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1. 发明申请

US20100256050A1 COMPOSITION FOR PREVENTING VIRUS INFECTION COMPRISING POLY-GAMMA-GLUTAMIC ACID 审中-公开
标题翻译：用于预防包含多糖 - 谷氨酸的病毒感染的组合物
公开(公告)号：US20100256050A1
公开(公告)日：2010-10-07
申请号：US12678027
申请日：2007-09-13
申请人： Moon-Hee Sung , Chul Joong Kim , Haryoung Poo , Young-Ki Choi , Il Han Lee , Dai-Won Yoo
发明人： Moon-Hee Sung , Chul Joong Kim , Haryoung Poo , Young-Ki Choi , Il Han Lee , Dai-Won Yoo
IPC分类号： A61K38/16 , A61P31/12
CPC分类号： A61K31/785 , A61K38/164
摘要： The present invention relates to a pharmaceutical composition for inhibiting or preventing viral infection, which comprises an effective dose of poly-gamma-glutamic acid (γ-PGA), and more particularly, to a pharmaceutical composition, a functional food, and a feedstuff additive capable of inhibiting viral infection and preventing viral diseases, which comprise poly-gamma-glutamic acid having an infection-inhibiting effect against viruses, such as an influenza virus, inducing respiratory infection or systemic infection, as an effective ingredient.The composition containing poly-gamma-glutamic acid as an effective ingredient according to the present invention, is effective for use as an animal feedstuff additive or a pharmaceutical agent for preventing influenza virus infection and various viral diseases as well as a pharmaceutical composition and a functional food to promote human health.
摘要翻译：本发明涉及用于抑制或预防病毒感染的药物组合物，其包含有效剂量的聚-γ-谷氨酸（γ-PGA），更具体地，涉及药物组合物，功能性食品和饲料添加剂能够抑制病毒感染和预防病毒性疾病，其包含对病毒（例如流感病毒）诱导呼吸道感染或全身感染具有感染抑制作用的聚-γ-谷氨酸作为有效成分。含有根据本发明的有效成分的聚-γ-谷氨酸的组合物可用作动物饲料添加剂或用于预防流感病毒感染和各种病毒性疾病的药剂以及药物组合物和功能性食物促进人体健康。

2. 发明授权

US09095605B2 Composition for preventing virus infection comprising poly-gamma-glutamic acid 有权
标题翻译：用于预防包含聚-γ-谷氨酸的病毒感染的组合物
公开(公告)号：US09095605B2
公开(公告)日：2015-08-04
申请号：US13234670
申请日：2011-09-16
申请人： Moon-Hee Sung , Chul Joong Kim , Haryoung Poo , Young-Ki Choi , Il Han Lee , Dai-Won Yoo
发明人： Moon-Hee Sung , Chul Joong Kim , Haryoung Poo , Young-Ki Choi , Il Han Lee , Dai-Won Yoo
IPC分类号： A61K38/16 , A61K31/785
CPC分类号： A61K31/785 , A61K38/164
摘要： The present invention relates to a pharmaceutical composition for inhibiting or preventing viral infection, which comprises an effective dose of poly-gamma-glutamic acid (γ-PGA), and more particularly, to a pharmaceutical composition, a functional food, and a feedstuff additive capable of inhibiting viral infection and preventing viral diseases, which comprise poly-gamma-glutamic acid having an infection-inhibiting effect against viruses, such as an influenza virus, inducing respiratory infection or systemic infection, as an effective ingredient.The composition containing poly-gamma-glutamic acid as an effective ingredient according to the present invention, is effective for use as an animal feedstuff additive or a pharmaceutical agent for preventing influenza virus infection and various viral diseases as well as a pharmaceutical composition and a functional food to promote human health.
摘要翻译：本发明涉及用于抑制或预防病毒感染的药物组合物，其包含有效剂量的聚-γ-谷氨酸（γ-PGA），更具体地，涉及药物组合物，功能性食品和饲料添加剂能够抑制病毒感染和预防病毒性疾病，其包含对病毒（例如流感病毒）诱导呼吸道感染或全身感染具有感染抑制作用的聚-γ-谷氨酸作为有效成分。含有根据本发明的有效成分的聚-γ-谷氨酸的组合物可用作动物饲料添加剂或用于预防流感病毒感染和各种病毒性疾病的药剂以及药物组合物和功能性食物促进人体健康。

