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1. 发明公开

EP3231435A1 METHODS OF ATTENUATING THE LOSS OF FUNCTIONAL STATUS 审中-公开
标题翻译：减轻功能状态损失的方法
公开(公告)号：EP3231435A1
公开(公告)日：2017-10-18
申请号：EP17164469.3
申请日：2010-07-15
申请人： Nestec S.A.
发明人： MILLER, Kevin , JURK, Ingo , ROUGHEAD, Zamzam, Kabiry (Fariba)
IPC分类号： A61K35/20 , A61K38/44 , A61K38/06 , A61K36/815 , A61K31/593 , A61K31/375 , A61K31/202 , A61K31/198 , A61K31/195 , A61K9/107 , A61P21/00 , A61P21/06 , A61K45/06 , A23L33/10 , A23L33/15 , A23L33/16 , A23L33/19
CPC分类号： A61K31/202 , A23L33/10 , A23L33/15 , A23L33/16 , A23L33/19 , A61K31/195 , A61K31/198 , A61K31/375 , A61K35/20 , A61K36/815 , A61K38/063 , A61K38/446 , A61K45/06 , A61K2300/00
摘要： Nutritional compositions and methods of using the nutritional compositions with exercise to attenuate the loss of functional status are provided. In a general embodiment, the present disclosure provides a nutritional composition including whey protein, and Vitamin D. The nutritional composition and exercise can be specifically used to attenuate the loss of functional status, especially in the elderly.
摘要翻译：提供营养组合物和使用营养组合物进行锻炼以减轻功能状态丧失的方法。在一般的实施方案中，本公开提供了包含乳清蛋白和维生素D的营养组合物。营养组合物和运动可以具体用于减弱功能状态的损失，特别是在老年人中。

2. 发明公开

EP3153173A1 METHODS AND COMPOSITIONS FOR ENHANCING STEM CELL MOBILIZATION 审中-公开
标题翻译： VERFAHREN UND ZUSAMMENSETZUNGEN ZUR VERBESSERUNG DER STAMMZELLENMOBILISIERUNG
公开(公告)号：EP3153173A1
公开(公告)日：2017-04-12
申请号：EP16191165.6
申请日：2011-06-28
申请人： Stemtech International, Inc.
发明人： DRAPEAU, Christian , JENSEN, Gitte
IPC分类号： A61K36/815 , A61K31/737 , A61K36/03 , A61K35/20 , A61K36/07 , A61P37/00 , A61P43/00 , A61K36/074 , A61K36/068 , A61K35/748
CPC分类号： A61K36/81 , A61K31/737 , A61K35/20 , A61K35/748 , A61K36/02 , A61K36/03 , A61K36/06 , A61K36/068 , A61K36/07 , A61K36/074 , A61K36/815
摘要： The present invention provides a method of using fucoidan to enhance stem cell mobilization in a subject, including hematopoietic stem cells (HSCs) and bone marrow stem cells (BMSCs). In one embodiment, a blended composition of fruits, mushrooms, microorganisms, maternal fluids, and extracts thereof are used to promote trafficking of stem cells, resulting in migration of the stem cells to specific sties of maintenance and and repair within tissues and/or organs. In other embodiments, the method involves the use of fucoidan obtained from particular algae species to support release and ciriculation of HSCs, as demonstrated by significantly increase circulation of HSCs in the peripheral blood. Increased circulation of HSCs and/or BMSCs and migration towards sites of maintenance and the natural regeneration mechanisms in the body. Further provided is a dosing regimen for the administration of fucoidan and a method of enhancing release and circulation of stem cells.
摘要翻译：本发明提供一种使用岩藻依聚糖来增强受试者（包括造血干细胞（HSCs）和骨髓干细胞（BMSCs））的干细胞移动的方法。在一个实施方案中，水果，蘑菇，微生物，母液和其提取物的混合组合物用于促进干细胞的运输，导致干细胞向组织和/或器官的维持和修复的特定状态迁移。在其他实施方案中，该方法涉及使用从特定藻类物质获得的岩藻依聚糖来支持HSC的释放和凝血，如通过显着增加外周血中HSC的循环所证明的。 HSCs和/或骨髓基质干细胞的循环增加，以及身体维持和自然再生机制的迁移。还提供了用于施用岩藻依聚糖的给药方案和增强干细胞释放和循环的方法。

