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1. 发明申请

US20130296459A1 MEDICAL ADHESIVE COMPOSITION 审中-公开
标题翻译：医用粘合剂组合物
公开(公告)号：US20130296459A1
公开(公告)日：2013-11-07
申请号：US13884912
申请日：2011-11-10
申请人： Moon-Hee Sung , Hiroshi Uyama , Iwamoto Mie , Jae-Chul Choi , Haryoung Poo , Chul Joong Kim
发明人： Moon-Hee Sung , Hiroshi Uyama , Iwamoto Mie , Jae-Chul Choi , Haryoung Poo , Chul Joong Kim
IPC分类号： A61L24/04 , C08K5/1545 , C08K5/053
CPC分类号： A61L24/046 , A61L15/58 , C08K5/053 , C08K5/1545 , C09J177/04 , C08L77/04
摘要： The present invention provides a medical adhesive composition containing poly-gamma-glutamic acid or its salt; and sugar or sugar alcohol, which is edible, water-soluble, anionic and biodegradable. The invention also provides a thickener composition containing poly-gamma-glutamic acid, which can be used as a moisture-absorbing agent, a moisturizing agent and a raw material for cosmetic products.
摘要翻译：本发明提供含有聚-γ-谷氨酸或其盐的医用粘合剂组合物; 和糖或糖醇，其是可食用的，水溶性的，阴离子的和可生物降解的。本发明还提供含有聚-γ-谷氨酸的增稠剂组合物，其可以用作吸湿剂，保湿剂和化妆品的原料。

2. 发明授权

US08916141B2 Hyaluronidase inhibitor containing poly-gamma-glutamic acid as an effective component 有权
标题翻译：含有聚-γ-谷氨酸作为有效成分的透明质酸酶抑制剂
公开(公告)号：US08916141B2
公开(公告)日：2014-12-23
申请号：US12090678
申请日：2005-10-31
申请人： Moon Hee Sung , Chung Park , Jae Chul Choi , Hiroshi Uyama , So Lim Park
发明人： Moon Hee Sung , Chung Park , Jae Chul Choi , Hiroshi Uyama , So Lim Park
IPC分类号： A61K31/74 , A61Q19/00 , A61Q19/10 , A61Q5/02 , A61Q19/08 , A61K8/88
CPC分类号： A61Q19/08 , A61K8/88 , A61K2800/782 , A61Q5/02 , A61Q19/00 , A61Q19/10
摘要： The present invention relates to a hyaluronidase inhibitor containing poly-gamma-glutamic acid (PGA) as an active ingredient, a composition for maintaining skin elasticity and a composition for improving allergy, wherein each of the compositions contains PGA as an active ingredient. The inventive compositions containing PGA are effective in maintaining skin moisturization and skin elasticity by effectively inhibiting the activity of hyaluronidase which is an enzyme that degrades hyaluronic acid present in the skin dermis. Also, the compositions can relieve allergic symptoms by inhibiting the permeability of inflammatory cells.
摘要翻译：本发明涉及含有聚-γ-谷氨酸（PGA）作为活性成分的透明质酸酶抑制剂，用于保持皮肤弹性的组合物和用于改善过敏的组合物，其中每种组合物含有PGA作为活性成分。含有PGA的本发明组合物通过有效地抑制透明质酸酶的活性来保持皮肤的保湿和皮肤弹性，其是使皮肤真皮中存在的透明质酸降解的酶。此外，组合物可以通过抑制炎性细胞的通透性来缓解过敏症状。

