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1. 发明申请

US20090186804A1 ANTICOAGULANT AND COMPOSITION FOR PREVENTING THROMBUS CONTAINING POLY-GAMMA-GLUTAMIC ACID 审中-公开
标题翻译：用于预防含有多糖 - 谷氨酸的含沙门氏菌的抗凝血剂和组合物
公开(公告)号：US20090186804A1
公开(公告)日：2009-07-23
申请号：US12159561
申请日：2006-12-22
申请人： Moon-Hee Sung , Chung Park , Seung-Pyo Hong , Haryoung Poo , Tae-Woo Kim
发明人： Moon-Hee Sung , Chung Park , Seung-Pyo Hong , Haryoung Poo , Tae-Woo Kim
IPC分类号： A61K38/00 , A61P7/02
CPC分类号： A61K31/74 , A23L33/175 , A61K9/0095
摘要： The present invention relates to an anticoagulant and a composition for preventing thrombus formation, which contain poly-gamma-glutamic acid (PGA) as an active ingredient. The inventive PGA is a water-soluble, anionic, biodegradable and edible amino acid polymer material, which has an anticoagulant effect of preventing thrombi from being accumulated in blood vessels, shows an excellent sustained-release effect and is harmless to the human body. Thus, it is useful as a high-value-added anticoagulant and a food or beverage composition for preventing thrombus formation.
摘要翻译：本发明涉及含有聚-γ-谷氨酸（PGA）作为活性成分的用于预防血栓形成的抗凝血剂和组合物。本发明的PGA是一种水溶性，阴离子，可生物降解和可食用的氨基酸聚合物材料，其具有防止血栓在血管中积聚的抗凝作用，显示出优异的持续释放作用并对人体无害。因此，作为高附加值抗凝剂和用于预防血栓形成的食品或饮料组合物是有用的。

2. 发明授权

US08618057B2 Anticoagulant and composition for preventing thrombus containing poly-gamma-glutamic acid 失效
标题翻译：用于预防含有聚-γ-谷氨酸的血栓的抗凝血剂和组合物
公开(公告)号：US08618057B2
公开(公告)日：2013-12-31
申请号：US13444324
申请日：2012-04-11
申请人： Moon-Hee Sung , Chung Park , Seung-Pyo Hong , Haryoung Poo , Tae-Woo Kim
发明人： Moon-Hee Sung , Chung Park , Seung-Pyo Hong , Haryoung Poo , Tae-Woo Kim
IPC分类号： A61K38/02
CPC分类号： A61K31/74 , A23L33/175 , A61K9/0095
摘要： The present invention relates to an anticoagulant and a composition for preventing thrombus formation, which contain poly-gamma-glutamic acid (PGA) as an active ingredient. The inventive PGA is a water-soluble, anionic, biodegradable and edible amino acid polymer material, which has an anticoagulant effect of preventing thrombi from being accumulated in blood vessels, shows an excellent sustained-release effect and is harmless to the human body. Thus, it is useful as a high-value-added anticoagulant and a food or beverage composition for preventing thrombus formation.
摘要翻译：本发明涉及含有聚-γ-谷氨酸（PGA）作为活性成分的用于预防血栓形成的抗凝血剂和组合物。本发明的PGA是一种水溶性，阴离子，可生物降解和可食用的氨基酸聚合物材料，其具有防止血栓在血管中积聚的抗凝作用，显示出优异的持续释放作用并对人体无害。因此，作为高附加值抗凝剂和用于预防血栓形成的食品或饮料组合物是有用的。