3. 发明申请

US20120164174A1 ADJUVANT COMPOSITION CONTAINING POLY-GAMMA-GLUTAMIC ACID-CHITOSAN NANOPARTICLES 有权
标题翻译：含有聚氨基酸 - 谷氨酸 - 壳聚糖纳米粒子的补充剂组合物
公开(公告)号：US20120164174A1
公开(公告)日：2012-06-28
申请号：US13380503
申请日：2010-06-25
申请人： Moon-Hee Sung , Haryoung Poo , Chul Joong Kim , Young-Ki Choi , Yong Taík Lim , Dong Jin Jeong , Sang-Mu Shim
发明人： Moon-Hee Sung , Haryoung Poo , Chul Joong Kim , Young-Ki Choi , Yong Taík Lim , Dong Jin Jeong , Sang-Mu Shim
IPC分类号： A61K39/39 , A61K39/145 , A61P29/00 , A61P35/00 , A61P31/16 , A61P31/00 , C07K17/10 , A61K39/00
CPC分类号： A61K39/39 , A61K39/12 , A61K39/145 , A61K2039/543 , A61K2039/55583 , C12N2760/16134
摘要： The present invention relates to an adjuvant composition containing poly-gamma-glutamic acid-chitosan nanoparticles and a vaccine composition containing the adjuvant composition, and more particularly to an adjuvant composition containing nanoparticles prepared by ionic bonding between poly-gamma-glutamic acid having ensured safety and chitosan, and a vaccine composition containing the poly-gamma-glutamic acid-chitosan nanoparticles and an antigen. The adjuvant containing the poly-gamma-glutamic acid-chitosan nanoparticles has little or no toxicity and side effects and is added to human or animal vaccines for the prevention and treatment of viral and bacterial infections and cancers to increase the production of antibodies.
摘要翻译：本发明涉及包含聚-γ-谷氨酸 - 壳聚糖纳米颗粒的佐剂组合物和含有佐剂组合物的疫苗组合物，更具体地说涉及含有通过确保安全性的聚-γ-谷氨酸之间的离子键合制备的纳米颗粒的佐剂组合物和壳聚糖，以及含有聚-γ-谷氨酸 - 壳聚糖纳米粒子和抗原的疫苗组合物。含有聚-γ-谷氨酸 - 壳聚糖纳米颗粒的佐剂很少或没有毒性和副作用，并加入到人或动物疫苗中，用于预防和治疗病毒和细菌感染和癌症以增加抗体的产生。

4. 发明申请

US20120156172A1 NEW LACTIC ACID BACTERIA HAVING ITS INHIBITORY EFFECT ON AVIAN INFLUENZA VIRUS INFECTION AND COMPOSITION CONTAINING THE SAME 审中-公开
标题翻译：具有对AVIAN流感病毒感染的抑制作用的新型酸性细菌和含有其的组合物
公开(公告)号：US20120156172A1
公开(公告)日：2012-06-21
申请号：US13378761
申请日：2010-06-17
申请人： Jong-Bok Rho , Haryoung Poo , Young-Ki Choi , Chul Joong Kim , Moon-Hee Sung
发明人： Jong-Bok Rho , Haryoung Poo , Young-Ki Choi , Chul Joong Kim , Moon-Hee Sung
IPC分类号： A61K35/74 , A61P31/16 , C12N1/20
CPC分类号： C12R1/01 , A23K10/18 , A23K50/75 , A61K35/744 , C12N1/20
摘要： The present invention relates to a new microorganism Weissella cibaria BLS13, and more specifically, to a Kimchi-derived new microorganism Weissella cibaria BLS13 which activates an inhibitory effect on avian influenza viruses, and to uses thereof. According to the present invention, the Weissella cibaria BLS13 or a culture medium thereof contains a substance having an anti-viral function, and thus can be used advantageously in feed additives, fermentation products, foods and medicine.
摘要翻译：本发明涉及一种新的微生物鼬螨BLS13，更具体地，涉及一种激活对禽流感病毒的抑制作用的泡菜来源的新型微生物鼬螨BLS13及其用途。根据本发明，茜草BIS13或其培养基含有具有抗病毒功能的物质，因此可以有利地用于饲料添加剂，发酵产品，食品和药物。

