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1. 发明授权

US5948883A Human CRM1 Protein 失效
标题翻译：人类CRM1蛋白
公开(公告)号：US5948883A
公开(公告)日：1999-09-07
申请号：US975527
申请日：1997-11-20
申请人： Minoru Yoshida , Sueharu Horinouchi , Kazunori Nishi
发明人： Minoru Yoshida , Sueharu Horinouchi , Kazunori Nishi
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12
CPC分类号： C07K14/4703 , A61K38/00
摘要： A protein which comprises the sane or substantially the same amino acid sequence as that represented by SEQ ID NO:1, its partial peptide and their salts are disclosed. DNA encoding the protein or its partial peptide is also disclosed. The protein, its partial peptide or a salt thereof is an inhibitory factor of a transcription factor and, therefore, it is useful as medicine such as prophylactic and therapeutic drugs of, for example, tumors. The DNA is useful as a gene diagnosing drug. The antibody against the protein, etc. is also disclosed. The antibody is used for, for example, quantitative determination of the protein, etc. in a specimen fluid. The protein, etc. are also useful as a reagent for screening for compounds or their salts which promote the function of the protein, etc.
摘要翻译：公开了包含与SEQ ID NO：1所示的基本相同的氨基酸序列的蛋白质，其部分肽及其盐。还公开了编码蛋白质或其部分肽的DNA。蛋白质，其部分肽或其盐是转录因子的抑制因子，因此可用作例如肿瘤的预防和治疗药物等药物。该DNA可用作诊断药物的基因。还公开了针对蛋白质等的抗体。抗体用于例如样品流体中蛋白质等的定量测定。蛋白质等也可用作筛选促进蛋白质等功能的化合物或其盐的试剂。

2. 发明授权

US07488712B2 Histone deacetylase inhibitors and methods for producing the same 失效
标题翻译：组蛋白脱乙酰酶抑制剂及其制备方法
公开(公告)号：US07488712B2
公开(公告)日：2009-02-10
申请号：US10505380
申请日：2003-02-20
申请人： Minoru Yoshida , Norikazu Nishino , Sueharu Horinouchi
发明人： Minoru Yoshida , Norikazu Nishino , Sueharu Horinouchi
IPC分类号： A61K38/00
CPC分类号： C07K5/126 , A61K38/00
摘要： Compounds represented by formula (1) have strong inhibitory activity that is selective towards HDAC1 and HDAC4. Therefore, the compounds of the present invention are useful as pharmaceutical agents for treating or preventing diseases caused by HDAC1 and HDAC4.
摘要翻译：由式（1）表示的化合物具有对HDAC1和HDAC4具有选择性的强抑制活性。因此，本发明的化合物可用作治疗或预防HDAC1和HDAC4引起的疾病的药剂。

3. 发明授权

US06825317B2 Cyclic tetrapeptide derivatives and pharmaceutical uses thereof 失效
标题翻译：环状四肽衍生物及其药物用途
公开(公告)号：US06825317B2
公开(公告)日：2004-11-30
申请号：US09945237
申请日：2001-08-31
申请人： Norikazu Nishino , Minoru Yoshida , Sueharu Horinouchi , Yasuhiko Komatsu
发明人： Norikazu Nishino , Minoru Yoshida , Sueharu Horinouchi , Yasuhiko Komatsu
IPC分类号： C07K752
CPC分类号： C07K5/126 , A61K38/00
摘要： The present invention provides a cyclic tetrapeptide derivative represented by the following general formula (I) or a pharmaceutically acceptable salt thereof: wherein each of R21 and R22 independently denotes hydrogen, a linear C1-C6-alkyl group to which a non-aromatic cycloalkyl group or an optionally substituted aromatic ring may be attached, or a branched C3-C6-alkyl group to which a non-aromatic cycloalkyl group or an optionally substituted aromatic ring may be attached; and each of R1 and R3 independently denotes a linear C1-C5-alkylene group which may have a C1-C6 side chain, in which the side chain may form a condensed ring structure on the alkylene chain. The present invention also provides a histone deacetylase inhibitor, an MHC class-I molecule expression-promoting agent and a pharmaceutical composition, each of which comprises the above cyclic tetrapeptide derivative or pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译：本发明提供由以下通式（I）表示的环状四肽衍生物或其药学上可接受的盐：R21和R22独立地表示氢，非芳香族环烷基的直链C 1 -C 6 - 烷基或可以连接任选取代的芳环，或者可以连接非芳族环烷基或任选取代的芳环的支链C 3 -C 6 - 烷基; R 1和R 3的每一个独立地表示可以具有C 1 -C 6侧链的直链C 1 -C 5亚烷基，其中侧链可以在亚烷基链上形成稠环结构。本发明还提供组蛋白脱乙酰酶抑制剂，MHC I类分子表达促进剂和药物组合物，其各自包含上述环状四肽衍生物或其药学上可接受的盐作为活性成分。

