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1. 发明专利

IL259047D0 Therapeutic nanoparticles comprising a therapeutic agent and methods of making and using same 未知
公开(公告)号：IL259047D0
公开(公告)日：2018-06-28
申请号：IL25904718
申请日：2018-04-30
申请人： PFIZER , YOUNG HO SONG , MARIA CONCEICAO FIGUEIREDO , DAVID DEWITT
发明人： YOUNG-HO SONG , MARIA CONCEICAO FIGUEIREDO , DAVID DEWITT
IPC分类号： A61K20060101

2. 发明申请

US20140328664A1 SINGLE CIRCUIT DOUBLE-ACTING PUMP 审中-公开
标题翻译：单电路双作用泵
公开(公告)号：US20140328664A1
公开(公告)日：2014-11-06
申请号：US13875754
申请日：2013-05-02
申请人： David Dewitt Hearn
发明人： David Dewitt Hearn
IPC分类号： F04B23/02
CPC分类号： F04B47/02 , E21B43/129 , F04B11/0008 , F04B47/04
摘要： Removing water from a subterranean formation entails pumping hydraulic oil from a surface-located hydraulic oil pump through a hydraulic oil line to a downhole water pump piston to drive it in a first direction to pump water through a downhole water line to a water chamber of a hydraulic accumulator at the surface. A piston separates the water chamber and an oil chamber and moves to compress the hydraulic oil in the oil chamber of the hydraulic accumulator. The hydraulic oil pump may then pump hydraulic oil into the oil chamber causing the piston to move toward the water chamber, thereby moving water in the downhole water line and resetting the piston in the downhole water pump. A water valve in the downhole water line at the surface may open and release water when the piston in the downhole water pump reaches a predetermined or reset position.
摘要翻译：从地层中去除水需要将液压油从表面定位的液压油泵通过液压油管线泵送到井下水泵活塞，以便在第一方向上驱动它，以将水泵送通过井下水管线到达水室液压蓄能器在表面。活塞将水室和油室分开并移动以压缩液压蓄能器的油室中的液压油。然后，液压油泵可以将液压油泵送到油室中，使得活塞朝向水室移动，从而移动井下水管线中的水并将井下水泵中的活塞复位。当井下水泵中的活塞达到预定或复位位置时，表面井下水线中的水阀可能打开并释放水。

3. 发明申请

US20140142165A1 THERAPEUTIC PARTICLES SUITABLE FOR PARENTERAL ADMINISTRATION AND METHODS OF MAKING AND USING SAME 有权
标题翻译：适用于外部管理的治疗颗粒及其制备和使用方法
公开(公告)号：US20140142165A1
公开(公告)日：2014-05-22
申请号：US14015549
申请日：2013-08-30
申请人： Amy Grayson , Stephen E. Zale , David Dewitt
发明人： Amy Grayson , Stephen E. Zale , David Dewitt
IPC分类号： A61K47/48 , A61K31/337
CPC分类号： A61K47/48346 , A61K9/0019 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/00 , A61K31/21 , A61K31/337 , A61K31/4353 , A61K47/62 , A61K47/66 , A61K47/6937 , B82Y5/00
摘要： Disclosed herein are therapeutic compositions for treating and preventing diseases such as neointimal hyperplasia (NIH), where the compositions comprise a therapeutic particle that has a localized association with a blood vessel and a therapeutic agent, such as an anti-NIH agent. Methods of use of the therapeutic compositions are also disclosed.
摘要翻译：本文公开了用于治疗和预防诸如新内膜增生（NIH）的疾病的治疗组合物，其中组合物包含与血管局部相关的治疗颗粒和治疗剂如抗NIH药剂。还公开了治疗组合物的使用方法。

4. 发明授权

US08518963B2 Therapeutic polymeric nanoparticle compositions with high glass transition temperature or high molecular weight copolymers 有权
标题翻译：具有高玻璃化转变温度或高分子量共聚物的治疗性聚合物纳米颗粒组合物
公开(公告)号：US08518963B2
公开(公告)日：2013-08-27
申请号：US13372036
申请日：2012-02-13
申请人： Mir Mukkaram Ali , Abhimanyu Sabnis , David Dewitt , Greg Troiano , James Wright , Maria Figueiredo , Michael Figa , Christina Van Geen Hoven , Young-Ho Song , Jason Auer , Tarikh Christopher Campbell
发明人： Mir Mukkaram Ali , Abhimanyu Sabnis , David Dewitt , Greg Troiano , James Wright , Maria Figueiredo , Michael Figa , Christina Van Geen Hoven , Young-Ho Song , Jason Auer , Tarikh Christopher Campbell
IPC分类号： A61K9/50 , A61K31/44
CPC分类号： G01N25/4866 , A61K9/0019 , A61K9/146 , A61K9/5153 , A61K31/00 , A61K31/337 , A61K31/427 , A61K31/436 , A61K31/475 , A61K31/573 , A61K31/58 , A61K31/585 , A61K31/69 , A61K47/34
摘要： The present disclosure relates in part to pharmaceutical compositions comprising polymeric nanoparticles having certain glass transition temperatures. Other aspects of the invention include methods of making such nanoparticles.
摘要翻译：本公开部分涉及包含具有某些玻璃化转变温度的聚合物纳米颗粒的药物组合物。本发明的其它方面包括制备这种纳米颗粒的方法。