3. 发明申请

US20080247986A1 Hyaluronidase Inhibitor Containing Poly-Gamma-Glutamic Acid as an Effective Component 有权
标题翻译：含有多糖 - 谷氨酸作为有效成分的透明质酸酶抑制剂
公开(公告)号：US20080247986A1
公开(公告)日：2008-10-09
申请号：US12090678
申请日：2005-10-31
申请人： Moon Hee Sung , Chung Park , Jae Chul Choi , Hiroshi Uyama , So Lim Park
发明人： Moon Hee Sung , Chung Park , Jae Chul Choi , Hiroshi Uyama , So Lim Park
IPC分类号： A61K31/785 , A61P17/00
CPC分类号： A61Q19/08 , A61K8/88 , A61K2800/782 , A61Q5/02 , A61Q19/00 , A61Q19/10
摘要： The present invention relates to a hyaluronidase inhibitor containing poly-gamma-glutamic acid (PGA) as an active ingredient, a composition for maintaining skin elasticity and a composition for improving allergy, wherein each of the compositions contains PGA as an active ingredient. The inventive compositions containing PGA are effective in maintaining skin moisturization and skin elasticity by effectively inhibiting the activity of hyaluronidase which is an enzyme that degrades hyaluronic acid present in the skin dermis. Also, the compositions can relieve allergic symptoms by inhibiting the permeability of inflammatory cells.
摘要翻译：本发明涉及含有聚-γ-谷氨酸（PGA）作为活性成分的透明质酸酶抑制剂，用于保持皮肤弹性的组合物和用于改善过敏的组合物，其中每种组合物含有PGA作为活性成分。含有PGA的本发明组合物通过有效地抑制透明质酸酶的活性来保持皮肤的保湿和皮肤弹性，其是使皮肤真皮中存在的透明质酸降解的酶。此外，组合物可以通过抑制炎性细胞的通透性来缓解过敏症状。

4. 发明申请

US20080132440A1 Poly-Gamma-Glutamic Acid-Vitamin Complex and Use Thereof 审中-公开
标题翻译：多糖 - 谷氨酸 - 维生素复合物及其用途
公开(公告)号：US20080132440A1
公开(公告)日：2008-06-05
申请号：US11571269
申请日：2005-03-04
申请人： Moon-Hee Sung , Chung Park , Seok Chan Kim , Gyoo Soon Park , Hiroshi Uyama , Ha Ryoung Poo , Jae Jun Song
发明人： Moon-Hee Sung , Chung Park , Seok Chan Kim , Gyoo Soon Park , Hiroshi Uyama , Ha Ryoung Poo , Jae Jun Song
IPC分类号： A61K38/02 , A61P17/00 , A61P3/02 , C07K2/00 , A61Q1/00
CPC分类号： A61Q19/00 , A61K8/67 , A61K8/676 , A61K8/88 , A61K31/375 , A61K2800/57 , A61Q5/02 , A61Q19/007 , A61Q19/08 , A61Q19/10
摘要： The present invention relates to PGA-vitamin complex containing poly-γ-glutamic acid(PGA), vitamin preparations containing said PGA-vitamin complex or cosmetic compositions. The inventive PGA-vitamin complex having excellent hygroscopicity, moisturizing property and skin compatibility, which is a complex of poly-γ-glutamic acid and vitamin, has the effect of sustained-release as well as improves stability of vitamin having the functions, such as promotion of metabolism, anti-oxidation effect, protection of cell wall, increasing immunity, prevention of dry skin and keratinization, anti-wrinkles and moisturizing skin, thereby being useful as cosmetic compositions and sustained-release vitamin preparations for various applications.
摘要翻译：本发明涉及含有聚-γ-谷氨酸（PGA）的PGA-维生素复合物，含有所述PGA-维生素复合物或化妆品组合物的维生素制剂。具有优异的吸湿性，保湿性和皮肤相容性的本发明的PGA-维生素复合物，其是聚-γ-谷氨酸和维生素的复合物，具有持续释放的作用，并提高具有功能的维生素的稳定性，例如促进新陈代谢，抗氧化作用，保护细胞壁，增加免疫力，预防皮肤干燥和角质化，抗皱和保湿皮肤，从而可用作各种用途的化妆品组合物和缓释维生素制剂。

5. 发明申请

US20100036093A1 CHOLESTEROLAMINE-INTRODUCED POLY-GAMMA-GLUTAMIC ACID DERIVATIVE 审中-公开
标题翻译：甾醇胺引入的多糖 - 谷氨酸衍生物
公开(公告)号：US20100036093A1
公开(公告)日：2010-02-11
申请号：US12300001
申请日：2007-05-09
申请人： Hiroshi Uyama , Yasushi Osanai , Moon-hee Sung
发明人： Hiroshi Uyama , Yasushi Osanai , Moon-hee Sung
IPC分类号： C07K1/10
CPC分类号： C08G69/10 , A61K47/645 , C08G69/48
摘要： Provided is a poly-γ-glutamic acid derivative having appropriately controlled hydrophilicity, which can be processed into a form of fine particles. Provided is a PGA derivative in a form of fine particles having a particle diameter of 50 to 1,000 nm, which is obtained by introducing cholesterol into poly-γ-glutamic acid (PGA). Thus, the PGA particles can be mixed with various biological materials (e.g., medicament) so as to be used in various applications in the field of biotechnology. Specifically, it can be used as a carrier of a medicament, or the like. Further, it is also made possible to use PGA in various applications in the field of nanotechnology that is studied in recent years.
摘要翻译：提供具有适当控制的亲水性的聚-γ-谷氨酸衍生物，其可以加工成细颗粒的形式。提供了通过将胆固醇引入聚-γ-谷氨酸（PGA）而获得的粒径为50〜1000nm的细颗粒形式的PGA衍生物。因此，PGA颗粒可以与各种生物材料（例如药物）混合，以便用于生物技术领域的各种应用中。具体地说，它可以用作药物的载体等。此外，也可以在近年来研究的纳米技术领域的各种应用中使用PGA。