4. 发明授权

US06399568B1 Cyclic tetrapeptide derivatives and medicinal use thereof 失效
标题翻译：环状四肽衍生物及其医药用途
公开(公告)号：US06399568B1
公开(公告)日：2002-06-04
申请号：US09486783
申请日：2000-03-01
申请人： Norikazu Nishino , Minoru Yoshida , Sueharu Horinouchi , Yasuhiko Komatsu , Tsutomu Mimoto
发明人： Norikazu Nishino , Minoru Yoshida , Sueharu Horinouchi , Yasuhiko Komatsu , Tsutomu Mimoto
IPC分类号： A61K3812
CPC分类号： C07K5/126 , A61K38/00
摘要： A cyclic tetrapeptide derivative represented by the general formula (I): wherein: R11, R12, R21 and R22 independently denote a monovalent group selected from hydrogen, a linear or branched alkyl group with 6 or less carbon atoms, benzyl group, 4-methoxybenzyl group, 3-indolylmethyl group, (N-methoxy-3-indolyl) methyl group, (N-formyl-3-indolyl)methyl group, etc.; R3 denotes a divalent group selected from a linear chained hydrocarbon group with 3 or 4 carbon atoms, or the linear branched hydrocarbon group having a branched chain added to the chain, or a divalent group substituted with a heteroatom; R4 denotes a divalent chained hydrocarbon group with 4 to 6 carbon atoms, or a divalent group derived from said hydrocarbon group by addition etc. of a branched chain on said chain; and a pharmaceutically acceptable salt thereof, or an analogous cyclic tetrapeptide derivative compound; as well as a histone deacetylase enzyme inhibitor, an MHC class-I molecule expression promoting agent and a pharmaceutical composition that comprise said cyclic tetrapeptide derivative as an effective ingredient.
摘要翻译：由通式（I）表示的环状四肽衍生物：其中：R11，R12，R21和R22独立地表示选自氢，碳原子数6以下的直链或支链烷基，苄基，4-甲氧基苄基（3-甲氧基-3-吲哚基）甲基，（N-甲酰基-3-吲哚基）甲基等。 R3表示选自具有3或4个碳原子的直链状烃基或者在该链上添加有支链的直链支链烃基或被杂原子取代的二价基团的二价基团; R4表示二价链状烃基或含有4〜6个碳原子的二价基团，或通过所述链上的支链的加成等衍生自所述烃基的二价基团; 和其药学上可接受的盐，或类似的环状四肽衍生物化合物; 以及组蛋白脱乙酰酶酶抑制剂，MHC class I分子表达促进剂和包含所述环状四肽衍生物作为有效成分的药物组合物。