5. 发明授权

US09314520B2 Adjuvant composition containing poly-gamma-glutamic acid-chitosan nanoparticles 有权
标题翻译：含有聚-γ-谷氨酸 - 壳聚糖纳米粒子的佐剂组合物
公开(公告)号：US09314520B2
公开(公告)日：2016-04-19
申请号：US13380503
申请日：2010-06-25
申请人： Moon-Hee Sung , Haryoung Poo , Chul Joong Kim , Young-Ki Choi , Yong Taik Lim , Dong Jin Jeong , Sang-Mu Shim
发明人： Moon-Hee Sung , Haryoung Poo , Chul Joong Kim , Young-Ki Choi , Yong Taik Lim , Dong Jin Jeong , Sang-Mu Shim
IPC分类号： A61K39/39 , A61K39/145 , A61K39/12 , A61K39/00
CPC分类号： A61K39/39 , A61K39/12 , A61K39/145 , A61K2039/543 , A61K2039/55583 , C12N2760/16134
摘要： The present invention relates to an adjuvant composition containing poly-gamma-glutamic acid-chitosan nanoparticles and a vaccine composition containing the adjuvant composition, and more particularly to an adjuvant composition containing nanoparticles prepared by ionic bonding between poly-gamma-glutamic acid having ensured safety and chitosan, and a vaccine composition containing the poly-gamma-glutamic acid-chitosan nanoparticles and an antigen. The adjuvant containing the poly-gamma-glutamic acid-chitosan nanoparticles has little or no toxicity and side effects and is added to human or animal vaccines for the prevention and treatment of viral and bacterial infections and cancers to increase the production of antibodies.
摘要翻译：本发明涉及包含聚-γ-谷氨酸 - 壳聚糖纳米颗粒的佐剂组合物和含有佐剂组合物的疫苗组合物，更具体地说涉及含有通过确保安全性的聚-γ-谷氨酸之间的离子键合制备的纳米颗粒的佐剂组合物和壳聚糖，以及含有聚-γ-谷氨酸 - 壳聚糖纳米粒子和抗原的疫苗组合物。含有聚-γ-谷氨酸 - 壳聚糖纳米颗粒的佐剂几乎没有或没有毒副作用，并加入到人或动物疫苗中，用于预防和治疗病毒和细菌感染和癌症以增加抗体的产生。

6. 发明申请

US20100255040A1 COMPOSITION FOR IMPROVING TLR-MEDIATED CELLULAR IMMUNITY COMPRISING POLY-GAMMA-GLUTAMIC ACID 审中-公开
标题翻译：用于改善包含多糖 - 谷氨酸的TLR介导的细胞免疫的组合物
公开(公告)号：US20100255040A1
公开(公告)日：2010-10-07
申请号：US12682662
申请日：2007-10-15
申请人： Moon-Hee Sung , Chul Joong Kim , Haryoung Poo , Il Han Lee , Yang-Hyun Kim
发明人： Moon-Hee Sung , Chul Joong Kim , Haryoung Poo , Il Han Lee , Yang-Hyun Kim
IPC分类号： A61K39/00 , A61P31/12 , A61P31/04 , A61P35/00
CPC分类号： A61K31/765
摘要： The present invention relates to a composition for improving cellular immunity, which comprises an effective dose of poly-gamma-glutamic acid, and more particularly, to a composition for improving cellular immunity comprising poly-gamma-glutamic acid, which has effects of inducing enhancement of TLR-mediated Th1 cellular immunity and improving antigen presenting activity to maintain the improved activity. The inventive composition comprising an effective dose of poly-gamma-glutamic acid has very little toxicity and side effects, and can be added to a vaccine composition for preventing and treating animal viral or bacterial infections and cancer, or a vaccine composition for preventing and treating human viral or bacterial infections and cancer to show cellular immunity-enhancing effects.
摘要翻译：本发明涉及一种用于改善细胞免疫的组合物，其包含有效剂量的聚-γ-谷氨酸，更具体地，涉及包含多聚γ-谷氨酸的组合物，所述组合物具有诱导增强的作用的TLR介导的Th1细胞免疫并改善抗原呈递活性以维持改善的活性。包含有效剂量的聚-γ-谷氨酸的本发明组合物具有非常少的毒性和副作用，并且可以加入用于预防和治疗动物病毒或细菌感染和癌症的疫苗组合物或用于预防和治疗的疫苗组合物人类病毒或细菌感染和癌症显示细胞免疫增强作用。