5. 发明申请

US20060236328A1 Integrated graphical user interface server for use with multiple client applications 审中-公开
标题翻译：集成图形用户界面服务器，用于多个客户端应用程序
公开(公告)号：US20060236328A1
公开(公告)日：2006-10-19
申请号：US11009502
申请日：2004-12-10
申请人： David DeWitt
发明人： David DeWitt
IPC分类号： G06F9/44
CPC分类号： G06F9/452
摘要： The graphical user interface or associated components for two or more different applications are integrated to provide a unified graphical user interface. Applications for different purposes or from different sources are run on a same processor, system or network. Programming calls are used to generate a common graphical user interface. Information from each of the different applications is used to generate the unified graphical user interface. For example, graphical buttons, text box, pull down menus, images, dialogues, data display boxes, selection indicators, menus or other user interface components for display on a screen from different applications are combined in a same window, dialogue box or other common graphical user interface.
摘要翻译：用于两个或多个不同应用的图形用户界面或相关组件被集成以提供统一的图形用户界面。用于不同目的或不同来源的应用程序在相同的处理器，系统或网络上运行。编程调用用于生成通用图形用户界面。来自每个不同应用程序的信息用于生成统一的图形用户界面。例如，用于在不同应用的屏幕上显示的图形按钮，文本框，下拉菜单，图像，对话，数据显示框，选择指示器，菜单或其他用户界面组件被组合在同一窗口，对话框或其他常见的图形用户界面。

6. 发明申请

US20060206822A1 Application communication with document embedded functions 审中-公开
标题翻译：应用程序与文档嵌入功能通信
公开(公告)号：US20060206822A1
公开(公告)日：2006-09-14
申请号：US11076619
申请日：2005-03-10
申请人： David DeWitt
发明人： David DeWitt
IPC分类号： G06F9/00
CPC分类号： G06F16/958
摘要： A document with embedded functions is provided for communications. A server application is responsible for generating a graphical user interface or other data and parses the document. Functions embedded within the document are identified. To acquire data or other information, the functions are called. For example, a function calls for text entered within a graphical user interface component. The data is obtained and inserted in the document, replacing the embedded function. As another example, the function causes the server application to acquire data for display as part of the graphical user interface. After population of data, the document is provided back to the client application.
摘要翻译：提供具有嵌入功能的文档进行通信。服务器应用程序负责生成图形用户界面或其他数据并解析文档。识别文档中嵌入的功能。要获取数据或其他信息，将调用这些功能。例如，函数调用在图形用户界面组件中输入的文本。数据获取并插入到文档中，代替嵌入的功能。作为另一个例子，该功能使得服务器应用程序获取用于显示的数据，作为图形用户界面的一部分。数据填充后，将文档提供给客户端应用程序。

7. 发明申请

US20050267367A1 Protocol controller for a medical diagnostic imaging system 审中-公开
公开(公告)号：US20050267367A1
公开(公告)日：2005-12-01
申请号：US11176875
申请日：2005-07-06
申请人： Cynthia Kerby , Laurence McCabe , David DeWitt
发明人： Cynthia Kerby , Laurence McCabe , David DeWitt
IPC分类号： A61B8/00
CPC分类号： G01S7/52098 , A61B8/00
摘要： The embodiments described herein relate to a protocol controller for a medical diagnostic imaging system. In one embodiment, two or more distinct study protocols are active on a medical diagnostic imaging system at the same time. In another embodiment, control of a medical diagnostic imaging system is changed at each stage of a study protocol sequence to optimize study performance. In yet another embodiment, a protocol is created from a collection of macros that control a medical diagnostic imaging system. Other embodiments are provided, and each of the embodiments described herein can be used alone or in combination with one another.

8. 发明申请

US20050244459A1 Coating compositions for bioactive agents 审中-公开
标题翻译：用于生物活性剂的涂料组合物
公开(公告)号：US20050244459A1
公开(公告)日：2005-11-03
申请号：US11099997
申请日：2005-04-06
申请人： David DeWitt , Michael Finley , Laurie Lawin
发明人： David DeWitt , Michael Finley , Laurie Lawin
IPC分类号： A61F2/00 , A61F2/86 , A61K9/14 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16
CPC分类号： A61L31/16 , A61F2/86 , A61F2250/0067 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/222 , A61L2300/404 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2300/43 , A61L2300/602 , A61L2300/606 , C08L33/06 , C08L33/10 , C08L71/02
摘要： A coating composition and related method for use in applying a bioactive agent to a surface in a manner that will permit the bioactive agent to be released from the coating in vivo. The composition is particularly well suited for coating the surface of implantable medical device, such as a stent or catheter, in order to permit the device to release bioactive agent to the surrounding tissue over time. The composition includes a plurality of compatible polymers having different properties that can permit them to be combined together to provide an optimal combination of such properties as durability, biocompatibility, and release kinetics.
摘要翻译：用于将生物活性剂施用于表面的涂料组合物和相关方法，其方式将允许生物活性剂在体内从涂层中释放。组合物特别适用于涂覆可植入医疗装置（例如支架或导管）的表面，以便允许装置随着时间的推移将生物活性剂释放到周围组织。该组合物包括具有不同性质的多种相容性聚合物，其可以将它们组合在一起，以提供诸如耐久性，生物相容性和释放动力学之类的最佳组合。