3. 发明公开

EP3010482A4 METHODS AND COMPOSITIONS FOR ENHANCING STEM CELL MOBILIZATION 无效
标题翻译：提高应变细胞移植的方法和组合物
公开(公告)号：EP3010482A4
公开(公告)日：2016-11-02
申请号：EP14813684
申请日：2014-06-19
申请人： STEMTECH INTERNATIONAL INC
发明人： DRAPEAU CHRISTIAN , JENSEN GITTE S
IPC分类号： A61K36/886 , A61K9/48 , A61K31/737 , A61K35/20 , A61K35/748 , A61K36/068 , A61K36/07 , A61K36/074 , A61K36/704 , A61K36/815
CPC分类号： A61K36/886 , A61K9/0053 , A61K9/14 , A61K9/48 , A61K31/715 , A61K31/737 , A61K35/20 , A61K35/748 , A61K36/06 , A61K36/068 , A61K36/07 , A61K36/074 , A61K36/70 , A61K36/704 , A61K36/815 , A61K2300/00

4. 发明公开

EP2857032A3 Tie2 activator, vascular endothelial growth factor (vegf) inhibitor, anti-angiogenic agent, agent for maturing blood vessels, agent for normalizing blood vessels, agent for stabilizing blood vessels, and pharmaceutical composition 审中-公开
标题翻译：的Tie2活化剂，血管内皮生长因子（VEGF），抗血管生成剂，抑制剂用于血管的成熟，用于血管正常化的装置，用于血管和药物组合物的稳定化
公开(公告)号：EP2857032A3
公开(公告)日：2015-07-15
申请号：EP14003460.4
申请日：2011-10-28
申请人： Maruzen Pharmaceuticals Co., Ltd.
发明人： Ohto, Nobuaki , Kiso, Akinori
IPC分类号： A61K36/73 , A61K36/00 , A61K36/18 , A61K36/28 , A61P9/00 , A61P43/00 , A61K36/48 , A61K36/67 , A61K36/734 , A61K36/725 , A61K36/16 , A61K36/185 , A61K36/287 , A61K36/53 , A61K35/618 , A61K36/61 , A61K36/62 , A61K36/815 , A61K36/88 , A61K36/9066
CPC分类号： A61K36/185 , A61K35/618 , A61K36/00 , A61K36/16 , A61K36/287 , A61K36/48 , A61K36/53 , A61K36/61 , A61K36/62 , A61K36/67 , A61K36/725 , A61K36/73 , A61K36/734 , A61K36/815 , A61K36/88 , A61K36/9066 , A61K2300/00
摘要： To provide a Tie2 activator, a vascular endothelial growth factor (VEGF) inhibitor, an angiogenesis inhibitor, a vascular maturing agent, a vascular normalizing agent and a vascular stabilizing agent, and a pharmaceutical composition having high safety, and an excellent Tie2 activating effect, vascular endothelial growth factor (VEGF) inhibitory effect, angiogenesis inhibitory effect, vascular maturing effect, vascular normalizing effect, and vascular stabilizing effect.
A Tie2 activator, a vascular endothelial growth factor (VEGF) inhibitor, an angiogenesis inhibitor, a vascular maturing agent, a vascular normalizing agent and a vascular stabilizing agent, and a pharmaceutical composition containing, as an active ingredient, a hawthorn extract, a starfruit extract, a shellflower extract, a lotus extract, a rooibos extract, an Indian date extract, a Chinese quince extract, a Psidium guava extract, a long pepper extract, a Quillaja extract, a Kouki extract, a ginkgo extract, an oyster extract, a turmeric extract, a chrysanthemum extract, a jujube extract, a Chinese wolfberry extract, a chamomile extract, or a Butcher's Broom extract, or any combination thereof.