7. 发明申请

US20100196956A1 NOVEL CONSTITUTIVE STRONG PROMOTER AND USE THEREOF 有权
标题翻译：新宪法强力促进者及其使用
公开(公告)号：US20100196956A1
公开(公告)日：2010-08-05
申请号：US12532605
申请日：2008-03-21
申请人： Moon Hee Sung , Chul Joong Kim , Seung-Pyo Hong , Haryoung Poo , Il Han Lee , Ji Yeon Kim , Kwang Kim
发明人： Moon Hee Sung , Chul Joong Kim , Seung-Pyo Hong , Haryoung Poo , Il Han Lee , Ji Yeon Kim , Kwang Kim
IPC分类号： C12P21/06 , C07H21/04 , C12N15/63 , C12N1/00 , C12N1/21
CPC分类号： C12N15/746 , C12N9/1276
摘要： Disclosed herein are an aldolase gene promoter and the use thereof, more particularly, disclosed are a promoter of aldolase gene derived from Lactobacillus casei, having a base sequence of SEQ ID NO: 1, an expression vector containing said promoter, and a recombinant microorganism transformed with said expression vector. The recombinant microorganism transformed with the expression vector containing the disclosed promoter can effectively express a target protein on the surface thereof, and thus will be useful as vaccine vehicles and the like.
摘要翻译：本文公开了醛缩酶基因启动子及其用途，更具体地，公开了源自干酪乳杆菌的醛缩酶基因的启动子，其具有SEQ ID NO：1的碱基序列，含有所述启动子的表达载体和转化的重组微生物与所述表达载体。用含有公开的启动子的表达载体转化的重组微生物可以在其表面上有效地表达靶蛋白质，因此可用作疫苗载体等。

8. 发明授权

US08236940B2 Constitutive strong promoter and use thereof 有权
标题翻译：组成型强启动子及其用途
公开(公告)号：US08236940B2
公开(公告)日：2012-08-07
申请号：US12532605
申请日：2008-03-21
申请人： Moon Hee Sung , Chul Joong Kim , Seung-Pyo Hong , Haryoung Poo , Il Han Lee , Ji Yeon Kim , Kwang Kim
发明人： Moon Hee Sung , Chul Joong Kim , Seung-Pyo Hong , Haryoung Poo , Il Han Lee , Ji Yeon Kim , Kwang Kim
IPC分类号： C07H21/04 , C12N15/63 , C12N1/21 , C12P21/00
CPC分类号： C12N15/746 , C12N9/1276
摘要： Disclosed herein are an aldolase gene promoter and the use thereof, more particularly, disclosed are a promoter of aldolase gene derived from Lactobacillus casei, having a base sequence of SEQ ID NO: 1, an expression vector containing said promoter, and a recombinant microorganism transformed with said expression vector. The recombinant microorganism transformed with the expression vector containing the disclosed promoter can effectively express a target protein on the surface thereof, and thus will be useful as vaccine vehicles and the like.
摘要翻译：本文公开了醛缩酶基因启动子及其用途，更具体地，公开了源自干酪乳杆菌的醛缩酶基因的启动子，其具有SEQ ID NO：1的碱基序列，含有所述启动子的表达载体和转化的重组微生物与所述表达载体。用含有公开的启动子的表达载体转化的重组微生物可以在其表面上有效地表达靶蛋白质，因此可用作疫苗载体等。

