36/29 , A61K36/35 , A61K36/45 , A61K36/736 , A61K31/7048 , A61K31/353 , A61K35/78
CPC分类号： A61K36/736 , A23L33/105 , A23V2002/00 , A61K36/185 , A61K36/29 , A61K36/35 , A61K36/45 , A23V2250/2104 , A61K2300/00
摘要： The present invention describes food supplements that contain one or more fruit extracts useful for pain relief and anti-inflammation. The food supplements may be used to inhibit inflammation mediated by cyclooxygenase and more particularly by cyclooxygenase-2.
摘要翻译：本发明描述了含有一种或多种可用于缓解疼痛和抗炎的水果提取物的食品添加剂。食物补充剂可用于抑制由环加氧酶介导的炎症，更特别地通过环氧合酶-2。

3. 发明申请

US20060198810A1 Plant based formulations for improving skin moisture, texture, and appearance 有权
标题翻译：用于改善皮肤水分，质地和外观的基于植物的制剂
公开(公告)号：US20060198810A1
公开(公告)日：2006-09-07
申请号：US11075006
申请日：2005-03-07
申请人： Mary Murray , Aaron Crawford , David Fast , Dora Dong , Michael Huang , Lynne Connor
发明人： Mary Murray , Aaron Crawford , David Fast , Dora Dong , Michael Huang , Lynne Connor
IPC分类号： A61K8/97 , A61K36/87 , A61K36/73 , A61K36/232 , A61K31/355
CPC分类号： A61K36/815 , A61K8/97 , A61K31/355 , A61K36/232 , A61K36/738 , A61K36/87 , A61Q19/08 , A61K2300/00
摘要： The present invention relates to formulations of ingredients that are useful for improving the appearance, texture and/or moisture of skin. In particular, the formulations of the present invention stimulate collagen, elastin, and lipid synthesis and/or inhibit or minimize the loss of collagen, elastin, and lipids in the skin. Additionally, the formulations of the present invention inhibit matrix metalloproteases, such as MMP-1, MMP-9, collagenase, or elastase.
摘要翻译：本发明涉及可用于改善皮肤的外观，质地和/或水分的成分配方。特别地，本发明的制剂刺激胶原蛋白，弹性蛋白和脂质合成和/或抑制或最小化皮肤中胶原，弹性蛋白和脂质的损失。此外，本发明的制剂抑制基质金属蛋白酶，例如MMP-1，MMP-9，胶原酶或弹性蛋白酶。

4. 发明申请

US20070149475A1 AUGMENTATION OF WOUND HEALING BY eIF-4E mRNA AND EGF mRNA 审中-公开
标题翻译：通过eIF-4E mRNA和EGF mRNA来治疗伤口愈合
公开(公告)号：US20070149475A1
公开(公告)日：2007-06-28
申请号：US11680243
申请日：2007-02-28
申请人： Mary Murray , Scott Dulchavsky
发明人： Mary Murray , Scott Dulchavsky
IPC分类号： A61K48/00 , C12N15/09
CPC分类号： C07K14/4705 , A61K48/00 , C07K14/485
摘要： There is provided a method of augmenting transient protein synthesis in a cell by delivering to the cell mRNA functionally related to protein production. Also provided is a method of augmenting transient protein synthesis in cells by increasing protein synthesis of growth factors from endogenous cellular mRNA and exogenous mRNA delivered to the cells. A treatment for transiently increasing protein production in cells, said treatment comprising mRNA functionally related to protein production is also provided. There is provided a method of augmenting wound healing by delivering mRNA functionally related to wound healing. Further provided is a therapeutic for transiently increasing protein synthesis in cells, said therapeutic comprising mRNA related to protein production.
摘要翻译：提供了通过递送到与蛋白质生产功能相关的细胞mRNA来增加细胞中瞬时蛋白质合成的方法。还提供了通过增加来自内源细胞mRNA的生长因子和递送至细胞的外源mRNA的蛋白质合成来增加细胞中瞬时蛋白质合成的方法。还提供了在细胞中瞬时增加蛋白质产生的治疗，所述治疗包括与蛋白质生产功能相关的mRNA。提供了通过递送与伤口愈合功能相关的mRNA来增加伤口愈合的方法。进一步提供了用于瞬时增加细胞中蛋白质合成的治疗剂，所述治疗剂包括与蛋白质生产相关的mRNA。

