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1. 发明授权

US07852551B2 Optical-scanning microscope examination apparatus 有权
标题翻译：光学扫描显微镜检查仪
公开(公告)号：US07852551B2
公开(公告)日：2010-12-14
申请号：US11628762
申请日：2005-06-09
申请人： Mitsuhiro Hara , Hiroshi Tosaka , Akihiro Horii , Kazunari Tokuda , Yoshihisa Tanikawa
发明人： Mitsuhiro Hara , Hiroshi Tosaka , Akihiro Horii , Kazunari Tokuda , Yoshihisa Tanikawa
IPC分类号： G02B21/00
CPC分类号： G02B21/22 , A61B5/0059 , A61B5/0068 , A61B2503/40 , G02B21/0036
摘要： A clear image having suppressed blurring due to pulsing is obtained by in-vivo examination of biological tissue or various internal organs of mammals, including small laboratory animals. The invention provides an optical-scanning microscope examination apparatus including a light source; a light-transmitting member for transmitting light from the light source; a collimator optical system for converting the transmitted light to a collimated beam; a beam-scanning unit for scanning the collimated beam on a subject; a focusing optical system for focusing the scanned beam onto the subject; a pupil-projection optical system; a light detector for detecting return light returning from the subject via the focusing optical system, the pupil-projection optical system, the beam-scanning unit, the collimator optical system, and the light-transmitting member; an actuator for moving the collimator optical system in an optical-axis direction; a control apparatus for controlling driving thereof; and a deflecting mechanism for deflecting the light issuing from the light-transmitting member in a direction intersecting the optical axis thereof, wherein the actuator is disposed in a space parallel to a plane including optical axes before and after deflection by the deflecting mechanism.
摘要翻译：通过对包括小实验室动物在内的哺乳动物的生物组织或各种内部器官的体内检查来获得抑制由于脉冲引起的模糊的清晰图像。本发明提供一种包括光源的光学扫描显微镜检查装置; 用于从光源透射光的透光构件; 用于将透射光转换成准直光束的准直器光学系统; 用于扫描被摄体上的准直光束的光束扫描单元; 用于将扫描光束聚焦到被摄体上的聚焦光学系统; 瞳孔投影光学系统; 光检测器，用于检测从对象经由聚焦光学系统，瞳孔投影光学系统，光束扫描单元，准直仪光学系统和透光元件返回的返回光; 用于沿准直光学系统沿光轴方向移动的致动器; 用于控制其驱动的控制装置; 以及偏转机构，用于偏转从所述透光部件发出的光沿与其光轴相交的方向，其中所述致动器设置在与所述偏转机构偏转前后包括光轴的平面平行的空间中。

2. 发明申请

US20080130103A1 Optical-Scanning Microscope Examination Apparatus 有权
标题翻译：光学扫描显微镜检查仪器
公开(公告)号：US20080130103A1
公开(公告)日：2008-06-05
申请号：US11628762
申请日：2005-06-09
申请人： Mitsuhiro Hara , Hiroshi Tosaka , Akihiro Horii , Yoshihisa Tanikawa
发明人： Mitsuhiro Hara , Hiroshi Tosaka , Akihiro Horii , Yoshihisa Tanikawa
IPC分类号： G02B21/06
CPC分类号： G02B21/22 , A61B5/0059 , A61B5/0068 , A61B2503/40 , G02B21/0036
摘要： A clear image having suppressed blurring due to pulsing is obtained by in-vivo examination of biological tissue or various internal organs of mammals, including small laboratory animals. The invention provides an optical-scanning microscope examination apparatus including a light source; a light-transmitting member for transmitting light from the light source; a collimator optical system for converting the transmitted light to a collimated beam; a beam-scanning unit for scanning the collimated beam on a subject; a focusing optical system for focusing the scanned beam onto the subject; a pupil-projection optical system; a light detector for detecting return light returning from the subject via the focusing optical system, the pupil-projection optical system, the beam-scanning unit, the collimator optical system, and the light-transmitting member; an actuator for moving the collimator optical system in an optical-axis direction; a control apparatus for controlling driving thereof; and a deflecting mechanism for deflecting the light issuing from the light-transmitting member in a direction intersecting the optical axis thereof, wherein the actuator is disposed in a space parallel to a plane including optical axes before and after deflection by the deflecting mechanism.
摘要翻译：通过对包括小实验室动物在内的哺乳动物的生物组织或各种内部器官的体内检查来获得抑制由于脉冲引起的模糊的清晰图像。本发明提供一种包括光源的光学扫描显微镜检查装置; 用于从光源透射光的透光构件; 用于将透射光转换成准直光束的准直器光学系统; 用于扫描被摄体上的准直光束的光束扫描单元; 用于将扫描光束聚焦到被摄体上的聚焦光学系统; 瞳孔投影光学系统; 光检测器，用于检测从对象经由聚焦光学系统，瞳孔投影光学系统，光束扫描单元，准直仪光学系统和透光元件返回的返回光; 用于沿准直光学系统沿光轴方向移动的致动器; 用于控制其驱动的控制装置; 以及偏转机构，用于偏转从所述透光部件发出的光沿与其光轴相交的方向，其中所述致动器设置在与所述偏转机构偏转前后包括光轴的平面平行的空间中。