5. 发明公开

EP2779834A1 USE OF FOTI TO ENHANCE STEM CELL MOBILIZATION AND PROLIFERATION 审中-公开
标题翻译： FO-TI用于改进干细胞的动员和增殖
公开(公告)号：EP2779834A1
公开(公告)日：2014-09-24
申请号：EP12848857.4
申请日：2012-11-15
申请人： Stemtech International Inc.
发明人： DRAPEAU, Christian , JENSEN, Gitte, S.
IPC分类号： A01N65/00
CPC分类号： A61K36/704 , A61K9/48 , A61K31/737 , A61K35/20 , A61K35/748 , A61K36/03 , A61K36/05 , A61K36/068 , A61K36/07 , A61K36/074 , A61K36/815 , A61K2236/33 , A61K2300/00
摘要： The present invention provides a method of using Polygonum multiflorum or extracts thereof to enhance stem cell mobilization in a subject, including hematopoietic stem cells (HSCs) and bone marrow stem cells (BMSCs). In one embodiment, a blended composition of plant parts, fruits, mushrooms, microorganisms, maternal fluids, and extracts thereof are used to promote mobilization of stem cells, resulting in migration of the stem cells to specific sties of maintenance and repair within tissues and/or organs. Increased circulation of HSCs and/or BMSCs and migration towards sites of maintenance promotes the natural regeneration mechanisms in the body.

6. 发明公开

EP2666470A4 PHARMACEUTICAL COMPOSITION FOR RELIEVING FATIGUE AND PREPARATION METHOD THEREFOR 有权
标题翻译：药物组合物缓解疲劳及其制造方法
公开(公告)号：EP2666470A4
公开(公告)日：2014-06-11
申请号：EP11855926
申请日：2011-07-15
申请人： JILIN ZIXIN PHARMACEUTICAL RES INSTITUTION LLC
发明人： SUN DEJUN , YIN JINLONG , SUN MIAONAN , ZHAO YIZHUO , GUO CHUNSHENG , LI XUE , GAO YANHUI
IPC分类号： A61K36/8969 , A61K36/258 , A61K36/296 , A61K36/39 , A61K36/481 , A61K36/815 , A61K36/8945 , A61P39/00
CPC分类号： A61K36/35 , A61K35/74 , A61K36/258 , A61K36/296 , A61K36/39 , A61K36/43 , A61K36/481 , A61K36/815 , A61K36/88 , A61K36/8945 , A61K36/8969 , A61K2300/00

7. 发明公开

EP2734195A1 COMPOSITIONS FOR TREATMENT OF SKIN DISORDERS 审中-公开
标题翻译： ZUSAMMENSETZUNGEN ZUR BEHANDLUNG VON HAUTERKRANKUNGEN
公开(公告)号：EP2734195A1
公开(公告)日：2014-05-28
申请号：EP12740197.4
申请日：2012-07-20
申请人： Lowe, Nicholas , Lowe, Philippa
发明人： Lowe, Nicholas , Lowe, Philippa
IPC分类号： A61K31/155 , A61K31/455 , A61K31/60 , A61K36/815 , A61K36/28 , A61P17/10 , A61P17/00
CPC分类号： A61K31/60 , A61K8/0212 , A61K8/368 , A61K8/43 , A61K8/675 , A61K9/0014 , A61K31/155 , A61K31/352 , A61K31/355 , A61K31/455 , A61K31/555 , A61K36/28 , A61K36/61 , A61K36/815 , A61K45/06 , A61Q19/00 , A61Q19/10 , A61K2300/00
摘要： Compositions are provided comprising: (i) chlorhexidine or a pharmaceutically acceptable salt thereof; (ii) niacinamide or niacin; and (iii) salicylic acidor a pharmaceutically acceptable salt or derivative thereof. The compositions are suitable for use in treating and preventing disorders of the skin. The compositions are also provided in the form of cosmetic products.
摘要翻译：提供的组合物包括：（i）氯己定或其药学上可接受的盐; （ii）烟酰胺或烟酸; 和（iii）水杨酸或其药学上可接受的盐或衍生物。该组合物适用于治疗和预防皮肤疾病。组合物也以化妆品的形式提供。