9. 发明授权

US08470551B2 Surface expression vector for fusion protein of Myo-2 peptide multimer and myostatin, and microorganism transformed by thereof 有权
标题翻译： Myo-2肽多聚体和肌生成抑制素融合蛋白的表面表达载体，以及由其转化的微生物
公开(公告)号：US08470551B2
公开(公告)日：2013-06-25
申请号：US12682453
申请日：2007-11-30
申请人： Moon-Hee Sung , Chul Joong Kim , Haryoung Poo , Ji Yeon Kim , Young Suk Kim , Long Chun Xu
发明人： Moon-Hee Sung , Chul Joong Kim , Haryoung Poo , Ji Yeon Kim , Young Suk Kim , Long Chun Xu
IPC分类号： C12N15/09 , C12N1/21 , C12N15/63 , C07K1/00
CPC分类号： C07K14/475
摘要： The present invention relates to a fusion protein in which a myostatin mature protein is fused to a multimer of myostatin-derived antigenic peptide Myo-2, a surface expression vector containing a polynucleotide encoding the fusion protein, a recombinant microorganism transformed with the vector, and a feedstuff additive or a pharmaceutical composition containing the microorganism as an effective ingredient. The feedstuff additive or pharmaceutical composition according to the present invention can be used for muscle development and regulation of muscle growth in livestock and poultry, as well as for preventing and treating muscle-wasting diseases and degenerative diseases such as muscular dystrophy, muscular atrophy and the like. In addition, the transformed strain shows the same effect even if the strain itself after culture thereof is directly used, and thus it is very economical.
摘要翻译：本发明涉及一种融合蛋白，其中肌生成抑制素成熟蛋白质与产生肌生成抑制素的抗原肽Myo-2的多聚体融合，含有编码融合蛋白的多核苷酸的表面表达载体，用载体转化的重组微生物，以及饲料添加剂或含有该微生物作为有效成分的药物组合物。根据本发明的饲料添加剂或药物组合物可用于肌肉发育和调节家畜和家禽中的肌肉生长，以及用于预防和治疗肌肉消瘦疾病和退行性疾病如肌营养不良症，肌肉萎缩症和喜欢。此外，即使直接使用其培养后的菌株本身，转化菌株也显示相同的效果，因此是非常经济的。

10. 发明申请

US20130296459A1 MEDICAL ADHESIVE COMPOSITION 审中-公开
标题翻译：医用粘合剂组合物
公开(公告)号：US20130296459A1
公开(公告)日：2013-11-07
申请号：US13884912
申请日：2011-11-10
申请人： Moon-Hee Sung , Hiroshi Uyama , Iwamoto Mie , Jae-Chul Choi , Haryoung Poo , Chul Joong Kim
发明人： Moon-Hee Sung , Hiroshi Uyama , Iwamoto Mie , Jae-Chul Choi , Haryoung Poo , Chul Joong Kim
IPC分类号： A61L24/04 , C08K5/1545 , C08K5/053
CPC分类号： A61L24/046 , A61L15/58 , C08K5/053 , C08K5/1545 , C09J177/04 , C08L77/04
摘要： The present invention provides a medical adhesive composition containing poly-gamma-glutamic acid or its salt; and sugar or sugar alcohol, which is edible, water-soluble, anionic and biodegradable. The invention also provides a thickener composition containing poly-gamma-glutamic acid, which can be used as a moisture-absorbing agent, a moisturizing agent and a raw material for cosmetic products.
摘要翻译：本发明提供含有聚-γ-谷氨酸或其盐的医用粘合剂组合物; 和糖或糖醇，其是可食用的，水溶性的，阴离子的和可生物降解的。本发明还提供含有聚-γ-谷氨酸的增稠剂组合物，其可以用作吸湿剂，保湿剂和化妆品的原料。

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