3. 发明授权

US07980540B2 Stabilizer for in vivo examination 有权
标题翻译：稳定剂用于体内检查
公开(公告)号：US07980540B2
公开(公告)日：2011-07-19
申请号：US11730074
申请日：2007-03-29
申请人： Yoshihisa Tanikawa , Ryoji Hyodo , Kayuri Muraki
发明人： Yoshihisa Tanikawa , Ryoji Hyodo , Kayuri Muraki
IPC分类号： B23Q3/00
CPC分类号： G02B21/24 , G02B21/26 , G02B23/2476 , Y10S269/909 , Y10T29/53961
摘要： Dynamic movement of a specimen in a pressing direction and in directions intersecting the pressing direction is effectively suppressed, while maintaining the viability of the specimen. A stabilizer for in vivo examination that is placed in contact with a biological specimen during examination of the specimen to suppress movement thereof includes a contact-area increasing portion that is provided on a contact surface with the biological specimen and that is configured to increase the contact area with the biological specimen by virtue of a pressure applied during the contact.
摘要翻译：在保持试样的活力的同时，有效地抑制试样在按压方向和与挤压方向交叉的方向上的动态运动。用于在检查试样以抑制其运动时与生物样品接触的体内检查的稳定剂包括设置在与生物样本接触表面并且被配置为增加接触的接触面积增加部分通过在接触期间施加的压力与生物样品的区域。

4. 发明授权

US07804642B2 Scanning examination apparatus 有权
标题翻译：扫描检查仪
公开(公告)号：US07804642B2
公开(公告)日：2010-09-28
申请号：US11913833
申请日：2006-05-16
申请人： Nobuyuki Nagasawa , Masahiro Oba , Tetsuya Koike , Yoshihisa Tanikawa , Yujin Arai
发明人： Nobuyuki Nagasawa , Masahiro Oba , Tetsuya Koike , Yoshihisa Tanikawa , Yujin Arai
IPC分类号： G02B21/06
CPC分类号： G02B21/002 , G02B21/008 , G02B21/365
摘要： A scanning examination apparatus 1 is provided, the apparatus including a detachable objective lens 6 or 6′, a scanner 3 for two-dimensionally scanning light F from a specimen 100 focused by the objective lens 6 or 6′, a scanner control device 13 for controlling the operation of the scanner 3, and an optical detector 9 for detecting light scanned by the scanner 3, wherein the scanner control device 13 changes the scanning direction of the light F depending on an image formation mode of the light F at the objective lens 6 or 6′ which is attached.
摘要翻译：提供了一种扫描检查装置1，该装置包括一个可拆卸的物镜6或6'，用于从由物镜6或6'聚焦的样本100二维地扫描光F的扫描器3，用于控制扫描仪3的操作，以及用于检测由扫描器3扫描的光的光学检测器9，其中扫描仪控制装置13根据物镜上的光F的图像形成模式改变光F的扫描方向 6或6'。

5. 发明申请

US20080174859A1 IN VIVO EXAMINATION APPARATUS 有权
标题翻译：体检检查装置
公开(公告)号：US20080174859A1
公开(公告)日：2008-07-24
申请号：US11842561
申请日：2007-08-21
申请人： Yoshihisa Tanikawa , Tomoaki Sato , Ryoji Hyodo
发明人： Yoshihisa Tanikawa , Tomoaki Sato , Ryoji Hyodo
IPC分类号： G02B21/00
CPC分类号： G02B27/646 , A61B5/0059 , A61B5/4244 , A61B90/20 , A61B2503/40 , A61B2562/146 , G02B21/24
摘要： An in vivo examination apparatus including an objective unit capable of being readily replaced during examination is provided. The in vivo examination apparatus includes a main body, a vibration suppressor configured to suppress vibrations in an examination region of an object under examination, and an objective optical system configured to observe the examination region where the vibrations are suppressed. The objective optical system and the vibration suppressor are attached to the main body. The objective optical system is attachable to and detachable from the main body in a direction crossing an optical-axis direction of the objective optical system.
摘要翻译：提供一种体内检查装置，其包括能够在检查期间容易地更换的目标单元。体内检查装置包括：主体，抑制检查对象的检查区域的振动的振动抑制器;以及被配置为观察被抑制振动的检查区域的物镜光学系统。物镜光学系统和振动抑制器安装在主体上。物镜光学系统可以在与物镜光学系统的光轴方向交叉的方向上与主体相连接和拆卸。