5. 发明授权

US07056884B2 Reduced FK228 and use thereof 有权
标题翻译：减少FK228及其使用
公开(公告)号：US07056884B2
公开(公告)日：2006-06-06
申请号：US10333063
申请日：2001-07-09
申请人： Hidenori Nakajima , Akito Tanaka , Minoru Yoshida , Sueharu Horinouchi
发明人： Hidenori Nakajima , Akito Tanaka , Minoru Yoshida , Sueharu Horinouchi
IPC分类号： A61K38/00 , C07K16/00
CPC分类号： C07K11/02 , A61K38/00 , C07K5/101 , Y02P20/55
摘要： The present invention relates to reduced FK228 of the formula (I) wherein R1 and R2 are the same or different and each is a hydrogen atom or a thiol-protecting group, or a salt thereof, and a histone deacetylase inhibitor containing this compound, an expression potentiator and a reactivation promoter of a transgene, and pharmaceutical agents containing them as active ingredients. The reduced FK228 or a salt thereof has a strong histone deacetylase inhibitory activity and this compound can be used for the prophylaxis or treatment of various diseases, in which histone deacetylation is involved, and for the gene therapy of such diseases.
摘要翻译：本发明涉及式（I）的还原型FK228，其中R 1和R 2相同或不同，各自为氢原子或硫醇保护基或其盐，以及含有该化合物的组蛋白脱乙酰酶抑制剂，转基因的表达增强子和再活化启动子以及含有它们作为有效成分的药剂。还原的FK228或其盐具有强的组蛋白脱乙酰酶抑制活性，该化合物可用于预防或治疗涉及组蛋白脱乙酰化的各种疾病和用于这些疾病的基因治疗。

6. 发明授权

US09959881B2 Voice processing device, audio and video output apparatus, communication system, and sound processing method 有权
公开(公告)号：US09959881B2
公开(公告)日：2018-05-01
申请号：US15664242
申请日：2017-07-31
申请人： Akihito Aiba , Minoru Yoshida
发明人： Akihito Aiba , Minoru Yoshida
IPC分类号： H04R3/00 , G10L21/02 , H04R1/40 , H04N7/15
CPC分类号： G10L21/0205 , G01S3/80 , G10L21/02 , H04N7/147 , H04N7/15 , H04R1/406
摘要： A voice processing device includes: a sound pickup to receive sounds respectively from a plurality of locations; and circuitry to: identify, from the plurality of locations, a sound source location at which a sound source exists, as a current sound source location; specify at least one location of the plurality of locations other than the current sound source location, from at least one sound source location that has been identified as the sound source location during a past predetermined time period, as a specified source location at which a sound to be enhanced exists; enhance a sound from the current sound source location, and a sound from the specified source location; and output an audio signal including the enhanced sounds.

7. 发明授权

US08730318B2 Inspection apparatus and method for producing image for inspection 有权
标题翻译：用于检查图像的检查装置和方法
公开(公告)号：US08730318B2
公开(公告)日：2014-05-20
申请号：US13160108
申请日：2011-06-14
申请人： Kenji Nakahira , Atsushi Miyamoto , Naoki Hosoya , Minoru Yoshida
发明人： Kenji Nakahira , Atsushi Miyamoto , Naoki Hosoya , Minoru Yoshida
IPC分类号： H04N9/47 , H04N5/235 , G06K9/00
CPC分类号： H04N5/265 , H04N5/217 , H04N5/2628 , H04N7/183
摘要： In order to obtain a quality image without deterioration owing to radiation noise in inspection using the optical video camera in high radiation environment, an inspection apparatus is formed of an image pick-up unit, an image obtaining unit which fetches a video image that contains a signal (noise) that is substantially independent of each frame obtained by the image pick-up unit, a local alignment unit which locally aligns frames with different time phases for forming the image fetched by the image obtaining unit, a frame synthesizing unit which synthesizes the plurality of frames aligned by the local alignment unit for generating a synthesis frame with an SN ratio higher than the SN ratio of the frame before frame synthesis, and an image output unit for displaying or recording the image formed of the synthesis frame generated by the frame synthesizing unit.
摘要翻译：为了在高辐射环境下使用光学摄像机的检查中的辐射噪声获得质量图像而不劣化，检查装置由图像拾取单元，图像获取单元，其获取包含信号（噪声），其基本上独立于由图像拾取单元获得的每个帧;局部对准单元，其对具有不同时间相位的帧进行局部对准，以形成由图像获取单元获取的图像;帧合成单元，由本地对准单元对准的多个帧，用于产生SN比高于帧合成之前的帧的SN比的合成帧;以及图像输出单元，用于显示或记录由帧生成的合成帧形成的图像合成单位。