3. 发明申请

US20060199185A1 Plasmid having a function of t-vector and expression vector, and expression of the target gene using the same 审中-公开
标题翻译：具有t载体和表达载体的功能的质粒以及使用其的靶基因的表达
公开(公告)号：US20060199185A1
公开(公告)日：2006-09-07
申请号：US10564880
申请日：2003-12-31
申请人： Young Song , Haryoung Poo , Moon-Hee Sung , Seung-Pyo Hong , Yoon Ho Choi , Kwang Kim , Il Han Lee , Je Hyun Park
发明人： Young Song , Haryoung Poo , Moon-Hee Sung , Seung-Pyo Hong , Yoon Ho Choi , Kwang Kim , Il Han Lee , Je Hyun Park
IPC分类号： C40B40/02 , C40B40/08 , C12Q1/68 , C12N15/74
CPC分类号： C12N15/64
摘要： The present invention relates to a plasmid (pHCE-FOREX) functioning as both a T-vector and an expression vector, which is produced by imparting a T-vector function to an HCE promoter derived from a constitutive high-level expression vector and can express a target protein in a simple and rapid manner. Also, the present invention relates to an expression vector having the target gene inserted into the plasmid, and the expression of the target gene using the same. The plasmid of the present invention can be converted into a vector that expresses the target protein by one-step T-vector cloning in a simple and rapid manner. The plasmid converted into the expression vector does not require a re-transformation step and allows the high-level expression of the target protein only by the culturing of transformed E. coli without the addition of an expensive inducer. Thus, according to the present invention, expression plasmids for large amounts of target genes can be produced at the same time, so that the present invention will be very efficient in establishing expression systems for certain genomes and gene groups.
摘要翻译：本发明涉及用作T载体和表达载体两者的质粒（pHCE-FOREX），其通过赋予来自组成型高水平表达载体的HCE启动子产生T载体功能而产生，并可表达目标蛋白以简单快速的方式。此外，本发明涉及将靶基因插入质粒的表达载体，以及使用该表达载体的靶基因的表达。本发明的质粒可通过简单快速的一步T载体克隆转化为表达靶蛋白的载体。转化成表达载体的质粒不需要再转化步骤，并且仅通过培养转化的大肠杆菌而不添加昂贵的诱导物才允许靶蛋白的高水平表达。因此，根据本发明，可以同时生产大量靶基因的表达质粒，从而本发明在建立某些基因组和基因组的表达系统方面将非常有效。

4. 发明申请

US20100196956A1 NOVEL CONSTITUTIVE STRONG PROMOTER AND USE THEREOF 有权
标题翻译：新宪法强力促进者及其使用
公开(公告)号：US20100196956A1
公开(公告)日：2010-08-05
申请号：US12532605
申请日：2008-03-21
申请人： Moon Hee Sung , Chul Joong Kim , Seung-Pyo Hong , Haryoung Poo , Il Han Lee , Ji Yeon Kim , Kwang Kim
发明人： Moon Hee Sung , Chul Joong Kim , Seung-Pyo Hong , Haryoung Poo , Il Han Lee , Ji Yeon Kim , Kwang Kim
IPC分类号： C12P21/06 , C07H21/04 , C12N15/63 , C12N1/00 , C12N1/21
CPC分类号： C12N15/746 , C12N9/1276
摘要： Disclosed herein are an aldolase gene promoter and the use thereof, more particularly, disclosed are a promoter of aldolase gene derived from Lactobacillus casei, having a base sequence of SEQ ID NO: 1, an expression vector containing said promoter, and a recombinant microorganism transformed with said expression vector. The recombinant microorganism transformed with the expression vector containing the disclosed promoter can effectively express a target protein on the surface thereof, and thus will be useful as vaccine vehicles and the like.
摘要翻译：本文公开了醛缩酶基因启动子及其用途，更具体地，公开了源自干酪乳杆菌的醛缩酶基因的启动子，其具有SEQ ID NO：1的碱基序列，含有所述启动子的表达载体和转化的重组微生物与所述表达载体。用含有公开的启动子的表达载体转化的重组微生物可以在其表面上有效地表达靶蛋白质，因此可用作疫苗载体等。