6. 发明申请

US20070167842A1 In-vivo examination method and in-vivo examination apparatus 有权
标题翻译：体内检查方法和体内检查装置
公开(公告)号：US20070167842A1
公开(公告)日：2007-07-19
申请号：US11640921
申请日：2006-12-19
申请人： Yoshihisa Tanikawa , Tadashi Hirata , Yasuaki Natori , Chika Nakajima , Yoshihiro Kawano
发明人： Yoshihisa Tanikawa , Tadashi Hirata , Yasuaki Natori , Chika Nakajima , Yoshihiro Kawano
IPC分类号： A61B6/00
CPC分类号： A61B1/045 , A61B1/043 , A61B5/0068 , A61B5/0071 , A61B5/0084
摘要： An object is to easily and reliably reach an examination site. The present invention provides an examination method of carrying out in-vivo examination using an in-vivo examination apparatus capable of fluorescence examination and reflected-light examination and includes the steps of setting a reference position so as to set an examination site by carrying out reflected-light examination, switching from reflected-light examination to fluorescence examination, and moving from the reference position to the examination site.
摘要翻译：目的是轻松可靠地到达考场。本发明提供使用能够进行荧光检查和反射光检查的体内检查装置进行体内检查的检查方法，包括以下步骤：设定参考位置，以便通过进行反射光线检查，从反射光检查切换到荧光检查，从参考位置移动到检查点。

7. 发明申请

US20060017920A1 Laser-scanning examination apparatus 有权
标题翻译：激光扫描检查仪
公开(公告)号：US20060017920A1
公开(公告)日：2006-01-26
申请号：US11182782
申请日：2005-07-18
申请人： Atsuhiro Tsuchiya , Yoshihiro Kawano , Yoshihisa Tanikawa , Tadashi Hirata
发明人： Atsuhiro Tsuchiya , Yoshihiro Kawano , Yoshihisa Tanikawa , Tadashi Hirata
IPC分类号： G01J3/30
CPC分类号： G01N21/6458 , G02B21/002 , G02B21/0064 , G02B21/0076 , G02B21/0084 , G02B21/16
摘要： The invention reduces the loss of fluorescence intensity obtained from a specimen to acquire clear fluorescence images when irradiating the specimen with ultrashort-pulse laser light produced by a laser light source. The invention provides a laser-scanning examination apparatus including a laser light source for producing ultrashort-pulse laser light; a laser light source for producing continuous-wave laser light; a measurement head including an optical scanning unit for scanning the laser light on a specimen and an objective optical system; an imaging unit for detecting return light from the specimen in response to the ultrashort-pulse laser light; and an imaging unit for detecting return light from the specimen in response to the continuous-wave laser light. The laser light sources and one imaging unit are connected to the measurement head by an optical fiber, and the other imaging unit is connected to the measurement head by another optical fiber with a larger core diameter.
摘要翻译：本发明减少了从样品获得的荧光强度的损失，以便在用激光光源产生的超短脉冲激光照射样品时获得清晰的荧光图像。本发明提供了一种激光扫描检查装置，其包括用于产生超短脉冲激光的激光光源; 用于产生连续波激光的激光源; 测量头，包括用于扫描样本上的激光的光学扫描单元和物镜光学系统; 用于响应于超短脉冲激光来检测来自样本的返回光的成像单元; 以及用于响应于连续波激光来检测来自样本的返回光的成像单元。激光光源和一个成像单元通过光纤连接到测量头，另一个成像单元通过具有较大芯直径的另一光纤连接到测量头。