6. 发明授权

US08359159B2 System which mediates providing of map information, server which mediates providing of map information, and method for providing map information 失效
标题翻译：介质提供地图信息的系统，介质提供地图信息的服务器以及用于提供地图信息的方法
公开(公告)号：US08359159B2
公开(公告)日：2013-01-22
申请号：US13145410
申请日：2009-01-26
申请人： Hiroshi Uyama
发明人： Hiroshi Uyama
IPC分类号： G01C21/32
CPC分类号： G01C21/32 , G09B29/00 , H04L67/18 , H04W4/02
摘要： When a map acquisition judgment means judges that the acquisition of map information is required, a terminal device transmits spot position information calculated by a spot information calculation means to a server which mediates providing of the map information, via a first map information providing server where the terminal device is positioned. The server causes an area judgment means to judge according to the spot information an area of providing map information including the spot, identifies a map information providing system on the basis of the judgment, and requests providing of the map information including the spot to a second map information providing server in the area according to the spot position information. The terminal device synthesizes map information held by the terminal and map information provided by the second map information providing server by a map synthesis means and displays the synthesized map information on a display means.
摘要翻译：当地图获取判断装置判断需要获取地图信息时，终端装置经由第一地图信息提供服务器将由点信息计算装置计算出的点位置信息发送到介质提供地图信息的服务器，终端设备定位。服务器使得区域判断装置根据点信息判断提供包括该地点的地图信息的区域，基于该判断来识别地图信息提供系统，并且请求提供包括该地点的地图信息到第二地图信息提供服务器。终端装置通过地图合成装置合成由终端保持的地图信息和由第二地图信息提供服务器提供的地图信息，并将合成的地图信息显示在显示装置上。

7. 发明申请

US20100016628A1 Polyester Polyol 有权
标题翻译：聚酯多元醇
公开(公告)号：US20100016628A1
公开(公告)日：2010-01-21
申请号：US12439765
申请日：2007-03-08
申请人： Hiroshi Uyama , Yinan Yin , Takashi Tsujimoto , Hideo Noda , Takahiko Terada
发明人： Hiroshi Uyama , Yinan Yin , Takashi Tsujimoto , Hideo Noda , Takahiko Terada
IPC分类号： C07C69/66
CPC分类号： C08G18/428 , C08G18/4288 , C08G63/08 , C08G63/78 , C08G2101/0025 , C08G2101/0083 , C08G2230/00
摘要： A star-branched polyester polyol is obtained by polymerizing lactide or lactic acid, using, as an initiator, a fat and oil composed mainly of a triacylglycerol that has at least three hydroxyl groups or epoxy groups in its molecule. This polyester polyol has low crystallinity and a low melting point, and thus shows good working properties when used in various applications. Furthermore, this polyester polyol is derived from renewable resources, and, thus, it is highly desirable in view of its effectiveness in protecting the global environment and preventing fossil resources from being depleted.
摘要翻译：以分支中具有至少三个羟基或环氧基的主要由三酰基甘油组成的脂肪和油作为引发剂，聚合丙交酯或乳酸得到星形支链聚酯多元醇。该聚酯多元醇具有低结晶度和低熔点，因此当用于各种应用时显示出良好的加工性能。此外，该聚酯多元醇来自可再生资源，因此鉴于其在保护全球环境和防止化石资源枯竭方面的有效性是非常需要的。