8. 发明授权

US08691578B2 Method for generating homoplasmic cells from heteroplasmic cells 有权
标题翻译：从异质细胞产生同质细胞的方法
公开(公告)号：US08691578B2
公开(公告)日：2014-04-08
申请号：US12965195
申请日：2010-12-10
申请人： Feng Ling , Takehiko Shibata , Rong Niu , Minoru Yoshida , Yu-ichi Goto
发明人： Feng Ling , Takehiko Shibata , Rong Niu , Minoru Yoshida , Yu-ichi Goto
IPC分类号： C12N15/01 , C07H21/04
CPC分类号： C12N5/04 , A01H1/06
摘要： A method includes providing a eukaryotic cell including mutant mtDNA in which there is at least one mutation in the mtDNA, allowing the cell to come into contact with an active oxygen species or a chemical species that generates such an active oxygen species in the cell (e.g., hydrogen peroxide) and thereby changing the percentage of mutant mtDNA (mitochondrial genomic DNA) in the cell as a result of the contact. Also featured are cells obtained by the above-described method.
摘要翻译：一种方法包括提供包括突变mtDNA的真核细胞，其中mtDNA中存在至少一个突变，允许细胞与活性氧物质或在细胞中产生这种活性氧物质的化学物质接触（例如，，过氧化氢），从而改变作为接触的结果的细胞中突变体mtDNA（线粒体基因组DNA）的百分比。还特征在于通过上述方法获得的细胞。

9. 发明申请

US20130204929A1 Information Generation System And Method Therefor 审中-公开
标题翻译：信息生成系统及其方法
公开(公告)号：US20130204929A1
公开(公告)日：2013-08-08
申请号：US13701338
申请日：2011-06-01
申请人： Minoru Yoshida
发明人： Minoru Yoshida
IPC分类号： H04L29/06
CPC分类号： H04L29/06047 , G06F21/572 , G06F21/6281 , G06F2221/2105 , H04L67/34
摘要： Provided are an information generation system and a method therefor capable of generating an operating system corresponding to a request from a user, wherein among operating system resource information managed by a server device, a desired operating system constituting component can be selectively transmitted to a client device. Among the operating system resource information and application resource information managed by a server device 20, a desired operating system constituting component and application is selectively transmitted to a client device 30.
摘要翻译：提供了一种能够生成与来自用户的请求对应的操作系统的信息生成系统及其方法，其中，在由服务器装置管理的操作系统资源信息之中，期望的操作系统构成部件能够选择性地发送到客户端装置。在由服务器装置20管理的操作系统资源信息和应用资源信息中，构成组件和应用的期望的操作系统被选择性地发送到客户端装置30。

10. 发明授权

US08451439B2 Apparatus and method for inspecting pattern 有权
标题翻译：用于检查图案的装置和方法
公开(公告)号：US08451439B2
公开(公告)日：2013-05-28
申请号：US13423862
申请日：2012-03-19
申请人： Sachio Uto , Minoru Yoshida , Toshihiko Nakata , Shunzi Maeda , Atsushi Shimoda
发明人： Sachio Uto , Minoru Yoshida , Toshihiko Nakata , Shunzi Maeda , Atsushi Shimoda
IPC分类号： G01N21/00
CPC分类号： G01N21/21 , G01N21/33 , G01N21/55 , G01N21/9501 , G01N21/956 , G01N21/95607 , G01N2021/151 , G01N2021/95615 , G01N2201/06113 , G01N2201/1035
摘要： A method and apparatus for inspecting defects includes emitting an ultraviolet light from an ultraviolet light source, illuminating a specimen with the ultraviolet light in which a polarization condition of the ultraviolet light is controlled, controlling a polarization condition of light reflected from the specimen which is illuminated by the polarization condition controlled ultraviolet light, detecting the light reflected from the specimen, processing the detected light so as to detect defects, and outputting information about the defects. The ultraviolet light source is disposed in a clean environment supplied with clean gas and separated from outside.
摘要翻译：用于检查缺陷的方法和装置包括从紫外光源发射紫外光，用受紫外光的偏振条件的紫外线照射样本，控制从被照射的样本反射的光的偏振状态通过偏光条件控制的紫外光，检测从样本反射的光，处理检测到的光以检测缺陷，并输出关于缺陷的信息。紫外光源设置在清洁环境中，并提供清洁气体并与外界分离。

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