5. 发明申请

US20080145858A1 DETECTION AND IDENTIFICATION OF TOXICANTS BY MEASUREMENT OF GENE EXPRESSION PROFILE 审中-公开
标题翻译：通过测量基因表达谱来检测和鉴定毒素
公开(公告)号：US20080145858A1
公开(公告)日：2008-06-19
申请号：US11964117
申请日：2007-12-26
申请人： Hyesook Kim , Mary Murray , Raymond F. Novak
发明人： Hyesook Kim , Mary Murray , Raymond F. Novak
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , A01K2227/50 , C12Q2600/142 , C12Q2600/158
摘要： A screen for detecting, identifying, and characterizing chemicals as toxicants is based on the affect of the chemical on gene expression in animal cleavage stage embryos. A microarray screen for detecting and measuring the affects of chemicals on gene expression in animal cleavage stage embryos. A screen for detecting, identifying and characterizing chemicals as toxicants based on the common or differential affects on gene expression in animal cleavage stage embryos and neurulation stage embryos. Markers of chemical exposure and teratogenesis identified using the screen disclosed herein. A treatment that enables the transfer of biotinylated PCR products or DNA to a membrane following gel electrophoresis by depurinating the PCR or DNA products and denaturing the PCR products or DNA.
摘要翻译：用于检测，鉴定和表征化学品作为有毒物质的屏幕是基于化学物质对动物切割阶段胚胎中基因表达的影响。一种用于检测和测量化学物质对动物切割期胚胎中基因表达的影响的微阵列筛选。基于对动物切割阶段胚胎和神经阶段胚胎中基因表达的共同或不同影响的用于检测，鉴定和表征化学品作为有毒物质的筛选。使用本文公开的屏幕鉴定化学暴露和致畸的标记。通过对PCR或DNA产物进行降解和变性PCR产物或DNA，可以在凝胶电泳后将生物素化的PCR产物或DNA转移到膜上进行处理。

6. 发明申请

US20050208161A1 Nutritional supplement containing alpha-glucosidase and alpha-amylase inhibitors 有权
标题翻译：营养补充剂含有α-葡萄糖苷酶和α-淀粉酶抑制剂
公开(公告)号：US20050208161A1
公开(公告)日：2005-09-22
申请号：US11131538
申请日：2005-05-18
申请人： Mary Murray , James Roufs , Haeri Roh-Schmidt
发明人： Mary Murray , James Roufs , Haeri Roh-Schmidt
IPC分类号： A23L1/29 , A23L1/30 , A23L1/307 , A61K31/133 , A61K31/7032 , A61K36/062 , A61K36/48 , A61K38/46 , A61K45/00 , A61P3/02 , A61K35/78 , A61K38/16
CPC分类号： A61K36/48 , A23L33/105 , A61K36/062 , A61K2300/00
摘要： A nutritional supplement composition contains inhibitors of alpha-glucosidase and alpha-amylase substantially in the absence of lipase inhibitors. The composition can include touchi extract and phaseolamin as the alpha-glucosidase and alpha-amylase inhibitor, respectively. A method of limiting the absorption of carbohydrates contained in a foodstuff includes administering the nutritional supplement composition prior to consumption of the carbohydrates, and a method promoting weight loss in an individual includes administering the nutritional supplement composition to the individual over a period of days.
摘要翻译：营养补充剂组合物含有基本上不存在脂肪酶抑制剂的α-葡糖苷酶和α-淀粉酶抑制剂。该组合物可以分别包括作为α-葡糖苷酶和α-淀粉酶抑制剂的触浸提取物和阶段酚胺。限制食品中包含的碳水化合物的吸收的方法包括在消耗碳水化合物之前施用营养补充剂组合物，并且促进个体减肥的方法包括在几天的时间内向个体施用营养补充剂组合物。

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