8. 发明公开

EP2680711A1 EXTENSIONAL VISCOSITY TO PROMOTE SAFE SWALLOWING OF FOOD BOLUSES 有权转让
标题翻译：拉伸粘度促进食物的安全吞咽BALLS
公开(公告)号：EP2680711A1
公开(公告)日：2014-01-08
申请号：EP12707286.6
申请日：2012-03-01
申请人： Nestec S.A.
发明人： BURBIDGE, Adam Stewart , ENGMANN, Jan , POPA NITA, Simina
IPC分类号： A23L1/052 , A23L1/0526 , A23L1/053 , A23L1/29
CPC分类号： A61K31/07 , A23L29/206 , A23L29/238 , A23L29/25 , A23L33/40 , A61K31/122 , A61K31/375 , A61K31/7048 , A61K33/00 , A61K35/741 , A61K35/744 , A61K35/747 , A61K36/815 , A61K47/36 , A61K47/46 , A61K2035/115
摘要： Nutritional products having improved cohesiveness of food boluses and methods of making and using same are provided. The nutritional products may include nutritional compositions and high molecular weight, water-soluble polymers such that the nutritional products have extensional viscosities that provide improved cohesiveness to the nutritional products and Trouton ratios of at least 6. Methods of administering such nutritional products to patients having impaired swallowing ability and/or dysphagia are also provided.

9. 发明公开

EP2647385A1 Tie2 ACTIVATOR, VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) INHIBITOR, ANTI-ANGIOGENIC AGENT, AGENT FOR MATURING BLOOD VESSELS, AGENT FOR NORMALIZING BLOOD VESSELS, AGENT FOR STABILIZING BLOOD VESSELS, AND PHARMACEUTICAL COMPOSITION 审中-公开
标题翻译： TIE2 AKTIVATOR，血管内皮生长因子（VEGF）抑制剂，抗血管生成活性，代理为老化的血管，手段正常化血管，MEDIUM用于稳定血管的药物组合物
公开(公告)号：EP2647385A1
公开(公告)日：2013-10-09
申请号：EP11845773.8
申请日：2011-10-28
申请人： Maruzen Pharmaceuticals Co., Ltd.
发明人： OHTO, Nobuaki , KISO, Akinori
IPC分类号： A61K36/73 , A61K36/00 , A61K36/18 , A61K36/28 , A61P9/00 , A61P43/00
CPC分类号： A61K36/185 , A61K35/618 , A61K36/00 , A61K36/16 , A61K36/287 , A61K36/48 , A61K36/53 , A61K36/61 , A61K36/62 , A61K36/67 , A61K36/725 , A61K36/73 , A61K36/734 , A61K36/815 , A61K36/88 , A61K36/9066 , A61K2300/00
摘要： To provide a Tie2 activator, a vascular endothelial growth factor (VEGF) inhibitor, an angiogenesis inhibitor, a vascular maturing agent, a vascular normalizing agent and a vascular stabilizing agent, and a pharmaceutical composition having high safety, and an excellent Tie2 activating effect, vascular endothelial growth factor (VEGF) inhibitory effect, angiogenesis inhibitory effect, vascular maturing effect, vascular normalizing effect, and vascular stabilizing effect.
A Tie2 activator, a vascular endothelial growth factor (VEGF) inhibitor, an angiogenesis inhibitor, a vascular maturing agent, a vascular normalizing agent and a vascular stabilizing agent, and a pharmaceutical composition containing, as an active ingredient, a hawthorn extract, a starfruit extract, a shellflower extract, a lotus extract, a rooibos extract, an Indian date extract, a Chinese quince extract, a Psidium guava extract, a long pepper extract, a Quillaja extract, a Kouki extract, a ginkgo extract, an oyster extract, a turmeric extract, a chrysanthemum extract, a jujube extract, a Chinese wolfberry extract, a chamomile extract, or a Butcher's Broom extract, or any combination thereof.
摘要翻译：以提供的Tie2活化剂，血管内皮生长因子（VEGF）抑制剂，血管生成抑制剂，血管成熟剂，血管正火剂和血管稳定剂，并且具有高安全性的药物组合物，和优异的Tie2活化作用，血管内皮生长因子（VEGF）的抑制作用，血管生成抑制作用，血管成熟作用，血管正常化的作用，和血管稳定作用。甲的Tie2活化剂，血管内皮生长因子（VEGF）抑制剂，血管生成抑制剂，血管成熟剂，血管正火剂和血管稳定剂，和含有作为活性成分，山楂提取物，杨桃的药物组合物提取物，贝壳花提取物，莲花提取物，路易波士茶提取物，印度的日期提取物，中国榅桲提取物，番石榴番石榴提取物，长辣椒提取物，皂树提取物，季提取物，银杏提取物，牡蛎提取物，姜黄提取物，菊花提取物，大枣提取物，枸杞中国提取物，甘菊提取物，或布彻的扫帚提取物，或其任何组合。