9. 发明授权

US09295649B2 Therapeutic polymeric nanoparticle compositions with high glass transition temperature or high molecular weight copolymers 有权
公开(公告)号：US09295649B2
公开(公告)日：2016-03-29
申请号：US12968625
申请日：2010-12-15
申请人： Mir Mukkaram Ali , Abhimanyu Sabnis , David Dewitt , Greg Troiano , James Wright , Maria Figueiredo , Michael Figa , Christina Van Geen Hoven , Young-Ho Song , Jason Auer , Tarikh Christopher Campbell
发明人： Mir Mukkaram Ali , Abhimanyu Sabnis , David Dewitt , Greg Troiano , James Wright , Maria Figueiredo , Michael Figa , Christina Van Geen Hoven , Young-Ho Song , Jason Auer , Tarikh Christopher Campbell
IPC分类号： A61K38/00 , C07K2/00 , A61K9/14 , A61K9/00 , A61K9/51 , A61K31/00 , A61K31/337 , A61K31/427 , A61K31/436 , A61K31/475 , A61K31/573 , A61K31/58 , A61K31/585 , A61K31/69 , A61K47/34
CPC分类号： G01N25/4866 , A61K9/0019 , A61K9/146 , A61K9/5153 , A61K31/00 , A61K31/337 , A61K31/427 , A61K31/436 , A61K31/475 , A61K31/573 , A61K31/58 , A61K31/585 , A61K31/69 , A61K47/34
摘要： The present disclosure relates in part to pharmaceutical compositions comprising polymeric nanoparticles having certain glass transition temperatures. Other aspects of the invention include methods of making such nanoparticles.

10. 发明申请

US20150056300A1 THERAPEUTIC NANOPARTICLES WITH HIGH MOLECULAR WEIGHT COPOLYMERS 审中-公开
标题翻译：具有高分子量共聚物的治疗纳米颗粒
公开(公告)号：US20150056300A1
公开(公告)日：2015-02-26
申请号：US13880853
申请日：2011-10-24
申请人： David Dewitt , Maria Figueiredo , Hong Wang , Greg Troiano , Young-Ho Song
发明人： David Dewitt , Maria Figueiredo , Hong Wang , Greg Troiano , Young-Ho Song
IPC分类号： A61K38/05 , A61K31/4375 , A61K31/4184 , A61K31/196 , A61K47/48 , A61K31/365 , A61K31/635 , A61K31/555 , A61K33/24 , A61K31/337 , A61K31/407
CPC分类号： A61K38/05 , A61K9/0019 , A61K9/5153 , A61K31/196 , A61K31/337 , A61K31/365 , A61K31/407 , A61K31/4184 , A61K31/4375 , A61K31/555 , A61K31/635 , A61K33/24 , A61K47/593 , A61K47/60
摘要： The present disclosure generally relates to therapeutic nanoparticles. Exemplary nanoparticles disclosed herein may include about 0.1 to about 40 weight percent of a therapeutic agent and about 10 to about 90 weight percent a diblock poly(lactic) acid-poly(ethylene)glycol copolymer or a diblock poly(lactic)-co-poly(glycolic) acid-poly(ethylene)glycol copolymer, wherein the diblock poly(lactic) acid-poly(ethylene)glycol copolymer comprises poly(lactic) acid having a number average molecule weight of about 30 kDa to about 90 kDa or the diblock poly(lactic)-co-poly(glycolic) acid-poly(ethylene)glycol copolymer comprises poly(lactic)-co-poly(glycolic) acid having a number average molecule weight of about 30 kDa to about 90 kDa.
摘要翻译：本公开一般涉及治疗性纳米颗粒。本文公开的示例性纳米颗粒可包括约0.1至约40重量％的治疗剂和约10至约90重量％的二嵌段聚（乳酸） - 聚（乙二醇）二醇共聚物或二嵌段聚（乳酸） - 共 - 聚（乙二醇）酸 - 聚（乙二醇）二醇共聚物，其中二嵌段聚（乳酸） - 聚（乙二醇）二醇共聚物包含数均分子量为约30kDa至约90kDa的聚（乳酸）或二嵌段聚（乳酸） - 共聚（乙醇酸） - 聚（乙二醇）二醇共聚物包含数均分子量为约30kDa至约90kDa的聚（乳酸） - 共聚（乙醇酸）酸。

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