5. 发明授权

US08236940B2 Constitutive strong promoter and use thereof 有权
标题翻译：组成型强启动子及其用途
公开(公告)号：US08236940B2
公开(公告)日：2012-08-07
申请号：US12532605
申请日：2008-03-21
申请人： Moon Hee Sung , Chul Joong Kim , Seung-Pyo Hong , Haryoung Poo , Il Han Lee , Ji Yeon Kim , Kwang Kim
发明人： Moon Hee Sung , Chul Joong Kim , Seung-Pyo Hong , Haryoung Poo , Il Han Lee , Ji Yeon Kim , Kwang Kim
IPC分类号： C07H21/04 , C12N15/63 , C12N1/21 , C12P21/00
CPC分类号： C12N15/746 , C12N9/1276
摘要： Disclosed herein are an aldolase gene promoter and the use thereof, more particularly, disclosed are a promoter of aldolase gene derived from Lactobacillus casei, having a base sequence of SEQ ID NO: 1, an expression vector containing said promoter, and a recombinant microorganism transformed with said expression vector. The recombinant microorganism transformed with the expression vector containing the disclosed promoter can effectively express a target protein on the surface thereof, and thus will be useful as vaccine vehicles and the like.
摘要翻译：本文公开了醛缩酶基因启动子及其用途，更具体地，公开了源自干酪乳杆菌的醛缩酶基因的启动子，其具有SEQ ID NO：1的碱基序列，含有所述启动子的表达载体和转化的重组微生物与所述表达载体。用含有公开的启动子的表达载体转化的重组微生物可以在其表面上有效地表达靶蛋白质，因此可用作疫苗载体等。

6. 发明申请

US20110318384A1 VECTOR FOR TREATMENT VACCINE FOR STABLE AND CONSTITUTIVE HIGH-EXPRESSION CERVICAL CANCER AND RECOMBINANT LACTOBACILLUS TRANSFORMED BY THE SAME 有权
标题翻译：用于稳定和构成型高表达癌细胞的转基因疫苗和由其转化的重组乳酸杆菌
公开(公告)号：US20110318384A1
公开(公告)日：2011-12-29
申请号：US13143700
申请日：2010-01-08
申请人： Moon-Hee Sung , Haryoung Poo , Il Han Lee
发明人： Moon-Hee Sung , Haryoung Poo , Il Han Lee
IPC分类号： A61K39/12 , A61P37/04 , A61P35/00 , C12N15/74 , C12N1/21
CPC分类号： C12N15/746 , A61K39/12 , A61K2039/523 , A61K2039/542 , C12N2710/20034 , C12N2710/20045 , C12N2810/55
摘要： A surface expression vector for preparing HPV vaccines, in which the surface expression vector contains a gene encoding a repE mutant protein having an amino acid sequence of SEQ ID NO: 1, a promoter, a poly-gamma-glutamate synthetase complex gene, and a gene which is linked with the poly-gamma-glutamate synthetase complex gene and encodes a tumor induction-associated antigen protein of human papillomavirus.An expression vector constitutively expressing a high level of the human papillomavirus (HPV) antigen protein is provided. Also, a recombinant lactic acid bacteria, transformed with the expression vector and expressing the HPV antigen protein on the surface thereof, and a composition comprising the recombinant lactic acid bacteria are provided. The recombinant lactic acid bacteria and the composition are very effective as a vaccine for the treatment of cervical cancer, because they can be applied orally or directly to the vagina.
摘要翻译：用于制备HPV疫苗的表面表达载体，其中所述表面表达载体含有编码具有SEQ ID NO：1的氨基酸序列的repE突变蛋白的基因，启动子，聚-γ-谷氨酸合成酶复合物基因和基因，其与多聚-γ-谷氨酸合成酶复合物基因连接并编码人乳头瘤病毒的肿瘤诱导相关抗原蛋白。提供了组成型表达高水平人乳头瘤病毒（HPV）抗原蛋白的表达载体。此外，提供了用表达载体转化并在其表面上表达HPV抗原蛋白的重组乳酸菌和包含重组乳酸菌的组合物。重组乳酸菌和组合物作为用于治疗子宫颈癌的疫苗非常有效，因为它们可以口服或直接施用于阴道。