8. 发明申请

US20090093034A1 Method for Separation of Lactic Acid Component from Lactic Acid Fermentation Liquor, and Separation Apparatus 有权
标题翻译：从乳酸发酵液中分离乳酸成分的方法和分离装置
公开(公告)号：US20090093034A1
公开(公告)日：2009-04-09
申请号：US12294376
申请日：2007-03-08
申请人： Hiroshi Uyama , Hideo Noda , Takahiko Terada
发明人： Hiroshi Uyama , Hideo Noda , Takahiko Terada
IPC分类号： C12P7/56 , C12M1/02
CPC分类号： B01D11/0488 , B01D11/0492 , C07C51/48 , Y02P20/582 , C07C59/08
摘要： A lactic acid component (e.g., lactic acid or oligo (lactic acid)) can be obtained by extraction from a lactic acid fermentation liquor with a pH of 4.8 or less, using at least one solvent selected from the group consisting of toluene, xylene, mesitylene, ethylbenzene, methanol, ethanol, propanol, butanol, and mineral spirit. Furthermore, oligo (lactic acid) can be obtained, by heating a lactic acid fermentation liquor with a pH of 4.8 or less under reduced pressure, and washing, with water, the fermentation liquor containing a produced oligo (lactic acid). Hence, a method is provided for separating a lactic acid component from a lactic acid fermentation liquor, which is free from incorporation of impurities and which includes simple steps.
摘要翻译：使用至少一种选自甲苯，二甲苯，二氯甲烷，二氯甲烷，二氯甲烷，二氯甲烷，均三甲苯，乙苯，甲醇，乙醇，丙醇，丁醇和矿物精。此外，通过在减压下加热pH4.8以下的乳酸发酵液，并用水洗涤含有生成的寡聚（乳酸）的发酵液，可以得到寡聚（乳酸）。因此，提供了从不含杂质的乳酸发酵液中分离乳酸成分的方法，其包括简单的步骤。

9. 发明授权

US5824414A Preparation of spherical polyphenol particles 失效
标题翻译：制备球形多酚颗粒
公开(公告)号：US5824414A
公开(公告)日：1998-10-20
申请号：US633378
申请日：1996-04-17
申请人： Shiro Kobayashi , Hiroshi Uyama , Sunao Maeda , Shinichirou Tawaki
发明人： Shiro Kobayashi , Hiroshi Uyama , Sunao Maeda , Shinichirou Tawaki
IPC分类号： C08G61/10 , C12P7/22 , C12P1/00
CPC分类号： C12P7/22 , C08G61/10 , Y10T428/2982
摘要： Phenols are reacted with hydrogen peroxide in a solution comprising an organic solvent compatible with water, water, a peroxidase and a dispersing agent to obtain spherical polyphenol particles.
摘要翻译：苯酚与含有与水，水，过氧化物酶和分散剂相容的有机溶剂的溶液中的过氧化氢反应，得到球状多酚颗粒。

10. 发明申请

US20130058858A1 POLYACRYLONITRILE POROUS BODY 审中-公开
标题翻译：聚异戊二烯多孔体
公开(公告)号：US20130058858A1
公开(公告)日：2013-03-07
申请号：US13696133
申请日：2011-05-02
申请人： Hiroshi Uyama , Takashi Tsujimoto , Keisuke Okada , Tatsuya Oka
发明人： Hiroshi Uyama , Takashi Tsujimoto , Keisuke Okada , Tatsuya Oka
IPC分类号： C08J9/00 , C01B31/02 , C08F120/44
CPC分类号： C08J9/28 , C08J2201/0522 , C08J2333/20
摘要： A method for producing a porous body containing polyacrylonitrile as a main component, and the method includes the steps of obtaining a polyacrylonitrile solution by heating and dissolving the polyacrylonitrile in a solvent, obtaining a product precipitated by cooling the polyacrylonitrile solution, and obtaining the porous body containing the polyacrylonitrile as a main component by separating and drying the product. The solvent contains a poor solvent for the polyacrylonitrile and a good solvent for the polyacrylonitrile.
摘要翻译：一种以聚丙烯腈为主要成分的多孔体的制造方法，其特征在于，通过将聚丙烯腈加热溶解在溶剂中而获得聚丙烯腈溶液，得到通过冷却聚丙烯腈溶液而沉淀的产物，得到多孔体通过分离和干燥产物，含有聚丙烯腈作为主要成分。该溶剂含有用于聚丙烯腈的不良溶剂和用于聚丙烯腈的良溶剂。

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