8. 发明申请

US20050211872A1 Optical-scanning examination apparatus 有权
标题翻译：光学扫描检查装置
公开(公告)号：US20050211872A1
公开(公告)日：2005-09-29
申请号：US11085047
申请日：2005-03-22
申请人： Yoshihiro Kawano , Tadashi Hirata , Tatsuo Nakata , Yoshihisa Tanikawa
发明人： Yoshihiro Kawano , Tadashi Hirata , Tatsuo Nakata , Yoshihisa Tanikawa
IPC分类号： G02B21/00 , G02B23/26 , G02B7/04
CPC分类号： G02B21/0048 , G02B21/004 , G02B21/0076
摘要： The invention provides an optical-scanning examination apparatus with a simple configuration, in which the resolution of acquired images can be freely changed and in which the fluorescence image intensity and examination depth can be adjusted to suit the purpose of examination. The optical-scanning examination apparatus includes a light source unit; a focusing lens for forming a first intermediate image of excitation light; an imaging lens; a first objective lens; an optical fiber bundle; a second objective lens; and an imaging unit for imaging return light that returns via the second objective lens, the optical fiber bundle, the first objective lens, and the imaging lens. In addition, a scanning mirror device, which is disposed at the first intermediate image position, is formed of a plurality of mirrors that simultaneously receive the first intermediate image and that can be selectively turned on and off.
摘要翻译：本发明提供了一种具有简单结构的光学扫描检查装置，其中可以自由地改变所获取的图像的分辨率，并且可以调整荧光图像强度和检查深度以适应检查的目的。光扫描检查装置包括：光源单元; 用于形成激发光的第一中间图像的聚焦透镜; 成像透镜; 第一个物镜; 光纤束; 第二个物镜; 以及用于对通过第二物镜，光纤束，第一物镜和成像透镜返回的返回光成像的成像单元。此外，设置在第一中间图像位置的扫描镜装置由同时接收第一中间图像并且可以选择性地打开和关闭的多个反射镜形成。

9. 发明授权

US07782528B2 Microscope examination apparatus 有权
标题翻译：显微镜检查仪
公开(公告)号：US07782528B2
公开(公告)日：2010-08-24
申请号：US12435600
申请日：2009-05-05
申请人： Hiroya Fukuyama , Yoshihisa Tanikawa , Tadashi Hirata , Seiya Takahashi
发明人： Hiroya Fukuyama , Yoshihisa Tanikawa , Tadashi Hirata , Seiya Takahashi
IPC分类号： G02B21/36
CPC分类号： G02B21/24 , G02B21/26 , G02B27/646
摘要： A microscope examination apparatus including a light source; an illumination optical system configured to guide light from the light source to a specimen; an objective lens configured to collimate return light from the specimen, the objective lens being provided in such a manner as to be displaceable at least in a direction intersecting an optical axis of the objective lens; an image-forming lens configured to image the return light from the specimen, which is collimated by the objective lens; an optical detector configured to detect the return light imaged by the image-forming lens; a microscope main body including the image-forming lens and the optical detector; and an objective-lens driving mechanism configured to drive the objective lens in a direction correcting image blur due to a displacement of the specimen.
摘要翻译：一种显微镜检查装置，包括光源; 照明光学系统，被配置为将来自所述光源的光引导到样本; 物镜，被配置为准直来自所述样本的返回光，所述物镜以至少在与所述物镜的光轴相交的方向可位移的方式设置; 成像透镜，被配置为对由所述物镜准直的来自所述样本的返回光进行成像; 光学检测器，被配置为检测由图像形成透镜成像的返回光; 包括图像形成透镜和光学检测器的显微镜主体; 以及物镜驱动机构，被配置为在校正由于样本的位移造成的图像模糊的方向上驱动物镜。

10. 发明申请

US20090073554A1 SCANNING EXAMINATION APPARATUS 有权
标题翻译：扫描检查装置
公开(公告)号：US20090073554A1
公开(公告)日：2009-03-19
申请号：US11913833
申请日：2006-05-16
申请人： Nobuyuki Nagasawa , Masahiro Oba , Tetsuya Koike , Yoshihisa Tanikawa , Yujin Arai
发明人： Nobuyuki Nagasawa , Masahiro Oba , Tetsuya Koike , Yoshihisa Tanikawa , Yujin Arai
IPC分类号： G02B21/06
CPC分类号： G02B21/002 , G02B21/008 , G02B21/365
摘要： A scanning examination apparatus 1 is provided, the apparatus including a detachable objective lens 6 or 6′, a scanner 3 for two-dimensionally scanning light F from a specimen 100 focused by the objective lens 6 or 6′, a scanner control device 13 for controlling the operation of the scanner 3, and an optical detector 9 for detecting light scanned by the scanner 3, wherein the scanner control device 13 changes the scanning direction of the light F depending on an image formation mode of the light F at the objective lens 6 or 6′ which is attached.
摘要翻译：提供了一种扫描检查装置1，该装置包括一个可拆卸的物镜6或6'，用于从由物镜6或6'聚焦的样本100二维地扫描光F的扫描器3，用于控制扫描仪3的操作，以及用于检测由扫描器3扫描的光的光学检测器9，其中扫描仪控制装置13根据物镜上的光F的图像形成模式改变光F的扫描方向 6或6'。

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