7. 发明申请

US20100256050A1 COMPOSITION FOR PREVENTING VIRUS INFECTION COMPRISING POLY-GAMMA-GLUTAMIC ACID 审中-公开
标题翻译：用于预防包含多糖 - 谷氨酸的病毒感染的组合物
公开(公告)号：US20100256050A1
公开(公告)日：2010-10-07
申请号：US12678027
申请日：2007-09-13
申请人： Moon-Hee Sung , Chul Joong Kim , Haryoung Poo , Young-Ki Choi , Il Han Lee , Dai-Won Yoo
发明人： Moon-Hee Sung , Chul Joong Kim , Haryoung Poo , Young-Ki Choi , Il Han Lee , Dai-Won Yoo
IPC分类号： A61K38/16 , A61P31/12
CPC分类号： A61K31/785 , A61K38/164
摘要： The present invention relates to a pharmaceutical composition for inhibiting or preventing viral infection, which comprises an effective dose of poly-gamma-glutamic acid (γ-PGA), and more particularly, to a pharmaceutical composition, a functional food, and a feedstuff additive capable of inhibiting viral infection and preventing viral diseases, which comprise poly-gamma-glutamic acid having an infection-inhibiting effect against viruses, such as an influenza virus, inducing respiratory infection or systemic infection, as an effective ingredient.The composition containing poly-gamma-glutamic acid as an effective ingredient according to the present invention, is effective for use as an animal feedstuff additive or a pharmaceutical agent for preventing influenza virus infection and various viral diseases as well as a pharmaceutical composition and a functional food to promote human health.
摘要翻译：本发明涉及用于抑制或预防病毒感染的药物组合物，其包含有效剂量的聚-γ-谷氨酸（γ-PGA），更具体地，涉及药物组合物，功能性食品和饲料添加剂能够抑制病毒感染和预防病毒性疾病，其包含对病毒（例如流感病毒）诱导呼吸道感染或全身感染具有感染抑制作用的聚-γ-谷氨酸作为有效成分。含有根据本发明的有效成分的聚-γ-谷氨酸的组合物可用作动物饲料添加剂或用于预防流感病毒感染和各种病毒性疾病的药剂以及药物组合物和功能性食物促进人体健康。

8. 发明授权

US08470551B2 Surface expression vector for fusion protein of Myo-2 peptide multimer and myostatin, and microorganism transformed by thereof 有权
标题翻译： Myo-2肽多聚体和肌生成抑制素融合蛋白的表面表达载体，以及由其转化的微生物
公开(公告)号：US08470551B2
公开(公告)日：2013-06-25
申请号：US12682453
申请日：2007-11-30
申请人： Moon-Hee Sung , Chul Joong Kim , Haryoung Poo , Ji Yeon Kim , Young Suk Kim , Long Chun Xu
发明人： Moon-Hee Sung , Chul Joong Kim , Haryoung Poo , Ji Yeon Kim , Young Suk Kim , Long Chun Xu
IPC分类号： C12N15/09 , C12N1/21 , C12N15/63 , C07K1/00
CPC分类号： C07K14/475
摘要： The present invention relates to a fusion protein in which a myostatin mature protein is fused to a multimer of myostatin-derived antigenic peptide Myo-2, a surface expression vector containing a polynucleotide encoding the fusion protein, a recombinant microorganism transformed with the vector, and a feedstuff additive or a pharmaceutical composition containing the microorganism as an effective ingredient. The feedstuff additive or pharmaceutical composition according to the present invention can be used for muscle development and regulation of muscle growth in livestock and poultry, as well as for preventing and treating muscle-wasting diseases and degenerative diseases such as muscular dystrophy, muscular atrophy and the like. In addition, the transformed strain shows the same effect even if the strain itself after culture thereof is directly used, and thus it is very economical.
摘要翻译：本发明涉及一种融合蛋白，其中肌生成抑制素成熟蛋白质与产生肌生成抑制素的抗原肽Myo-2的多聚体融合，含有编码融合蛋白的多核苷酸的表面表达载体，用载体转化的重组微生物，以及饲料添加剂或含有该微生物作为有效成分的药物组合物。根据本发明的饲料添加剂或药物组合物可用于肌肉发育和调节家畜和家禽中的肌肉生长，以及用于预防和治疗肌肉消瘦疾病和退行性疾病如肌营养不良症，肌肉萎缩症和喜欢。此外，即使直接使用其培养后的菌株本身，转化菌株也显示相同的效果，因此是非常经济的。