10. 发明公开

EP2601960A1 ANTI-FATIGUE COMPOSITION OF PLANT MATERIAL AND PREPARATION METHOD, USE AND PRODUCTS THEREOF 审中-公开
标题翻译：蔬菜组成反对疲劳和方法，用途及其制品
公开(公告)号：EP2601960A1
公开(公告)日：2013-06-12
申请号：EP10855522.8
申请日：2010-08-05
申请人： Xie, Chen , Zhong, Zhong
发明人： Xie, Chen , Zhong, Zhong
IPC分类号： A61K36/815 , A61K36/424 , A61K36/41 , A61P39/00 , A23L1/29 , A61K125/00 , A61K131/00 , A61K127/00
CPC分类号： A23L2/52 , A23L33/105 , A61K36/41 , A61K36/424 , A61K36/815 , A61K2300/00
摘要： The present invention provides a composition of a plant material with anti-fatigue activity, its preparation method, usage and related products. The said composition is manufactured from the following plant materials: 20-80% from the genus Rhodiola; 10-60% Gynostemma; 10-60% Lycium. The said composition can be used to manufacture health product, food or anti-fatigue medicine which is able to significantly reduce the fatigue symptoms of those people suffering from fatigue, improve sleeping quality with no impact on normal body physiology. It is shown that the medicine derived from the present invention exerts its anti-fatigue effect through improving the functions of erythrocytes and thrombocytes to enhance the body's ability of supplying oxygen. The medicinal composition of the present invention is characterized by the small effective dose and good water solubility and thus suitable to be made into a variety of dosage forms for use.
摘要翻译：本发明提供了具有抗疲劳作用，其制备方法，使用方法和相关产品的植物材料的组合物。从该属红景天20-80％;：所述组合物由下列规划的材料制造 10-60％绞股蓝; 10-60％枸杞。该组合物可用于制造保健品，食品，抗疲劳药所有它能够显着降低疲劳症状那些人疲劳的痛苦，提高对正常的人体生理机能没有影响睡眠质量。它被示出，DASS死于本发明衍生的药物通过改善红细胞和血小板的功能，以增强身体的供氧能力发挥其抗疲劳作用。本发明小的药用组合物是由有效剂量和良好的水溶性，因此适合于制成各种的用于剂型的特征的。

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