9. 发明申请

US20120164174A1 ADJUVANT COMPOSITION CONTAINING POLY-GAMMA-GLUTAMIC ACID-CHITOSAN NANOPARTICLES 有权
标题翻译：含有聚氨基酸 - 谷氨酸 - 壳聚糖纳米粒子的补充剂组合物
公开(公告)号：US20120164174A1
公开(公告)日：2012-06-28
申请号：US13380503
申请日：2010-06-25
申请人： Moon-Hee Sung , Haryoung Poo , Chul Joong Kim , Young-Ki Choi , Yong Taík Lim , Dong Jin Jeong , Sang-Mu Shim
发明人： Moon-Hee Sung , Haryoung Poo , Chul Joong Kim , Young-Ki Choi , Yong Taík Lim , Dong Jin Jeong , Sang-Mu Shim
IPC分类号： A61K39/39 , A61K39/145 , A61P29/00 , A61P35/00 , A61P31/16 , A61P31/00 , C07K17/10 , A61K39/00
CPC分类号： A61K39/39 , A61K39/12 , A61K39/145 , A61K2039/543 , A61K2039/55583 , C12N2760/16134
摘要： The present invention relates to an adjuvant composition containing poly-gamma-glutamic acid-chitosan nanoparticles and a vaccine composition containing the adjuvant composition, and more particularly to an adjuvant composition containing nanoparticles prepared by ionic bonding between poly-gamma-glutamic acid having ensured safety and chitosan, and a vaccine composition containing the poly-gamma-glutamic acid-chitosan nanoparticles and an antigen. The adjuvant containing the poly-gamma-glutamic acid-chitosan nanoparticles has little or no toxicity and side effects and is added to human or animal vaccines for the prevention and treatment of viral and bacterial infections and cancers to increase the production of antibodies.
摘要翻译：本发明涉及包含聚-γ-谷氨酸 - 壳聚糖纳米颗粒的佐剂组合物和含有佐剂组合物的疫苗组合物，更具体地说涉及含有通过确保安全性的聚-γ-谷氨酸之间的离子键合制备的纳米颗粒的佐剂组合物和壳聚糖，以及含有聚-γ-谷氨酸 - 壳聚糖纳米粒子和抗原的疫苗组合物。含有聚-γ-谷氨酸 - 壳聚糖纳米颗粒的佐剂很少或没有毒性和副作用，并加入到人或动物疫苗中，用于预防和治疗病毒和细菌感染和癌症以增加抗体的产生。

10. 发明申请

US20120156172A1 NEW LACTIC ACID BACTERIA HAVING ITS INHIBITORY EFFECT ON AVIAN INFLUENZA VIRUS INFECTION AND COMPOSITION CONTAINING THE SAME 审中-公开
标题翻译：具有对AVIAN流感病毒感染的抑制作用的新型酸性细菌和含有其的组合物
公开(公告)号：US20120156172A1
公开(公告)日：2012-06-21
申请号：US13378761
申请日：2010-06-17
申请人： Jong-Bok Rho , Haryoung Poo , Young-Ki Choi , Chul Joong Kim , Moon-Hee Sung
发明人： Jong-Bok Rho , Haryoung Poo , Young-Ki Choi , Chul Joong Kim , Moon-Hee Sung
IPC分类号： A61K35/74 , A61P31/16 , C12N1/20
CPC分类号： C12R1/01 , A23K10/18 , A23K50/75 , A61K35/744 , C12N1/20
摘要： The present invention relates to a new microorganism Weissella cibaria BLS13, and more specifically, to a Kimchi-derived new microorganism Weissella cibaria BLS13 which activates an inhibitory effect on avian influenza viruses, and to uses thereof. According to the present invention, the Weissella cibaria BLS13 or a culture medium thereof contains a substance having an anti-viral function, and thus can be used advantageously in feed additives, fermentation products, foods and medicine.
摘要翻译：本发明涉及一种新的微生物鼬螨BLS13，更具体地，涉及一种激活对禽流感病毒的抑制作用的泡菜来源的新型微生物鼬螨BLS13及其用途。根据本发明，茜草BIS13或其培养基含有具有抗病毒功能的物质，因此可以有利地用于饲料添加剂，发酵产品，食品和药物。

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